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Expression and preliminary functional analysis of Siglec-F on mouse macrophages

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 386-394页

作者： Yin-he FENG hui mao Department of Respiratory Medicine West China HospitalSichuan UniversityChengdu 610041China

Sialic acid-binding immunoglobulin-like lectin (Siglec)-F is a mouse functional paralog of human Siglec-8 that induces apoptosis in human eosinophils, and therefore may be useful as the basis of treatments for a variety of disorders associated with eosinophil hyperactivity, such as asthma. The expression pattern and functions of this protein in various cell types remain to be elucidated. The aim of this study was to determine the expression of Siglec-F on mouse macrophages by immunocytochemical staining, and also to investigate the effects of Siglec-F engagement by a Siglec-F antibody on phagocytic activity of macrophages. The results showed that Siglec-F expression was detected on mouse alveolar macrophages, but not on peritoneal macrophages. Furthermore, Siglec-F engagement did not affect the phagocytic activity of alveolar macrophages in the resting state or in the activated state following stimulation by the proinflammatory mediator tumor necrosis factor alpha (TNF-α) or lipopolysaccharide (LPS). Siglec-F expression on alveolar macrophages may be a result of adaptation. Macrophages actively regulate immune responses via production of cytokines. Therefore, further investigation of the effects of Siglec-F engagement on immune mediators or cytokines released by alveolar macrophages is required.

关键词： Siglec-F Expression Macrophages Phagocytosis Eosinophil

Risk preferences and the low-carbon agricultural technology adoption:Evidence from rice production in China

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Journal of Integrative Agriculture 2023年第8期22卷 2577-2590页

作者： mao hui QUAN Yu-rong FU Yong Northwest Institute of Historical Environment and Socio-Economic Development Shaanxi Normal UniversityXi'an 710119P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China

Climate change which is mainly caused by carbon emissions is a global problem affecting the economic development and well-being of human ***-carbon agriculture is of particular significance in slowing down global warming and reaching the goal of“carbon peak and carbon neutrality”.Therefore,taking straw incorporation as an example,this paper aims to investigate the impact of risk preferences on farmers’low-carbon agricultural technology(LCAT)*** on a two-phase micro-survey data of 1038 rice farmers in Jiangsu,Jiangxi,and Hunan provinces,this paper uses experimental economics methods to measure farmers’risk aversion and loss aversion to obtain the real risk preferences information of the *** also explore the data to examine the actual LCAT adoption behavior of *** results revealed that both risk aversion and loss aversion significantly inhibit farmers’LCAT adoption:more risk-averse or more loss-averse farmers are less likely to adopt *** is further found that crop insurance,farm scale and governmental regulations can alleviate the negative impact of risk aversion and loss aversion on farmers’LCAT ***,we propose that local governments need to promote low-carbon agricultural development by propagating the benefits of LCAT,extending crop insurance,promoting appropriate scale operations,and strengthening governmental regulations to promote farmers’LCAT adoption.

关键词： risk preferences crop insurance farm scale governmental regulations low-carbon agricultural technology

Constructing temporal and spatial water vapor figures by GPS remote sensing along slant rays

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Science China Earth Sciences 2007年第2期50卷 296-305页

作者： mao hui mao JieTai BI YanMeng LI ChengCai LIU XiaoYang Department of Atmospheric Sciences School of PhysicsPeking UniversityBeijing 100871China Shenzhen Meteorological Bureau Shenzhen 518001China

A Global Positioning System (GPS) receiver can generally track 5-7 rays from GPS satellites at any moment, and water vapor along these ray paths (slant-path water vapor, SWV) may be retrieved using the methods developed in recent years. This paper suggests two new parameters-absolute vertical SWV (VSWV) and relative VSWV derived from SWV, and their temporal and spatial figures can reflect the heterogeneous distribution and variation of water vapor field. This approach has been applied to the weather diagnoses in a severe storm event in Beijing during July 2004, and it is concluded that the temporal and spatial figures of absolute VSWV and relative VSWV can be useful in monitoring the evolution of water vapor field and be potential in better understanding the precipitation process.

