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Acta Metallurgica Sinica(English Letters) 2016年第3期29卷 228-236页

作者： manuela stan Adriana Popa Dana Toloman Teofil-Danut Silipas Dan Cristian Vodnar National Institute for Research and Development of Isotopic and Molecular Technologies 67-103 Donat 400293Cluj-Napoca Romania Department of Food Science and Technology University of Agricultural Sciences and Veterinary Medicine 3-5 ManasturStreet 400372 Cluj-Napoca Romania

ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basilicum）.The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was *** X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite *** particle size of ZnO NPs estimated by transmission electron microscopy analysis（between 14 and 27 nm） varies depending on the synthesis method of nanoparticles and the type of extracts from the plants *** functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared *** presence of Mn^（2＋）ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance *** green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial *** NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.

关键词： Zinc oxide nanoparticles Antioxidant activity Antibacterial activity Green synthesis Plant extracts

Analyzing the Interplay of Sintering Conditions on Microstructure and Hardness in Indirect Additive Manufacturing of 17-4PH Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1611-1620页

作者： Erika Lannunziata Mohammad Hossein Mosallanejad manuela Galati Gabriele Piscopo Abdollah Saboori Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Indirect additive manufacturing(AM)methods have recently attracted attention from researchers thanks to their great potential for cheap,straightforward,and small-scale production of metallic *** diffusion additive manufacturing(ADAM),a variant of indirect AM methods,is a layer-wise indirect AM process recently developed based on fused deposition modeling and metal injection ***,there is still limited knowledge of the process conditions and material properties fabricated through this process,where sintering plays a crucial role in the final consolidation of ***,this research,for the first time,systematically investigates the impact of various sintering conditions on the shrinkage,relative density,microstructure,and hardness of the 17-4PH ADAM *** this reason,as-washed samples were sintered under different time-temperature *** sample density was evaluated using Archimedes,computed tomography,and image analysis *** outcomes revealed that sintering variables significantly impacted the density of brown 17-4PH Stainless Steel *** results indicated more than 99% relative densities,higher than the value reported by Markforged Inc.(~96%).Based on parallel porosities observed in the computed tomography results,it can be suggested that by modifying the infill pattern during printing,it would be possible to increase the final relative *** microhardness of the sintered samples in this study was higher than that of the standard sample provided by Markforged *** at 1330℃ for 4 h increased the density of the printed sample without compromising its mechanical *** to X-ray diffraction analysis,the standard sample provided by Markforged ***“1330℃—4 h”one had similar stable phases,although copper-rich intermetallics were more abundant in the microstructure of reference *** study is expected to facilitate the adoption of indirect metal AM methods by different sector

关键词： Indirect additive manufacturing Atomic diffusion additive manufacturing 17-4PH stainless steel Computed tomography Sintering

Influence of Interrupted Childhood Biographies on Health Development: Evaluation of the Scientific Literature on the Example of Being Taken into Care*

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Journal of Biosciences and Medicines 2024年第7期12卷 108-119页

作者： manuela Loderer Ursula Gresser Dental Office for Orthodontics Dingolfing Germany Outpatient Clinic for Internal Medicine and Medical Expert Reports Munich Germany

Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. Results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.

关键词： Taking into Care Out-of-Home-Care Interrupted Family History Physical Outcomes Internal Medicine

Does the provision of live black soldier fly and yellow mealworm larvae improve Muscovy duck welfare?

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Journal of Animal Science and Biotechnology 2024年第1期15卷 442-455页

作者： Marta Gariglio Sihem Dabbou manuela Renna Ilaria Biasato Sara Bellezza Oddon Marco Meneguz Raul Daniel Miazzo Stefania Bergagna Elena Colombino Elisabetta Macchi Achille Schiavone Department of Veterinary Sciences University of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy Center Agriculture Food Environment(C3A) University of TrentoVia Edmund Mach 1San Michele All’AdigeTrento(TN)38098Italy Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 2GrugliascoTorino(TO)10095Italy BEF Biosystems s.r.l Via Tancredi Canonico 18/CTorino(TO)10156Italy Unidad de Investigacion Aviar Produccion AvicolaFac.Agr.y Vet.Universidad Nacional de Rio CuartoCordobaArgentina Veterinary Medical Research Institute for Piemonte Liguria and Valle d’AostaVia Bologna 148Torino(TO)10154Italy

