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Dietary processed former foodstuffs for broilers:impacts on growth performance,digestibility,hematobiochemical profiles and liver gene abundance

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Journal of Animal Science and Biotechnology 2025年第1期16卷 364-376页

作者： Karthika Srikanthithasan mar.a Gariglio elena Diaz Vicuna Edoardo Fiorilla Barbara Miniscalco Valeria Zambotto Eleonora Erika Cappone Nadia Stoppani Dominga Soglia Federica Raspa Joana Nery Andrea Giorgino Roser Sala Andrés luis martínez marínz Josefa Madrid Sanchez Achille Schiavone Claudio Forte Department of Veterinary Sciences University of TurinGrugliascoItaly Animal Nutrition and Welfare Service(SNiBA) Department of Animal and Food SciencesUniversitat Autònoma de BarcelonaBarcelonaSpain Departamento de Producción Animal Universidad de CórdobaCórdobaSpain Department of Animal Production University of MurciaMurciaSpain

Background The present experiment aimed to evaluate the effects of commercially processed former foodstuffs(cFF)as dietary substitutes of corn,soybean meal and soybean oil on the growth performance,apparent total tract digestibil-ity(ATTD),hematobiochemical profiles,and liver gene abundance in broiler *** hundred one-day-old male ROSS-308 chicks were assigned to 4 dietary groups(5 replicates of ten birds per replicate)according to their average body weight(BW,38.0±0.11 g).All groups received a two-phase feeding program:starter,d 1–12 and grower,d 12–*** control group(cFF0)was fed a standard commercial feed based on corn,soybean meal and soybean *** other three groups received diets in which the feed based on corn,soybean meal,and soybean oil was partially replaced with cFF at a substitution level of 6.25%(cFF6.25),12.5%(cFF12.5)or 25%(cFF25)for the following 33 *** The growth performance data showed no differences in BW or average daily gain among groups,although the average daily feed intake decreased during the grower period(12–33 d)and over entire experimental period(1–33 d)in a linear manner as the cFF inclusion level rose(P=0.026),positively affecting the gain to feed ratio(P=0.001).The ATTD of dry matter of the cFF-fed groups were greater with respect to control group and increased throughout the experimental period,whereas the ATTD of ether extract linearly decreased with increasing levels of cFF-fed groups compared with control group and throughout the experimental period(Plly,a lin-ear increase in the heterophil to lymphocyte ratio,serum cholesterol,triglycerides and alanine-aminotransferase were observed with increasing dietary levels of cFF(Plipoprotein lipase or sterol regulatory element binding transcription factor gene *** The results of this experiment demonstrate that it is possible to incorporate cFF into nutritionally balanced diets for broiler ch

关键词： Alternative feed Broiler chicken Digestibility Former foodstuff Gene abundance Growth performance

Grasslands Response to livestock Grazing Intensity in the Austral Pampas(Argentina):Testing the Intermediate Disturbance Hypothesis

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2037-2050页

作者： Ana elena de Villalobos mar.a Andrea long Grupo de Investigación en Ecosistemas de Pastizal(GIEP) CERZOSCONICETBahía Blanca8000Argentina Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del SurBahía Blanca8000Argentina

livestock grazing has a significant impact on natural grasslands,with approximately one-third of the world’s land area dedicated to this *** 20%of global grasslands are highly degraded due to overgrazing,affecting their productivity and conservation *** practices are required to ensure sustainable livestock production that supports *** Intermediate Disturbance Hypothesis(IDH)suggests that environments with moderate levels of disturbance exhibit a higher species *** grazing can reduce the dominance of certain species,thereby enhancing plant ***,concerns arise regarding the increase of exotic and unpalatable species under moderate grazing levels,complicating grassland conservation *** impact of livestock grazing on the functional structure of grasslands depends on factors such as grazing intensity,livestock species,and environmental *** in grazing intensity may increase specific and functional diversity under moderate grazing,potentially masking the presence of invasive exotic *** the Austral Pampas(Pampean phytogeographic province,Buenos Aires,Argentina),grasslands face various pressures from domestic livestock grazing that endanger their integrity if not properly ***,our study aims to investigate potential differences in species richness and diversity,functional diversity,exotic plant abundance,and the number and distribution of plant functional groups across varying grazing *** IDH is utilized as a tool to regulate livestock pressure for grassland *** and functional diversity indices were used to assess the impact of grazing on grassland *** grazing increased species and functional diversity,while intensively grazed or ungrazed areas showed reduced *** presence influenced the balance between native and exotic plants,with ungrazed areas having higher native plant abundance and grazed areas exhibiti

