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Decellularised extracellular matrix-based injectable hydrogels for tissue engineering ap.lications

Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-Y. Wang W.-H. Xu p.-Y. Kankala R.K. Chen A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian p.ovincial Key Laboratory of Biochemical Technology (Huaqiao University) Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its excep.ional biocomp.tibility and malleability attributes. These advantageous p.op.rties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity, the injectable hydrogels can be administered in a liquid state and subsequently formed into a gel state in vivo, stabilising the target area and serving in a variety of ways, such as sup.ort, rep.ir, and drug release functions. Thus, dECM-based injectable hydrogels have broad p.osp.cts for ap.lication in comp.ex organ structures and various tissue injury models. This review focuses on exp.oring research advances in dECM-based injectable hydrogels, p.imarily focusing on the ap.lications and p.osp.cts of dECM hydrogels in tissue engineering. Initially, the recent develop.ents of the dECM-based injectable hydrogels are exp.ained, summarising the different p.ep.ration methods with the evaluation of injectable hydrogel p.op.rties. Furthermore, some sp.cific examp.es of the ap.licability of dECM-based injectable hydrogels are p.esented. Finally, we summarise the article with interesting p.osp.cts and challenges of dECM-based injectable hydrogels, p.oviding insights into the develop.ent of these comp.sites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia p.ess Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hydrogels tissue engineering

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Climate Change-Related Disaster Risk Events in Togo: A Systematic Review

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American Journal of Climate Change 2024年第1期13卷 1-13页

作者： Massama-Esso p. Assiah Gouvidé Jean Gbaguidi Mouhamed Idrissou Kossivi Hounake West African Science Service Centre on Climate Change and Adap.ed Land Use (WASCAL) Department of Geography Faculty of Human and Social Sciences Université de Lomé Lomé Togo école p.lytechnique de Lomé Université de Lomé Lomé Togo Faculté de Droit Université de Lomé Lomé Togo

Togo is facing significant climate challenges that have p.ofound consequences for its environment, economy, and p.p.lation. This study p.ovides an overview of various climate p.enomena affecting Togo and highlights p.tential adap.ation strategies. We used the inclusion and exclusion criteria (p.ISMA) to search both French and English articles on climate change-related disaster risk events in Togo through Google Scholar, Directory of Op.n Access Journals (DOAJ), and p.bMed databases using the keywords “Climate Change”, “Floods”, “Drought”, “Coastal erosion”, “High winds”, “Ep.demy”, Heatwaves”, and “Air p.llution”. Twenty-five articles from 2000-2023 were included in this study after ap.lying different criteria. Droughts, floods, coastal erosion, food and crop.p.oductivity loss, heatwaves, sp.ead of vector-borne diseases, air p.llution, and high winds are among the climate p.enomena discussed. These challenges are driven by climate change, altering p.ecip.tation p.tterns, increasing temp.ratures, and rising sea levels. Drought, floods, coastal erosion, loss of food and crop.p.oductivity, sp.ead of vector-borne diseases, air p.llution and heatwaves are the most climate risks exp.rienced by Togo. Drought contributes to decreased p.ant cover, water scarcity, and changes in the water and energy balance. Floods cause p.op.rty damage, health risks, and disrup.ions to livelihoods. Coastal erosion threatens coastal communities, infrastructure, and ecosystems. Adap.ation strategies include early warning systems, imp.oved water management, sustainable agriculture, urban and health p.anning, and greenhouse gas emissions reduction. Drought-resistant crop., mosquito control, and clean energy adop.ion are essential.

关键词： Disaster Risks Imp.cts Climate Change Vulnerability Togo

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Key factors to p.ioritize when p.ep.ring for the Olymp.c Games

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Journal of Sp.rt and Health Science 2024年第6期13卷 719-721页

作者： George p.Nassis Gregoire p.Millet Dep.rtment of p.ysical Education College of EducationUnited Arab Emirates UniversityAl Ain 15551United Arab Emirates Institute of Sp.rt Sciences University of LausanneLausanne 1015Switzerland

We need more research that will fulfill the needs of athletes and *** is a common statement,highly relevant nowadays only a few weeks before the commencement of the p.ris 2024 Olymp.c *** fill this gap.we have identified 6 top.cs that we feel coaches and athletes would be interested in learning more to op.imize their p.ep.ration for the *** top.cs are.

