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Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats

neuroscience & Medicine 2012年第2期3卷 174-180页

作者： Lucas Toibaro Magdalena Pereyra Julieta Pastorino Ariela Smigliani Florencia Ocariz Germán Ortmann maría Milagros Galardi maría belén gori Silvia Kochen Epilepsy Laboratory Institute of Cellular Biology and Neuroscience—National Council for Scientific and Technical Research (CONICET) School of Medicine University of Buenos Aires Buenos Aires Argentina

Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not become seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. However, the optimal stimulation parameters remain undetermined and active research in humans and animals is necessary. The present study was designed to investigate the effect of unilateral Low Frequency Stimulation (LFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK;n = 6) received only RK stimulus, while the treated group (LFS-hRK;n = 8) received also LFS (biphasic square wave pulses, 1 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing on day 3, 62% (P nimals receiving LFS treatment were still not fully kindled staying in stages 0-III (P number of stimulations needed to achieve generalized seizures (stage IV-V of Racine scale) was significantly higher (P n the LFS group with respect to control group. no significant differences in the cumulative daily afterdischarge duration were observed between both groups. These findings suggest that preemptive LFS can significantly decrease the incidence of hippocampus-kindled seizures and delay the progression and secondary generalization of focal seizures.

关键词： Hippocampal Rapid Kindling Epilepsy Electrical Stimulation Low-Frequency Stimulation Electrical Stimulation Protective Effect

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nGR-tagged nano-gold： A new CD13-selective carrier for cytokine delivery to tumors

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nano Research 2016年第5期9卷 1393-1408页

作者： Flavio Curnis martina Fiocch Angelina Sacchi Alessandro gori Anna Gasparri Angelo Corti Division of Experimental Oncology IRCCS San Raffaele Scientific Institute Milan 20132 Italy Istituto di Chimica del Riconoscimento Molecolare CNR Milan 20131 Italy Vita Salute San Raffaele University Milan 20132 Italy

Colloidal gold （Au）, a well-tolerated several applications in nanomedicine. nanomaterial, is currently exploited for We show that gold nanoparticles tagged with a novel tumor-homing peptide containing Asn-Gly-Arg （nGR）, a ligand of CD13 expressed by the tumor neovasculature, can be exploited as carriers for cytokine delivery to tumors. Biochemical and functional studies showed that the nGR molecular scaffoldflinker used for gold functionalization is critical for CD13 recognition. Using fibrosarcorna-bearing mice, nGR-tagged nanodrugs could deliver extremely low, yet pharmacologically active doses of tumor necrosis factor （TnF）, an anticancer cytokine, to tumors with no evidence of toxicity. Mechanistic studies confirmed that CD13 targeting was a primary mechanism of drug delivery and excluded a major role of integrin targeting consequent to nGR deamidation, a degradation reaction that generates the isoAsp-Gly-Arg （isoDGR） integrin ligand. nGR-tagged gold nanoparticles can be used, in principle, as a novel platform for single- or multi-cytokine delivery to tumor endothelial cells for cancer therapy.

关键词： Asn-Gly-Arg (nGR) isoAsp-Gly-Arg (isoDGR) CD13 integrin tumor necrosis factor albumin gold nanoparticles

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Cretaceous tectonic evolution of the neo-Tethys in Central Iran:Evidence from petrology and age of the nain-Ashin ophiolitic basalts

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Geoscience Frontiers 2020年第1期11卷 57-81页

作者： Tahmineh Pirnia Emilio Saccani Ghodrat Torabi marco Chiari Spela gorican Edoardo Barbero Department of Physics and Earth Sciences Ferrara UniversityFerrara44122Italy Department of Geology Faculty of ScienceUniversity of IsfahanIran CnR Istituto di Geoscienze e GeorisorseFlorenceItaly Paleontoloski institut Ivana Rakovca ZRC SAZU LjubljanaSlovenia

