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Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez maría fernanda gonzález Ana maría Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Low-Temperature Synthesis of ZnO Nanorods Stabilized with PVP

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材料科学与工程（中英文A版） 2020年第4期10卷 111-123页

作者： Armando Flores Moreno maría fernanda gonzález Pérez Escuela de Ingeniería Universidad La Salle PachucaAv.San Juan Bautiste de La Salle No.1San Juan TilcuautlaSan Agustín TlaxiacaHidalgoC.P.42160México Licenciatura en Ingeniería Civil Universidad La Salle PachucaAv.San Juan Bautiste de La Salle No.1San Juan TilcuautlaSan Agustín TlaxiacaHidalgoC.P.42160México

Small-diameter ZnO nanorods with lengths of 35-50 nm were synthesized by solvothermal treatment route at low temperature(70℃)for 48,96 and 144 hours using polyvinylpyrrolidone(PVP)as stabilizing *** optical band gap energy of nanorods was calculated by Tauc’s approximation,obtaining values of 3.30-3.21 *** X-ray diffraction(XRD)it was determined that ZnO samples crystallize in Wurtzite hexagonal structure and present changes in lattice *** XRD patterns reveal a preferential growth of ZnO nanostructures along the plane with Miller indices(002).Stabilization process of ZnO nanoparticles and nanorods was studied by Fourier-transform infrared(FT-IR)spectroscopy,determining that the presence of amide group in polymer structure confers the ability to interact electrostatically with ZnO nanostructures ***-IR results revealed that O and N atoms of amide group interact strongly with the surface of ZnO *** length/diameter ratio of ZnO nanorods at 48 and 96 hours of reflux was 2.3 and 2.7,respectively.

关键词： ZnO nanorods PVP stabilization low-temperature synthesis

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Geochemical Characterization of Soils in the Playa Lake Environment of Laguna de Encinillas, Chihuahua, Mexico

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Open Journal of Geology 2024年第9期14卷 900-918页

作者： maría fernanda Ponce-gonzález Alejandro Villalobos-Aragón Vanessa Verónica Espejel-García Daphne Espejel-García Facultad de Ingeniería Universidad Autónoma de Chihuahua Chihuahua México

Laguna de Encinillas, located in Chihuahua, Mexico, is an ephemeral lake situated within a playa lake sedimentary depositional environment. This region plays a significant role in the aquifer supplying water to Chihuahua City. A surficial soil sampling campaign was conducted in 2017, 2018, and 2021 to assess the potential impact of surface soil composition on groundwater quality. The collected soil samples were analyzed using inductively coupled plasma mass spectrometry (ICP-MS) following microwave-assisted digestion. The analytical results were employed to generate spatial distribution maps of elemental concentrations using QGIS, applying interpolation methods such as inverse distance weighting (IDW) and Kriging. The analysis revealed elevated concentrations of beryllium (Be), calcium (Ca), cadmium (Cd), chromium (Cr), magnesium (Mg), and strontium (Sr) in the eastern part of the study area. In contrast, arsenic (As) and iron (Fe) were more prevalent in the western sector. Notably, high levels of barium (Ba), silver (Ag), cobalt (Co), potassium (K), and scandium (Sc) were identified in the northeastern region. At the same time, nickel (Ni), titanium (Ti), and vanadium (V) were concentrated in the northern portion. Manganese (Mn) was particularly prominent in the southern area. The geogenic source of these elements is likely linked to the volcanic rocks from the surrounding mountain ranges.