关键词： Natural grasslands grazing effects disturbance specific and functional diversity

Determination of l-norvaline and l-tryptophan in dietary supplements by nano-lC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11- dihydroquinidine-silica hybrid monolithic column

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Journal of Pharmaceutical Analysis 2020年第1期10卷 70-77页

作者： Dongsheng Xu elena Sanchez-lopez Qiqin Wang Zhengjin Jiang mar.a luisa marina Departamento de Química Analítica Química Física e Ingeniería QuímicaUniversidad de AlcalaCtra.Madrid-Barcelona Km.33.60028871Alcala de Henares(Madrid)Spain Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou510632China Department of Pharmacy and Guangdong Province Key laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New Drug Research Jinan UniversityGuangzhou510632China Instituto de Investigacion Química“Andres M.del Río”(IQAR) Universidad de AlcalaCtra.Madrid-Barcelona Km.33.60028871Alcala de Henares(Madrid)Spain

An analytical methodology based on an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine(MQD)-silica hybrid monolithic column was developed for the enantioseparation of 9-fluorenylmethoxycarbonyl(FMOC)derivatized amino acids by nano-liquid *** mobile phase was optimized including the apparent pH,content of ACN,and concentration of the buffer to obtain a satisfactory enantioresolution performance.27 FMOC derivatized amino acids including 19 protein and 8 non-protein amino acids were tested,and 19 out of them were enantiomerically discriminated obtaining baseline separation for 11 of *** characteristics of the method were evaluated for norvaline and tryptophan in terms of linearity,precision,accuracy,limits of detection(lOD)and quantitation(lOQ)showing good performance to be applied to the enantiomeric determination of these amino acids in dietary *** and lOQ values were 9.3 and 31 mM for norvaline enantiomers and 7.5 and 25 mM for tryptophan enantiomers,*** contents of D-norvaline and D-tryptophan were below their respective lODs in all the analyzed *** of l-tryptophan and l-norvaline showed good agreement with the labeled contents except for one sample which did not show presence of l-norvaline,contrary to the label indication.

关键词： 9-Fluorenylmethoxycarbonyl Amino acids Chiral separation Nano-lC Quinidine-silica hybrid monolithic column

Alexander disease:the road ahead

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Neural Regeneration Research 2023年第10期18卷 2156-2160页

作者： mar.a A.Pajares elena Hernández-Gerez Milos Pekny Dolores Pérez-Sala Department of Structural and Chemical Biology Centro de Investigaciones Biológicas Margarita SalasMadridSpain laboratory of Astrocyte Biology and CNS Regeneration Center for Brain RepairDepartment of Clinical NeuroscienceInstitute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden University of Newcastle NewcastleNSWand the Florey Institute of Neuroscience and Mental HealthParkvilleVICAustralia

Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein,a type III intermediate filament protein expressed in *** early(infantile or juvenile)and adult onsets of the disease are known and,in both cases,astrocytes present characteristic aggregates,named Rosenthal *** are spread along the glial fibrillary acidic protein sequence disrupting the typical filament network in a dominant *** the presence of aggregates suggests a proteostasis problem of the mutant forms,this behavior is also observed when the expression of wild-type glial fibrillary acidic protein is ***,several isoforms of glial fibrillary acidic protein have been described to date,while the impact of the mutations on their expression and proportion has not been exhaustively ***,the posttranslational modification patterns and/or the protein-protein interaction networks of the glial fibrillary acidic protein mutants may be altered,leading to functional changes that may modify the morphology,positioning,and/or the function of several organelles,in turn,impairing astrocyte normal function and subsequently affecting *** particular,mitochondrial function,redox balance and susceptibility to oxidative stress may contribute to the derangement of glial fibrillary acidic protein mutant-expressing *** study the disease and to develop putative therapeutic strategies,several experimental models have been developed,a collection that is in constant *** fact that most cases of Alexander disease can be related to glial fibrillary acidic protein mutations,together with the availability of new and more relevant experimental models,holds promise for the design and assay of novel therapeutic strategies.

