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Liver disease and erythropoietic protoporphyria:A concise review

World Journal of Gastroenterology 2010年第36期16卷 4526-4531页

作者： mar.a josé Casanova-González mar.a Trapero-marugán E Anthony Jones Ricardo Moreno-Otero Department of the Gastroenterology and Hepatology Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBEREHD)Madrid 28006Spain

The porphyries are a group of metabolic disorders characterized by deficiencies in the activity of enzymes involved in the biosynthesis of *** erythropoietic protoporphyria(EPP),in the majority of cases an autosomal dominant disease,there is a mutation of the gene that encodes ferrochelatase(FECH).FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes,plasma,skin and *** prevalence of this inherited disorder oscillates between 1:75 000 and 1:200 *** manifestations of EPP appear in early infancy upon first exposure to the ***,approximately 5%-20% of patients with EPP develop liver *** of protoporphyrin in the liver is associated with cholestatic phenomena and oxidative stress that predisposes to hepatobiliary disease of varying degrees of severity,such as cholelithiasis,mild parenchymal liver disease,progressive hepatocellular disease with end-stage liver disease and acute liver *** damage is the major risk in EPP patients,so surveillance and frequent clinical and biochemical liver follow-up is *** diagnostic approach consists in detecting increased levels of protoporphyrin,decreased activity of FECH and genetic analysis of the FECH gene.A variety of nonsurgical therapeutic approaches have been adopted for the management of EPP associated with liver disease,but none of these has been shown to be unequivocally ***,some may have a place in preparing patients for liver *** transplantation does not correct the constitutional deficiency of ***,there is a risk of recurrence of liver disease after liver transplantation as a result of continuing overproduction of *** authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease.

关键词： Erythropoietic protoporphyria Protoporphyrin Liver Ferrochelatase

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Rheological and tribological approaches as a tool for the development of sustainable lubricating greases based on nano-montmorillonite and castor oil

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Friction 2021年第2期9卷 415-428页

作者： jose Enrique marTÍN-ALFONSO mar.a jose marTÍN-ALFONSO Concepción VALENCIA mar.a Teresa CUBERES Department of Chemical Engineering and Materials Science Campus de“El Carmen”University of HuelvaChemical Product and Process Technology Research Center(Pro2TecS)Huelva 21071Spain Department of Applied Mechanics and Project Engineering University of Castilla-La ManchaAlmadén 13400Spain

This study investigates the development of novel montmorillonite/castor oil blends to formulate sustainable lubricating greases to promote the replacement of petrochemicals industry-derived materials by substances obtained from renewable ***,the effect of the thickener concentration on the rheological,chemical,thermal,tribological properties,and atomic force microscopy(AFM)microstructure of these systems were *** results showed that the C20A nanoclay content could be used to modulate the viscosity values,the linear viscoelastic functions,and tribological properties of these montmorillonite *** general,these gel-like dispersions exhibited remar.able lubricant properties;the samples showed values of the friction coefficient and wear scars similar or lower than those obtained with model bentonite grease.

关键词： lubricating greases nanoclay vegetable oil rheology tribology

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Adalimumab-induced interstitial pneumonia in a patient with Crohn's disease

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World Journal of Gastroenterology 2015年第7期21卷 2260-2262页

作者： mar.a josé Casanova mar.a Chaparro Claudia Valenzuela Carolina Cisneros Javier P Gisbert Gastroenterology Department Hospital Universitario de La Princesa Instituto de Investigación Sanitaria Princesa (IIS-IP) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Pneumology Department Hospital Universitario de La Princesa

There are several reports of anti-tumor necrosis factor(TNF)-induced lung disease,especially in patients with rheumatologic *** is an antiTNF drug used to induce and maintain remission in patients with immune-mediated diseases,such as Crohn’s *** pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease,biologic therapy could also be a cause of lung *** few cases of adalimumab-induced lung toxicity have been reported,and the majority of them were in patients with rheumatologic *** injury secondary to anti-TNF therapy should,after ruling out other etiologies,be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs.A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis.

关键词： Adalimumab Anti-tumor necrosis factor Crohn’s dise

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On a Variant of Giuga Numbers

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Acta Mathematica Sinica,English Series 2012年第4期28卷 653-660页

作者： jos mar.a GRAU Florian LUCA Antonio M. OLLER-marCN Departmento de Matemáticas Universidad de Oviedo Avda. Calvo Sotelo s/n Instituto de Matemáticas Universidad Nacional Autnoma de México The John Knopfmacher Centre for Applicable Analysis and Number Theory University of the Witwatersrand Centro Universitario de la Defensa Academia General Militar Ctra. Huesca s/n

In this paper, we characterize the odd positive integers n satisfying the congruence ∑j=1^n-1 j n-1/2 We show that the set of such positive integers has an asymptotic densitywhich turns out to be slightly larger than... 详细信息

关键词： Congruence Giuga numbers asymptotic density

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The immune system:uncharted pathways between senses and the brain

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Neural Regeneration Research 2024年第6期19卷 1173-1174页

作者： Noelia Casares mar Cuadrado-Tejedor Ana García-Osta Juan joséLasarte Immunology and Immunotherapy Program Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Division of Gene Therapy for Neurological Disorders Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Pathology Anatomy and Physiology DepartmentSchool of MedicineUniversity of NavarraIDISNAPamplonaSpain

Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth *** perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological *** addition to the direct effects of sense-induced mediators in the brain.

