检索结果-南通市图书馆

Heat stress induced hepatocyte apoptosis in largemouth bass Micropterus salmoides via IRE1α/TRAF2/ASK1/JNK pathway

Journal of Oceanology and Limnology 2024年第3期42卷 988-1000页

作者： Xuqian zhao Wenjia mao Zijie LIN Qufei LING School of Biology and Basic Medical Sciences Suzhou Medical College of Soochow UniversitySuzhou 215000China

Heat stress(HS)has been shown to adversely affect fish livers and can lead to extensive *** investigate the relationship between endoplasmic reticulum(ER)stress and HS-induced apoptosis in fish livers,we isolated and cultured primary hepatocytes of largemouth bass,Micropterus salmoides by trypsin method,then established an in-vitro model of liver cells under HS(35℃).The contents of lactic dehydrogenase(LDH)and hydrogen peroxide(H2O2)were determined to evaluate the effects of HS on hepatocyte injury and oxidative ***-qPCR was performed to discover the key genes in unfolded protein response(UPR)pathways involved at different HS *** inhibitor 4-PBA and IRE1αinhibitor 4μ8C were used to further investigate the effects of HS on IRE1αapoptosis pathway in *** show that HS led to significant increases in the release of LDH,the content of H2O2,and the expressions of oxidative protein folding genes(ero1αand pdi)under HS,suggesting severe hepatocyte injury and oxidative stress happened in heat-stressed largemouth bass *** continuous activation of IRE1αpathway genes(grp78,grp94,atf6,perk,eif2a,atf4,chop,ire1α,traf2,ask1,jnk1,and jnk2)indicated that HS led significantly to ER *** particular,the mRNA expression levels of ER stress-related genes(grp78,grp94,atf6,perk,ire1α,chop,jnk1,and jnk2)in the high temperature(HT)+4-PBA group and the HT+4μ8C group were significantly down-regulated under *** 4μ8C treatment,the expression levels of apoptosis-related genes(caspase-2,caspase-3,caspase-6,caspase-7,caspase-8,caspase-9,and caspase-10)and LDH content were significantly decreased,whereas the cell survival rate was significantly increased when given 4-PBA or 4μ8C *** findings demonstrate that HS could induce liver apoptosis of largemouth bass through the IRE1αpathway,which may act as a key switch mediating liver apoptosis of largemouth bass under HS.

关键词： heat stress Micropterus salmoides endoplasmic reticulum stress apoptosis oxidative stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-scale collaborative design method for macroscopic thermal optimization and mesoscopic woven structure of hypersonic vehicle's TOCMC leading edge

引用

Chinese Journal of Aeronautics 2024年第4期37卷 524-541页

作者： Chenwei zhao Zecan TU Junkui mao Jian HUI Pingting CHEN College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 21016China Integrated Energy Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A new thermal protection design method for hypersonic vehicle's leading edge is proposed, which can effectively reduce temperature of the leading edge without additional cooling measures. This method reduces the leading-edge's temperature by the multi-scale collaborative design of the macroscopic thermal optimization and the mesoscopic woven structures of Three-dimensional Orthogonal Woven Ceramic Matrix Composites(TOCMC). The macroscopic thermal optimization is achieved by designing different mesoscopic woven structures in different regions to create combined heat transfer channels to dredge the heat. The combined heat transfer channel is macroscopically represented by the anisotropic thermal conductivity of TOCMC. The thermal optimization multiple linear regression model is established to optimize the heat transport channel, which predicts Theoretical Optimal Thermal Conductivity Configuration(TOTCC) in different regions to achieve the lowest leading-edge temperature. The function-oriented mesostructure design method is invented to design the corresponding mesostructure of TOCMC according to the TOTCC, which consists of universal thermal conductivity prediction formulas for TOCMC. These universal formulas are firstly derived based on the thermal resistance network method, which is verified by experiments with an error of 6.25%. The results show that the collaborative design method can effectively reduce the leading edge temperature by about 12.8% without adding cooling measures.

