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The assembly of plant-patch networks in Mediterranean alpine grasslands

Journal of Plant Ecology 2020年第3期13卷 273-280页

作者： David S.Pescador josé mar.a Iriondo Gianalberto Losapio Adrián Escudero Departamento de Biología y Geología Física y Química InorgánicaEscuela Superior de Ciencias Experimentales y TecnologíaUniversidad Rey Juan CarlosMóstolesSpain Department of Environmental Systems Science ETH ZurichZurichSwitzerland Department of Biology Stanford UniversityStanfordCAUSA

Aims Harsh environmental conditions in alpine ecosystems shape vegetation structure into patches,where many different plant species cluster and grow ***,which factors are important for the structure and dynamics of such plant–patch networks remains poorly *** aim to assess which and how environmental and biotic factors predict the assembly of plant–patch networks along a mountain *** We examined the distribution of plant species in more than 5500 vegetation patches in 37 Mediterranean alpine grasslands distributed along a 500 m altitudinal gradient(National Park of Sierra Guadarrama,Spain).We established a plant–patch network for each grassland community and analyzed how nestedness and modularity vary with environmental(altitude,insolation and soil conditions)and biotic factors(number of species per plot,mean patch area and total pasture area).Important Findings Plant–patch networks showed consistent,non-random patterns characterized by a nested,but not modular,structure,which suggests that positive associations among co-occurring specialists promote their growth within patches as subsets of a pool with more generalist *** nestedness and modularity of plant–patch networks varied among ***,nestedness decreased with increasing species per plot and increased with mean patch area,while it was independent of environmental variables;modularity increased with increasing pasture area and species per *** negative relationship between species per plot and nested patterns may be linked to the restricted number of species that can coexist within the same patch at a given ***,the positive relationship between patch size and nestedness indicates that the growth of rare plant species within vegetation patches occupied by more abundant species is facilitated in bigger rather than smaller ***,these results indicate that the nested assembly of vegetation patches may be independent of abiotic cond

关键词： alpine ecosystems community assembly ecological networks metacommunity modularity nestedness patch dynamics

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Crosslinked hyaluronic acid with liposomes and crocin for management symptoms of dry eye disease caused by moderate meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1368-1373页

作者： josé-mar.a Sánchez-González Concepción De-Hita-Cantalejo mar.a Carmen Sánchez-González Department of Physics of Condensed Matter Optics AreaUniversity of SevilleSeville 41012Spain

AIM:To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland ***:Prospective,single-blind,contralateral eye *** eyes(25 patients)were *** selection for each tear type was random,and the eye drop formulations,0.4%uncrosslinked hyaluronic acid and 0.2%galactoxyloglucan(tear A)and 0.15%crosslinked hyaluronic acid,crocin,and liposomes(tear B)were *** determined dosing schedule was three times a day for six weeks,and the study participants underwent a clinical examination before and 45 d after lubricant *** Schirmer test,tear breakup time(TBUT)test,and Ocular Surface Disease Index(OSDI)questionnaire were applied before and after instillation period with both types of artificial ***:On the Schirmer test,a significant improvement was obtained with both tear A(Pmarind seed polysaccharide,and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease.

关键词： liposome crosslinked hyaluronic acid meibomian gland dysfunction contact lens dry eye disease

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Integral Representation Formulas Related to the Lamé–Navier System

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Acta Mathematica Sinica,English Series 2020年第12期36卷 1341-1356页

作者： Ricardo ABREU-BLAYA Juan BORY-REYES marcos Antonio-HERRERA-PELáEZ josé mar.a SIGARRETA-ALMIRA Facultad de Matemáticas Universidad Autónoma de GuerreroGuerreroMéxico Instituto Politécnico Nacional SEPI-ESIME-ZAC CD-MXMéxico

The paper provides integral representations for solutions to a certain first order partial differential equation natural arising in the factorization of the Lamé–Navier system with the help of Clifford analysis *** representations look like in spirit to the Borel–Pompeiu and Cauchy integral formulas both in three and higher dimensional setting.

