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Management of cerebral amyloid angiopathy and atrial fibrillation:We are still far from precision medicine

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World Journal of Cardiology 2024年第5期16卷 231-239页

作者： Liuba fusco Zefferino Palamà Antonio Scarà Alessio Borrelli Antonio Gianluca Robles Gabriele De Masi DeLuca Silvio Romano Luigi Sciarra Department of Cardiology University Hospital of NorthamptonshireNorthampton NN15BDUnited Kingdom Department of Cardiology Casa di Cura Villa VerdeTaranto 70124Italy Department of Life Health and Environmental SciencesUniversity of l'AquilaL'Aquila 67100Italy Department of Cardiology GVM Care and ResearchSan Carlo di Nancy HospitalRome 00100Italy

The use of anticoagulation therapy could prove to be controversial when trying to balance ischemic stroke and intracranial bleeding risks in patients with concurrent cerebral amyloid angiopathy(CAA)and atrial fibrillation(AF).In fact,CAA is an age-related cerebral vasculopathy that predisposes patients to intracerebral ***,many AF patients require oral systemic dose-adjusted warfarin,direct oral anticoagulants(such as factor Xa inhibitors)or direct thrombin inhibitors to control often associated with cardioembolic stroke *** prevalence of both CAA and AF is expected to rise,due to the aging of the *** clinical dilemma is becoming increasingly *** patients with coexisting AF and CAA,the risks/benefits profile of anticoagulant therapy must be assessed for each patient individually due to the lack of a clear-cut consensus with regard to its risks in scientific *** review aims to provide an overview of the management of patients with concomitant AF and CAA and proposes the implementation of a risk-based decision-making algorithm.

关键词： Anticoagulation Atrial fibrillation Cerebral amyloid angiopathy Intracerebral hemorrhage Stroke Watchman Secondary prevention Left atrial appendage closure

Effect of Dietary Components on the Shear Bond Strength of Orthodontics Brackets after Thermal Aging

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Open Journal of Stomatology 2024年第6期14卷 309-315页

作者： Philip Punzalan Tanya Al Talib Anthony fusco Neamat Hassan Abubakr School of Dental Medicine University of Nevada Las Vegas Nevada USA

Introduction: The stability of orthodontic brackets throughout orthodontic treatment plays a critical role in the treatment’s effectiveness. The present in vitro study was designed to assess the impact of various dietary components on the performance of orthodontic brackets. Methods: Metal orthodontic brackets were bonded to 66 extracted anterior teeth divided into groups based on the solution type: Milk, Gatorade, Cold Coffee, and a control group using water. Each group consisted of 20 teeth except for the control group, which included six teeth. The bracketed teeth were submerged in their respective solutions for 15 minutes three times daily at different intervals to mimic an in vivo environment and were stored in artificial saliva at room temperature (23?C). The specimens underwent artificial aging through 10,000 cycles of thermocycling (representing one clinical year) between 5?C and 55?C. Shade measurements were taken using a VITA Easy Shade device, capturing the classic shade and L*, a*, and b* values. Delta E values were calculated immediately post-bonding and after 7 days, 1 month, 1, and 2 clinical years. The shear bond strength of each bracket was measured using an ultra-tester machine. Results: After two clinical years, significant differences in ΔE color values were observed across all groups, with the most substantial change noted in teeth immersed in cold coffee. Brackets submerged in milk demonstrated lower shear bond strength than other solutions, whereas the control group exhibited the highest shear bond strength (P = 0.01). Conclusion: The study indicates that dietary components significantly influence tooth color stability and the shear bond strength of orthodontic brackets, underscoring the importance of considering these factors in orthodontic treatment planning.

关键词： Shear Bond Orthodontic Brackets Color Stability Thermal Aging

The Potentiality of Non Timber Forest Products. Fruit Availability, Phytochemical Properties of Rosa rubiginosa L. Rose Hips

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American Journal of Plant Sciences 2016年第15期7卷 2272-2287页

作者： Gerardo U. Aguirre martín Loza José Gasquez maría fusco Angela Sosa Gladys M. Ciuffo Liliana E. C. Ciuffo Ecología y Conservación Facultad de Química Bioquímica y Farmacia Universidad Nacional de San Luis San Luis Argentina UNSL/FQBF/Química Analítica Ejército de los Andes San Luis Argentina UNSL/FQBF/Farmacognosia Ejército de los Andes San Luis Argentina UNSL/FQBF/Bioquímica Avanzada Ejército de los Andes San Luis Argentina IMIBIO/CONICET Ejército de los Andes San Luis Argentina

