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Prevalence of and risk factors for erectile dysfunction in young nondiabetic obese men:results from a regional study

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Asian journal of Andrology 2020年第4期22卷 372-378页

作者： mar.a Molina-Vega Maite Asenjo-Plaza mar.a joséBanderas-Donaire mar.a Dolores Hernández-Ollero Silvia Rodríguez-Moreno juan jálvarez-Millán Pablo Cabezas-Sanchez Fernando Cardona-Díaz juan Alcaide-Torres Lourdes Garrido-Sánchez Daniel Castellano-Castillo Francisco j Tinahones joséC Fernández-García Department of Endocrinology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición(CIBEROBN) Instituto de Salud Carlos IIIMadrid 28029Spain Cruz de Humilladero Primary Care Center Málaga 29010Spain Teatinos Primary Care Center Málaga 29010Spain Chemical Sanitary Consulting(CQS Lab) Madrid 28003Spain

Erectile dysfunction(ED),a condition closely related to cardiovascular morbidity and mortality,is frequently associated with *** this study,we aimed to determine the prevalence of ED and evaluate the associated risk factors in a cohort of 254 young(18–49 years)nondiabetic obese(body mass index[BMI]≥30 kg m−2)men from primary *** function(International Index of Erectile Function[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS scale]),and body composition analysis(Tanita MC-180MA)were *** testosterone was determined using high-performance liquid chromatography–mass *** logistic regression analysis was used to study the factors associated with *** prevalence was 42.1%.Subjects with ED presented higher BMI,waist circumference,number of components of the metabolic syndrome,AMS score,insulin resistance,and a more unfavorable body composition than those without *** logistic regression analysis showed that a pathological AMS score(odds ratio[OR]:4.238,Pmary care-based cohort of nondiabetic young obese men,ED affected>40%of subjects.A pathological AMS score,the degree of obesity,and age were positively associated with ED,while elevated HDL-cholesterol levels were inversely associated with the odds of presenting *** prospective studies are needed to evaluate the long-term consequences of ED in this population.

关键词： Aging Males'Symptoms score erectile dysfunction International Index of Erectile Function-5 questionnaire obesity testosterone

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Conserved Curvature of RNA Polymerase Ⅰ Core Promoter Beyond rRNA Genes: The Case of the Tritryps

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Genomics, Proteomics & Bioinformatics 2015年第6期13卷 355-363页

作者： Pablo Smircich mar.a Ana Duhagon Beatriz Garat Molecular Interactions Laboratory School of Sciences University of the Republic Genetics Departament School of Medicine University of the Republic

In trypanosomatids, the RNA polymerase I （RNAPI）-dependent promoters controlling the ribosomal RNA （rRNA） genes have been well identified. Although the RNAPI transcription machinery recognizes the DNA conformation instead of the DNA sequence of promoters, no con- formational study has been reported for these promoters. Here we present the in silico analysis of the intrinsic DNA curvature of the rRNA gene core promoters in Trypanosoma brucei, Trypanosoma cruzi, and Leiskmania major. We found that, in spite of the absence of sequence conservation, these promoters hold conformational properties similar to other eukaryotic rRNA promoters. Our results also indicated that the intrinsic DNA curvature pattern is conserved within the Leishmania genus and also among strains of T. cruzi and T. brucei. Furthermore, we analyzed the impact of point mutations on the intrinsic curvature and their impact on the promoter activity. Furthermore, we found that the core promoters of protein-coding genes transcribed by RNAPI in T. brucei show the same conserved conformational characteristics. Overall, our results indicate that DNA intrinsic curvature of the rRNA gene core promoters is conserved in these ancient eukaryotes and such con- served curvature might be a requirement of RNAPI machinery for transcription of not only rRNA genes but also protein-coding genes.

关键词： Intrinsic curvature RNA polymerase I Core promoter Trypanosoma Leishmania

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Geomorphic indices and relative tectonic uplift in the Guerrero sector of the Mexican forearc

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Geoscience Frontiers 2017年第4期8卷 885-902页

作者： Krzysztof Gaidzik mar.a Teresa Ramírez-Herrera Laboratorio Universitario de Geofísica Ambiental & Instituto de Geografía Universidad Nacional Autónoma de MéxicoCiudad Universitaria Berkeley Seismological Laboratory Department of Earth and Planetary ScienceUniversity of California Berkeley

