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The Future of

空中英语教室（高级版．彭蒙惠英语） 2013年第4期 8-9页

作者： page DESIGN MICHAEL TSE

The Global Boundary Stratotype Section and point （GSSp） for the base of the pliensbachian Stage （Lower Jurassic）, Wine Haven, Yorkshire, UK

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Episodes 2006年第2期29卷 93-106页

作者： Christian Meister martin Aberhan Joachim Blau Jean-Louis Dommergues Susanne Feist-Burkhardt Ernie A. Hailwood Malcom Hart Stephen p. Hesselbos mark W. Hounslow mark Hylton Nicol Morton Kevin page Greg D. price Département de Géologie et de paléontologie 1 route de Malagnou c.p. 6434 CH-1211 Genève 6 Switzerland Museum der Naturkunde Zentralinstitut der Humboldt-Universitat zu Berlin Institut für Palaiontolgie Invalidenstr. 43 D-10115 Berlin Germany Institut für Geowissenschaften Diezstrasse 15 D-35390 Giessen Germany Centre des Sciences de la Terre de I＇Université de Bourgogne UMR CNRS 5561： Paléontologie analytique et Géologie sédimentaire 6 Boulevard Gabriel F-21100 Dijon. France Department of palaeontology The Natural History Museum Cromwell Road London SW7 5BD UK Core Magnetics The Green Sedbergh Cumbria LA10 5JS UK Department of Geological Sciences University of Plymouth Drake Circus Plymouth Devon PL4 8AA UK Department of Earth Sciences University of Oxford Parks Road Oxford OXI 3PR UK CEMp Geography Dept. Lancaster Environment Centre Lancaster University Bailrigg Lancaster UK. LA1 4YB Le Chardon Quarrier Brugière F-07200 Vogüé France

Following votes by the pliensbachian Working Group, the Jurassic Subcommission and the International Commission on Stratigraphy, lUGS ratified the proposed Global Boundary Stratotype Section and point （GSSp） for the base of the pliensbachian Stage （Lower Jurassic） at the base of bed 73b in the Wine Haven section, Robin Hood＇s Bay, Yorkshire Coast, UK. This level contains the characteristic ammonite association Bifericeras donovani Dommergues and Meister and Apoderoceras sp. Complementary data include： a） Strontium-isotope stratigraphy, based on analysis of belemnites which yield a calcite 87Sr/^86Sr ratio for the boundary level of 0. 707425 and data supporting interpretation of continuous sedimentation; b） Belemnite oxygen-isotope data indicate a significant temperature drop （-5 ℃） across the boundary at this locality; c） A Transgressive Systems Tract （TST） initiated in the Aplanaturn Subzone （uppermost Sinemurian） continues into the Lowermost pliensbachian （Taylori Subzone）; it forms part of a transgressive facies cycle sensu Graciansky et al. （1998）; d） The Upper Sinemurian to lowermost plensbachian at Wine Haven section has a predominantly norreal magnetic polarity, but two discrete reversed polarity magnetozones are present. The first spans much of the latest Sinemurian Aplanatum Subzone. It terminates 〈0.5m below the Sinemurian-pliensbachian boundary and may prove a valuable chronostratigraphic marker The second extends from the latest Oxynotum Subzone probably through to the lower part of the Raricostatum Subzone.

关键词：普连斯巴奇阶侏罗纪 GSSp 全球界线层型剖面点

Androgen receptor deficiency in monocytes/ macrophages does not alter adiposity or glucose homeostasis in male mice

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Asian Journal of Andrology 2018年第3期20卷 276-283页

作者： Katya B Rubinow Barbara Houston Shari Wang Leela Goodspeed Kayoko Ogimoto Gregory J Morton Christopher McCarty Robert E Braun Stephanie T page Division of Metabolism Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine Seattle WA 98195 USA Jackson Laboratory Bar Harbor ME 04609 USA

Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor （AR） is expressed in monocytes/macrophages, which are resident in key metabolic tissues and influence energy metabolism in surrounding cells. Male mice bearing a cell-specific knockout of the AR in monocytes/macrophages （M-ARKO） were generated to determine whether selective loss of androgen signaling in these cells would lead to altered body composition. Wild-type （WT） and M-ARKO mice （12-22 weeks of age, n = 12 per group） were maintained on a regular chow diet for 8 weeks and then switched to a high-fat diet for 8 additional weeks. At baseline and on both the regular chow and high-fat diets, no differences in lean mass or fat mass were observed between groups. Consistent with the absence of differential body weight or adiposity, no differences in food intake （3.0 ± 0.5 g per day for WT mice vs 2.8 ± 0.4 g per day for M-ARKO mice） or total energy expenditure （0.6 ± 0.1 Kcal h-1 for WT mice vs 0.5 ± 0.1 Kcal h-1 for M-ARKO mice） were evident between groups during high-fat feeding. Liver weight was greater in M-ARKO than that in WT mice （1.5 ± 0.1 g vs 1.3 ± 0.0 g, respectively, p = 0.02）. Finally, M-ARKO mice did not exhibit impairments in glucose tolerance or insulin sensitivity relative to WT mice at any study time point. In aggregate, these findings suggest that AR signaling specifically in monocytes/macrophages does not contribute to the regulation of systemic energy balance, adiposity, or insulin sensitivity in male mice.