We evaluated fruit availability, phytochemical characteristics and mineral content of R. rubiginosa L. rose hips, at two experimental sites in San Luis province: Potrero de los Funes-El Volcán (PF-V) and Estancia Grande (EG). Plant density was 70 plants/ha (1 ha = 10,000 m2) in PF-V and 50 plants/ha in EG. Fruit availability (DF) in fresh fruits (FF) was 4.39 kg (PF-V) and 3.10 kg (EG) during march, and decreased during June. Ascorbic acid in FF increased during ripening period, peaking on late April, early May, and diminished 75% - 85% in dried fruits. Total soluble solids in FF ranged from 32.55 to 55.20 °Brix. Elements Ba, Ca, Fe, K, Zn and Cu, determined by inductively coupled plasma optical emission spectrometry (ICP-OES), were significant for human health. Dried fruits maintain a high level of ascorbic acid, a characteristic added to content of mineral elements, particularly calcium content, providing an important nutritional value to R. rubiginosa rose hips.

关键词： Rosa rubiginosa Rose Hips Fruit Chemical Contents Ascorbic Acid Mineral Elements

Biomarkers for targeted rehabilitation strategies after breast cancer: Proposal for the next-generation management of survivorship issues

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BIOCELL 2022年第10期46卷 2221-2223页

作者： marCO INVERNIZZI NICOLA fusco Translational Medicine Dipartimento AttivitàIntegrate Ricerca e Innovazione(DAIRI)Azienda Ospedaliera SS.Antonio e Biagio e Cesare ArrigoAlessandria15121Italy Physical and Rehabilitation Medicine Department of Health SciencesUniversity of Eastern PiedmontNovara28100Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan20122Italy

Breast cancer(BC)is the most common malignant tumor and one of the top causes of cancer-related death worldwide(Sung et al.,2021).The recent advances in early tumor diagnosis coupled with more effective treatment strategies resulted in a steady increase of long-term survivors(Nardin et al.,2020;Invernizzi et al.,2022).These improved survival rates led to a significantly higher incidence of disabling complications related to breast cancer and/or its treatment(Invernizzi et al.,2020a;D’Egidio et al.,2017;Zhong et al.,2020).

关键词： Breast cancer Biomarkers Survivorship Rehabilitation Precision medicine

Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules

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Translational Neurodegeneration 2022年第1期11卷 161-177页

作者： Francesca Natale Salvatore fusco Claudio Grassi Department of Neuroscience UniversitàCattolica del Sacro Cuore00168 RomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS 00168 RomeItaly.

Neurodegenerative disorders are one of the most common causes of disability and represent 6.3%of the global burden of *** them,Alzheimer’s,Parkinson’s,and Huntington’s diseases cause cognitive decline,representing the most disabling symptom on both personal and social *** molecular mechanisms underlying the onset and progression of dementia are still poorly understood,and include secretory factors potentially affecting differentiated neurons,glial cells and neural stem cell *** the last decade,much attention has been devoted to exosomes as novel carriers of information exchanged among both neighbouring and distant *** vesicles can be generated and internalized by different brain cells including neurons,neural stem cells,astrocytes,and microglia,thereby affecting neural plasticity and cognitive functions in physiological and pathological ***,we review data on the roles of exosomes as carriers of bioactive molecules potentially involved in the pathogenesis of neurodegenerative disorders and detectable in biological fluids as biomarkers of *** also discuss the experimental evidence of the therapeutic potential of stem cell-derived vesicles in experimental models of neurodegeneration-dependent cognitive decline.

关键词： Extracellular vesicles Neurodegenerative diseases Stem cells Biomarkers Cognitive decline

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Improving HER2 testing reproducibility in HER2-low breast cancer

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Cancer Drug Resistance 2022年第4期5卷 882-888页

作者： Elham Sajjadi Konstantinos Venetis mariia Ivanova Nicola fusco Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan 20141Italy Department of Oncology and Hemato-Oncology University of MilanMilan 20122Italy

HER2 is a pillar biomarker in breast cancer,and it is assessed by immunohistochemistry(IHC)using a three-tier scoring system and reflex in situ hybridization(ISH)for IHC score 2+.Novel HER2-directed antibody-drug conjugates have demonstrated significant antitumor activity in breast cancers with low levels of HER2 expression,*** score 1+or ISH-negative IHC score 2+.Both primary and acquired resistance to anti-HER2 therapies remains a challenge in the treatment of breast cancers according to the HER2 positivity ***,the ability to precisely discriminate among HER2-zero,HER2-low,and HER2-positive breast cancers is no longer a mere academic ***2 testing criteria,guidelines,and quality controls are re-gaining momentum for this new clinical ***,all preanalytical and analytical variables that might trouble the sensitivity and reproducibility of this test should be carefully considered to address all possible issues and open all possible therapeutic opportunities for breast cancer patients.

