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Food Bioscience 2023年第3期53卷 1044-1050页

作者： Claudia Inés Vénica Irma Verónica Wolf maría Julia Spotti maría luján capra Diego Javier Mercanti maría Cristina Perotti Instituto de Lactología Industrial(InLAIn) Universidad Nacional del Litoral(UNL)/Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ingeniería Química(FIQ)Santiago del Estero 2829S3000AOMSanta FeArgentina Instituto de Tecnología de Alimentos(ITA) FIQUNLSantiago del Estero 2829S3000AOMSanta FeArgentina

The impact of skim milk(SM),demineralized whey(DW),whey protein concentrate(WPC40-WPC80),isolated(WPI)and hydrolyzed(WPH)on different parameters of yogurts have been evaluated using SLB95 and Yoflex *** of whey proteins shortened the fermentation time in yogurts with the exception of WPH,which extended it and presented the highest titratable *** increased the Lactobacillus and decreased Streptococcus population in yogurts with SLB95 *** and WPC80 increased water-holding *** and WPC80 yogurts exhibited larger aggregates,compared to the rest ingredients,and be bigger with the SLB95 *** volatile compounds differ,though not greatly,among yogurts.

关键词： Fermented milks Milk proteins Flavor compounds Microscopy images Microbial counts Quality properties

RULEMAKInG POSSIBILITIES： EFFORTS OF THE UnITED STATES JUDICIAL COnFEREnCE ADVISORY COMMITTEE On EVIDEnCE RULES TO ADDRESS THE CHALLEnGES TO FOREnSIC EXPERT TESTIMOnY

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Frontiers of Law in China-Selected Publications from Chinese Universities 2018年第1期13卷 34-42页

作者： Daniel J. capra School of Law University of California Berkeley USA Reed Professor School of Law Fordharn University New York 10023 USA

This piece is an echo to one of the main subjects of the Sixth International Conference on Evidence Law and Forensic Science which is to determine what evidentiary reforms are necessary for regulating forensic expert testimony, and how those reforms might be implemented. In United States, the predominant way of evidentiary reform is through rulemaking. As the Reporter of Judicial Conference Advisory Committee on the Federal Rules of Evidence since 1996, the author, with a pragmatic spirit throughout the article, examines such an effort at the federal level of U.S. in six parts （levels）, starting from the most general, abstract level till fmishing with the most detailed and substantive points. Part I begins with a brief introduction of the hierarchies of evidentiary rulemaking authorities at the federal level of the United States, various interested groups and their interesting interactions in the rulemaking process. The author then shifts to the general topic of writing rules with a specific focus on the level of detail that is to be provided in doing so; Part II further narrows down the scrutiny into writing a rule on forensic expert testimony with an emphasis on the necessity of making such a rule change to the current general standards of FRE; Part III directly addresses the challenges of drafting a rule on forensic evidence in FRE, including a comparation of various alternative drafting models; Part IV and Part V respectively discusses the Reporter＇s comments and the Justice Department＇s concerns over the drafted rules; and Part VI briefly discusses the feasibility and effectiveness of a Best Practices Manual on forensic evidence in lieu of rulemaking.

关键词： forensics rulemaking reliability expert

Unveiling the geometric meaning of quantum entanglement:Discrete and continuous variable systems

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Frontiers of physics 2024年第5期19卷 193-206页

作者： Arthur Vesperini Ghofrane Bel-Hadj-Aissa Lorenzo capra Roberto Franzosi DSFTA University of SienaVia Roma 5653100 SienaItaly QSTAR&CnR-Istituto nazionale di Ottica Largo Enrico Fermi 2I-50125 FirenzeItaly InFn Sezione di Perugia I-06123 PerugiaItaly