关键词： prompt system transmitting

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How does anodization time affect morphological and photocatalytic properties of iron oxide nanostructures?

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Journal of Materials Science & Technology 2020年第3期38卷 159-169页

作者： Bianca Lucas-Granados Rita Sánchez-Tovar Ramón MFernández-Domene josémar.a Estívalis-martínez joséGarcía-Antón Ingeniería Electroquímica y Corrosión(IEC).Instituto Universitario de Seguridad Industrial Radiofísica y Medioambiental(ISIRYM)Universitat Politècnica de ValènciaCamino de Vera s/n46022ValenciaSpain Departmento de Ingeniería Química Universitat de ValènciaAv de les Universitatss/n46100 BurjassotSpain

Iron oxide nanostructures are promising materials to be used as photocatalysts in different photoelectrochemical applications. There are different techniques in order to synthesize these nanostructures, but one of the most inexpensive and simple method is electrochemical anodization. This method can lead to different nanostructures by controlling its parameters. Anodization time is one of the most critical parameters since it considerably affects the properties of the obtained nanostructures. In this work, different anodization times(5, 10, 15, 30 and 60 min) were studied. The resulting nanotubes were characterized by field emission scanning electron microscopy, Raman laser confocal microscopy, water splitting measurements, Mott-Schottky analysis and electrochemical impedance spectroscopy, in order to test their viability for being used as photocatalysts in photoelectrochemical applications. Results showed that the best photocurrent density values in water splitting tests(0.263 m A m-2) were achieved for the sample anodized for 10 min under hydrodynamic conditions.

关键词： Iron oxide Metallic nanostructures Photoelectrochemistry Anodization Time

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Driving factors of tree biomass and soil carbon pool in xerophytic forests of northeastern Argentina

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Ecological Processes 2023年第1期12卷 916-928页

作者： Silvana mar.a joséSione marcelo Germán Wilson Silvia Gabriela Ledesma Emmanuel Adrián Gabioud joséDaniel Oszust Leandro Javier Rosenberger Centro de Investigación Científica y de Transferencia Tecnológica a la Produc-ción(CICyTTP-CONICET) España 149(3105)DiamanteEntre RíosArgentina Facultad de Ciencias Agropecuarias(FCA-UNER) Universidad Nacional de Entre RíosRuta 11 Km 10.5(3101)Oro VerdeEntre RíosArgentina Instituto Nacional de Tecnología Agropecuaria(INTA) EEA ParanáRuta 11 Km 12.5(3101)Oro VerdeEntre RíosArgentina

Background The conversion of forests into agricultural lands can be a threat because the forests carbon stored could be a source of emissions. The capacity to improve the predictions on the consequences of land use change depends on the identification of factors that influence carbon pools. We investigated the key driving factors of tree biomass and soil carbon pools in xerophytic forests in northeastern Argentina. Based on analyses of forest structure variables and abiotic factors (topography and soil properties) from 18 mature forests, we evaluated carbon pools using uniand multivariate (redundancy analysis) methods. Results The total carbon pool was estimated at 102.4 ± 24.0 Mg ha−1. Soil organic carbon storage is the single largest carbon pool relative to tree biomass, representing 73.1% of total carbon. Tree canopy cover and basal area were positively correlated with biomass carbon pool (r = 0.77 and r = 0.73, p < 0.001, respectively), proving to be significant drivers of carbon storage in this compartment. Slope, soil clay content and cation-exchange capacity had a better explanation for the variability in soil carbon pools, and all showed significant positive correlations with soil carbon pools (r = 0.64, 0.60 and 0.50;p < 0.05, respectively). The vertisols showed a 27.8% higher soil carbon stock than alfisols. Conclusions The relevance of our study stems from a dearth of information on carbon pools and their drivers in xerophytic forests, and in particular, the importance of this ecosystems’ type for Argentina, because they cover 81.9% of native forest area. Basal area and tree canopy cover exert a strong effect on the carbon pool in tree biomass but not in the soil. The results suggests that there is a potentially major SOC accumulation in forests located in slightly sloping areas and soils with higher topsoil clay content, such as vertisols. This could provide an important reference for implementing forestry carbon sink projects.