关键词： Breast cancer biomarkers HER2 HER2 low targeted therapy antibody-drug conjugates immunohistochemistry ISH

Productive and physiological implications of top-dress addition of branched-chain amino acids and arginine on lactating sows and offspring

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1080-1101页

作者： Diana Luise Federico Correa Claudio Stefanelli Aude Simongiovanni Tristan Chalvon-Demersay Maddalena Zini Luciano fusco Paolo Bosi Paolo Trevisi Department of Agricultural and Food Sciences University of Bologna40127 BolognaItaly Department for Life Quality Studies Alma Mater StudiorumUniversity of Bologna47921 RiminiItaly Metex Noovistago 32 Rue Guersant75017 ParisFrance Department of Biomedical and Neuromotor Sciences Alma Mater StudiorumUniversity of Bologna40126 BolognaItaly Freelancer Reggio nell’EmiliaItaly.

Background Branched-chain amino acids(BCAAs),including L-leucine(L-Leu),L-isoleucine(L-Ile),L-valine(L-Val),and L-arginine(L-Arg),play a crucial role in mammary gland development,secretion of milk and regulation of the catabolic state and immune response of lactating ***,it has recently been suggested that free amino acids(AAs)can also act as microbial *** study aimed at evaluating whether the supplementation of lactating sows with BCAAs(9,4.5 and 9 g/d/sow of L-Val,L-Ile and L-Leu,respectively)and/or L-Arg(22.5 g/d/sow),above the estimated nutritional requirement,could influence the physiological and immunological parameters,microbial profile,colostrum and milk composition and performance of sows and their *** At d 41,piglets born from the sows supplemented with the AAs were heavier(P=0.03).The BCAAs increased glucose and prolactin(P<0.05)in the sows’serum at d 27,tended to increase immunoglobulin A(IgA)and IgM in the colostrum(P=0.06),increased the IgA(P=0.004)in the milk at d 20 and tended to increase lymphocyte%in the sows’blood at d 27(P=0.07).Furthermore,the BCAAs tended to reduce the Chao1 and Shannon microbial indices(P<0.10)in the sows’*** BCAA group was discriminated by Prevotellaceae_UCG-004,Erysipelatoclostridiaceae UCG-004,the Rikenellaceae_RC9_gut_group and *** reduced piglet mortality pre-(d 7,d 14)and post-weaning(d 41)(P<0.05).Furthermore,Arg increased the IgM in the sow serum at d 10(P=0.05),glucose and prolactin(P<0.05)in the sow serum at d 27 and the monocyte percentage in the piglet blood at d 27(P=0.025)and their jejunal expression of NFKB2(P=0.035)while it reduced the expression of GPX-2(P=0.024).The faecal microbiota of the sows in Arg group was discriminated by *** combination of BCAAs and Arg tended to increase spermine at d 27(P=0.099),tended to increase the Igs(IgA and IgG,P<0.10)at d 20 in the milk,favoured the faecal colonisation of Oscillospiraceae UCG

关键词： Microbiota Post-weaning mortality Prolactin Sows diet

Loss of HER2 in breast cancer: biological mechanisms and technical pitfalls

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Cancer Drug Resistance 2022年第4期5卷 971-980页

作者： Stefania Morganti mariia Ivanova Emanuela Ferraro Liliana Ascione Grazia Vivanet Giuseppina Bonizzi Giuseppe Curigliano Nicola fusco Carmen Criscitiello Division of Early Drug Development for Innovative Therapies IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Department of Oncology and Haemato-Oncology University of MilanoMilan 20122Italy Breast Oncology Center Dana-Farber Cancer InstituteBostonMA 02215USAHarvard Medical SchoolBostonMA 02215USA Biobank for Translational and Digital Medicine Unit IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Division of Pathology IEOEuropean Institute of Oncology IRCCSMilan 20144Italy Breast Medicine Service Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA.

Loss of HER2 in previously HER2-positive breast tumors is not rare, occurring in up to 50% of breast cancers;however, clinical research and practice underestimate this issue. Many studies have reported the loss of HER2 afterneoadjuvant therapy and at metastatic relapse and identified clinicopathological variables more frequentlyassociated with this event. Nevertheless, the biological mechanisms underlying HER2 loss are still poorlyunderstood. HER2 downregulation, intratumoral heterogeneity, clonal selection, and true subtype switch have beensuggested as potential causes of HER2 loss, but translational studies specifically investigating the biology behindHER2 loss are virtually absent. On the other side, technical pitfalls may justify HER2 loss in some of these *** best treatment strategy for patients with HER2 loss is currently unknown. Considering the prevalence of thisphenomenon and its apparent correlation with worse outcomes, we believe that correlative studies specificallyaddressing HER2 loss are warranted.

关键词： HER2 loss breast cancer subtype switch tumor heterogeneity clonal selection HER2 downregulation technical pitfalls