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Neural regeneration research 2024年第3期19卷 542-547页

作者： maría Norte-Muñoz David García-Bernal Diego García-Ayuso Manuel Vidal-Sanz marta Agudo-Barriuso Grupo de Investigación Oftalmología experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de Investigación Trasplante Hematopoyético y Terapia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical *** stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and *** studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional ***,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous ***,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation.

关键词： adaptive immunity cell therapy central nervous system immune system innate immunity mesenchymal stromal cells neuroregeneration preclinical studies retina transplantation

environmental drivers of long-term variations in the abundance of the red hocicudo mouse (Oxymycterus rufus) in Pampas agroecosystems

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Integrative Zoology 2024年第1期19卷 37-51页

作者： Laura mariel CALFAYAN regino CAVIA Jimena FrASCHINA Juan Santiago GUIDOBONO Irene Laura GOrOSITO maría BUSCH Laboratorio de ecología de Poblaciones Departamento de EcologíaGenética y EvoluciónFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires and Instituto de EcologíaGenética y Evolución de Buenos Aires(IEGEBA)Buenos AiresArgentina

During the 20th century,there has been an ongoing agricultural expansion and global warming,two of the main determinants influencing biodiversity changes in *** red hocicudo mouse(Oxymycterus rufus)inhabits subtropical grasslands and riparian habitats and has increased its abundance in recent years in central Argentina *** paper describes the long-term temporal changes in *** abundance in exaltación de la Cruz department,Buenos Aires province,Argentina,in relation to weatherfluctuations and landscape features,as well as analyzes the spatio-temporal structure of captures of *** used generalized liner models,semi-variograms,the Mantel test,and autocorrelation functions for the analysis of rodent data obtained from trappings conducted between 1984 and *** showed an increase in abundance across the years of study,with its distribution depending on landscape features,such as habitat types and the distance *** rates showed a spatio-temporal aggregation,suggesting expansion from previously occupied *** was more abundant at lower minimum temperatures in summer,higher precipitation in spring and summer,and lower precip-itations in *** conditions affected *** abundance,but there was local variation that differed from global patterns of climate change.

关键词： agroecosystems climate change linear habitats Oxymycterus rufus rodent

Au-Fe_(3)O_(4) dumbbell-like nanoparticles based lateral flow immunoassay for colorimetric and photothermal dual-mode detection of SArS-CoV-2 spike protein

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Chinese Chemical Letters 2024年第6期35卷 536-540页

作者： Gengchen Guo Tianyu Zhao ruichang Sun Mingzhe Song Hongyu Liu sen Wang Jingwen Li Jingbin Zeng College of Chemistry and Chemical engineering and State Key Laboratory of heavy oil processing China University of Petroleum(East China)Qingdao 266580China Huangdao Customs of the People’s republic of China Qingdao 266580China

Lateral flow immunoassay(LFIA)has become popular in laboratories,at-home testing,and medical diagnostics due to its minimal cost and ***,conventional test strips based on colloidal gold can only obtain qualitative or semi-quantitative results with low *** this work,AuFe_(3)O_(4) dumbbell-like nanoparticles were synthesized and used as the LFIA labelling marker for highly sensitive colorimetric-photothermal dual-mode detection of SArS-CoV-2 spike(S)*** unique dumbbell structure of Au-Fe_(3)O_(4) NPs makes it possible to combine the best features of both Au NPs and Fe_(3)O_(4) *** increased surface area of these NPs enhances their LSPr effect and photothermal effect,which achieves signal amplification to increase *** Au-Fe_(3)O_(4) NPs modified with S protein antibody could identify S protein in samples,which were recognized and accumulated on T-line by another antibody,generating color band for qualitative colorimetric *** T-line was irradiated by laser to obtain temperature change for quantitative detection of *** optimized conditions,the detection limit was 1.22 pg/m L,three orders of magnitude more sensitive than colorimetric ***,the approach was performed on SArS-CoV-2 pseudovirus samples and outperformed traditional colloidal gold *** LFIA platform exhibits significant promise for practical implementation,as it can satisfy the need for low-cost,high-sensitivity,and home-based quantitative detection for respiratory infectious diseases.

关键词： Au-Fe_(3)O_(4) dumbbell-like nanoparticles Photothermal effect LFIA S protein

Three‐dimensional(3D)‐printed MXene high‐voltage aqueous micro‐supercapacitors with ultrahigh areal energy density and low‐temperature tolerance

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Carbon energy 2024年第8期6卷 36-48页

作者： Yuanyuan Zhu Qingxiao Zhang Jiaxin Ma Pratteek Das liangzhu Zhang Hanqing Liu sen Wang Hui Li Zhong‐Shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianChina Key Laboratory of Spin electron and Nanomaterials of Anhui Higher education Institutes Suzhou UniversitySuzhouChina Shanghai Key Laboratory of rare earth Functional Materials and education Ministry Key Laboratory of resource Chemistry Shanghai Normal UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina Dalian National Laboratory for Clean energy Chinese Academy of SciencesDalianChina

The rapid advancement in the miniaturization,integration,and intelligence of electronic devices has escalated the demand for customizable microsupercapacitors(MSCs)with high energy ***,efficient microfabrication of safe and high‐energy MXene MSCs for integrating microelectronics remains a significant challenge due to the low voltage window in aqueous electrolytes(typically≤0.6 V)and limited areal mass loading of MXene ***,we tackle these challenges by developing a highconcentration(18mol kg^(−1))“water‐in‐LiBr”(WiB)gel electrolyte for MXene symmetric MSCs(M‐SMSCs),demonstrating a record high voltage window of 1.8 ***,additive‐free aqueous MXene ink with excellent rheological behavior is developed for three‐dimensional(3D)printing customizable all‐MXene microelectrodes on various *** the synergy of a highvoltage WiB gel electrolyte and 3D‐printed microelectrodes,quasi‐solid‐state MSMSCs operating stably at 1.8 V are constructed,and achieve an ultrahigh areal energy density of 1772μWhcm^(−2)and excellent low‐temperature tolerance,with a long‐term operation at−40℃.Finally,by extending the 3D printing protocol,M‐SMSCs are integrated with humidity sensors on a single planar substrate,demonstrating their reliability in miniaturized integrated microsystems.