关键词： Groundwater Quality Soils El Sauz-Encinillas Aquifer Chihuahua GIS

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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-gonzález Elena gonzález-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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Systematic Conservation Assessment for Most of the Colombian Territory as a Strategy for Effective Biodiversity Conservation

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Natural Resources 2014年第16期5卷 981-1006页

作者： marcela Portocarrero-Aya Germán Corzo Angélica Diaz-Pulido maría fernanda gonzález Magnolia Longo Lina Mesa Andrea Paz Wilson Ramírez Olga Lucía Hernández-Manrique Alexander von Humboldt Institute for Research on Biological Resources Bogotá Colombia

Colombian ecosystems maintain key ecological processes that support thousands of species, including human beings. With the expansion of the country’s population, and the implementation of a government’s development plan based on an economy centred on extraction patterns, the conservation of these ecosystems is at serious risk. It is a priority to implement effective strategies that ensure the protection of the country’s biological diversity as well as the mitigation and prevention of threats and to contribute to its proper use. Colombia’s development strategies as well as its peoples’ wellbeing depend on the suitable condition of its natural assets. The identification of surrogates of conservation, the formulation of conservation goals, the prioritization of key areas and the formulation of conservation strategies based on the preservation, restoration and sustainable use of the territory and its biodiversity are proposed for 60% of the emerged land (~ 700,000 Km2). This research aims at giving proper guidelines to manage the territory and finding common points between development and biodiversity conservation, as well as to use this input for the development and implementation of a National Decision-making Support System (DSS) that will potentially have an impact on Colombia’s environmental policies and territorial planning schemes.

关键词： Decision-Making Support System Key Areas for Conservation Biodiversity Colombia Sustainable Development

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玻璃游戏上海儿童玻璃博物馆2.0

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室内设计与装修 2021年第9期 50-57页

作者：无 Tilman Thürmer(设计) Francesca Inchingolo(设计) David Keohane(设计) maría fernanda gonzález Prendes(设计) 陈怡君(设计) 文思宁(设计) 协调亚洲COORDINATION ASIA 不详

众打造的当代艺术与设计博物馆。由玻璃工作车间改造而成的博物馆占地2320 m2,为儿童设计的内容结合探索性的参观体验,鼓励孩子们进行独立自主的学习。博物馆的展览在多个层面吸引观众,与其开展互动,而且所有展品都由一个寻宝游戏串联,... 详细信息

众打造的当代艺术与设计博物馆。由玻璃工作车间改造而成的博物馆占地2320 m2,为儿童设计的内容结合探索性的参观体验,鼓励孩子们进行独立自主的学习。博物馆的展览在多个层面吸引观众,与其开展互动,而且所有展品都由一个寻宝游戏串联,邀请观众们在空间中寻找线索。互动性十足的博物馆让孩子们主导参观体验,探索更多他们感兴趣的主题,并积极主动学习关于玻璃、环境、科学、技术、艺术、设计与人类文明的知识。多媒体与数字内容在展览设计中扮演着重要的角色,包含镜子迷宫、声音装置、追踪动态的互动展项以及探讨与玻璃相关的各种主题视频。

关键词：展览设计多媒体艺术与设计博物馆车间改造参观体验互动性

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Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： maría Belén Cieri Alberto Javier Ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

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Exclusion of tourist species from assemblages in ecological studies:a methodological approach using spiders

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Ecological Processes 2022年第1期11卷 825-844页

作者： maría Florencia Nadal Alda gonzález Gilberto Avalos Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos AiresArgentina Laboratorio de Biología de los Artrópodos Facultad de Ciencias Exactas y Naturales y AgrimensuraUniversidad Nacional del NordesteAvenida Libertad 54703400 CorrientesArgentina Centro de Estudios Parasitológicos y de Vectores(CEPAVE-UNLP) Boulevard 120 s/n(e/60-64)1900 La PlataArgentina

Background:The exclusion of tourist species from samples is important to avoid bias in community ***,in practice,this is a very difficult *** commonly used methods by researchers,when the habitat of the species is not known,have several shortcomings:first,they exclude not only pseudo-rare species but also genuinely rare species;second,the results obtained with those methods depend on the abundance of the sampling;and third,they follow very subjective *** aims of this study were:(i)to propose a methodology to detect and exclude habitat-tourist species from the database used to carry out analyses in community ecology studies,(ii)to evaluate how the presence of habitat-tourist species affects the richness estimates,and(iii)to assess the effect of including juvenile spiders in the detection of tourist species and the effect of removing them from the richness ***:When the adult+juvenile dataset was considered,twenty-one habitat-tourist species were detected:8 in forest foliage,11 in forest leaf litter,and 2 in *** habitat-tourist species were considered with this dataset,richness overestimation was significant in foliage and in leaf litter,and the final slopes of the richness estimation curves were significantly steeper in leaf *** only the adult dataset was considered,eight habitat-tourist species were detected:3 in forest foliage,4 in forest leaf litter,and just one in *** inclusion of habitat-tourist species in this dataset showed an overestimation of richness,but this was not ***:The proposed methodology contributes to solving the problem of tourist species,which was recognized as one of the great problems in biodiversity *** study showed that common estimators overestimate species richness when habitat-tourist species are included,leading to erroneous ***,this research showed that the inclusion of juveniles(***)could improve the analysis outputs be

