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美国医学会眼科杂志（中文版） 2003年第3期15卷 186-186页

作者： DavidJ.Lee OrlandoGámez-marín ByronL.Lam D.DianeZheng 钟铮

目的：研究全美国成人范围内有代表性的抽样中视力损害(VI)和死亡率的关系。

关键词：美国成年人视敏度损害死亡率调查

P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析

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中华医学杂志 2016年第33期96卷 2611-2615页

作者：冯斯婷严妍范婧尧王晓郑文聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 100029 University Hospital Alvaro Cunqueiro Vigo Spain Academic Medical Center Amsterdam the Netherlands Dipartimento di Scienze Mediche Divisione di Cardiologia Citta della Salute e della Scienza Turin Italy North Shore University Hospital Chicago USA University Clinical Hospital of Santiago de Compostela Santiago de compostela Spain Libin Cardiovascular Institute of Alberta Calgary Canada San Carlos Hospital Madrid Spain Bellvitge University Hospital Barcelona Spain University Patras Hospital Athens Greece Kerckhoff Heart and Thorax Center Frankfurt Germany Graduate School of Medicine Kyoto University Kyoto Japan University Clinical Hospital Warsaw Poland Hospital Sao Rafael Salvador Brazil Kanazawa University Graduate School of Medicine Kanazawa Japan University Clinic of Cardiology Skopje Macedonia

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分... 详细信息

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分为PPI组及非PPI组并随访1年，主要临床终点为全因死亡／再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类，将入组患者分为氯吡格雷组及替格瑞洛组，并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者，PPI组占54．8％，具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡／再发心肌梗死复合事件的发生差异无统计学意义（HR1．00，95％CI 0．86—1．18）。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组，不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异，联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险，尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。

关键词：急性冠脉综合征氯吡格雷质子泵抑制剂患者结局评价替格瑞洛

Fabry病及α-半乳糖苷酶A基因一个新突变的家族患者出现伴有血栓的长基底动脉变异

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世界核心医学期刊文摘(眼科学分册) 2005年第12期 1-1页

作者： Garzuly F maró di L Erds M H. Budka 杨秀梅 Institute of Neurology Medical University of Vienna Waehringer Guertel 18- 20 4J 1097 Vienna Austria Prof.

Fabry’s disease is an X-linked lysosomal storage disorder. α -Galactosidase deficiency leads to accumulation of globotriaosylceramide mainly in endothelial and smooth muscle cells. Cerebrovascular symptoms with predominant affection of the vertebrobasilar circulation are one of the major sources of morbidity in Fabry’s disease. We present a Hungarian family with Fabry’s disease caused by a new mutation in the α -galactosidase A gene (GLA), and describe a variant expression of the disease. Megadolichoba- silar anomaly was diagnosed in two male patients in the family who died of thrombosis. In another female patient who had suffered from disturbance of the vertebrobasilar circulation, a strongly dilated basilar artery without thrombosis was found at autopsy. Another three family members had basilar strokes and large and elongated basilar arteries on MRI. Genetic analysis disclosed a c.47T→ C missense mutation resulting in L16P in the amino acid sequence of the α -galactosidase protein. This report suggests that megadolichobasilar anomaly is potentially life-threaten-ing, and that L16P is a diseasecausing mutation in patients with Fabry’s disease. Early enzyme replacement therapy may prevent the development of these irreversible cerebrovascular complications.

关键词：基底动脉 α-半乳糖苷 Fabry 血栓家族新突变基因

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中国香港17种植物新记录

热带亚热带植物学报 2021年第2期29卷 123-131页

作者：刘金刚幸敬阳黄筑君韩卓希 WILLIAMS Craig 马锡成李玉来张金龙 FISCHER Gunter A 嘉道理农场暨植物园植物保育部中国香港英华书院中国香港香港空运货站有限公司中国香港