关键词： 3D printing aqueous electrolyte high voltage micro‐supercapacitors MXene

Wideband spectrum sensing using step-sampling based on the multipath nyquist folding receiver

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defence Technology（防务技术） 2024年第1期31卷 523-536页

作者： Kai-lun Tian Kai-li Jiang sen Cao Jian Gao Ying Xiong Bin Tang Xu-ying Zhang Yan-fei Li University of electronic Science and Technology of China Chengdu611731China China electronics Technology Group Corporation 29th research Institute Chengdu610036China

Wideband spectrum sensing with a high-speed analog-digital converter(ADC) presents a challenge for practical *** Nyquist folding receiver(NYFr) is a promising scheme for achieving cost-effective real-time spectrum sensing,which is subject to the complexity of processing the modulated *** this case,a multipath NYFr architecture with a step-sampling rate for the different paths is *** different numbers of digital channels for each path are designed based on the Chinese remainder theorem(CrT).Then,the detectable frequency range is divided into multiple frequency grids,and the Nyquist zone(NZ) of the input can be obtained by sensing these ***,high-precision parameter estimation is performed by utilizing the NYFr *** with the existing methods,the scheme proposed in this paper overcomes the challenge of NZ estimation,information damage,many computations,low accuracy,and high false alarm *** simulation experiments verify the effectiveness of the proposed architecture in this paper.

关键词： Wideband spectrum sensing Sub-Nyquist sampling Step-sampling Nyquist folding receiver(NYFr) Multisignal processing

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-martinez Cielo García-Montero Sergio Haro Miguel Ángel Álvarez-Mon Diego de Leon-Oliva Ana M.Gomez-Lahoz Jorge Monserrat mar Atienza-Pérez David Díaz elisa Lopez-Dolado Melchor Álvarez-Mon department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain ramón y Cajal Institute of Sanitary research(IrYCIS) 28034 MadridSpain department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIe)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIe perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively pr.sen.ed with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIe) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

University Corporate Governance in the Literature From 2019 to 2024

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Journalism and Mass Communication 2024年第3期14卷 179-188页

作者： maría del rosario Molina González maría Teresa Gaxiola Sánchez maría de Jesús Camargo Pacheco marco Antonio Velderrain rodríguez rafael Campoy Mendoza Cruz García Lirios Universidad de Sonora NavojoaMexico

Anti-pandemic policies impacted the governance of Higher education Institutions(HeIs)through confinement and distancing *** an impact was observed in the identity,reputation,and image of the HeI in the face of the health *** objective of this work was to establish an empirical contrast between the theoretical structure consulted regarding the evaluations of summaries published from 2019 to 2024 by judges.A documentary,cross-sectional,and retrospective study was carried out with a sample of sources indexed in international *** results demonstrate that image and age regulate the impact of identity and income on *** relation to the state of the art,it is recommended to extend the study to sociocultural,demographic,economic,and educational variables in order to anticipate the transition from university governance to corporate governance.

关键词： COVID governance model nodes neural networks

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural regeneration research 2025年第4期20卷 973-989页

作者： maría Belén Cieri Alberto Javier ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with mirNAs or lncrNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： Jia-xin Yu Xiao-yu Wang Jun-wei Shen Jin-sen Hu Xiang-qing Zhang Da-qing He Yu-ning Zhang Key Laboratory of Power Station energy Transfer Conversion and System(Ministry of education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden *** present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the ***,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are ***,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and ***,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

The rNA-binding domain of DCL3 is required for long-distance rNAi signaling

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aBIOTeCH 2024年第1期5卷 17-28页

作者： Jie Li Bo-sen Zhang Hua-Wei Wu Cheng-Lan Liu Hui-Shan Guo Jian-Hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for excellence in Biotic Interactions University of the Chinese Academy of SciencesBeijing 100049China Qilu Zhongke Academy of Modern Microbiology Technology Jinan 250022China

Small rNA(srNA)-mediated rNA silencing(also known as rNA interference,or rNAi)is a conserved mechanism in eukaryotes that includes rNA degradation,DNA methylation,heterochromatin formation and protein translation *** plants,srNAs can move either cell-to-cell or systemically,thereby acting as mobile silencing signals to trigger noncell autonomous ***,whether and what proteins are also involved in noncell autonomous silencing have not been *** this study,we utilized a previously reported inducible rNAi plant,PDSi,which can induce systemic silencing of the endogenous PDS gene,and we demonstrated that DCL3 is involved in systemic PDS silencing through its rNA binding *** confirmed that the C-terminus of DCL3,including the predicted rNA-binding domain,is capable of binding short *** affecting rNA binding,but not processing activity,reduced systemic PDS silencing,indicating that DCL3 binding to rNAs is required for the induction of systemic *** mosaic virus infection assays showed that the rNA-binding activity of DCL3 is required for antiviral rNAi in systemically noninoculated *** findings demonstrate that DCL3 acts as a signaling agent involved in noncell autonomous silencing and an antiviral effect in addition to its previously known function in the generation of 24-nucleotide srNAs.

关键词： rNAi signaling DCL3 rBD rNAs Cucumber mosaic virus