关键词： Multi-scale collaborative design Thermal optimization Ceramic matrix composite Hypersonic vehicle Thermal protection Intelligent optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integration of Multiple Spectral Data via a Logistic Regression Algorithm for Detection of Crop Residue Burned Areas:A Case Study of Songnen Plain,Northeast China

引用

Chinese Geographical Science 2024年第3期34卷 548-563页

作者： ZHANG Sumei ZHANG yuan zhao Hongmei College of Mining and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China

The burning of crop residues in fields is a significant global biomass burning activity which is a key element of the terrestrial carbon cycle,and an important source of atmospheric trace gasses and *** estimation of cropland burned area is both crucial and challenging,especially for the small and fragmented burned scars in *** we developed an automated burned area mapping algorithm that was implemented using Sentinel-2 Multi Spectral Instrument(MSI)data and its effectiveness was tested taking Songnen Plain,Northeast China as a case using satellite image of *** employed a logistic regression method for integrating multiple spectral data into a synthetic indicator,and compared the results with manually interpreted burned area reference maps and the Moderate-Resolution Imaging Spectroradiometer(MODIS)MCD64A1 burned area *** overall accuracy of the single variable logistic regression was 77.38%to 86.90%and 73.47%to 97.14%for the 52TCQ and 51TYM cases,*** comparison,the accuracy of the burned area map was improved to 87.14%and 98.33%for the 52TCQ and 51TYM cases,respectively by multiple variable logistic regression of Sentind-2 *** balance of omission error and commission error was also *** integration of multiple spectral data combined with a logistic regression method proves to be effective for burned area detection,offering a highly automated process with an automatic threshold determination *** method exhibits excellent extensibility and flexibility taking the image tile as the operating *** is suitable for burned area detection at a regional scale and can also be implemented with other satellite data.

关键词： crop residue burning burned area Sentinel-2 Multi Spectral Instrument(MSI) logistic regression Songnen Plain,China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

λ/20-Thick cavity for mimicking electromagnetically induced transparency at telecommunication wavelengths

引用

Advanced Photonics 2024年第3期6卷 42-50页

作者： Hua Lu Shouhao Shi Dikun Li Shuwen Bo Jianxu zhao Dong mao Jianlin zhao Northwestern Polytechnical University School of Physical Science and Technology MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions Key Laboratory of Light-Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology

Optical cavities play crucial roles in enhanced light–matter interaction, light control, and optical communications, but their dimensions are limited by the material property and operating *** planar cavities are urgently in demand for large-area and integrated optical devices. However,extremely reducing the planar cavity dimension is a critical challenge, especially at telecommunication wavelengths. Herein, we demonstrate a type of ultrathin cavities based on large-area grown Bi2Te3topological insulator（TI） nanofilms, which present distinct optical resonance in the near-infrared region. The result shows that the Bi2Te3TI material presents ultrahigh refractive indices of >6 at telecommunication wavelengths. The cavity thickness can approach 1/20 of the resonance wavelength, superior to those of planar cavities based on conventional Si and Ge high refractive index materials. Moreover, we observed an analog of the electromagnetically induced transparency（EIT） effect at telecommunication wavelengths by depositing the cavity on a photonic crystal. The EIT-like behavior is derived from the destructive interference coupling between the nanocavity resonance and Tamm plasmons. The spectral response depends on the nanocavity thickness, whose adjustment enables the generation of obvious Fano *** experiments agree well with the simulations. This work will open a new door for ultrathin cavities and applications of TI materials in light control and devices.