We show that the manifold of quantum states is endowed with a rich and nontrivial geometric *** derive the Fubini−Study metric of the projective Hilbert space of a multi-qubit quantum system,endowing it with a Riemannian metric structure,and investigate its deep link with the entanglement of the states of this *** a measure,we adopt the entanglement distance E preliminary proposed in ***.A 101,042129(2020).Our analysis shows that entanglement has a geometric interpretation:E(|ψ>)is the minimum value of the sum of the squared distances between|ψ>and its conjugate states,namely the statesυ^(μ).σ^(μ)|ψ>,whereυ^(μ)are unit vectors andμruns on the number of *** the proposed geometric approach,we derive a general method to determine when two states are not the same state up to the action of local unitary ***,we prove that the entanglement distance,along with its convex roof expansion to mixed states,fulfils the three conditions required for an entanglement measure,that is:i)E(|ψ>)=0 iff|ψ>is fully separable;ii)E is invariant under local unitary transformations;iii)E does not increase under local operation and classical *** different proofs are provided for this latter *** also show that in the case of two qubits pure states,the entanglement distance for a state|ψ>coincides with two times the square of the concurrence of this *** propose a generalization of the entanglement distance to continuous variable ***,we apply the proposed geometric approach to the study of the entanglement magnitude and the equivalence classes properties,of three families of states linked to the Greenberger−Horne−Zeilinger states,the Briegel Raussendorf states and the W *** an example of application for the case of a system with continuous variables,we have considered a system of two coupled Glauber coherent states.

关键词： entanglements quantum information entanglement measure

Autoimmune hepatitis in genetic syndromes:A literature review

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World Journal of Hepatology 2021年第10期13卷 1328-1340页

作者： Anna Paola capra Emanuele Chiara Silvana Briuglia Department of Biomedical DentalMorphological and Functional Imaging SciencesUniversity of MessinaMessina 98100Italy Department of Clinical Pathology University of MessinaMessina 98100Italy

Genetic syndromes represent relevant and rare *** conditions include a large amount of epidemiological,pathogenetic and clinical ***,a systematic approach to genetic syndromes is often prevented by the rareness of these ***,although clinical features are usually precisely defined,nowadays more uncommon associations between genetic syndromes and internal medicine related diseases have been insufficiently *** hepatitis(AIH)is a chronic liver disease caused by loss of tolerance to hepatocyte-specific ***,a better knowledge about specific genetic syndromes in which AIH is more frequent could be important in the clinical management of patients,both for an early diagnosis and for a prompt ***,a systematic approach could explain if onset,clinical course,and response to treatment of AIH are typical for specific genetic *** took in consideration all the scientific articles reported in PubMed in the last 10 years,from 2010 to *** purpose of this review is to explore the prevalence of AIH in genetic syndrome,but also to suggest new classification,that could be useful for pathogenetic hypothesis and clinical approach to genetic *** the 139 publications selected using keywords“autoimmune hepatitis”and“genetic syndrome”,30 papers(21.6%)respected the chosen inclusion criteria,reporting the association between AIH in patients with a genetic *** have collected in all 47 patients with AIH and genetic syndrome,and with median age of *** suggest that when a patient presents a clinical picture of cryptogenic chronic hepatitis,that is unexplained,it is useful to explore differential diagnosis of AIH associated with genetic *** the clinical relevance of this topic,further reports are needed to demonstrate our hypothesis and collect new evidence in this field.

关键词： Autoimmunity Hepatitis Gene Syndrome Liver Disease Immunity

Transcriptome‑wide mapping of milk somatic cells upon subclinical mastitis infection in dairy cattle

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2630-2648页

作者： Vittoria Bisutti nuria Mach Diana Giannuzzi Alice Vanzin Emanuele capra Riccardo negrini maria Elena Gelain Alessio Cecchinato Paolo Ajmone‑marsan Sara Pegolo DAFnAE University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy. IHAP Universite de ToulouseINRAEENVT23 Chemin Des CapellesToulouse 31300France. IBBA National Research CouncilVia EinsteinLodi 26900Italy. DIAnA Universita Cattolica del Sacro CuoreVia E.Parmense 84Piacenza 29122Italy. BCA University of PadovaViale Dell’Universita 16LegnaroPD 35020Italy.