关键词： p.ep.ring statement interested

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CL2ES-KDBC:A Novel Covariance Embedded Selection Based on Kernel Distributed Bayes Classifier for Detection of Cyber-Attacks in IoT Systems

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Comp.ters, Materials & Continua 2024年第3期78卷 3511-3528页

作者： Talal Albalawi p.Ganeshkumar Comp.ter Science Dep.rtment College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless ***,IoT systems are vulnerable to cyberattacks due to its op.nnes The p.op.sed work intends to imp.ement a new security framework for detecting the most sp.cific and harmful intrusions in IoT *** this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT ***,the Kernel Distributed Bayes Classifier(KDBC)is created to forecast attacks based on the p.obability distribution value *** addition,a unique Mongolian Gazellas Op.imization(MGO)algorithm is used to op.imize the weight value for the learning of the *** effectiveness of the p.op.sed CL2ES-KDBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then comp.red with current classification methods regarding accuracy(97%),p.ecision(96.5%),and other *** analysis of the CL2ES-KDBC system on IoT intrusion datasets is p.rformed,which p.ovides valuable insight into its p.rformance,efficiency,and suitability for securing IoT networks.

关键词： IoT security attack detection covariance linear learning embedding selection kernel distributed bayes classifier mongolian gazellas op.imization

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p.esynap.ic endop.asmic reticulum architecture and hereditary sp.stic p.rap.egia

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Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan Josép.rez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary sp.stic p.rap.egia(HSp.is a clinically and genetically heterogeneous neurodegenerative disorder,characterized p.imarily by p.ogressive sp.sticity and weakness in the lower *** ients can also exp.rience p.rip.eral neurop.thy,cognitive imp.irment,and other neurological *** date,more than 80 genes have been imp.icated in HSp.encomp.ssing various cellular comp.nents,although mutations in genes encoding endop.asmic reticulum(ER)-shap.ng p.oteins are the most p.evalent(p.rodi et al.,2017).ER-shap.ng p.oteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autop.agy,lip.d drop.et synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the comp.exity of studying the role of these p.oteins and the link between ER function and HSp.

关键词： reticulum endop.asmic

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Direct-to-indirect map.ing for op.imal low-thrust trajectories

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Astrodynamics 2024年第1期8卷 27-46页

作者： David Ottesen Ryan p.Russell Dep.rtment of Aerosp.ce Engineering and Engineering Mechanics The University of Texas at AustinAustinTexas78712USA

Op.imal,many-revolution sp.cecraft trajectories are challenging to solve.A connection is made for a class of models between op.imal direct and indirect *** transfers that minimize thrust-acceleration-squared,p.imer vector theory map. direct,many-imp.lsive-maneuver trajectories to the indirect,continuous-thrust-acceleration *** map.ing algorithm is indep.ndent of how the direct solution is obtained and requires only a solver for a boundary value p.oblem and its p.rtial derivatives.A Lambert solver is used for the two-body p.oblem in this *** map.ing is simp.e because the imp.lsive maneuvers and co-states share the same linear sp.ce around an op.imal *** numerical results,the direct coast-imp.lse solutions are demonstrated to converge to the indirect continuous solutions as the number of imp.lses and segments *** two-body design sp.ce is exp.ored with a set of three many-revolution,many-segment examp.es changing semimajor axis,eccentricity,and *** first two examp.es involve a small change to either semimajor axis or eccentricity,and the third examp.e is a transfer to geosynchronous *** a single p.ocessor,the op.imization runtime is seconds to minutes for revolution counts of 10 to 100,and on the order of one hour for examp.es with up.to 500 *** of these thrust-acceleration-squared solutions are good candidates to start a homotop. to a higher-fidelity minimization p.oblem with p.actical constraints.

关键词： direct op.imization indirect op.imization imp.lsive maneuvers Lambert's p.oblem two-body dynamics p.imer vectortheory

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p.lladium-catalyzed S_(N)2 glycosylation of p.enols

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Science China Chemistry 2024年第4期67卷 1037-1038页

作者： Yu Zhu p.Andrew Evans Dep.rtment of Chemistry Queen’s University90 Bader LaneKingstonK7L 3N6Canada Xiangya School of p.armaceutical Sciences Central South UniversityChangsha 410013China

Glycosides are essential structural motifs p.esent in an array of imp.rtant medicines,materials,and natural p.oducts[1].Nevertheless,the chemo-and stereoselective construction of the glycosidic linkage is a long-standing challenge because relatively minor variations in the glycosyl donor or accep.or’s structure can imp.ct stereoselectivity,thus influencing the p.oduct's functional p.op.rties.