关键词： Bismuth Tellurium Refractive index Nanofilms Photonic crystals Transparency Silver Telecommunications Crystals Plasmons

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rotor cross-tilt optimization for yaw control improvement of multi-rotor eVTOL aircraft

引用

Chinese Journal of Aeronautics 2024年第3期37卷 153-167页

作者： Xufei YAN Ye yuan Yanqin zhao Renliang CHEN Zhejiang Lab Hangzhou 311100China Department of Aerospace Engineering Swansea UniversitySwanseaWales SA28PPUK National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Manned multi-rotor electric Vertical Takeoff and Landing(eVTOL)aircraft is prone to actuator saturation due to its weak yaw control *** address this inherent problem,a rotor cross-tilt configuration is applied in this paper,with an optimization method proposed to improve the overall control efficiency of the ***,a flight dynamics model of a 500-kg manned multi-rotor eVTOL aircraft is *** accuracy of the co-axial rotor model is verified using a single arm test bench,and the accuracy of the flight dynamics model is verified by the flight test ***,an optimization method is designed based on the flight dynamics model to calculate an optimal rotor cross-tilt mounting angle,which not only improves the yaw control efficiency,but also basically maintains the efficiency of other control *** ideal rotor cross-tilt mounting angle for the prototype is determined by comprehensively considering the optimal results with different payloads,forward flight speeds,and rotor mounting angle ***,the feasibility of the rotor cross-tilt mounting angle is proved by analyzing the control derivatives of the flight dynamics model,the test data of a ground three Degree-of-Freedom(3DOF)platform,and the actual flight data of the *** results show that a fixed rotor cross-tilt mounting angle can achieve ideal yaw control effectiveness,improving yaw angle tracking and hold ability,increasing endurance time,and achieving good yaw control performance with different payloads and forward speeds.

关键词： Multi-rotor eVTOL Control efficiency Flight dynamics model Cross-tilt optimization Endurance time

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Broadband intelligent programmable metasurface with polarization-modulated self-adaptive electromagnetic functionality switching

引用

Photonics Research 2024年第7期12卷 1395-1409页

作者： XIMING LI RUI XU XIAOFENG SUN yuan zhao zhao YANG GUOHONG DU College of Electronic Engineering Chengdu University of Information TechnologyChengdu 610225China

Programmable metasurfaces have received a great deal of attention due to their ability to dynamically manipulate electromagnetic(EM) waves. Despite the rapid growth, most of the existing metasurfaces require manual control to switch among different functionalities, which poses severe limitations on practical applications. Here, we put forth an intelligent metasurface that has self-adaptive EM functionality switching in broadband without human participation. It is equipped with polarization discrimination antennas(PDAs) and feedback components to automatically adjust functionalities for the different incident polarization information.

关键词： equipped adjust polarization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CuInS_(2)quantum-dot-modified g-C_(3)N_(4)S-scheme heterojunction photocatalyst for hydrogen production and tetracycline degradation

引用

Journal of Materials Science & Technology 2024年第5期172卷 145-155页

作者： Jingjing Zhang Yue zhao Kezhen Qi Shu-yuan Liu College of Pharmacy Dali UniversityDali 671000China Department of Pharmacology Shenyang Medical CollegeShenyang 110034China

CuInS_(2)quantum-dot(CIS QD)-modified g-C_(3)N_(4)(CN)catalysts(CIS/CN)were prepared with the aid of an in-situ growth *** as-obtained photocatalysts were explored by measuring their crystallinity,surface morphology,binding energy and light absorption *** photocatalytic efficiency of the pho-tocatalysts was evaluated through photocatalytic water splitting for hydrogen production and tetracycline(TC)antibiotic degradation under the simulated solar light and visible light *** optimized sample(10CIS/CN)showed the best photocatalytic activity:producing 102.4μmol g^(-1)h^(-1)of hydrogen in 1 h,or degrading 52.16%of TC in 120 min,which were respectively 48 or 3.4 times higher than the photocatalytic activity of CN *** enhancement in the efficiency of the composite system was prin-cipally accredited to the enlargement of light absorption,the more effective in charge transfer and the dropping of the charge carrier pair recombination through a formed S-scheme heterojunctional *** work is an effort to adjust CN-based polysulfide QD for speedy *** enriched photo-catalytic activity grants a new sense for adjusting the optical properties of CN.