The nain and Ashin ophiolites consist of Mesozoic melange units that were emplaced in the Late Cretaceous onto the continental basement of the Central-East Iran microcontinent(CEIM).They largely consist of serpentinized peridotites slices;nonetheless,minor tectonic slices of sheeted dykes and pillow lavas-locally stratigraphically associated with radiolarian cherts-can be found in these ophiolitic *** on their whole rock geochemistry and mineral chemistry,these rocks can be divided into two geochemical *** sheeted dykes and most of the pillow lavas show island arc tholeiitic(IAT)affinity,whereas a few pillow lavas from the nain ophiolites show calc-alkaline(CA)*** modeling based on trace elements composition indicates that both IAT and CA rocks derived from partial melting of depleted mantle sources that underwent enrichment in subduction-derived components prior to *** modeling shows that these components were represented by pure aqueous fluids,or sediment melts,or a combination of both,suggesting that the studied rocks were formed in an arc-forearc tectonic *** new biostratigraphic data indicate this arc-forearc setting was active in the Early *** tectonic interpretations suggested that the nain ophiolites formed,in a Late Cretaceous backarc basin located in the south of the CEIM(the so-called nain-Baft basin).However,recent studies showed that the CEIM underwent a counter-clockwise rotation in the Cenozoic,which displaced the nain and Ashin ophiolites in their present day position from an original northeastward *** evidence combined with our new data and a comparison of the chemical features of volcanic rocks from different ophiolites around the CEIM allow us to suggest that the nain-Ashin volcanic rocks and dykes were formed in a volcanic arc that developed on the northern margin of the CEIM during the Early Cretaceous in association with the subduction,below the CEIM,of a neo

关键词： Ophiolite Volcanic arc Early Cretaceous nain Ashin Iran

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Pulsed export of carbon in the north-western Mediterranean Sea

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Journal of Oceanology and Limnology 2023年第1期41卷 189-202页

作者： Michel DEnIS Dominique LEFEVRE Melilotus THYSSEn Ian RJEnKInSOn Gérald GRÉgori Aix marseille Université Universitéde ToulonCNRS/INSUIRDInstitut Méditerranéen d'Océanologie(MIO)Marseille cedex09 13288France Key Laboratory of marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Agency for Consultation and Research in Oceanography Lavergne19320 La Roche CanillacFrance

The short term(hourly scale)variability of heterotrophic prokaryote(HP)vertical distribution and respiratory activity,was investigated in the north-western(nW)Mediterranean *** vertical distribution was determined on board by flow cytometry analysis of seawater samples collected by series of CTD *** counts and viability were determined for all *** respiratory rates were determined later in the laboratory from filtered seawater samples(23 dm^(3))from 300-1150-m *** average cell viability was 94.8%±2.2%(n=240).There was no accumulation of dead cells,due to quick decay of damaged *** the epipelagic layer,three HP groups were distinguished,two(HnA1,HnA2)who se cells exhibited a high nucleic acid content and one(LnA)with low nucleic acid content ***2 was most populated at 50 m but not detected at 90 m and below,presumably aerobic anoxygenic photoheterotrophic bacteria(AAPs).The variability in HP abundance was mainly confined in the upper 80 m.A few secondary peaks of HP abundance were observed(80-150 m)in connection with abundance troughs in the surface *** cells were continuously present in a wide layer around 500 m(mean 191×10^(3)cells/cm^(3)).below this layer,HP abundance randomly exhibited peaks,coupled to respiratory rate *** HP abundance and variability in the water column was suppressed during a strong wind *** observed sporadic variability was tentatively interpreted through a pulsed carbon-export mechanism induced by the microorganism production of dissolved poly saccharide s,followed by flocculation and rapid *** mechanism would thus contribute to(ⅰ)preventing organic matter accumulation in the epipelagic layer,(ⅱ)seeding the water column with live HP cells,and(ⅲ)supplying the aphotic water column with fre sh and labile organic *** important vertical flux mechanism needs further observations and modelling.