关键词： GPS absolute VSWV relative VSWV water vapor precipitation

Effect of MgO Critical Particle Size on Properties of MgO-C Continuous Temperature-Measuring Sensor for Liquid Steel

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Journal of Iron and Steel Research International 2011年第12期18卷 12-21页

作者： ZHAO Shu-mao MEI Guo-hui XIE Zhi College of Information Science and Engineering Northestern University Shenyang 110004 Liaoning China

MgO-C continuous temperature-measuring sensors for liquid steel were made of fused magnesia with different critical particle sizes from 0.5 to 2.0 mm,thus the effects what magnesia＇s particle size affect sensors＇ properties and lifetime were *** result shows that the MgO-C continuous temperature-measuring sensor has good aggression resistance to basic tundish powders and meets the requirement for response time of temperature measuring practice in *** sensor＇s service life,which is affected by multi-properties of material and operating environment,reached its maximum when the critical particle size of magnesia was 1.0 *** average lifetime of sensors was 43 or 40 h when served for casting SPHC or Q195 steel.

关键词： MgO carbon microstructure sensors lifetime particle size

Primary pulmonary rhabdomyosarcoma in an adult:a case report and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 859-865页

作者： Gui-yi JI hui mao Department of Respiratory Medicine West China Hospital of Sichuan University

Primary pulmonary rhabdomyosarcoma (RMS)is one of the most common soft-tissue malignancies in children, but is rare in persons aged >45 years (Triche,1997; Ferrari et al., 2003). RMS is considered to result from the m... 详细信息

关键词： Ferrari neoplasm primitive children extremely Sorensen Ellison vincristine histological regimen

Efficacy and safety of benralizumab in patients with eosinophilic asthma： a meta-analysis of randomized placebo-controlled trials

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Frontiers of Medicine 2018年第3期12卷 340-349页

作者： Ting Liu Faping Wang Geng Wang hui mao Department of Respiratory Medicine West China Hospital Sichuan University Chengdu 610041 China

Benralizumab is a monoclonal antibody that targets interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthma. We conducted a meta-analysis to evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthma. All randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthma, which were searched in PubMed, Embase, and the Cochrane Library published until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthma control, quality of life scores, and adverse events were included. Randomized-effect models were used in the meta-analysis to calculate the pooled mean difference, relative risks, and 95% confidence intervals. Five studies involving 1951 patients were identified. Compared with the placebo, benralizumab treatment demonstrated significant improvements in the forced expiratory volume in 1 s （FEV1）, Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control Questionnaire-6 （ACQ-6） scores. Benralizumab treatment was also not associated with increased adverse events. These findings indicated that benralizumab can be safely used to improve FEV1, enhance patient symptom control and quality of life, and reduce the risk of exacerbations and ACQ-6 scores in patients with eosinophilic asthma. Furthermore, our meta-analysis showed that benralizumab with 30 mg （every eight weeks） dosage can improve the health-related quality of life and appear to be more effective than 30 mg （every four weeks） dosage. Overall, data indicated that the optimal dosing regimen for benralizumab was possibly 30 mg （every eight weeks）.

关键词： benralizumab anti-interleukin-5 monoclonal antibody eosinophilic asthma meta-analysis

Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer

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World Journal of Clinical Cases 2019年第15期7卷 1996-2002页