关键词： CuInS_(2)QDs g-C_(3)N_(4) Photocatalysis Hydrogen production S-scheme heterojunction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant

引用

National Science Review 2024年第4期11卷 15-16页

作者： yuan-yuan zhao Bokyeong Hwang Yeju Lee Juyoung Yoon Department of Chemistry and Nanoscience Ewha Womans University

Kidney transplantation is a life-saving approach for treating end-stage renal diseases (ESRDs)[1]. However, the scarcity of donor kidneys has resulted in an increasing number of ESRD patients being stuck on the transp... 详细信息

关键词： TIME

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A regression approach for seismic first-break picking

引用

Petroleum Science 2024年第3期21卷 1584-1596页

作者： Huan yuan San-Yi yuan Jie Wu Wen-Jing Sang Yu-He zhao CNPC Key Laboratory of Geophysical Exploration China University of Petroleum(Beijing)Beijing 102249China Research Institute of Petroleum Exploration&Development—Northwest(NWGI) Key Laboratory of reservoir characterization of CNPCPetroChinaLanzhou 730020GansuChina

The picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(DL)***,the picking accuracy and efficiency of DL methods still face huge challenges in low signal-to-noise ratio(SNR)*** address this issue,we propose a regression approach to pick FBs based on bidirectional long short-term memory(Bi LSTM)neural network by learning the implicit Eikonal equation of 3D inhomogeneous media with rugged topography in the target *** employ a regressive model that represents the relationships among the elevation of shots,offset and the elevation of receivers with their seismic traveltime to predict the unknown FBs,from common-shot gathers with sparsely distributed *** from image segmentation methods which automatically extract image features and classify FBs from seismic data,the proposed method can learn the inner relationship between field geometry and *** addition,the predicted results by the regressive model are continuous values of FBs rather than the discrete ones of the binary *** picking results of synthetic data shows that the proposed method has low dependence on label data,and can obtain reliable and similar predicted results using two types of label data with large *** picking results of9380 shots for 3D seismic data generated by vibroseis indicate that the proposed method can still accurately predict FBs in low SNR *** subsequent stacked profiles further illustrate the reliability and effectiveness of the proposed *** results of model data and field seismic data demonstrate that the proposed regression method is a robust first-break picker with high potential for field application.

关键词： First-break picking Low signal-to-noiseratio Regression BiLSTM Traveltime Geometry Noisy seismic data

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in immunotherapy for biliary tract cancers

引用

Chinese Medical Journal 2024年第5期137卷 524-532页

作者： Yuhao zhao mao Yang Jiayi Feng Xu’an Wang Yingbin Liu Department of Biliary–Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Cancer Institute State Key Laboratory of Oncogenes and Related GenesShanghai 200127China Shanghai Key Laboratory of Biliary Tract Disease Shanghai 200082China

Biliary tract cancers(BTC),a heterogeneous disease with poor prognosis,including gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICC),and extrahepatic cholangiocarcinoma(ECC).Although surgery is currently the primary regimen to treat BTC,most BTC patients are diagnosed at an advanced stage and miss the opportunity of surgical *** a result,non-surgical therapy serves as the main intervention for advanced *** recent years,immunotherapy has emerged as one of the most promising therapies in a number of solid cancers,and it includes immune checkpoint inhibitors(ICIs)monotherapy or combined therapy,tumor vaccines,oncolytic virus immunotherapy,adoptive cell therapy(ACT),and cytokine ***,these therapies have been practiced in limited clinical settings in patients with *** this review,we focus on the discussion of latest advances of immunotherapy in BTC and update the progress of multiple current clinical trials with different immunotherapies.

关键词： Immunotherapy Biliary tract cancers Immune checkpoint inhibitors Cholangiocarcinoma Gallbladder cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：