关键词： north-western Mediterranean Sea heterotrophic prokaryote(HP) cell viability cell respiration transparent exopolymeric particle(TEP) aggregation flow cytometry

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自身骨髓移植在恶性血液疾患中的应用（一）

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中华血液学杂志 1991年第3期12卷 113-115页

作者： gori.,nC 法国巴黎 Saint-Antoine医院

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先进的大中型型钢轧制技术

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钢铁 2009年第6期44卷 94-96页

作者： Loris Maestrutti Luca gori 苏宏蕾达涅利摩根沙玛公司

介绍了达涅利先进的中型和大型型钢轧制工艺和设备。主要包括:PSP型钢定径轧制工艺,SCC(机芯概念)机架,轧机准备区,以及最近安装的设备和最新的轧机订单等。

关键词：型钢定径轧制 SCC机架

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Difference of planktonic ciliate communities of the tropical West Pacific, the Bering Sea and the Arctic Ocean

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Acta Oceanologica Sinica 2020年第4期39卷 9-17页

作者： Chaofeng Wang Haibo Li Zhiqiang Xu Shan Zheng Qiang Hao Yi Dong Li Zhao Wuchang Zhang Yuan Zhao Gérald Grégori Tian Xiao CAS Key Laboratory of marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Jiaozhou Bay marine Ecosystem Research Station Institute of OceanologyChinese Academy of SciencesQingdao 266071China State Key Laboratory of Satellite Ocean Environment Dynamics Hangzhou 310012China Second Institute of Oceanography Ministry of Natural ResourcesHangzhou 310012China Aix-marseille University Toulon UniversityCNRSIRDMediterranean Institute of Oceanology UM110Marseille 13288France

Ciliates are important components in planktonic food webs,but our understanding of their community structures in different oceanic water masses is *** report pelagic ciliate community characteristics in three seas:the tropical West Pacific,the Bering Sea and the Arctic *** ciliate abundance had"bimodal-peak","surface-peak"and"DCM(deep chlorophyll a maximum layer)-peak"vertical distribution patterns in the tropical West Pacific,the Bering Sea and the Arctic Ocean,*** abundance proportion of tintinnid to total ciliate in the Bering Sea(42.6%)was higher than both the tropical West Pacific(7.8%)and the Arctic Ocean(2.0%).The abundance proportion of small aloricate ciliates(10–20μm size-fraction)in the tropical West Pacific was highest in these three *** Arctic Ocean had higher abundance proportion of tintinnids in larger LOD(lorica oral diameter)*** of redundant species increased from the Arctic Ocean to the tropical West *** result provided useful data to further understand ecology roles of planktonic ciliates in different marine habitats.

关键词： planktonic ciliates vertical distribution community structure tropical West Pacific Bering Sea Arctic Ocean

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Botanic Garden Collections—An Under-Utilised Resource

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American Journal of Plant Sciences 2021年第9期12卷 1436-1444页

作者： Alex Hudson Paul Smith Benedetta gori Suzanne Sharrock Botanic Gardens Conservation International Richmond UK Royal Botanic Gardens Kew Richmond UK

Botanic gardens and arboreta around the world are repositories of diverse collections of useful plants in their gardens and seed banks. However, the crop and forestry communities often overlook these collections, and so they are an underutilised resource. For example, in analysis of the ex situ conservation status of 6,941 socio-economically important plant taxa using data from forestry and crop collections, but omitted collections in botanic gardens and arboreta. In this paper, we compared the socio-economically important taxa identified by Khoury et al. from GRIN-Global World Economic Plants (WEP) with data on living and seed collections held in botanic garden and arboreta, as recorded in BGCI’s global PlantSearch and ThreatSearch datasets. This analysis produced an assessment of the proportion of these taxa that are found in botanic gardens and arboreta, the number of gardens or arboreta they are found in and what potential they have to contribute to research, conservation and sustainable use. We also compared the species conservation comprehensiveness assessments carried out by Khoury et al. with the threatened status of those species, according to the IUCn Red List and other threat assessment methodologies in order to ascertain whether threatened, useful species are well-conserved in botanic gardens. At least 6017 of the 6941 socio-economin>n style="font-family:;" "="">cally important WEP taxa (86.7%) were currently found in the living and seed collections of botanic gardens and arboreta with 1456 taxa (21%) held in >40 collections. Khoury et al. suggested that 6748 of the WEP taxa are of either medium or high conservation priority. However, our analysis suggested that just 1153 taxa have been assessed as threatened at a national or international level. We concluded that the botanic garden/arboretum community can contribute significantly to plant conserv