Background Subclinical intramammary infection(IMI)represents a significant problem in maintaining dairy cows’*** severity and extent depend on the interaction between the causative agent,environment,and *** investigate the molecular mechanisms behind the host immune response,we used RnA-Seq for the milk somatic cells(SC)transcriptome profiling in healthy cows(n=9),and cows naturally affected by subclinical IMI from Proto-theca spp.(n=11)and Streptococcus agalactiae(***;n=11).Data Integration Analysis for Biomarker discov-ery using Latent Components(DIABLO)was used to integrate transcriptomic data and host phenotypic traits related to milk composition,SC composition,and udder health to identify hub variables for subclinical IMI *** A total of 1,682 and 2,427 differentially expressed genes(DEGs)were identified when comparing Prototheca *** *** to healthy animals,***-specific pathway analyses evidenced that Proto-theca’s infection upregulated antigen processing and lymphocyte proliferation pathways while *** induced a reduction of energy-related pathways like the tricarboxylic acid cycle,and carbohydrate and lipid *** integrative analysis of commonly shared DEGs between the two pathogens(n=681)referred to the core-mastitis response genes,and phenotypic data evidenced a strong covariation between those genes and the flow cytometry immune cells(r2=0.72),followed by the udder health(r2=0.64)and milk quality parameters(r2=0.64).Variables with r≥0.90 were used to build a network in which the top 20 hub variables were identified with the Cytoscape cyto-hubba *** genes in common between DIABLO and cytohubba(n=10)were submitted to a ROC analysis which showed they had excellent predictive performances in terms of discriminating healthy and mastitis-affected animals(sensitivity>0.89,specificity>0.81,accuracy>0.87,and precision>0.69).Among these genes,CIITA could play a key role in re

关键词： Data integration Immune response Milk somatic cells RnA-sequencing Subclinical mastitis

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Intraoperative cell salvage with autologous transfusion in liver transplantation

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World Journal of Gastrointestinal Surgery 2019年第1期11卷 11-18页

作者： marcelo A Pinto marcio F Chedid Leo Sekine Andre P Schmidt Rodrigo P capra Carolina Prediger Jo?o E Prediger Tomaz JM Grezzana-Filho Cleber RP Kruel Division of Gastrointestinal Surgery and Liver Transplantation Hospital de Clínicas de Porto Alegre Medical School of UFRGS Division of Hematology Hospital de Clínicas de Porto Alegre Medical School of UFRGS Division of Anesthesia and Perioperative Medicine Hospital de Clínicas de Porto Alegre Medical School of UFRGS

Liver transplant(LT) is the primary treatment for patients with end-stage liver disease. About 25000 LTs are performed annually in the world. The potential for intraoperative bleeding is quite variable. However, massive bleeding is common and requires blood transfusion. Allogeneic blood transfusion has an immunosuppressive effect and an impact on recipient survival, in addition to the risk of transmission of viral infections and transfusion errors, among *** to prevent excessive bleeding or to use autologous blood have been proposed to minimize the negative effects of allogeneic blood *** reinfusion of autologous blood is possible through previous selfdonation or blood collected during the operation. However, LT does not normally allow autologous transfusion by prior self-donation. Hence, using autologous blood collected intraoperatively is the most feasible option. The use of intraoperative blood salvage autotransfusion(IBSA) minimizes the perioperative use of allogeneic blood, preventing negative transfusion effects without negatively impacting other clinical outcomes. The use of IBSA in patients with cancer is still a matter of debate due to the theoretical risk of reinfusion of tumor cells. However, studies have demonstrated the safety of IBSA in several surgical procedures, including LT for hepatocellular carcinoma. Considering the literature available to date, we can state that IBSA should be routinely used in LT, both in patients with cancer and in patients with benign diseases.

关键词： Liver transplantation Cell saver Hepatocellular carcinoma Blood transfusion Cell salvage

Multi-methodological Approach to Evaluate Performances of Mucoadhesive Oral Gel Based on nanoparticles

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Journal of Pharmacy and Pharmacology 2016年第7期4卷 307-317页

作者： P. capra M. Bleve G. Musitelli F. Pavanetto P. Peruginil Department of Drug Sciences University of Pavia Via Taramelli 12 27100 Pavia Etichub s.r.l. Department of Drug Sciences Via Taramelli 12 27100 Pavia.

Oral mucositis due to chemotherapy and irradiation continues to be an important clinical problem. The effectiveness of hyaluronic acid-based compounds in accelerated healing and helping manage pain in patients with oral mucositis was demonstrated. It was investigated a protective and regenerative effect of hyaluronic acid based gel formulation enriched with nAG （n-acetyl glucosamine） loaded solid lipid nanoparticles against degenerative process of the oral mucosa. Gel formulations were obtained by adding sHA （sodium hyaluronate） into SLn aqueous suspension. Gel performances were evaluated by multi-methodological approach： mucoadhesive and barrier properties evaluation, cell viability. It was shown that gel formulation based sHA, enriched with nAG loaded SLns, when added as suspension, demonstrated to have a good mucoadhesion profile comparable in terms of tensile work and fracture strength to Carbomer 934 2%. The presence of nAG encapsulated and not in gel formulation enhances also the biocompatibility of the system, demonstrating also to have a proliferative effect. Finally, any barrier property was altered. Finally, results demonstrated that sHA based gel formulation enriched SLns, demonstrated good mucoadeshion property, comparable to carbopol gel, positive control. The proposed gel formulation enriched with SLns setting up in this work could be used as innovation strategy to treat oral mucositis.

