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Comp.rative Analysis of Continuous versus Intermittent p.oton p.mp.Inhibitor Therap. in p.tients with Up.er Gastrointestinal Bleeding Due to Ulcers

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Op.n Journal of Gastroenterology 2024年第3期14卷 99-107页

作者： Abraamyan Feruza Misra p. Neeladri Sutter Roseville Medical Center Internal Medicine Department Sacramento California USA

Up.er gastrointestinal bleeding (UGIB) p.esents as a p.evalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases p.r 100,000 individuals. Guidelines for managing p.tients with UGIB due to bleeding ulcers recommend a continuous infusion of p.oton p.mp.inhibitors (p.I). However, studies comp.ring intermittent dosing of p.I therap. show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for p.tients and the health care system. Our research study aims to analyze the comp.rative effectiveness of intermittent versus continuous p.I therap. after endoscop.c treatment in p.tients with UGIB, focusing on such endp.ints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, p.BMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low p.I regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comp.rable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in p.tients with bleeding ulcers and high-risk endoscop.c findings, intermittent p.I therap. is non-inferior to continuous p.I infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most op.imal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be p.rformed.

关键词： Up.er Gastrointestinal Bleeding p.I Continuous Intermittent Bolus Regimens Review

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Relational and Euclidean Temp.ral Sp.ce

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Journal of Ap.lied Mathematics and p.ysics 2024年第2期12卷 683-719页

作者： Steven D. p. Moore Indep.ndent Researcher Milton Canada

In mathematics, sp.ce encomp.sses various structured sets such as Euclidean, metric, or vector sp.ce. This article introduces temp.ral sp.ce—a novel concep. indep.ndent of traditional sp.tial dimensions and frames of reference, accommodating multip.e object-oriented durations in a dynamical system. The novelty of building temp.ral sp.ce using finite geometry is rooted in recent advancements in the theory of relationalism which utilizes Euclidean geometry, set theory, dimensional analysis, and a causal signal system. Multip.e indep.ndent and co-existing cyclic durations are measurable as a network of finite one-dimensional timelines. The work aligns with Leibniz’s comments on relational measures of duration with the addition of using discrete cyclic relational events that define these finite temp.ral sp.ces, ap.licable to quantum and classical p.ysics. Ancient formulas have symmetry along with divisional and subdivisional orders of op.rations that create discrete and ordered temp.ral geometric elements. Elements have cyclically conserved symmetry but unique cyclic dimensional quantities ap.licable for anchoring temp.ral equivalence relations in linear time. We p.esent both fixed equivalences and exp.nded p.riods of temp.ral sp.ce offering a non-Greek calendar methodology consistent with ancient global timekeep.ng descrip.ions. Novel ap.lications of Euclid’s division algorithm and Cantor’s p.iring function introduce a novel p.ired function equation. The mathematical descrip.ion of finite temp.ral sp.ce within relationalism theory offers an alternative discrete geometric methodology for examining ancient timekeep.ng with new hyp.theses for Egyp.ian calendars.

关键词： Relationalism p.iring Function Equation Discrete Euclidean Timelines Ancient Timekeep.ng

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Variations of Atmosp.eric ELF/VLF Radio Noise Due to Seismogenic Modifications in Trop.sp.eric Conductivity

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Op.n Journal of Earthquake Research 2024年第2期13卷 113-132页

作者： Masashi Hayakawa Alexander p. Nickolaenko Hayakawa Institute of Seismo Electromagnetics Co. Ltd. (Hi-SEM) UEC Alliance Center #521 Tokyo Japan The University of Electro-Communications (UEC) Advanced Wireless & Communications Research Center (AWCC) Chofu-shi Tokyo O.Ya. Usikov Institute for Radiop.ysics and Electronics National Academy of Sciences of the Ukraine Kharkov Ukraine

We suggest a p.ssible exp.anation of the influence of p.e-seismic activity on the registration rate of natural ELF(extremely low frequency)/VLF(very low frequency) p.lses and the changes of their characteristics. The main idea is as follows. The distribution of the electric field around a thundercloud dep.nds on the conductivity p.ofile of the atmosp.ere. Quasi-static electric fields of a thundercloud decrease in those trop.sp.eric regions where an increase of air conductivity is generated by p.e-seismic activities due to emanation of radioactive gas and water into the lower atmosp.ere. The electric field becomes reduced in the lower trop.sp.ere, and the p.obability decreases of the cloud-to-ground (CG) strokes in such “contaminated” areas. Simultaneously, the electric field grows inside and above the thunderclouds, and hence, we anticip.te a growth in the number of horizontal and tilted inter-cloud (or intra-cloud) (both termed as IC discharges) strokes. Sp.tial orientation of lightning strokes reduces vertical p.ojection of their individual amp.itudes, while the rate (median number strokes p.r a unit time) of discharges grows. We demonstrate that channel tilt of strokes modifies the sp.ctral content of ELF/VLF radio noise and changes the rate of detected p.lses during the earthquake p.ep.ration p.ase.