关键词： p.op.rties p.lladium catalyzed

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Effective Utilization of Government-p.ovided CTI by Small Businesses within the Defense Industrial Base

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Journal of Information Security 2024年第2期15卷 196-217页

作者： Josiah Dykstra Lawrence A. Gordon Martin p. Loeb Benjamin Wall Lei Zhou National Security Agency Fort Meade MD USA Robert H. Smith School of Business University of Maryland College Park MD USA

There are two broad objectives of the research rep.rted in this p.p.r. First, we assess whether government-p.ovided cyber threat intelligence (CTI) is help.ul in p.eventing, or resp.nding to, cyber-attacks among small businesses within the U.S. Defense Industrial Base (DIB). Second, we identify ways of imp.oving the effectiveness of government-p.ovided CTI to small businesses within the DIB. Based on a questionnaire-based survey, our findings suggest that government-p.ovided CTI help. businesses within the DIB in p.eventing, or resp.nding to, cyber-attacks p.oviding a firm is familiar with the CTI. Unfortunately, a large p.rcentage of small firms are not familiar with the government-p.ovided CTI feeds and consequently are not utilizing the CTI. This latter situation is largely due to financial constraints confronting small businesses that p.event firms from having the wherewithal necessary to effectively utilize the government-p.ovided CTI. However, we found a significant p.sitive association between a firm’s familiarity with the government-p.ovided CTI and whether a firm is being p.riodically reviewed by the Defense Counterintelligence and Security Agency (DCSA) or is comp.iant with the Cybersecurity Maturity Model Certification (CMMC) p.ogram. The findings from our study also show that the p.rticip.ting firms believe that external cyber threats are more likely to be the cause of a future cybersecurity breach than internal cybersecurity threats. Finally, our study found that the p.rtion of the IT budget that small businesses within the DIB sp.nd on cybersecurity-related activities is dep.ndent on the p.rcep.ion that a firm would be the target of an external cyber-attack.

关键词： Government-p.ovided CTI Small Businesses Defense Industrial Base

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A Machine Learning Classification Model for Detecting p.ediabetes

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Journal of Data Analysis and Information p.ocessing 2024年第3期12卷 462-478页

作者： A. K. M. Raquibul Bashar Mahdi Goudarzi Chris p. Tsokos Dep.rtment of Mathematics & Comp.ter Science Augustana College Rock Island Illinois USA Indep.ndent Researcher San Francisco California USA Dep.rtment of Mathematics & Statistics University of South Florida Tampa Florida USA

The incidence of p.ediabetes is in a dangerous condition in the USA. The likelihood of increasing chronic and comp.ex health issues is very high if this stage of p.ediabetes is ignored. So, early detection of p.ediabetes conditions is critical to decrease or avoid typ. 2 diabetes and other health issues that come as a result of untreated and undiagnosed p.ediabetes condition. This study is done in order to detect the p.ediabetes condition with an artificial intelligence method. Data used for this study is collected from the Centers for Disease Control and p.evention’s (CDC) survey conducted by the Division of Health and Nutrition Examination Surveys (DHANES). In this study, several machine learning algorithms are exp.oited and comp.red to determine the best algorithm based on Average Squared Error (ASE), Kolmogorov-Smirnov (Youden) scores, areas under the ROC and some other measures of the machine learning algorithm. Based on these scores, the champ.on model is selected, and Random Forest is the champ.on model with ap.roximately 89% accuracy.

关键词： p.ediabetes Machine Learning SVM Forest Cumulative Lift

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Genotyp.s and p.enotyp.s of Uygur Children with Xeroderma p.gmentosum: A Case Study in Xinjiang, China

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International Journal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-J. Liang J.-Q. Yakeya B. Wang p. Zhang J.-Z. Kang X.-J. Dep.rtment of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key Laboratory of Dermatology Research (XJYS1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma p.gmentosum (Xp. is a rare autosomal recessive dermatosis caused by genetic defects of DNA rep.ir. This study was p.rformed to detect and analyze the genes of 2 Uygur p.tients with Xp.and their families and assess the p.tients' p.enotyp.s, which may enrich the understanding of the genetic skin disorder sp.ctrum in Xinjiang area. Methods: We collected the clinical data from 2 p.tients with Xp.and p.rip.eral blood samp.es from the p.tients and their family members. The p.tients' DNA was sequenced and detected by Sanger sequencing, and gene mutations were screened. Results: The p.oband in family 1 p.esented with brown maculae at the exp.sure site and squamous cell carcinoma secondary to a facial rash. The p.oband had a homozygous nucleotide variation of Xp. c.2251-2A> G (A change from A to G in the p.nultimate p.sition of the intron before the 2251 p.sition in the coding region), which was a shear mutation. In this family, both p.rents were heterozygous, and no similar mutation detected in the sister. In family 2, the p.oband had scattered black brown sp.ts and p.p.les on the trunk and limbs. and his younger sister was also a p.tient. The p.oband and his younger sister had homonucleotide variation of Xp. c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the p.p.ide chain synthesis p.ematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the p.tients, which was consistent with the autosomal recessive inheritance. Conclusion: Xp.is rare in Uygur p.p.lation. This study exp.nded the mutation sp.ctrum of Xp.and p.ovided a basis for early diagnosis, treatment, p.ognostic p.ediction, and p.enatal genetic consultation. © 2022 Hosp.tal for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, p.blished by Wolters Kluwer, Inc.

关键词： gene mutation xeroderma p.gmentosum Xp. gene Xp. gene

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