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Endobronchial Ultrasound Elastography for Diagnosing Mediastinal and Hilar Lymph Nodes

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Chinese Medical Journal 2015年第20期128卷 2720-2725页

作者： Hai-Yan He mao huang Jie Zhu Hang Ma Xue-Dong Lyu Department of Respiratory The First People's Hospital of Nantong Nantong Jiangsu 226001 China Department of Respiratory The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China

Background： Pathophysiological processes, such as malignancy, can lead to the formation of stiffer tissue in lung cancers. Endobronchial ultrasound rEBUS） elastography is a novel technique for measuring tissue stiffness during EBUS-guided transbronchial needle aspiration （EBUS-TBNA）. The current study was conducted to investigate the diagnostic value of EBUS elastography tbr mediastinal and hilar lymph node metastasis in lung cancers. Methods： From January 2014 to January 2015, 40 patients suspected of lung cancer were enrolled, and a total of 68 lymph nodes were evaluated by EBUS-TBNA. EBUS-guided elastography of lymph nodes was perfornaed prior to EBUS-TBNA. Standard EBUS characteristics were also described. Pathological determination of malignant or benign lymph nodes was used as the gold standard for this study. If EBUS-TBNA did not result in a tbrmal pathological diagnosis of malignancy, patients were referred for a surgical procedure. Comparisons of elastography and standard EBUS characteristics were made between benign and malignant lymph nodes. Results： Elastography grading scores and strain ratios showed significant differences between benign and malignant lymph nodes （P = 0.000）. The elastography strain ratio was more sensitive and specific for determining malignant lymph nodes than elastography grading score or standard EBUS criteria. The receiver operating characteristic curve for the elastography strain ratio showed an area under the curve of 0.933. The best cut-off point of the strain ratio for differentiating malignant from benign lymph nodes was 32.07. The elastography strain ratio had a sensitivity of 88.1%, the specificity of 80.8%, positive predictive value of 88.1%, and negative predictive value of 80.8% for distinguishing malignant from benign nodes. The overall accuracy of elastography strain ratio was 85.3%. The strain ratio of malignant and benign lymph nodes positively correlated with the elastography grading score （r = 0.561, P = 0.000）. Conclusions： EBUS elastography can be effectively

关键词： Elastography Endobronchial Ultrasound Lung Cancer Mediastinal and Hilar Lymph Node Strain Ratio

基于计算流体力学-离散元耦合的相对密实度对断级配土体渗蚀效应的影响研究

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岩土力学 2024年第1期45卷 267-283页

作者：张沛云木林隆黄茂松同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092

土体几何因素(粒径比、细粒含量、相对密实度等)不仅影响土体内部稳定性,同时对侵蚀进程有着重要影响。基于离散单元法(discrete element method,简称DEM)与计算流体动力学(computational fluid dynamics,简称CFD)耦合方法,建立了内部... 详细信息

土体几何因素(粒径比、细粒含量、相对密实度等)不仅影响土体内部稳定性,同时对侵蚀进程有着重要影响。基于离散单元法(discrete element method,简称DEM)与计算流体动力学(computational fluid dynamics,简称CFD)耦合方法,建立了内部不稳定土渗流-侵蚀三维计算模型。考虑细粒含量及相对密实度对内部侵蚀过程的耦合影响,对细观变量:土体孔径分布曲线、颗粒接触数目以及内部传力机制进行分析,以揭示细粒含量与相对密实度的影响的细观机制。研究结果表明:相对密实度的增加降低了侵蚀质量比,且该影响程度与细粒含量相关,细粒含量越高,相对密实度的影响更加明显;内部不稳定土体渗蚀后沿渗流方向可分为上游侵蚀区、中部稳定区及下游侵蚀区。土体渗透性在侵蚀过程中的增长幅度随相对密实度的降低而逐渐增加,随细粒含量的增加而增加;相对密实度对渗蚀过程的影响可归因于三方面:相同水力梯度下渗流流量不同,内部孔隙尺寸分布存在差异,以及细颗粒对土体内部应力传递的贡献不同。研究结果加深了土体几何因素对内部渗蚀过程影响的理解,并为宏观侵蚀本构的建立提供了参考。