关键词： astrocytes endoplasmic reticulum stress glial fibrillary acidic protein mutants metabolism misassembly misfolding neurodegeneration oxidative stress posttranslational modifications unfolded protein response

Role of vitamin B_(12) on methylmalonyl-CoA mutase activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第6期13卷 423-437页

作者： Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA mar.a elena FlORES Department of Molecular Biology and Biotechnology Institute of Biomedical ResearchNational Autonomous University of MexicoD.F.04510Mexico Department of Chemistry of Biomacromolecules Institute of ChemistryNational Autonomous University of MexicoD.F.04510Mexico

Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their *** them,methylmalonyl-CoA mutase (MCM) has been extensively *** enzyme catalyzes the reversible isomerization of l-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the *** crystal structure of MCM determined in Propionibacterium freudenreichii *** has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and *** existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in *** recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two *** studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated *** interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in *** is still necessary to study the mechanisms involved in more detail using new methods.

关键词： Vitamin B 12 Methylmalonyl-CoA mutase (MCM) MMAA MeaB Methylmalonic academia (MMA) Protectase Reactivase

Characterization and QTl identification in eggplant introgression lines under two N fertilization levels

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Horticultural Plant Journal 2023年第5期9卷 971-985页

作者： elena Rosa-martínez Gloria Villanueva Ahmet Sahin Pietro Gramazio mar.a Dolores García-martínez mar.a Dolores Raig on Santiago Vilanova Jaime Prohens mariola Plazas Instituto de Conservacion y Mejora de la Agrodiversidad Valenciana Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain Instituto de Biología Molecular y Celular de Plantas Consejo Superior de Investigaciones Científicas-Universitat Politecnica de ValenciaCamino de Vera 1446022 ValenciaSpain

lowering nitrogen inputs is a major goal for sustainable *** the present study,a set of 10 Solanum melongena introgression lines(Ils)developed using Solanum incanum as the exotic donor parent were grown under two nitrogen fertilization doses supplied with the irrigation system:1)8.25 mmol·l-1NH4NO3,corresponding to the high nitrogen treatment(HN),and 2)no external nitrogen supply,corresponding to the low nitrogen treatment(lN).Twenty traits,including plant growth and yield parameters,fruit size and morphology,nitrogen and carbon content in leaf and fruit,and phenolics content in fruit,were *** aim was to select of potential materials for eggplant breeding under low N inputs,as well as to identify and locate putative QTls associated with the traits *** significant differences were observed between the soil characteristics of the HN and lN treatments,except for nitrogen and iron content,which was slightly lower in the HN,probably as a consequence of higher nutrient removal from soil by plants in the latter *** of variance showed that lowering nitrogen inputs did not significantly affect the final yield,fruit morphology,size and phenolics *** agronomic traits were highly and positively correlated with each other under both treatments,as well as total phenolics with chlorogenic acid *** assessment of the differences between each Il and the recipient parent resulted in the identification of 36 QTls associated with most of the traits—12 were specific to the HN,17 specific to the lN,and 7 were stable across *** introgressed fragment of *** generally had a negative effect on the trait,except for QTls for fruit dry matter,for fruit length on chromosome 10 under the HN,and for fruit pedicel length on chromosome 9 under the *** increase over AN-S-26 of the allele of *** for the QTls detected ranged between-73.98% and 26.03% in HN and-73.67%and 34.43% in *** findings provide useful tools fo

关键词： Solanum melongena Solanum incanum Wild relatives N fertilization Abiotic stress QTl

Interference in the production of bacterial virulence factors by olive oil processing waste

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Food Bioscience 2022年第5期49卷 1144-1155页

作者： Carolina mar.a Viola Romina Torres-Carro mar.a Cecilia Verni Eliana del Valle leal Stefano Dall’Acqua Francisca Rodrigues elena Cartagena mar.a Rosa Alberto mario Eduardo Arena Instituto de Biotecnología Farmaceutica y Alimentaria(INBIOFAl)CONICET-UNT Avenida N Kirchner 1900CP 4000TucumanArgentina Facultad de Bioquímica Química y FarmaciaUniversidad Nacional de Tucuman(UNT)Ayacucho 471CP 4000TucumanArgentina Department of Pharmaceutical and Pharmacological Sciences University of PadovaVia Marzolo 535121PadovaItaly REQUIMTE/lAQV Polytechnic of Porto-School of EngineeringRua Dr.Antonio Bernardino de Almeida4249-015PortoPortugal