关键词： androgen receptor knockout mice macrophages male hypogonadism metabolic syndrome

Mind-reading Machine Knows What You See

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当代外语研究 2005年第6期 33-34页

作者： Michael Le page 邱楠

有时候你是否很想知道别人的心思呢?或许你会说,那是不可能的事情!但是最近研究者发现,通过遥测一个人的大脑活动而了解他的心思是很有可能的,而且这种技术还可以获得人们自己都可能没有意识到的信息!

关键词： Mind-reading Machine Knows What You See

The demands of the extra-time period of soccer:A systematic review

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Journal of Sport and Health Science 2022年第3期11卷 403-414页

作者： Adam Field Robert Joseph Naughton Matthew Haines Steve Lui Liam David Corr mark Russell Richard Michael page Liam David Harper School of Human and Health Sciences University of HuddersfieldHuddersfieldHD13DHUK School of Social and Health Sciences Leeds Trinity UniversityBrownberrie LaneHorsforthLeedsLS185HDUK Department of Sport&physical Activity Edge Hill UniversitySt.Helens RoadOrmskirkLancashireL394QPUK

Background:Soccer match-play is typically contested over 90 min;however,in some cup and tournament scenarios,when matches are tied,they proceed to an additional 30 min,which is termed "extra-time^(ET).This systematic review sought to appraise the literature available on 120-min of soccer-specific exercise,with a view to identifying practical recommendations and future research ***:The review was conducted according to the pRISMA *** researchers performed a systematic search of pubMed,CINAHL,and psycINFO in May 2019,with the following keywords entered in various combinations:"soccer","football","extra-time","extra time","extratime","120 minutes","120 min","additional 30 minutes",and "additional 30 min".Results:The search yielded an initial 73 *** the screening process,11 articles were accepted for *** were subsequently organized into the following 5 categories:movement demands of ET,performance responses to ET,physiological and neuromuscular response during ET,nutritional interventions,and recovery and *** results highlighted that during competitive match-play,players cover5%-12% less distance relative to match duration(i.e.,meters per minute) during ET compared to the preceding 90 *** in technical performance(i.e.,shot speed,number of passes and dribbles) were also observed during ***,carbohydrate provision may attenuate and improve dribbling performance during ***,objective and subjective measures of recovery may be further compromised following ET when compared to 90 ***:Additional investigations are warranted to further substantiate these findings and identify interventions to improve performance during ET.

关键词： Movement demands Neuromuscular fatigue Nutritional intervention performance physiology

potassium channel blockers restore axonal conduction in CNS trauma and diseases

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Neural Regeneration Research 2016年第8期11卷 1226-1227页

作者： Jessica C.page Riyi Shi Department of Basic Medical Sciences College of Veterinary MedicinePurdue University Weldon School of Biomedical Engineering Purdue University

Myelin damage in the central nervous system（CNS）plays an important role in motor and sensory dysfunction（Shi and Sun,2011）.This neuropathology is observed widely in neurotrauma such as spinal cord injuries（SCI）and is also a distinguishing feature of many neurological diseases such as multiple sclerosis（MS）and amyotrophic lateral sclerosis（ALS）（Shi and Sun,2011）.

关键词： conduction axonal restore amyotrophic myelin trauma consequences neurological potassium distinguishing

Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis

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Food Bioscience 2022年第3期47卷 918-927页

作者： Afaf Kheroufi maría E.Brassesco Débora A.Campos Halima Boughellout Manuela E.pintado Laboratoire de Génie Agro-alimentaire équipe Génie des Procédés AlimentairesBiodiversité et Agro environnementInstitut de la Nutritionde l’Alimentation et des Technologies Agroalimentaires INATAAUniversité Frères Mentouri Constantine 1BP 325 Route de Ain El BeyConstantineAlgeria CBQF – Centro de Biotecnologia e Química Fina – Laboratório Associado Escola Superior de BiotecnologiaUniversidade Católica Portuguesa/PortoRua de Diogo Botelho 13274169-005PortoPortugal

Enzymatic whey proteins concentrates (WpC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WpC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FpLC),Tricine SDS-page,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other *** showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and *** results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other *** hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients.