关键词：渗蚀 CFD-DEM 相对密实度细粒含量传力机制

The prognosis and short-term efficacy of corticosteroid therapy for COVID-19 patients

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The Journal of Biomedical Research 2021年第3期35卷 247-252页

作者： Xinyu Jia Hengrui Zhang Yuan Ma Zhenzhen Wu Ningfei Ji mao huang Department of Respiratory Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Dear Editor:Corticosteroids are widely used in the treatment of critically ill patients for active anti-inflammatory and immunosuppressive effects.However,the therapeutic effects of corticosteroid treatment are still disputable.Some studies have shown that corticosteroids can delay coronavirus RNA clearance[1],increase mortality[2]and cause adverse events[3].Conversely,other studies have confirmed the clinical value of corticosteroids in shortening hospital stays and decreasing the need for mechanical ventilation[4].

关键词： cor patients mortality

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肺肉瘤样癌免疫治疗新进展

南京医科大学学报（自然科学版） 2024年第7期44卷 1002-1009页

作者：杨澜吉宁飞黄茂南京医科大学第一附属医院呼吸与危重症医学科江苏南京210029

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是非小细胞肺癌的一种罕见类型,具有高度侵袭性和异质性,对传统放化疗不敏感,预后极差。免疫治疗作为肺癌治疗领域的里程碑式进展,为驱动基因阴性的PSC患者提供治疗新方向,有望改善患... 详细信息

肺肉瘤样癌(pulmonary sarcomatoid carcinoma,PSC)是非小细胞肺癌的一种罕见类型,具有高度侵袭性和异质性,对传统放化疗不敏感,预后极差。免疫治疗作为肺癌治疗领域的里程碑式进展,为驱动基因阴性的PSC患者提供治疗新方向,有望改善患者临床预后。基于此,文章对国内外有关PSC免疫治疗的最新研究进展进行综述。

关键词：肺肉瘤样癌免疫治疗上皮-间充质转化外泌体 PD-L1

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黄泛区非饱和粉土动模量和阻尼比特性研究

Journal of Central South University 2024年第1期31卷 237-249页

作者：彭飞李梦瑶李永辉黄茂松 School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China School of Transportation Southeast UniversityNanjing 210096China School of Civil Engineering Tongji UniversityShanghai 200092China

黄泛区粉土水敏感性强,力学性质独特,易受振动荷载的影响。本文通过循环三轴试验,研究固结围压和饱和度对黄泛区粉土动模量、阻尼比特性的影响。研究结果表明,黄泛区粉土骨干曲线符合双曲线关系;随动应变的增大,黄泛区粉土动弹性模量先... 详细信息

黄泛区粉土水敏感性强,力学性质独特,易受振动荷载的影响。本文通过循环三轴试验,研究固结围压和饱和度对黄泛区粉土动模量、阻尼比特性的影响。研究结果表明,黄泛区粉土骨干曲线符合双曲线关系;随动应变的增大,黄泛区粉土动弹性模量先急剧减小而后逐渐趋于稳定;随固结围压的增大和饱和度的减小,粉土动弹性模量逐渐增大,阻尼比则逐渐减小;二元线性方程可用于估算最大动弹性模量随固结围压和饱和度的变化规律,修正Hardin-Drnevich模型可较为准确预测黄泛区非饱和粉土的动弹性模量和阻尼比。本研究可为黄河流域工程建设提供理论支撑。

关键词：黄泛区非饱和粉土动弹性模量阻尼比计算模型

A SARS-CoV-2 neutralizing antibody discovery by single cell sequencing and molecular modeling

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The Journal of Biomedical Research 2023年第3期37卷 166-178页

作者： Zheyue Wang Qi Tang Bende Liu Wenqing Zhang Yufeng Chen Ningfei Ji Yan Peng Xiaohui Yang Daixun Cui Weiyu Kong Xiaojun Tang Tingting Yang Mingshun Zhang Xinxia Chang Jin Zhu mao huang Zhenqing Feng National Health Commission Key Laboratory of Antibody Technique Jiangsu Province Engineering Research Center of Antibody DrugDepartment of PathologyNanjing Medical UniversityNanjingJiangsu 211166China Department of Cardiology the First People's Hospital of Jiangxia DistrictWuhanHubei 430299China Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Rheumatology and Immunology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China Huadong Medical Institute of Biotechniques NanjingJiangsu 210028China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China.