关键词： Pseudo-rare species Richness estimation Indicator value Habitat

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Tracking the change in Spanish greenhouse gas emissions through an LMDI decomposition model:A global and sectoral approach

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Journal of Environmental Sciences 2024年第5期139卷 114-122页

作者： Paula Fernández gonzález maría José Presno Manuel Landajo Department of Applied Economics University of OviedoAuda del Cristos/n 33011 OviedoSpain

The reduction of GHG emissions to reverse the greenhouse effect is one of the main challenges in this *** this paper we pursue two ***,we analyze the evolution of GHG emissions in Spain in 2008–2018,at both the global and sectoral levels,with the variation in emissions decomposed into a set of determining ***,we propose several actions specifically oriented to more tightly controlling the level of *** results showed a remarkable reduction(18.44%)in GHG emissions,mainly due to the intensity effect,but also to the production-per-capita *** detected somewhat different patterns among the various sectors *** the intensity effect was the most influential one in the agricultural,transport,and others sectors,the production-per-capita effect was predominant in the case of *** carbonization effect was revealed as crucial in the commerce *** above findings highlight the importance of the energy efficiency measures taken in recent years in the Spanish economy,also pointing to the need to deepen those strategies and to propose new measures that entail greater efficiency in *** efforts in areas like innovation,R&D,diffusion of more eco-friendly technologies,and a greater use of greener energies all prove to be essential reduction actions to fight the greenhouse effect.

关键词： LMDI Decomposition Spain GHG emissions

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Contribution of the Open Access Modality to the Impact of Hybrid Journals Controlling by Field and Time Effects

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Journal of Data and Information Science 2022年第2期7卷 57-83页

作者： Pablo Dorta-gonzález maría Isabel Dorta-gonzález University of Las Palmas de Gran Canaria TiDES Research Institute35017 Las Palmas de Gran CanariaSpain University of La Laguna 38271 La LagunaSpain

Purpose:Researchers are more likely to read and cite papers to which they have access than those that they cannot ***,the objective of this work is to analyze the contribution of the Open Access(OA)modality to the impact of hybrid ***/methodology/approach:The“research articles”in the year 2017 from 200 hybrid journals in four subject areas,and the citations received by such articles in the period 2017-2020 in the Scopus database,were *** hybrid OA papers were compared with the paywalled *** journals were randomly selected from those with share of OA papers higher than some minimal *** than 60 thousand research articles were analyzed in the sample,of which 24%under the OA ***:We obtain at journal level that cites per article in both hybrid modalities(OA and paywalled)strongly ***,there is no correlation between the OA prevalence and cites per *** is OA citation advantage in 80%of hybrid ***,the OA citation advantage is consistent across fields and held in *** obtain an OA citation advantage of 50%in average,and higher than 37%in half of the hybrid ***,the OA citation advantage is higher in Humanities than in Science and Social *** limitations:Some of the citation advantage is likely due to more access allows more people to read and hence cite articles they otherwise would ***,causation is difficult to establish and there are many possible *** factors can affect the observed differences in citation *** mandates can be one of *** are likely to have OA requirement,and well-funded studies are more likely to receive more citations than poorly funded *** discussed factor is the selection bias postulate,which suggests that authors choose only their most impactful studies to be open *** implications:For hybrid journals,the open access modality is positive,in the sense that it provides a greater

关键词： Open access Open science Scholarly communication Hybrid journals Citation advantage

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