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The Low Energy X-ray telescope (LE) onboard the Insight-HXMT astronomy satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 49-61页

作者： Yong Chen WeiWei Cui Wei li Juan Wang YuPeng Xu FangJun Lul YuSa Wang TianXiang Chen DaWei Han Wei Hu Yi Zhang Jia Huo YanJi Yang maoshun li Bo Lu Ziliang Zhang TiPei li ShuangNan Zhang Shaolin Xiong Shu Zhang RongFeng Xue XiaoFan Zhao Yue Zhu YuXuan Zhu HongWei liu YiJung Yang Fan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Physics Tsinghua UniversityBeijing 100084China Department of Education Lu Liang UniversityLuliang 033000China Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China College of Physics Jilin UniversityChangchun 130023China

The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2 and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2°-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(libration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response.

关键词： LE X-ray telescope SCD collimators

In-orbit performance of LE onboard Insight-HXMT in the first 5 years

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Radiation Detection Technology and Methods 2023年第1期7卷 25-33页

作者： Xiaobo li Yong Chen liming Song Weiwei Cui Wei li Juan Wang Shuang-Nan Zhang Fangjun Lu Yupeng Xu Haisheng Zhao Mingyu Ge Youli Tuo Yusa Wang Tianxiang Chen Dawei Han Jia Huo Yanji Yang maoshun li Ziliang Zhang Yuxuan Zhu Xiaofan Zhao Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Science19B Yuquan RoadShijingshan DistrictBeijing 100049China

Purpose The low-energy X-ray telescope(LE)is a main instrument of the Insight-HXMT mission and consists of 96 swept charge devices covering the 1–10 keV energy *** energy gain and resolution are continuously calibrated by analyzing Cassiopeia A(Cas A)and blank sky data,while the effective areas are also calibrated with the observations of the Crab *** this paper,we present the evolution of the in-orbit performances of LE in the first 5 years since *** The Insight-HXMT data analysis software package(HXMTDAS)is utilized to extract the spectra of Cas A,blank sky,and Crab Nebula using different good time interval *** fit a model with a power-law continuum and several Gaussian lines to different ranges of Cas A and blank sky spectra to get peak energies of their lines through *** updating the energy gain calibration in CAlibration DataBase(CALDB),we rerun the Cas A data to obtain the energy *** empirical function is used to modify the simulated effective areas so that the background-subtracted spectrum of the Crab Nebula can best match the standard model of the Crab *** The energy gain,resolution,and effective areas are calibrated every *** corresponding calibration results are duly updated in CALDB,which can be downloaded and used for the analysis of Insight-HXMT *** observations with NuSTAR and NICER can also be used to verify our derived *** LE is a well-calibrated X-ray telescope working in 1–10 keV *** uncertainty of LE gain is less than 20eV in 2–9 keV band,and the uncertainty of LE resolution is less than *** systematic errors of LE,compared to the model of the Crab Nebula,are lower than 1.5%in 1–10 keV.

关键词： X-ray Calibration SCD In-orbit performance

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2984-2998页

作者： Xin Wang Jie Zhang maoshun liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou George F.Gao Jun liu Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China NHC Key Laboratory of Biosafety Research Unit of Adaptive Evolution and Control of Emerging VirusesChinese Academy of Medical SciencesNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing 102206China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Institute of Infectious Diseases Beijing 100015China National Center for Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015P.R.China School of Laboratory Medicine and life Sciences Wenzhou Medical UniversityWenzhou 325035China School of Ophthalmology&Optometry Wenzhou Medical UniversityWenzhou 325027China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Shijiazhuang Fifth Hospital Shijiazhuang 050011China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China

The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing ***,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 to other human coronaviruses is not well *** our research,we assessed T cell responses to both conserved and nonconserved peptides shared by SARS-CoV-2 and SARS-CoV,identifying cross-reactive CD8^(+)T cell epitopes using enzyme-linked immunospot and intracellular cytokine staining ***,in vitro refolding and circular dichroism were performed to evaluate the thermal stability of the HLA/peptide ***,single-cell T cell receptor reservoir was analyzed based on tetramer ***,we discovered that cross-reactive T cells targeting SARS-CoV were present in individuals who had recovered from COVID-19,and identified SARS-CoV-2 CD8^(+)T cell epitopes spanning the major structural antigens.T cell responses induced by the nonconserved peptides between SARS-CoV-2 and SARS-CoV were higher and played a dominant role in the cross-reactivity in COVID-19 ***-T cell reactivity was also observed within the identified series of CD8^(+)T cell *** representative immunodominant peptide pairs,although the HLA binding capacities for peptides from SARS-CoV-2 and SARS-CoV were similar,the TCR repertoires recognizing these peptides were *** results could provide beneficial information for the development of peptide-based universal vaccines against coronaviruses.

关键词： immunity conserved assessed

An online survey among convalescents 5 months post SARS-CoV-2 infection in China

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生物安全与健康(英文) 2024年第04期06卷 206-215页

作者： Wang Yalan liu maoshun Guo Yuanyuan li Min Guo Peipei He Wenjun Ma Tian liu Peipei Guo Yaxin Ye Beiwei liu Jun Wu Guizhen NHC Key Laboratory of Biosafety National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID) National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Beijing China College of life Sciences Beijing Normal University Beijing China Department of Epidemiology School of Public Health Cheeloo College of Medicine Shandong University Shandong China School of Public Health and Management Shandong First Medical University &amp Shandong Academy of Medical Sciences Jinan China

The effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection persist months and years after recovery. We conducted an online survey to assess the health condition of convalescents approximately 5 months following the primary infection of SARS-CoV-2. The study recruited 5,510 individuals who were primary infected, 626 participants who had experienced reinfection, and 521 participants who were without infective history. The most common disorders after the primary infection group were fatigue (15.18 %), memory issue (13.13 %), post-exertional malaise (PEM, 11.68 %), and brain fog (11.29 %) at the time of survey. In addition, SARS-CoV-2 infection had an impact on the reproductive systems. In stepwise logistic regression analysis, smoking currently, with background diseases, and outpatient visits in the acute phase could be associated with moderate /severe disorders. Further analysis of different background diseases showed that allergic rhinitis, hyperlipidemia, cardiovascular disease, autoimmune diseases, neurological diseases, and asthma likely increased the risk of moderate/severe disorders. The probability of developing disorders of individuals with SARS-CoV-2 reinfection was higher before the secondary infection than uninfected people. Fatigue, PEM, muscle pain/spasms, chills, joint pain, excessive sweating at rest, headache /dizziness, sore throat or foreign body sensation in the throat, cough, expectoration, dry /painful /watery eyes, loss of appetite and constipation were associated with an increased risk of reinfection. It was essential to undertake further research with enhanced randomization in a larger sample in the community, and to strengthen the validation of the research conclusions. The findings of this study contribute to a deeper understanding of the health recovery process among coronavirus disease 2019 (COVID-19) convalescents. Moreover, the findings help identify characteristic health risk factors associated with convalescen

关键词： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Disorders Reinfection

The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 35-48页

作者： XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu liang Sun XiaoJing liu JiaWei Yang Xian li Ying Tan ShaoZhen liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei li ChengMo Zhang XiangYang Wen JinLu Qu liMing Song XiaoBo li MingYu Ge YuPeng Zhou Shaolin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang maoshun li XiaoHua liang Min Gao EnBo Yang XiaoHang liu HongWei liu YiJung Yang Fan Zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Space Thermal Control Technology Beijing Institute of Spacecraft System EngineeringBeijing 100094China Department of Modern Physics School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230022China School of Physical Sciences Guizhou UniversityGuivang 550025China School of Opto-Electronic Information Science and Technology Yantai UniversityYantai 264005China University of Chinese Academy of Sciences Beijing 100049China

The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background *** energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME.

关键词： Si-PIN ASIC medium energy X-ray

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基层盐政管理长效机制建设浅探

苏盐科技 2005年第1期 31-32页

作者：李茂顺江苏省盐城市建湖县盐务局江苏建湖224700

盐政管理是党和政府赋予盐业部门的重要职能之一,长期以来深受各级盐务管理部门的高度重视,盐政执法部门始终坚持国家食盐专营方针政策,狠抓盐业市场整治,严厉打击盐业违法犯罪.

关键词：盐政管理部门盐业市场盐务管理盐政执法食盐专营长效机制标的打击保证

Insight-HXMT observations of the first binary neutron star merger GW170817

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Science China(Physics,Mechanics & Astronomy) 2018年第3期61卷 26-33页

作者： TiPei li Shaolin Xiong ShuangNan Zhang FangJun Lu liMing Song XueLei Cao Zhi Chang Gang Chen li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing li ChengKui li Gang li maoshun li Wei li Xian li XiaoBo li XuFang li YanGuo li ZiJian li ZhengWei li XiaoHua liang JinYuan liao CongZhan liu GuoQing liu HongWei liu ShaoZhen liu XiaoJing liu Yuan liu YiNong liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai liang Sun Yin Tan lian Tao WenHui Tao Youli Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu linli Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang Ziliang Zhang HaiSheng Zhao Jianling Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu Changlin Zou Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Physics Tsinghua University Beijing 100084 China University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100049 China Department of Astronomy Beijing Normal University Beijing 100088 China Department of Engineering Physics Tsinghua University Beijing 100084 China

Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced liGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.

关键词： GW170817 BNS merger gravitational wave electromagnetic counterpart

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 2-19页

作者： Shuang-Nan Zhang TiPei li FangJun Lu liMing Song YuPeng X u CongZhan liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing li ChengKui li Gang li maoshun li Wei li Xian li XiaoBo li XuFang li YanGuo li ZiJian li ZhengWei li XiaoHua liang JinYuan liao GuoQing liu HongWei liu ShaoZhen liu XiaoJing liu Yuan liu YiNong liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen liang Sun Ying Tan lian Tao Youli Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao Shaolin Xiong linli Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang Ziliang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu Renlin Zhuang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China

As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be *** we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

关键词： X-and γ-ray telescopes and instrumentation neutron stars black holes X-ray binaries γ-ray bursts

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烹饪中油脂性状与菜品感官质量相关性研究

中国油脂 2018年第11期43卷 156-160页

作者：魏跃胜王辉亚李茂顺潘东潮王菁武汉商学院烹饪与食品工程学院武汉430056

以3种品牌的菜籽油为实验对象,大豆油为对照,研究高温条件下油脂性状变化与烹饪菜品感官质量的关系。测定4种油脂的色度、碘值、不同温度下黏度和氧化稳定指数,并使用4种油脂烹制3个相同菜品进行感官评价。结果表明:菜籽油与大豆油在加... 详细信息

以3种品牌的菜籽油为实验对象,大豆油为对照,研究高温条件下油脂性状变化与烹饪菜品感官质量的关系。测定4种油脂的色度、碘值、不同温度下黏度和氧化稳定指数,并使用4种油脂烹制3个相同菜品进行感官评价。结果表明:菜籽油与大豆油在加热过程中表现出相同的流体行为,随着温度的升高其黏度趋同,氧化稳定指数差值缩小;黏度、氧化稳定指数与温度的回归方程R值大于0. 92;不同油脂烹制菜品感官质量间存在显著差异(P 0. 05)。

关键词：烹饪油脂菜品感官质量