Although vaccines have been developed,mutations of SARS-CoV-2,especially the dominant B.1.617.2(delta)and B.1.529(omicron)strains with more than 30 mutations on their spike protein,have caused a significant decline in prophylaxis,calling for the need for drug improvement.Antibodies are drugs preferentially used in infectious diseases and are easy to get from immunized organisms.The current study combined molecular modeling and single memory B cell sequencing to assess candidate sequences before experiments,providing a strategy for the fabrication of SARS-CoV-2 neutralizing antibodies.A total of 128 sequences were obtained after sequencing 196 memory B cells,and 42 sequences were left after merging extremely similar ones and discarding incomplete ones,followed by homology modeling of the antibody variable region.Thirteen candidate sequences were expressed,of which three were tested positive for receptor binding domain recognition but only one was confirmed as having broad neutralization against several SARS-CoV-2 variants.The current study successfully obtained a SARS-CoV-2 antibody with broad neutralizing abilities and provided a strategy for antibody development in emerging infectious diseases using single memory B cell BCR sequencing and computer assistance in antibody fabrication.

关键词： SARS-CoV-2 neutralizing antibody single B cell BCR sequencing molecular modeling

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道砟嵌入路基土试样离散元虚拟三轴试验

交通运输工程学报 2024年第2期24卷 137-151页

作者：张杰聂如松李列列黄茂桐谭永长中南大学土木工程学院湖南长沙410075 中南大学重载铁路工程结构教育部重点实验室湖南长沙410075 华北水利水电大学土木与交通学院河南郑州450045

采用离散元法(DEM)从宏细观角度研究了有砟轨道道砟嵌入对路基土变形特性的影响;基于三维结构光扫描系统对道砟颗粒外形进行重构,实现道砟颗粒的精细化建模;基于DEM软件PFC3D V6.0建立高度为600 mm、直径为300 mm的道砟嵌入试样与纯土... 详细信息

采用离散元法(DEM)从宏细观角度研究了有砟轨道道砟嵌入对路基土变形特性的影响;基于三维结构光扫描系统对道砟颗粒外形进行重构,实现道砟颗粒的精细化建模;基于DEM软件PFC3D V6.0建立高度为600 mm、直径为300 mm的道砟嵌入试样与纯土试样三轴计算模型;通过有限差分法(FDM)与DEM耦合,实现三轴围压柔性加载,分别对2种试样进行三轴试验模拟;对比分析了道砟嵌入试样与纯土试样的模拟结果,明确道砟嵌入对路基土变形特性的影响。研究结果表明:围压为30 kPa时,道砟嵌入试样峰值强度为257 kPa,纯土试样峰值强度为199 kPa,相比于纯土试样,道砟嵌入会使土体承受荷载的能力降低;剪切结束时纯土试样体应变为-3.24%,道砟嵌入试样为-14.59%,道砟嵌入试样剪胀效应更为明显;纯土试样与道砟嵌入试样侧向变形机理不同,纯土试样中部产生鼓胀变形是因为其中部区域不受约束,颗粒可自由运动,道砟嵌入试样土样表层发生侧向鼓胀是因为道砟-土界面处发生的道砟嵌入对表层土颗粒向两侧挤压的排挤作用;2种试样土颗粒配位数变化趋势一致,均表现出随轴向应变先增加、后减小、最后趋于平缓的趋势,但纯土试样土颗粒配位数明显高于道砟嵌入试样;纯土试样力链沿轴向发展且分布均匀,道砟嵌入试样会在道砟-土接触界面出现明显接触力集中。