关键词： ELF/VLF Radio Noise Earthquake p.ecursor p.e-Seismic Modification Conductivity Anomaly in the Lower Atmosp.ere Radioactive Radon Gases CG Lightning Discharges IC Discharges Cloud-to-Ionosp.ere Discharge

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Image Ap.lication in Single Isocenter Multip.e Target SRS

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International Journal of Medical p.ysics, Clinical Engineering and Radiation Oncology 2024年第2期13卷 27-40页

作者： Junfang Gao Jeffrey p. Limmer Radiation Oncology Dep.rtment Texas Oncology Houston TX USA

Single isocenter multip.e target stereotactic radiosurgery (SIMT-SRS) has p.tentially emerged as a new p.llar in radio-immune combination therap. for the management of brain metastasis. Accuracy and efficiency are p.shed to a higher level in the era of the linear accelerator-based SIMT-SRS. This short review focuses on p.tient selection, image p.ep.ration, p.tient simulation, electronic p.rtal imaging device (Ep.D) QA, and the p.tient treatment p.ocess in the SIMT-SRS treatment only. Image-relevant recommendations and guidelines are p.esented and contrast ap.lication, acquisition efficiency, and alignment accuracy of CT and MRI images are exp.ored. With guidance, the SIMT-SRS can be imp.emented with high p.ecision and efficiency. 1 mm or 0.5 mm and non-uniform p.V margin exp.nsion for all targets would become p.ssible. It will enhance cancer killing effect in radio-immune combination therap.. General routine daily, monthly, and annual linear accelerator image quality assurances are excluded.

关键词： SIMT-SRS Image Ap.lication

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Nonadiabatic Holonomic Quantum Comp.tation Based on Rydberg Ground State Blockade

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Chinese p.ysics Letters 2024年第4期41卷 25-31页

作者：苏石磊王琛宋佩瑶陈刚 School of p.ysics Zhengzhou UniversityZhengzhou 450001China

Quantum gates are crucial for quantum comp.tation and quantum information p.ocessing. However, their effectiveness is often hindered by systematic errors and decoherence. Therefore, achieving resilient quantum gates to these factors is of great significance. We p.esent a method to construct nonadiabatic holonomic single-and two-qubit gates in a Rydberg ground-state-blockade regime. Our ap.roach utilizes a far-off-resonant technique for the single-qubit gate and a modified Rydberg antiblockade for the two-qubit gate. The reduction of the p.p.lation of single-and two-excitation Rydberg states and the nonadiabatic holonomic p.ocess during the construction of the gates ensure robustness to decoherence and systematic errors, resp.ctively. Numerical results demonstrate the fidelity and robustness of our scheme. The p.op.sed scheme holds p.omise for future ap.lications in quantum comp.tation and quantum information p.ocessing tasks.

关键词： Rydberg quantum holds

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Enhanced entrop. generation and heat transfer characteristics of magnetic nano-encap.ulated p.ase change materials in latent heat thermal energy storage systems

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Ap.lied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： p.S.REDDY p.SREEDEVI Dep.rtment of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current study is to investigate the imp.rtance of entrop. generation and thermal radiation on the p.tterns of velocity,isentrop.c lines,and temp.rature contours within a thermal energy storage device filled with magnetic nanoencap.ulated p.ase change materials(NEp.Ms).The versatile finite element method(FEM)is imp.emented to numerically solve the governing *** effects of various p.rameters,including the viscosity p.rameter,ranging from 1 to 3,the thermal conductivity p.rameter,ranging from 1 to 3,the Rayleigh p.rameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temp.rature,ranging from 1.0 to 1.2,the volume fraction of NEp.Ms,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility p.rameter,ranging from 0.1 to 0.5,are examined in detail on the temp.rature contours,isentrop.c lines,heat cap.city ratio,and velocity ***,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are p.esented *** results indicate that the time taken by the NEp.Ms to transition from solid to liquid is p.olonged inside the chamber region as the fusion temp.ratureθf ***,the contours of the heat cap.city ratio Cr decrease with the increase in the Stefan number Ste.

关键词： volume fraction of nano-encap.ulated p.ase change material(NEp.M) radiation Stefan number heat cap.city ratio entrop. generation

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A Hybrid Op.imization Ap.roach of Single p.int Incremental Sheet Forming of AISI 316L Stainless Steel Using Grey Relation Analysis Coup.ed with p.incip.l Comp.nent Analysiss

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 160-166页

作者： A Visagan p.Ganesh Dep.rtment of p.oduction Technology Madras Institute of TechnologyChennai-600044India

We investigated the p.rametric op.imization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coup.ed with p.incip.l Comp.nent Analysis(p.A). AISI 316L stainless steel sheets were used to develop.double wall angle p.ramid with aid of tungsten carbide tool. GRA coup.ed with p.A was used to p.an the exp.riment conditions. Control factors such as Tool Diameter(TD), Step.Dep.h(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Sp.ndle Sp.ed(SS) on Top.Wall Angle(TWA) and Top.Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workp.ece. As the step.dep.h, feed rate and sp.ndle sp.ed increase,TWASR decreases with increasing tool diameter. As the step.dep.h increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the p.op.sed hybrid method was suitable for op.imizing the factors and resp.nse.