Tectonically active areas,such as forearc regions,commonly show contrasting relief,differential tectonic uplift,variations in erosion rates,in river incision,and in channel gradient produced by ongoing tectonic ***,information on the tectonic activity of a defined area could be derived via landscape *** study uses topography and geomorphic indices to extract signals of ongoing tectonic deformation along the Mexican subduction forearc within the Guerrero *** this purpose,we use field data,topographical data,knickpoints,the ratio of volume to area（Rva）.the stream-length gradient index（St）,and the normalized channel steepness index（k_（sn））.The results of the applied landscape analysis reveal considerable variations in relief,topography and geomorphic indices values along the Guerrero sector of the Mexican subduction *** argue that the reported differences are indicative of tectonic deformation and of variations in relative tectonic uplift along the studied forearc.A significant drop from central and eastern parts of the study area towards the west in values of R_（VA）（from ~500 to^300）,St（from ~500 to ca.400）,maximum St（from ~1500-2500 to ~ 1000） and k_（sn）（from ~150 to ~100） denotes a decrease in relative tectonic uplift in the same *** suggest that applied geomorphic indices values and forearc topography are independent of climate and *** mechanisms responsible for the observed variations and inferred changes in relative forearc tectonic uplift call for further studies that explain the physical processes that control the forearc along strike uplift variations and that determine the rates of *** proposed methodology and results obtained through this study could prove useful to scientists who study the geomorphology of forearc regions and active subduction zones.

关键词： Relative tectonic uplift Forearc Active tectonics Geomorphic index Drainage network Mexican subduction zone

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Adaptive Fault Detection Based on Neural Networks and Multiple Sampling Points for Distribution Networks and Microgrids

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journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1648-1657页

作者： j.marín-Quintero C.Orozco-Henao A.S.Bretas j.C.Velez A.Herrada A.Barranco-Carlos W.S.Percybrooks Electric and Electronic Engineering Program Universidad Tecnológica de BolívarCartagenaColombia Electrical and Electronic Engineering Department Universidad del NorteBarranquillaColombia Distributed Systems Group Pacific Northwest National LaboratoryGainesvilleUSA

Smart networks such as active distribution network(ADN)and microgrid(MG)play an important role in power system *** design and implementation of appropriate protection systems for MG and ADN must be addressed,which imposes new technical *** paper presents the implementation and validation aspects of an adaptive fault detection strategy based on neural networks(NNs)and multiple sampling points for ADN and *** solution is implemented on an edge *** are used to derive a data-driven model that uses only local measurements to detect fault states of the network without the need for communication *** sampling points are used to derive a data-driven model,which allows the generalization considering the implementation in physical *** adaptive fault detector model is implemented on a jetson Nano system,which is a single-board computer(SBC)with a small graphic processing unit(GPU)intended to run machine learning loads at the *** proposed method is tested in a physical,real-life,low-voltage network located at Universidad del Norte,*** testing network is based on the IEEE 13-node test feeder scaled down to 220 *** validation in a simulation environment shows the accuracy and dependability above 99.6%,while the real-time tests show the accuracy and dependability of 95.5%and 100%,*** hard-to-derive parameters,the easy-to-implement embedded model highlights the potential for real-life applications.

关键词： Distribution network microgrid adaptive protection intelligent electronic device machine learning

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THE MUON ANOMALOUS MAGNETIC MOMENT

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Chinese Physics C 2016年第10期40卷 635-638页

作者： A. Hoecker W.j. mar- ciano CERN BNL

The Dirac equation predicts a muon magnetic moment, M→=gμe/2mμS^→, with gyromagnetic ratio gμ = 2. Quantum loop effects lead to a small calculable deviation from gμ = 2, parameterized by the anomalous magnetic m...

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Tracking the change in Spanish greenhouse gas emissions through an LMDI decomposition model:A global and sectoral approach

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journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula Fernández González mar.a josé Presno Manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this *** this paper we pursue two ***,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining ***,we propose several actions specifically oriented to more tightly controlling the level of *** results showed a remar.able reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita *** detected somewhat different patterns among the various sectors *** the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of *** carbonization effect was revealed as crucial in the commerce *** above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in *** efforts in areas like innovation,R&D,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMDI Decomposition Spain GHG emissions

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Drought and Spatiotemporal Variability of Forest Fires Across Mexico

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Chinese Geographical Science 2018年第1期28卷 25-37页

作者： Pompa-García maríN Camarero j.jULIO Rodríguez-Trejo DANTE ARTURO Vega-Nieva DANIEL jOSE Facultad de Ciencias Forestales Universidad Juarez del Estado de Durango Durango 34120 MExico Instituto Pirenaico de Ecologia IPE-CSIC 50059 Spain Divisian de Ciencias Forestales Universidad Autonoma Chapingo Chapingo 56230 MExico

Understanding the spatiotemporal links between drought and forest fire occurrence is crucial for improving decision-making in fire management under current and future climatic conditions. We quantified forest fire activity in Mexico using georeferenced fire records for the period of 2005–2015 and examined its spatial and temporal relationships with a multiscalar drought index, the Standardized Precipitation-Evapotranspiration Index(SPEI). A total of 47975 fire counts were recorded in the 11-year long study period, with the peak in fire frequency occurring in 2011. We identified four fire clusters, i.e., regions where there is a high density of fire records in Mexico using the Getis-Ord G spatial statistic. Then, we examined fire frequency data in the clustered regions and assessed how fire activity related to the SPEI for the entire study period and also for the year 2011. Associations between the SPEI and fire frequency varied across Mexico and fire-SPEI relationships also varied across the months of major fire occurrence and related SPEI temporal scales. In particular, in the two fire clusters located in northern Mexico(Chihuahua, northern Baja California), drier conditions over the previous 5 months triggered fire occurrence. In contrast, we did not observe a significant relationship between drought severity and fire frequency in the central Mexico cluster, which exhibited the highest fire frequency. We also found moderate fire-drought associations in the cluster situated in the tropical southern Chiapas where agriculture activities are the main causes of forest fire occurrence. These results are useful for improving our understanding of the spatiotemporal patterns of fire occurrence as related to drought severity in megadiverse countries hosting many forest types as Mexico.