关键词：铁道工程有砟轨道离散元法模拟虚拟三轴试验道砟嵌入柔性加载

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道砟嵌入路基土三轴试验及离散元模拟研究

岩土力学 2024年第6期45卷 1720-1730页

作者：张杰聂如松黄茂桐谭永长李亚峰中南大学土木工程学院湖南长沙410075 中南大学重载铁路工程结构教育部重点实验室湖南长沙410075 安徽理工大学土木建筑学院安徽淮南232001

有砟轨道道砟嵌入对路基服役性能具有显著影响。基于此设计上层为道砟、下层为路基土的单元试样,通过室内动三轴试验和离散元法(discrete element method,简称DEM)数值仿真研究了动荷载作用下道砟嵌入路基土的宏观变形行为和局部变形特... 详细信息

有砟轨道道砟嵌入对路基服役性能具有显著影响。基于此设计上层为道砟、下层为路基土的单元试样,通过室内动三轴试验和离散元法(discrete element method,简称DEM)数值仿真研究了动荷载作用下道砟嵌入路基土的宏观变形行为和局部变形特征。研究结果表明:在动荷载作用下,道砟与路基土之间仅通过接触面上有限数量的离散接触传递应力,随动应力幅值增加,道砟嵌入深度也不断增加,嵌入深度与动应力呈指数函数变化。道砟嵌入路基土变形过程分为局部挤压阶段、剪切带形成阶段及剪切带发展阶段,道砟嵌入会使得道砟−路基土接触界面的土样孔隙率显著增加,同时也会使得接触界面发生显著的侧向变形。孔隙率较高的饱和试样在较低的动应力作用下会发生翻浆冒泥现象,道砟嵌入导致的路基面孔隙率升高是既有路线发生翻浆冒泥的重要原因,防治翻浆冒泥需重点防止道砟嵌入导致的土样局部孔隙率升高。该研究成果可加深对道砟嵌入现象以及由此引发的路基表层变形行为的认识。

关键词：有砟轨道道砟嵌入变形特征动三轴试验离散元模拟

云南思茅银子山金多金属矿床成矿流体特征及演化

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矿物岩石地球化学通报 2024年第1期43卷 178-191页

作者：周琪彭惠娟张云龙罗泽雄黄茂坤毛星星陈曦成都理工大学地球科学学院成都610059 云南省地质矿产勘察院昆明650051 云南思茅山水铜业有限公司云南普洱665000 西南石油大学地球科学与技术学院成都610500 攀钢集团矿业有限公司设计研究院四川攀枝花617000

为探讨云南思茅银子山金多金属矿床金的迁移和沉淀机制,对该矿床开展了流体包裹体岩相学和热力学研究。结果表明,银子山金多金属矿床成矿期主要发育气液两相流体包裹体(LV类)、含子矿物多相流体包裹体(LD类)和单相包裹体(L/V类);成矿流... 详细信息

为探讨云南思茅银子山金多金属矿床金的迁移和沉淀机制,对该矿床开展了流体包裹体岩相学和热力学研究。结果表明,银子山金多金属矿床成矿期主要发育气液两相流体包裹体(LV类)、含子矿物多相流体包裹体(LD类)和单相包裹体(L/V类);成矿流体为中-低温(140~330℃)、中低盐度(3.23%~8.41%NaCleqv)的H2O-NaCl的流体体系,其捕获深度为0.4~1.2 km;成矿流体的温度、盐度、压力等从成矿早期到晚期均呈逐渐降低的特征。矿床蚀变矿物组合及成矿流体性质表明,银子山金多金属矿床为一典型的浅成低温热液型矿床,Au主要以Au(HS)_(2)^(–)形式迁移,在成矿流体运移过程中,由于流体-围岩反应以及大气水的混合导致Au沉淀并富集成矿。

关键词：银子山金多金属矿床浅成低温热液型矿床金的迁移沉淀机制流体包裹体成矿流体