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Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports

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World Journal of Gastroenterology 2020年第16期26卷 1979-1986页

作者： Apolonia Novillo maría gaibar Alicia Romero-Lorca maría Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander Department of Pre-clinical Dentistry Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Health Sciences Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Medicine Health Sciences FacultyUniversidad Europea de MadridVillaviciosa de OdónMadrid 28670Spain Department of Oncology University Hospital of FuenlabradaFuenlabradaMadrid 28942Spain Department of Pathological Anatomy University Hospital of FuenlabradaFuenlabradaMadrid 28942Spain

BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)*** benefit is not,however,observed in all *** increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug *** study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to *** SUMmarY We report six cases of stage IV KRAS-mutated *** were given first line treatment with BVZ-containing chemotherapy in University Hospital of *** six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease *** treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR *** main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of *** A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment.

关键词： Colorectal cancer Bevacizumab Chemokine CXCL5 Gene expression Progression-free survival Case report

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