Background The provision of environmental enrichments to Muscovy ducks could reduce the expression of the aggressive *** aim of the present study was to evaluate the effects of black soldier fly(BSF)and yellow mealworm(YM)live larva provision on Muscovy duck performance,excreta corticosterone metabolites(ECM),behavior,and blood *** A total of 1263-day-old female Muscovy ducklings were allotted to 18 pens(6 replicates/treatment,7 birds/pen)and assigned to 3 experimental treatments:a control group fed commercial feed,and two experimental treatments fed commercial feed plus the 5%(based on the expected daily feed intake,as fed basis)of BSF and YM live larvae(BSF and YM groups,respectively).A two-phase feeding program was applied:starter(from 3 to 31 days of age)and grower-finisher(from 32 to 55 days of age).The live weight,average daily gain,average daily feed intake,and feed conversion ratio were *** consumption times were collected,and video recordings were performed during 3 periods(P)each day:the hour before(P1),during(P2),and after(P3)the larva *** were evaluated at 3,31,and ***,the total red and white blood cell counts,serum proteins,lipids,and liver and renal function serum enzymes were evaluated on 12 birds/*** The experimental treatment did not affect the growth performance of the birds(P>0.05).Larva consumption times were always similar between the two insect species,except at 14–18 days of age,were BSF larvae were consumed faster than YM larvae(PP3;P<0.05).Finally,the provision of live BSF and YM larvae significantly reduced the ECM at 55 days of age and the heterophil to lymphocyte ratio(P<0.05).Conclusions Live BSF and YM larva supplementatio

关键词： Behavior Cairina moschata Environmental enrichment Hermetia illucens Poultry Tenebrio molitor Welfare

Normothermic regional perfusion mobile teams in controlled donation after circulatory death pathway: Evidence and peculiarities

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World Journal of Transplantation 2024年第4期14卷 78-83页

作者： Chiara Lazzeri manuela Bonizzoli Giuseppe Feltrin Adriano Peris Department of Emergency Extracorporeal Membrane Oxygenation CenterRegional Transplant CenterFlorence 50134Italy Department of Emergency Extracorporeal Membrane Oxygenation CenterFlorence 50134Italy Centro Nazionale Trapianti Roma 00161Italy

To facilitate the implementation of controlled donation after circulatory death(cDCD)programs even in hospitals not equipped with a local Extracorporeal Membrane Oxygenation(ECMO)team(Spokes),some countries and Italian Regions have launched a local cDCD network with a ECMO mobile team who move from Hub hospitals to Spokes for normothermic regional perfusion(NRP)implantation in the setting of a cDCD *** ECMO teams have been clearly defined by the Extracorporeal Life Support Organization,regarding composition,responsibilities and training programs,no clear,widely accepted indications are to date available for NRP *** existing NRP mobile networks were developed due to the urgent need to increase the number of cDCDs,there is now the necessity for transplantation medicine to identify the peculiarities and responsibility of a NRP team for all those centers launching a cDCD ***,in the present manuscript we summarized the character-istics of an ECMO mobile team,highlighting similarities and differences with the NRP mobile *** also assessed existing evidence on NRP teams with the goal of identifying the characteristic and essential features of an NRP mobile team for a cDCD program,especially for those centers who are starting the *** were identified between the mobile ECMO team and NRP mobile *** common essential feature for both mobile teams is high skills and experience to reduce complications and,in the case of cDCD,to reduce the total warm ischemic *** training programs should be developed for the launch of de novo NRP teams.

关键词： Controlled donation after circulatory death Extracorporeal membrane oxygenation Normothermic regional perfusion Mobile teams Warm ischemia time

Reducing strain on primary healthcare systems through innovative models of care:the impact of direct access physiotherapy for musculoskeletal conditions—an interrupted time series analysis

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Family Medicine and Community Health 2024年第3期12卷 1-12页

作者： James Henry Zouch Bjørnar Berg Are Hugo Pripp Kjersti Storheim Claire E Ashton-James manuela L Ferreira Margreth Grotle Paulo H Ferreira Sydney Musculoskeletal Health Faculty of Medicine and HealthThe University of SydneySydneyNew South WalesAustralia Centre for Intelligent Musculoskeletal Health Oslo Metropolitan University Faculty of Health SciencesOsloNorway Oslo Metropolitan University Faculty of Health Sciences OsloNorway Oslo Centre of Biostatistics and Epidemiology Oslo University HospitalOsloNorway Department of Rehabilitation Science and Health Technology Oslo Metropolitan University Faculty of Health SciencesOsloNorway Department of Research and Innovation Oslo University Hospital Division of Clinical NeuroscienceOsloNorway Sydney Medical School Kolling InstituteThe University of Sydney Faculty of Medicine and HealthSydneyNew South WalesAustralia The George Institute for Global Health SydneyNew South WalesAustralia Department of Research and Innovation Oslo University HospitalOsloNorway Department of Rehabilitation and Technology Oslo Metropolitan University Faculty of Health SciencesOsloNorway Charles Perkins Centre Sydney Musculoskeletal HealthThe University of Sydney Faculty of Medicine and HealthSydneyNew South WalesAustralia