报道了香港17种植物新记录:无配膜叶铁角蕨[Hymenasplenium apogamum(***.&Hatan.)Nakaike]、似薄唇蕨(Leptochilus decurrens Blume)、穿心藤[Amydrium hainanense(***,***&***)***]、毛背桂樱[Laurocerasus hypotricha(Rehder)***&***]、寒莓(Rubus buergeri Miq.)、毛果青冈(Quercus pachyloma Seemen)、粉绿柯(Lithocarpus glaucus Chun&*** ex ***)、龙眼柯(*** ***&***)、豆叶九里香(Murraya euchrestifolia Hayata)、崖柿(Diospyros chunii ***&***)、打铁树[Myrsine linearis(Lour.)Poir.]、针齿铁仔(*** Wall.)、疏齿木荷(Schima remotiserrata Hung ***)、台湾醉魂藤(Heterostemma brownii Hayata)、华南水壶藤[Urceola napeensis(Quint.)***]、斜果挖耳草(Utricularia minutissima Vahl)、馥芳艾纳香(Blumea aromatica DC.);其中,醉魂藤属(Heterostemma Wight&Arn.)为香港新记录属。同时描述了每种植物的生境、主要识别特征以及与相似种的区别。多数新记录种都发现于山地或沟谷中的偏僻生境。对这些生境的持续探索有望进一步丰富香港的植物类群。

关键词：香港新记录植物区系物种保存维管植物

在腐植酸存在的条件下动态模拟铜在贻贝类体内的富积

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腐植酸 2018年第1期 48-48页

作者： Paula Sánchez-marín Eneko Aierbe J.Ignacio Lorenzo 袁晓娜(译) 不详中国腐植酸工业协会

依据金属生物利用度模型，腐植酸对铜的络合作用有望降低水生生物对铜的生物利用度，就如生物配体模型（BLM）。这个模型在海洋无脊椎动物胚胎或是微藻类等不进食生物中得到了证实。但对于像紫贻贝等滤食性生物体，在腐植酸存在的条件... 详细信息

依据金属生物利用度模型，腐植酸对铜的络合作用有望降低水生生物对铜的生物利用度，就如生物配体模型（BLM）。这个模型在海洋无脊椎动物胚胎或是微藻类等不进食生物中得到了证实。但对于像紫贻贝等滤食性生物体，在腐植酸存在的条件下铜的富积较高，表明摄取的铜-腐植酸复合物可被吸收。

关键词：腐植酸动态模拟生物利用度富积体内贝类铜体模型

Relationship between D90 and D100 with Biochemical and Local Failure in Low-risk Prostate Cancer Treated with Low-rate Brachytherapy(LDR)

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Journal of Oncology Research 2022年第2期4卷 1-12页

作者： marta Domínguez Morcillo Carmen Ibáñez Villoslada Joaquín Navarro Castellón Paula Sáez Bueno Eliseo Carrasco Esteban Andrea Matas Escamillas Zigor Zalabarría Zarrabeitia maría Concepción López Carrizosa Department of Radiation Oncology Hospital Central de la DefensaUniversidad de Alcaláde HenaresMadridSpain

Low dose rate brachytherapy(LDR)is an accepted,effective treatment with few local side effects,used as monotherapy in patients with low-risk prostate cancer(PC).The aim of this paper is to analyse 245 patients treated with LDR in the Radiation Oncology Department of the Hospital Gómez Ulla,from 2004 to 2016,evaluating the relationship of dosimetric parameters with biochemical and local recurrence as well as genitourinary and gastrointestinal toxicity derived from the *** results obtained show a clear relationship between the dose used and biochemical and local failure.

关键词： Brachytherapy Prostate Cancer Dose Failure Biochemical Local

Hydatidosis and the duodenum: A systematic review of the literature

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World Journal of Meta-Analysis 2020年第3期8卷 265-274页

作者： Víctor de la Fuente-Aguilar Patricia Beneitez-Mascaraque Sergio Bergua-Arroyo maría Fernández-Riesgo Irene Camón-García Iris Cruza-Aguilera Kennia Ugarte-Yáñez JoséM Ramia Faculty of Medicine Universidad of AlcaláAlcaláde Henares 28801Spain Servicio de Cirugía General y del Aparato Digestivo Hospital General Universitario de Alicante and Institute for Health and Biomedical Research(ISABIAL)Alicante 03010Spain