作者： Mian-Li Zhou Fang-Shan Chen hui mao Department of Gynecology and Obstetrics Traditional Chinese Medicine Hospital Affiliated to Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Serpin peptidase inhibitor,clade A member 3(SERPINA3)belongs to the serpin family with an inhibitory activity against *** aberrant expression has been observed in a wide range of tumor ***,its clinical significance and biological function in endometrial cancer have been rarely *** designed a study to determine the levels of SERPINA3 and its significance in patients with endometrial *** To investigate the clinical significance and role of SERPINA3 expression in endometrial cancer *** Eighty endometrial tissue samples collected from patients with endometrial cancer were included in an observation group and 80 paraffin-embedded tissues samples collected from patients with normal endometrial tissues undergoing myomectomy were employed as a control group between January 2014 and December *** expression of SERPINA3 mRNA was detected by quantitative polymerase chain reaction(PCR)for all endometrial tissues included in the *** The positive expression rate of SERPINA3 protein in endometrial cancer cells was 71.25%in the observation group,which was significantly higher than that in the control group(31.25%;P0.05).However,it was associated with pathological grade,clinical stage,vascular invasion,and lymph node metastasis(P<0.05).Pathological grade,clinical stage,vascular invasion,and lymph node metastasis were independent prognostic factors for endometrial *** The follow-up study of SERPINA3 can be used as a prognostic biomarker for endometrial cancer and as one of the targets for bio-targeted therapy for endometrial cancer.

关键词： Serpin peptidase inhibitor,clade A member 3 Endometrial cancer Quantitative polymerase chain reaction Expression

Effect of Sulfur Content and Sulfide Shape on Fracture Ductility in Case Hardening Steel

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Journal of Iron and Steel Research International 2011年第8期18卷 58-64页

作者： XIAO Guo-hua DONG Han WANG mao-qiu hui Wei-jun National Engineering Research Center of Advanced Steel Technology Central Iron andSteel Research Institute Beijing 100081 China

The effects of sulfur content and calcium addition on smooth axisymmetric tensile fracture ductility of case hardening steel DIN 18CrNiMo7-6 have been investigated. The quantitative metallographic analysis of sulfide inclusions and the correlations between sulfide inclusions and fracture ductility were examined. Sulfide inclusions were found to have deleterious effect on fracture ductility, whereas the effect can be offset to some extent by calcium-treat- ment due to less easily deforming of sulfides during hot-working. The product （AA·λAW） of sulfide inclusion area fraction （An） and its area-weighted aspect ratio （λAW） can be used as a parameter to describe the effect of sulfide inclusions on fracture true strain.

关键词： case hardening steel calcium treatment sulfide fracture ductility

Machine learning method to predict dynamic compressive response of concrete-like material at high strain rates

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Defence Technology（防务技术） 2023年第5期23卷 100-111页

作者： Xu Long Ming-hui mao Tian-xiong Su Yu-tai Su Meng-ke Tian School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'anChina School of Civil Engineering Liaoning Petrochemical UniversityFushunChina Beijing Microelectronics Technology Institute BeijingChina

Machine learning(ML)methods with good applicability to complex and highly nonlinear sequences have been attracting much attention in recent years for predictions of complicated mechanical properties of various *** one of the widely known ML methods,back-propagation(BP)neural networks with and without optimization by genetic algorithm(GA)are also established for comparisons of time cost and prediction *** the aim to further increase the prediction accuracy and efficiency,this paper proposes a long short-term memory(LSTM)networks model to predict the dynamic compressive performance of concrete-like materials at high strain *** explicit analysis is performed in the finite element(FE)software ABAQUS to simulate various waveforms in the split Hopkinson pressure bar(SHPB)experiments by applying different stress waves in the incident *** FE simulation accuracy is validated against SHPB experimental results from the viewpoint of dynamic increase *** order to cover more extensive loading scenarios,60 sets of FE simulations are conducted in this paper to generate three kinds of waveforms in the incident and transmission bars of SHPB *** training the proposed three networks,the nonlinear mapping relations can be reasonably established between incident,reflect,and transmission *** measures are used to quantify the network prediction accuracy,confirming that the predicted stress-strain curves of concrete-like materials at high strain rates by the proposed networks agree sufficiently with those by FE *** is found that compared with BP network,the GA-BP network can effectively stabilize the network structure,indicating that the GA optimization improves the prediction accuracy of the SHPB dynamic responses by performing the crossover and mutation operations of weights and thresholds in the original BP *** eliminating the long-time dependencies,the proposed LSTM network achieves better results than the BP

关键词： Deep learning LSTM network GA-BP network Dynamic behaviour Concrete-like materials