关键词： Lamésystem Clifford analysis Dirac operator

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Seed provenance determines germination responses of Rumex crispus (L.) under water stress and nutrient availability

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Journal of Plant Ecology 2019年第6期12卷 949-961页

作者： mar.a Pérez-Fernández Carole PElliott Alex Valentine joséAntonio Oyola Ecology Area University Pablo de OlavideCarretera de Utrera Km 141013 SevillaSpain Kings Park Science Botanic Garden and Parks AuthorityDepartment of BiodiversityConservation and AttractionsKattidj CloseKings ParkWA 6005Australia School of Biological Science The University of Western AustraliaCrawleyWA 6009Australia Department of Botany and Zoology Stellenbosch UniversityPrivate Bag X1Matieland 7602South Africa Physics Department University of ExtremaduraAvenida de Elvas s/n06006 BadajozSpain

Aims Seeds of Rumex crispus from six provenances were studied in relation to their germination under drought and presence of nitrogen in the germination and emergence *** also investigated whether adaptation to soil increases the ability of the species to colonize and establish in contrasting environments along a longitudinal gradient in western Spain by means of a reciprocal transplantation *** We conducted a germination trial in the lab to test for the germination responses to water scarcity along a polyethylene glycol gradient and to varying concentrations of nitrogen *** reciprocal transplantations experiment was conducted,where seeds from six provenances were grown in the soils from the very same *** emergence,survivorship and fitness-related variables were measured in all *** Findings We found that *** has a cold-stratification requirement that enhances its *** differences between the six provenances were detected for time-to-germination,total seedling emergence,plant mortality and reproductive effort in all the *** differences between provenances with respect to germination were confirmed by the significant statistical analyses of the variance,thus providing evidence that seeds from parent plants grown in different environmental conditions have an intrinsically different abilities to germinate and *** nitrogen content where seed germination and seedlings establish also play an important role in their performance in terms of survivorship and reproduction,being the higher levels of inorganic nitrogen and of microbial biomass those that increased biomass production,enhanced inflorescence formation and reduced plant *** conclude that one of the main reasons for the spread and maintenance of *** would be the increased levels of nitrogen in agricultural soils.

关键词： seed provenance germination latitudinal gradient drought N-compounds soil properties

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Bayés syndrome and acute cardioembolic ischemic stroke

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World Journal of Clinical Cases 2017年第3期5卷 93-101页

作者： Adrià Arboix Lucía martí Sebastien Dorison mar.a josé Sánchez Division of Cerebrovascular Universitat de Barcelona Department of Neurology Hospita Universitari del Sagrat Cor Medicine School Universidad de los Andes 111711 Bogotá Medical Library Hospital Universitari Sagrat Cor

Bayés syndrome is an under-recognized clinical condition characterized by advanced interatrial ***és syndrome is a subclinical disease that manifests electrocardiographically as a prolonged P wave duration>120 ms with biphasic morphology±in the inferior *** clinical relevance of Bayés syndrome lies in the fact that is a clear arrhythmological syndrome and has a strong association with supraventricular arrhythmias,particularly atypical atrial flutter and atrial ***,Bayés syndrome has been recently identified as a novel risk factor for non-lacunar cardioembolic ischemic stroke and vascular *** interatrial block can be a risk for embolic stroke due to its known sequelae of left atrial dilation,left atrial electromechanical dysfunction or atrial tachyarrhythmia(paroxysmal or persistent atrial fibrillation),conditions predisposing to ***és syndrome may be responsible for some of the unexplained ischemic strokes and shall be considered and investigated as a possible cause for cryptogenetic *** summary,Bayés syndrome is a poorly recognized cardiac rhythm disorder with important cardiologic and neurologic implications.

关键词： Bayés syndrome Cardioembolic stroke Electrophysiological processes Cardiovascular risk factors Heart conduction system

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High-density mapping suggests cytoplasmic male sterility with two restorer genes in almond×peach progenies

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Horticulture Research 2015年第1期2卷 234-241页

作者： joséManuel Donoso Iban Eduardo Roger Picañol Ignasi Batlle Werner Howad mar.a joséAranzana Pere Arús IRTA Centre de Recerca en Agrigenòmica CSIC-IRTA-UAB-UB Campus UAB Bellaterra(Cerdanyola del Vallès)08193 BarcelonaSpain IRTA.Centre de Mas de Bover.Crta.De Reus–El Morell Km 3.8.43120 Constantί TarragonaSpain INIA Av.Salamanca s/nSector Los ChoapinosRengoChile Rijk Zwaan Finca La Marina-Pj Lo Contreras s/n30395 La PueblaCartagenaSpain