关键词： Carbon pool Forest biomass Soil parameters Ecosystem services

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Simultaneous analysis of the intestinal parasites and diet through eDNA metabarcoding

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Integrative Zoology 2023年第3期18卷 399-413页

作者： Xabier CABODEVILLA Benjamín Juan GÓMEZ-MOLINER Naiara ABAD mar.a joséMADEIRA Department of Zoology and Animal Cell Biology Faculty of PharmacyUniversity of the Basque Country(UPV/EHU)AlavaSpain Instituto de Investigación en Recursos Cinegéticos(IREC)(CSIC-UCLM-JCCM) Ciudad RealSpain

Agricultural expansion and intensiﬁcation are having a huge impact on plant and arthropod diversity and abun-dance,affecting food availability for farmland ***ﬁcult food access,in turn,can lead to immunosuppression and a higher incidence of *** the studies designed to examine changes in the diet of birds and their par-asites,metabarcoding is proving particularly *** technique requires mini-barcodes capable of amplifying the DNA of target organisms from fecal environmental *** help to understand the impact of agricultural expansion on biodiversity,this study sought to design and identify mini-barcodes that might simultaneously as-sess diet and intestinal parasites from the feces of farmland *** capacity to identify diet and parasites of 2 existing and 3 newly developed mini-barcodes was tested“in silico”in relation to the behavior of a reference eukaryotic *** the newly designed mini-barcodes,MiniB18S_81 showed the higher taxonomic cover-age of eukaryotic taxa and a greater ampliﬁcation and identiﬁcation capacity for diet and parasite ***,when it was tested on fecal samples from 5 different steppe bird species,MiniB18S_81 showed high taxonomic resolution of the most relevant diet and parasite phyla,Arthropoda,Nematoda,Platyhelminthes,and Apicomplexa at the order ***,the mini-barcode developed emerges as an excellent tool to simultaneously provide detailed information regarding the diet and parasites of birds,essential for conservation and management.

关键词： biomonitoring broad-spectrum primers eukaryotic mini-barcodes fecal eDNA farmland birds parasitology

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Biofilm and Helicobacter pylori:From environment to human host

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World Journal of Gastroenterology 2014年第19期20卷 5632-5638页

作者： Apolinaria García mar.a josé Salas-Jara Carolina Herrera Carlos González Laboratorio de Patogenicidad Bacteriana Departamento de MicrobiologíaFacultad de Ciencias BiológicasUniversidad de ConcepciónConcepción 4030000Chile

Helicobacter pylori(***)is a Gram negative pathogen that selectively colonizes the human gastric *** 50%of the world population is infected with *** reaching up to 90%of infected individuals in developing *** the increased impact upon public health care,its reservoir and the transmission pathway of the species has not been clearly established *** studies allowed the detection of *** in various aquatic environments,even forming biofilm in tap water distribution systems in several countries,suggesting a role of water as a possible reservoir of the *** persistence of human infection with *** and the resistance of clinical isolates to commonly used antibiotics in eradication therapy have been related to the genetic variability of the species and its ability to develop biofilm,demonstrated both in vivo and in vitro ***,during the last years,experimental work with this pathogen has been focused in the search for biofilm inhibitors and biofilm destabilizing ***,only two *** biofilm disrupting agents have been successfully used:Curcumin-a natural dye-and N-acetyl cysteine-a mucolytic agent used in respiratory *** main goal of this review was to discuss the evidences available in the literature supporting the ability of *** to form biofilm upon various surfaces in aquatic environments,both in vivo and in *** results published and our own observations suggest that the ability of *** to form biofilm may be important for surviving under stress conditions or in the spread of the infection among humans,mainly through natural water sources and water distribution systems.

关键词： Helicobacter pylori Biofilm,Water Infection

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Impact of rutin and buckwheat(Fagopyrum esculentum)extract applications on the volatile and phenolic composition of wine

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Food Bioscience 2022年第5期49卷 941-952页

作者： Juan Alberto Anaya Victoria Lizama Inmaculada Alvarez mar.a jos´e García Institut Universitari d’Enginyeria d’Aliments per al Desenvolupament Universitat Polit`ecnica de Val`encia46022ValenciaSpain

The aim of this research is to study the possibility of increasing the quality of red wins made with the Monastrell grape variety.A methodology was established to improve the concentration levels of polyphenol and aroma in these *** flavonoids,the copigmenting effect of rutin stands out,and was tested in both winery and field *** extract(Fagopyrum esculentum),in which rutin is the main flavonoid,may be of interest for viticulture given its biological *** paper focuses on researching the effect of applying the prefermentative vegetable extract of buckwheat(Fagopyrum esculentum)on the concentration of polyphenols and aroma compounds in ***,a study was carried out to compare the effect of pure copigment(rutin)when applied in vineyards and *** vinification was done,plus prefermentative cold *** application of buckwheat extract,and rutin extract to a lesser extent,to Monastrell grapes increased the concentration of malvidin and other anthocyanins,and total *** 12-month storage,no differences were observed in the percentage of copigmented,polymerised and free anthocyanin,the total polyphenol concentration,and the tannin quality parameters like DMACH(aldehyde p-dimethylaminoacimaldehyde)and the Gelatin *** concentrations of diethyl succinate,2 phenylethyl acetate,vanillin and ethyl octanoate increased,while other compounds decreased when the copigment was *** maceration technique followed during the vinification process had very little effect on polyphenolic *** prefermentative maceration slightly increasing the concentration of total polyphenols,but had no effect on the parameters related to colour,anthocyanin concentration,nature of anthocyanins,their binding state or tannin quality *** results showed that cold prefermentation maceration increased the concentration of some volatile compounds,including alcohols and esters,which should be con

关键词： Buckwheat Rutin Copigmentation Prefermentation maceration Wine Polyphenols Volatile compounds

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