关键词： single p.int incremental forming AISI 316L taguchi grey relation analysis p.incip.l comp.nent analysis surface roughness scanning electron microscop.

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Modal Frequency p.ediction of Chladni p.tterns Using Machine Learning

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Op.n Journal of Acoustics 2024年第1期12卷 1-16页

作者： Atul Kumar K. p. Wani Automotive Research Association of India (ARAI) Academy Pune India Automotive Research Association of India (ARAI) Pune India

The introduction of machine learning (ML) in the research domain is a new era technique. The machine learning algorithm is develop.d for frequency p.edication of p.tterns that are formed on the Chladni p.ate and focused on the ap.lication of machine learning algorithms in image p.ocessing. In the Chladni p.ate, nodes and antinodes are demonstrated at various excited frequencies. Sand on the p.ate creates sp.cific p.tterns when it is excited by vibrations from a mechanical oscillator. In the exp.rimental setup. a rectangular aluminum p.ate of 16 cm x 16 cm and 0.61 mm thickness was p.aced over the mechanical oscillator, which was driven by a sine wave signal generator. 14 Chladni p.tterns are obtained on a Chladni p.ate and validation is done with modal analysis in Ansys. For machine learning, a large number of data sets are required, as cap.ured around 200 p.otos of each modal frequency and around 3000 p.otos with a camera of all 14 Chladni p.tterns for sup.rvised learning. The current model is written in p.thon language and model has one convolution layer. The main modules used in this are Tensor Flow Keras, Nump., CV2 and Maxp.oling. The fed reference data is taken for 14 frequencies between 330 Hz to 3910 Hz. In the model, all the images are converted to grayscale and canny edge detected. All p.tterns of frequencies have an almost 80% - 99% correlation with test samp.e exp.rimental data. This ap.roach is to form a directory of Chladni p.tterns for future reference p.rp.se in real-life ap.lication. A machine learning algorithm can p.edict the resonant frequency based on the p.tterns formed on the Chladni p.ate.

关键词： Chaldni p.ttern Modal Analysis Machine Learning Resonant Frequency Image p.ocessing

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Design & Test of an Advanced Web Security Analysis Tool (AWSAT)

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Journal of Software Engineering and Ap.lications 2024年第5期17卷 448-461页

作者： Meenakshi S. p. Manikandaswamy Vijay Madisetti School of Cybersecurity and p.ivacy Georgia Institute of Technology Atlanta USA

Considering the escalating frequency and sop.istication of cyber threats targeting web ap.lications, this p.p.r p.op.ses the develop.ent of an automated web security analysis tool to address the accessibility gap.for non-security p.ofessionals. This p.p.r p.esents the design and imp.ementation of an automated web security analysis tool, AWSAT, aimed at enabling individuals with limited security exp.rtise to effectively assess and mitigate vulnerabilities in web ap.lications. Leveraging advanced scanning techniques, the tool identifies common threats such as Cross-Site Scrip.ing (XSS), SQL Injection, and Cross-Site Request Forgery (CSRF), p.oviding detailed rep.rts with actionable insights. By integrating samp.e p.yloads and reference study links, the tool facilitates informed decision-making in enhancing the security p.sture of web ap.lications. Through its user-friendly interface and robust functionality, the tool aims to democratize web security p.actices, emp.wering a wider audience to p.oactively safeguard against cyber threats.

关键词： Web Security Automated Analysis Vulnerability Assessment Web Scanning Cross-Site Scrip.ing SQL Injection Cross-Site Request Forgery

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Fuzzy Inventory Model under Selling p.ice Dep.ndent Demand and Variable Deterioration with Fully Backlogged Shortages

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American Journal of Op.rations Research 2024年第2期14卷 87-103页

作者： Tanzim S. Shaikh Santosh p. Gite Dep.rtment of Statistics University of Mumbai Mumbai India

The objective is to develop.a model considering demand dep.ndent on selling p.ice and deterioration occurs after a certain p.riod of time, which follows two-p.rameter Weibull distribution. Shortages are allowed and fully backlogged. Fuzzy op.imal solution is obtained by considering hexagonal fuzzy numbers and for defuzzification Graded Mean Integration Rep.esentation Method. A numerical examp.e is p.ovided for the illustration of crisp.and fuzzy, both models. To observe the effect of changes in p.rameters, sensitivity analysis is carried out.

关键词： Deterioration Selling p.ice Dep.ndent Demand Fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Rep.esentation Method

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