Peach(Prunus persica)and almond(Prunus dulcis)are two sexually compatible species that produce fertile ***,a highly polymorphic species,is a potential source of new genes for peach that has a strongly eroded gene *** we describe the genetics of a male sterile phenotype that segregated in two almond(‘Texas’)×peach(‘Earlygold’)progenies:an F2(T×E)and a backcross one(T1E)to the‘Earlygold’***-density maps were developed using a 9k peach SNP chip and 135 simple-sequence *** highly syntenic and collinear maps were obtained:one for the F2(T×E)and two for the backcross,T1E(for the hybrid)and E(for‘Earlygold’).A major reduction of recombination was observed in the interspecific maps(T×E and T1E)compared to the intraspecific parent(E).The E map also had extensive monomorphic genomic regions suggesting the presence of large DNA fragments identical by *** data for the male sterility character were consistent with the existence of cytoplasmic male sterility,where individuals having the almond cytoplasm required the almond allele in at least one of two independent restorer genes,Rf1 and Rf2,to be *** restorer genes were located in a 3.4 Mbp fragment of linkage group 2(Rf1)and 1.4 Mbp of linkage group 6(Rf2).Both fragments contained several genes coding for pentatricopeptide proteins,demonstrated to be responsible for restoring fertility in other *** implications of these results for using almond as a source of novel variability in peach are discussed.

关键词： linkage restore mapping

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Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation

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World Journal of Gastroenterology 2019年第26期25卷 3291-3298页

作者： jose Tiago Silva Rafael San-Juan mario Fernández-Ruiz josé mar.a Aguado Unit of Infectious Diseases Hospital Universitario "12 de Octubre" Instituto de Investigación Hospital "12 de Octubre" (imas12) School of Medicine Universidad Complutense

Solid organ transplantation(SOT)is the best treatment option for end-stage organ *** immunosuppressive agents have reduced the incidence of graft rejection but have increased the risk of infection,particularly due to the reactivation of latent infections due to opportunistic agents such as Mycobacterium *** tuberculosis(TB)after SOT is a significant cause of morbidity and *** cases of posttransplant TB are secondary to reactivation of latent tuberculosis infection(LTBI)due to the effects of long-term immunosuppressive *** minimization strategies have been developed to diagnose LTBI and initiate treatment prior to *** with vitamin B6 supplementation is the treatment of ***,liver transplantation(LT)candidates and recipients have an increased risk of isoniazid-induced liver toxicity,leading to lower treatment completion rates than in other SOT ***(FQs)exhibit good in vitro antimycobacterial activity and a lower risk of drug-induced liver injury than *** the present review,we highlight the disease burden posed by posttransplant TB and summarize the emerging clinical evidence supporting the use of FQs for the treatment of LTBI in LT recipients and candidates.

关键词： Fluoroquinolones Mycobacterium tuberculosis Latent tuberculosis infection Liver transplantation Drug-induced liver graft injury

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Advantages of early cholecystectomy in clinical practice of a terciary care center

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 87-93页

作者： mar.a Barceló Dulce mar.a Cruz-Santamar.a Cristina Alba-López mar.a josé Devesa-Medina Manuel Díaz-Rubio Enrique Rey Health Research Institute San Carlos Clinical HospitalDepartment of MedicineSchool of MedicineComplutense University

BACKGROUND:Despite a number of studies show the superiority of early over delayed cholecystectomy in the treatment of acute cholecystitis,there is still controversy over the time for *** study aimed to assess the use of early versus delayed cholecystectomy for the treatment of acute cholecystitis in terms of complications,conversion to open surgery and mean hospital ***:We collected patients with acute cholecystitis treated at a referral center for a year,and retrospectively analyzed the chosen therapeutic approach,the percentage of conversion of early cholecystectomy to open surgery,appearance of surgical complications,and mean hospital ***:The study included 117 patients,44 women and 73 men,who had a mean age of 67.36±15.74 *** cholecystectomy was chosen in 31(26.5%) and delayed cholecystectomy in 74 patients(63.2%).Of the 74 patients,28(37.8%) required emergency performance of delayed cholecystectomy,and 19(25.7%) had not undergone surgery by the end of the *** no differences were observed between early and delayed cholecystectomy in terms of surgical complications and conversion to open surgery,mean hospital stay was nevertheless significantly shorter in the early versus the delayed cholecystectomy group(8.32±4.98 vs 15.96±8.89 days).CONCLUSION:Under the routine working conditions of a hospital that is neither specially dedicated to the surgical treatment of acute cholecystitis nor provided with specific management guidelines,early cholecystectomy can reduce the hospital stay without increase of the conversion rate or complications.