关键词： Solid lipid nanoparticle n-Acetyl Glucosamine Oral injuries Mucoadesion In vitro TEWL (trans epidermal water loss)evaluation.

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抗体多样性理论的新进展

国外医学(分子生物学分册) 1982年第2期 82-84页

作者： capra JD 谢蜀生马大龙

第四届国际免疫学大会于80年7月在巴黎举行,会议报告了有关抗体多样性问题的一些进展。在这一领域里,出现了一些令人惊异的戏剧性变化:在过去十年里,在抗体多样性问题上提出理论的各方既正确又有错误。正确的是因为一切有关多样性问题... 详细信息

第四届国际免疫学大会于80年7月在巴黎举行,会议报告了有关抗体多样性问题的一些进展。在这一领域里,出现了一些令人惊异的戏剧性变化:在过去十年里,在抗体多样性问题上提出理论的各方既正确又有错误。正确的是因为一切有关多样性问题的主要理论看来确实都起作用,而其错

关键词：个体型特异性编码抗体多样性遗传单位基因片段胚系基因体细胞突变高变区

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性别与心力衰竭的不良结局

世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 15-16页

作者： Lee W.Y. capra A.M. Jensvold n.G. 郝广华

Congestive heart failure(CHF) is the leading cause of hospitalization in the elderly, and these patients are at high risk for subsequent hospitalization. Whether gender affects the risk of rehospitalization in patients who have CHF is less well understood. We studied a random sample of 1,700 adults who had been hospitalized with CHF (from July 1,1999 to June 30,2000) and identified all readmissions through June 30,2001. We used proportional hazards regression to evaluate whether gender affects the risk of all-cause and CHF-specific rehospitalization, after adjusting for differences in demographic characteristics, health-related behaviors, co-morbid conditions, left ventricular systolic function status, and use of CHF therapies. Among 1,591 adults who had confirmed CHF, 752 were women (47.3%). Women were older than men (73 vs 71 years, pnd more likely to have preserved systolic function(55.3%vs 40.9%, pnsion(83.1%vs 75.2%, pnd prior renal insufficiency(46.8%vs 34.6%, pno significant differences existed between women and men with respect to crude rates of any readmission(144.7 vs 134.6 per 100 person-years, p=0.36) or CHF-specific readmission (39.9 vs 37.4 per 100 person-years, p=0.65). After adjusting for potential confounders, there was no significant difference between women and men with respect to risk of any readmission(adjusted hazard ratio 0.88, 95%confidence interval 0.76 to 1.02) or readmission for CHF (adjusted hazard ratio 0.89, 95%confidence interval 0.71 to 1.11). Among a contemporary, diverse population of patients who had CHF, rates of readmission overall and for CHF remained high, but gender was not independently associated with a differential risk of readmission.

关键词：再入院左室收缩功能治疗应用健康相关行为高危人群统计学特征住院治疗肾功能不全伴发疾病混杂因素

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独特型基础研究及其应用进展

国外医学(免疫学分册) 1989年第1期 38-40页

作者： capra J D Bona C 陈桦

一九八七年十一月十八日至二十日在美园安圣安东尼奥召开了第二届免疫网络与免疫调节会议。会议显示独特型与抗独特型研究已经开始渗透到一些实用领域,会上还讨论了独特型的结构、特性及命名等问题。本届会议的议题主要是:在过去的几年... 详细信息

一九八七年十一月十八日至二十日在美园安圣安东尼奥召开了第二届免疫网络与免疫调节会议。会议显示独特型与抗独特型研究已经开始渗透到一些实用领域,会上还讨论了独特型的结构、特性及命名等问题。本届会议的议题主要是:在过去的几年中独特型只是用来发现B 和T 细胞受体免疫学标志的试剂。大多数文章的主题是在调节淋巴细胞的功能中独特型作为靶物质的作用,目前研究已进入到一些明确的实际应用

关键词：独特型重链轻链可变区抗独特型抗体