关键词： Whey proteins Ficin Hydrolysis Antioxidant Solubility

Cyber risk at the edge:current and future trends on cyber risk analytics and artificial intelligence in the industrial internet of things and industry 4.0 supply chains

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Cybersecurity 2018年第1期1卷 767-787页

作者： petar Radanliev David De Roure Kevin page Jason R.C.Nurse Rafael Mantilla Montalvo Omar Santos La’Treall Maddox pete Burnap Oxford e-Research Centre Engineering Sciences DepartmentUniversity of OxfordOxfordEngland School of Computing University of KentKentEnglandUK Cisco Research Centre Research Triangle ParkDurhamNorth CarolinaUSA School of Computer Science and Informatics Cardiff UniversityCardiffWalesUK

Digital technologies have changed the way supply chain operations are *** this article,we conduct systematic syntheses of literature on the impact of new technologies on supply chains and the related cyber risks.A taxonomic/cladistic approach is used for the evaluations of progress in the area of supply chain integration in the Industrial Internet of Things and Industry 4.0,with a specific focus on the mitigation of cyber *** analytical framework is presented,based on a critical assessment with respect to issues related to new types of cyber risk and the integration of supply chains with new *** paper identifies a dynamic and self-adapting supply chain system supported with Artificial Intelligence and Machine Learning(AI/ML)and real-time intelligence for predictive cyber risk *** system is integrated into a cognition engine that enables predictive cyber risk analytics with real-time intelligence from IoT networks at the *** enhances capacities and assist in the creation of a comprehensive understanding of the opportunities and threats that arise when edge computing nodes are deployed,and when AI/ML technologies are migrated to the periphery of IoT networks.

关键词： Industry 4.0 Supply chain design Transformational design roadmap IIoT supply chain model Decision support for information management artificial intelligence and machine learning(AI/ML) dynamic self-adapting system cognition engine predictive cyber risk analytics

IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice

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International Journal of Oral Science 2020年第1期12卷 31-39页

作者： Angustias page Ana Bravo Cristian Suarez-Cabrera Raquel Sanchez-Baltasar marta Oteo Miguel Angel Morcillo MLlanos Casanova Jose CSegovia Manuel Navarro Angel Ramirez Molecular Oncology Unit.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT)MadridSpain Instituto de Investigación 12 de Octubre i+12 MadridSpain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) MadridSpain Department of Anatomy Animal Production and Veterinary Clinical SciencesLaboratory of Pathology Phenotyping of Genetically Engineered MiceFaculty of Veterinary MedicineUniversity of Santiago de CompostelaLugoSpain Biomedical Applications and pharmacokinetics Unit Centro de Investigaciones EnergéticasMedioambientales y Tecnológicas(CIEMAT)MadridSpain Hematopoietic Innovative Therapies Division.Centro de Investigaciones Energéticas Medioambientales y Tecnológicas(CIEMAT).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)MadridSpain Unidad Mixta de Terapias Avanzadas Fundación Instituto de Investigaciones Sanitarias Fundación Jiménez DíazMadridSpain

Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures that differentiate as teeth. Due to the diversity of their histopathological characteristics and clinical behaviour, the classification of these tumours is still under debate. Alterations in morphogenesis pathways such as the Hedgehog,MApK and WNT/β-catenin pathways are implicated in the formation of odontogenic lesions, but the molecular bases of many of these lesions are still unknown. In this study, we used genetically modified mice to study the role of IKKβ(a fundamental regulator of NF-κB activity and many other proteins) in oral epithelial cells and odontogenic tissues. Transgenic mice overexpressing IKKβ in oral epithelial cells show a significant increase in immune cells in both the oral epithelia and oral submucosa. They also show changes in the expression of several proteins and mi RNAs that are important for cancer development. Interestingly, we found that overactivity of IKKβ in oral epithelia and odontogenic tissues, in conjunction with the loss of tumour suppressor proteins(p53, or p16 and p19), leads to the appearance of odontogenic tumours that can be classified as ameloblastic odontomas, sometimes accompanied by foci of secondary ameloblastic carcinomas. These tumours show NF-κB activation and increased β-catenin *** findings may help to elucidate the molecular determinants of odontogenic tumourigenesis and the role of IKKβ in the homoeostasis and tumoural transformation of oral and odontogenic epithelia.

关键词： IKKβ tumour suppressor