关键词： cluster drought forest fires geostatistics spatial clusters Standardised Precipitation-Evapotranspiration Index (SPEI)

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Antarctic red algae in dye-sensitized photoelectrochemical cells for water splitting

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Advances in Polar Science 2024年第2期35卷 219-227页

作者： Florentina ARISPE mar.a Fernanda CERDÁ Laboratorio de Biomateriales IQBFacultad de CienciasUdelaRMontevideo 11400Uruguay

Phycoerythrin extracted from Antarctic red seaweeds shows promising characteristics to be applied as an anode sensitizer in water-splitting photoelectrochemical *** light irradiation and using an LED lamp,the red-colored protein shows an interesting ability to profit the incident light,as confirmed by the presence of oxygen bubbles next to the electrode surface without applying any external *** results showed that the addition of iodide is helpful to allow the regeneration of the dye;nevertheless,oxygen evolution is not *** analysis of the involved semi-reactions is also helpful to understand the observed *** exploration of Antarctic resources offers then an alternative for the development of green energies,with a particular focus on their use as sensitizers to profit from the sunlight in water-splitting as well as in photovoltaic devices.

关键词： sensitizers water-splitting red algae electrochemical

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MicroRNAs in biliary diseases

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World journal of Gastroenterology 2012年第43期18卷 6189-6196页

作者： Patricia munoz-Garrido Maite García-Fernández de Barrena Elizabeth Hijona Miguel Carracedo joséj G marín Luis Bujanda jesús M Banales Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpain Division of Oncology Research Schulze Center for Novel TherapeuticsMayo ClinicRochesterMN 55905United States Division of Hepatology and Gastroenterology Biodonostia Research InstituteDonostia Universitary Hospital20014 San SebastiánSpains Department of Liver and Gastrointestinal Diseases National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehdfunded by the Spanish CarlosⅢInstitute)08036 BarcelonaSpain Department of Physiology and Pharmacology Experimental Hepatology and Drug Targeting(HEVEFARM)Biomedical Research Institute of Salamanca(IBSAL)University of Salamanca37008 SalamancaSpain Ikerbasque Basque Foundation for Science48011 BilbaoSpain

Cholangiopathies are a group of diseases primarily or secondarily affecting bile duct cells, and result in cholangiocyte proliferation, regression, and/or transformation. Their etiopathogenesis may be associated with a broad variety of causes of different nature, which includes genetic, neoplastic, immune-associated, infectious, vascular, and drug-induced alterations, or being idiopathic. miRNAs, small non-coding endogenous RNAs that post-transcriptionally regulate gene expres sion, have been associated with pathophysiological processes in different organs and cell types, and are postulated as potential targets for diagnosis and therapy. In the current manuscript, knowledge regarding the role of miRNAs in the development and/or progression of cholangiopathies has been reviewed and the most relevant findings in this promising field of hepatology have been highlighted.

关键词： miRNAs Cholangiopathies Cholangiocarcinoma Polycystic liver diseases Primary biliary cirrhosis

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Deep excavation of the impact from endogenous and exogenous uncertaintieson long-term energy planning

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Energy and AI 2023年第1期11卷 150-160页

作者： Xiang Li François maréchal Industrial Process and Energy Systems Engineering Ecole Polytechnique Fédérale de LausanneRue de l’industrie 17Sion1950Switzerland

Endogenous and exogenous uncertainties exert significant influences on energy planning. In this study,we propose a systematic methodology to excavate the uncertainty space, by combining mix-integer linearprogramming (MILP), Monte Carlo simulation, and machine learning for quantification of the uncertaintyimpacts on a national-level energy system from global and local perspectives. This approach allows in-depthcorrelation analysis highlighting potential synergies and risks in the energy transition, and can be easily applie for assisting policy making. The case study for Switzerland shows that both carbon neutrality (even negativeemissions) and energy autonomy can be achieved by 2050, but the energy system’s configuration variessignificantly under uncertainty. Through conditional distribution analyses, carbon capture and storage (CCS),Photovoltaic (PV), and wood gasification show the most strong correlation for decarbonization. This study isbased on the whole uncertainty space taking into account heterogeneous uncertainties, leading to increasedreliability compared to sensitivity analysis from single scenarios’ comparisons. The synergy between energymodels and artificial intelligence (AI) is promising to be widely applied in energy planning area, particularlyfor emerging technologies with large uncertainty in development.

关键词： Uncertainty Energy planning Monte Carlo simulation Machine learning

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