The reuse of agricultural waste is essential to mitigate environmental pollution ***,this work focused on the valorization of the most extensive olive processing residue,alperujo,in terms of its ability to interfere with the virulence processes of Pseudomonas aeruginosa and Staphylococcus aureus contaminating food and reference *** activity of alperujo extracts of different polarities on virulence factors producing bacteria,and its relationship with antioxidant capacity and polyphenolic content was comparatively *** results indicated that the polar extracts significantly reduced the biofilm formed by both *** were also able to act against a previously formed biofilm by reducing its biomass and the cells’*** extracts,rich in polyphenolic compounds,exhibited antioxidant capacity and Quorum sensing(QS)inhibitory activity against Chromobacterium ***,they limited the spread of *** by restricting swarming and swimming *** also interfere in other QS controlled phenotypes like elastase and *** antipathogenic ability of the polar extracts could be mainly due to the synergistic effect of several phenolic compounds identified by lC-MS/MS analysis,such as luteolin,vanillic acid hexoside,oleuropein and derivates,quinic acid,apigenin,among *** a result,this study contributes to the developing of sustainable strategies to revalorize a polluting waste into a value-added byproduct that could be used in the food and sanitary industries.

关键词： Alperujo Biofilm Motility Quorum sensing Phenolic compounds Elastase

Multicriteria approach for evaluating biowaste-valorization cases

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Energy Storage and Saving 2024年第4期3卷 288-294页

作者： Carlota Díaz García maryori Díaz elena laborda mar.a P´erez Pantelis Pekakis Research Centre for Energy Resources and Consumption(CIRCE) Zaragoza50018Spain DRAXIS Environmental S.A Thessaloniki54655Greece

The selection of waste-valorization projects is a complex decision process that involves many factors and variables to guarantee an appropriate definition of the best waste-management strategy to be applied for a specific waste *** technological approaches can be identified based on the diverse waste types,such as fish byproducts,spent coffee grounds,used cooking oils,and sewage *** identify the most suitable and sustainable method for processing each residue type,one must consider multiple criteria in the decision-making process(i.e.,economic,technological,environmental,social,and political)to define a specific wastemanagement *** this study,the analytical-hierarchy-process model is applied to evaluate wastetreatment projects based on the criteria *** methodological approach involves several ***,existing state-of-the-art projects are critically reviewed to identify more advanced solutions for waste ***,biowaste projects are characterized by the application of multiple criteria and ***,prioritized solutions are generated to elucidate the ranking of biowaste based on a hierarchical structure.

关键词： Biowaste Valorization technologies Analytic hierarchy process(AHP) Multicriteria decision analysis(MCDA) Sustainability

Modeling Bacterial Species: Using Sequence Similarity with Clustering Techniques

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Computers, Materials & Continua 2021年第8期68卷 1661-1672页

作者： Miguel-Angel Sicilia elena García-Barriocanal mar.al Mora-Cantallops Salvador Sánchez-Alonso lino González University of Alcalá Alcaláde Henares(Madrid)28871Spain Camilo JoséCela University Madrid28007Spain

Existing studies have challenged the current definition of named bacterial species,especially in the case of highly recombinogenic *** has led to considering the use of computational procedures to examine potential bacterial clusters that are not identified by species *** paper describes the use of sequence data obtained from MlST databases as input for a k-means algorithm extended to deal with housekeeping gene sequences as a metric of similarity for the clustering *** implementation of the k-means algorithm has been developed based on an existing source code implementation,and it has been evaluated against MlST *** point out to potential bacterial clusters that are close to more than one different named species and thus may become candidates for alternative classifications accounting for genotypic *** use of hierarchical clustering with sequence comparison as similarity metric has the potential to find clusters different from named species by using a more informed cluster formation strategy than a conventional nominal variant of the algorithm.

关键词： Clustering bacterial species k-means sequence alignment