关键词： acute cholecystitis cholecystectomy complications

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Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights

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Nano Research 2024年第10期17卷 9111-9125页

作者： Ana M.López-Estévez Y.Zhang mar.a Medel Iker Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia mar.a J.Vicent Defang Ouyang Dolores Torres mar.a josé Alonso Center for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmacology Pharmacy and Pharmaceutical TechnologySchool of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Health Research Institute of Santiago de Compostela(IDIS) Santiago de Compostela 15782Spain State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Polymer Therapeutics Laboratory and CIBERONC Prince Felipe Research Centre Valencia E-46012Spain Structure and Cell Biology of Viruses Lab CIC bioGUNEBasque Research and Technology Alliance(BRTA)Derio 48160Spain ALBA Synchrotron Light Source Experiments DivisionCerdanyola del VallèsBarcelona 08290Spain IKERBASQUE Basque Foundation for ScienceBilbao 48009Spain

The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation related to their inability to cross cell membranes and reach intracellular *** offers promising solutions to overcome this limitation,however,formulation challenges *** challenges are the limited loading capacity(often insufficient to achieve clinical dosing),the complex formulation methods,and the insufficient characterization of mAb-loaded ***,we present a new nanocarrier consisting of hyaluronic acid-based nanoassemblies(HANAs)specifically designed to entrap mAbs with a high efficiency and an outstanding loading capacity(50%,w/w).HANAs composed by an mAb,modified HA and phosphatidylcholine(PC)resulted in sizes of~100 nm and neutral surface *** modeling identified the principal factors governing the high affinity of mAbs with the amphiphilic HA and *** composition and structural configuration were analyzed using the orthogonal techniques cryogenic transmission electron microscopy(cryo-TEM),asymmetrical flow field-flow fractionation(AF4),and small-angle X-ray scattering(SAXS).These techniques provided evidence of the formation of core-shell nanostructures comprising an aqueous core surrounded by a bilayer consisting of phospholipids and amphiphilic *** vitro experiments in cancer cell lines and macrophages confirmed HANAs’low toxicity and ability to transport mAbs to the intracellular *** reproducibility of this assembling process at industrial-scale batch sizes and the long-term stability was *** conclusion,these results underscore the suitability of HANAs technology to load and deliver biologicals,which holds promise for future clinical translation.

关键词： monoclonal antibody nanoparticles hyaluronic acid characterization particle size computational modeling

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Dendritic nanoarchitecture imparts ZSM-5 zeolite with enhanced adsorption and catalytic performance in energy applications

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Journal of Energy Chemistry 2023年第5期80卷 77-88,I0003页

作者： mar.a del mar.alonso-Doncel Cristina Ochoa-Hernández Gema Gómez-Pozuelo Adriana Oliveira joséGonzález-Aguilar ángel Peral Raúl Sanz David P.Serrano Thermochemical Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Heterogeneous Catalysis Max-Planck-Institut für KohlenforschungKaiser-Wilhem-Platz14540Muheim an der RuhGermay Department of Chemical and Environmental Technology Rey Juan Carlos UniversityC/Tulipan s/nE28933MostolesMadridSpain High Temperature Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Chemical Energy and Mechanical TechnologyRey Juan Carlos UniversityC/Tulipan s/n28933MostolesMadridSpain

The development of zeolites possessing dendritic features represents a great opportunity for the design of novel materials with applications in a large variety of fields and,in particular,in the energy sector to afford its transition towards a low carbon *** the current work,ZSM-5 zeolite showing a dendritic3D nanoarchitecture has been synthesized by the functionalization of protozeolitic nanounits with an amphiphilic organosilane,which provokes the branched aggregative growth of zeolite *** ZSM-5 exhibits outstanding accessibility arising from a highly interconnected network of radially-oriented mesopores(3-10 nm)and large cavities(20-80 nm),which add to the zeolitic micropores,thus showing a well-defined trimodal pore size *** singular features provide dendritic ZSM-5 with sharply enhanced performance in comparison with nano-and hierarchical reference materials when tested in a number of energy related applications,such as VOCs(toluene)adsorption(improved capacity),plastics(low-density polyethylene)catalytic cracking(boosted activity)and hydrogen production by methane catalytic decomposition(higher activity and deactivation resistance).

关键词： Dendritic ZSM-5 VOCs adsorption Plastics cracking Methane decomposition Hydrogen production

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