BACKGROUND Injury to the duodenum(fistula formation,compression,or other complications)by a hydatid cyst(HC)is an exceptional *** To perform a systematic review of the literature on the fistulization of HC in the *** Following PRISMA guidelines,a search for HC with duodenal involvement was carried out in the databases of PubMed,SCielo and EMBASE without time *** Fourteen patients were identified,seven men and seven women,with a mean age of 53.14 years(SD=17.65,range:28-78).Three out of the 14(21%)had HC *** most frequent clinical manifestations were abdominal pain and nausea and/or *** imaging studies were performed in almost all cases,the most commonly used being abdominal computed tomography(10/14,71%).A range of surgical techniques were reported,most frequently HC drainage(41%)and enucleations(16%).Ten of the 14 patients had no complications and one patient *** follow-up period and recurrences could not be *** The most frequent symptoms were abdominal pain,nausea and *** tomography was the most used diagnostic imaging technique,and HC drainage and fistula closure via laparotomy was the most frequent ***,all diagnostic and therapeutic options for HC fistulizing the duodenum had a low level of evidence.

关键词： Echinococcosis Hydatidosis Duodenum Surgery Review

不符伦理的伊维菌素治疗新型冠状病毒肺炎研究有缺陷的研究意味着我们仍然不知道这种药物是否安全或有效

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英国医学杂志中文版 2022年第7期25卷 365-366页

作者： Gideon Meyerowitz-Katz Sarah Wieten maría de Jesús Medina Arellano Gavin Yamey 黄雯(译) School of Health and Society University of WollongongWollongongNew South WalesAustralia Department of Philosophy Durham UniversityDurhamEngland Bioethics Health and Biolaw ProgramInstituto de Investigaciones JurildicasUniversidad Nacional Autónoma de MéxicoMxico CityMexico Center for Policy Impact in Global Health Duke Global Health InstituteDuke UniversityDurhamNCUSA 北京协和医学院生命伦理学研究中心

在疾病暴发期间,考虑到开发新疗法的紧迫性,为了速度而牺牲研究中科学的严谨性可能是很有诱惑力的。然而,在2014-2016年西非埃博拉疫情暴发后,美国国家.医学科学院(National Academy of Medicine)发布的一份关于科研伦理的报告明确指出... 详细信息

在疾病暴发期间,考虑到开发新疗法的紧迫性,为了速度而牺牲研究中科学的严谨性可能是很有诱惑力的。然而,在2014-2016年西非埃博拉疫情暴发后,美国国家.医学科学院(National Academy of Medicine)发布的一份关于科研伦理的报告明确指出:“疫情期间的研究仍需遵循与所有涉及人类;受试者研究相同的核心科学和伦理要求1.”

关键词：伊维菌素科研伦理疾病暴发伦理要求肺炎新疗法

A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice

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Journal of Integrative Medicine 2021年第5期19卷 439-450页

作者： Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Araujo De Miranda Katrin Radloff Raquel Galvao Figuerêdo Costa Joyce de Cassia Rosade Jesus Jéssica Alves De Freitas Nayara Izabel Viana Ruan Pimenta Katia Ramos Moreira Leite JoséPinhata Otoch Ana Flávia marcal Pessoa Laboratory of Medical Investigation(LIM-26) Department of SurgeryUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Laboratory of Medical Investigation(LIM-29) Clinic Medical DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Department of Physiology Escola Paulista de Medicina/Universidade Federal de Sao PauloSP 04023062Brazil Max Rubner-Institut Federal Research Institute of Nutrition and FoodKarlsruheBW 76131Germany Cancer and Inflammation Program Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892United States Laboratory of Medical Investigation(LIM-55) Urology DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil D'Or Institute for Research and Education RJ 22281-100Brazil Program in Anesthesiology Surgical Sciencesand Perioperative MedicineUniversity of Sao PauloSao PauloSP 01246903Brazil Brazilian Academic Consortium for Integrative Health(CABSIN) Natural Products CommitteeSao PauloSP 05449-070Brazil

Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese ***: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of ***: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the ***: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.

关键词： Supplement Silymarin Prebiotic Obese Mice Steatosis Inflammation Mitochondrial biogenesis

The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo martínez Ávila Lliset Álvarez Pérez Gisselle martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano margarita De Quesada Amigó Rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa maría Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David marquez Department of Medical Oncology INOR La Habana Cuba Department of Gynaeco-Oncology INOR La Habana Cuba Department of Anatomical Pathology INOR La Habana Cuba Department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba Department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory Department INOR La Habana Cuba Clinical Trials Pharmacy Department INOR La Habana Cuba Department of Biostatistics CENCEC La Habana Cuba Scientific Department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care