Objectives To evaluate the longitudinal impact of introducing a national,direct access physiotherapy model of care on the rates of primary and secondary care consultations for musculoskeletal(MSK)*** Interrupted time series analysis using segmented linear *** Norway primary care Participants A cohort of 82072 participants was derived from 3 population-based health surveys conducted across separate geographical regions in *** participants surveyed were eligible for inclusion as a national representative sample of the Norwegian *** MSK consultations were linked to the Norwegian Control and Payment of Health Reimbursement database and the Norwegian Patient Register using the International Classification of Primary Care diagnostic medical codes L-chapter for MSK conditions and spine related International Classification of Diseases,10th Revision,*** Direct access to physiotherapy model of care introduced nationally in Norway in *** model allowed Norwegians to consult directly with qualified physiotherapists for MSK conditions(eg,back pain,knee osteoarthritis)without the need for a medical referral in order to claim a social security *** outcomes measured Rates of primary care consultations per 10000 population(general practitioner(GP)and physiotherapist consultations)and secondary care(specialist consultations and surgical procedures)measured from 2014 to *** The introduction of the direct access physiotherapy model was associated with an immediate stepped reduction of 391 general practice consultations per 10000 population,(95%CI:−564 to−216),without an associated change in physiotherapy *** analyses suggested there was an associated reduction in physiotherapy consultations for those in the lowest education group of 150 consultations per quarter(95%CI:−203 to−97),70 consultations per quarter in the intermediate education group(95%CI:−115 to−27)and a step

关键词： impact analysis strain

Cold ischemia time in liver transplantation:An overview

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World Journal of Hepatology 2024年第6期16卷 883-890页

作者： manuela Cesaretti Alessandro Izzo Roberta Anna Pellegrino Alessandro Galli Orestes Mavrothalassitis Department of HPB and Liver Transplantation Brotzu HospitalCagliari 09122Italy Department of Nanophysic Istituto Italiano di TecnologiaGenova 16163Italy Department of Critical Care Medicine and Anesthesia ASST Papa Giovanni XXIIIBergamo 24100Italy Department of Anesthesia and Perioperative Care University of California San FranciscoSan FranciscoCA 94143United States

The standard approach to organ preservation in liver transplantation is by static cold storage and the time between the cross-clamping of a graft in a donor and its reperfusion in the recipient is defined as cold ischemia time(CIT).This simple definition reveals a multifactorial time frame that depends on donor hepatectomy time,transit time,and recipient surgery time,and is one of the most important donor-related risk factors which may influence the graft and recipient’s ***,the growing demand for the use of marginal liver grafts has prompted scientific exploration to analyze ischemia time factors and develop different organ preservation *** review details the CIT definition and analyzes its different *** also explores the most recent strategies developed to implement each timestamp of CIT and to protect the graft from ischemic injury.

关键词： Cold ischemia time Liver transplantation Organ donation Donation after cardiac death Warm ischemia time Machine perfusion

Seasonal Dynamic of the Fall Armyworm, Spodoptera frugiperda (J.E Smith, 1797) (Lepidoptera: Noctuidae) on Maize Crop in the Sub-Sudanese Zone of Côte d’Ivoire

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Advances in Entomology 2024年第2期12卷 78-92页

作者： Stéphanie manuela Klamansoni Akissi Konan Laya Kansaye Nondenot Roi Louis Aboua West Africa Science Service Centre on Climate Change and Land Used (WASCAL) Abidjan C&#244te d&#8217Ivoire Rural Polytechnic Institute of Training and Applied Research Katibougou Mali Department of Entomology and Ecosystem Management F&#233lix Houphou&#235t-Boigny University Abidjan C&#244te d&#8217Ivoire

In Côte d’Ivoire, maize (Zea mays L) is the second most cultivated cereal after rice. Since the first report of Spodoptera frugiperda in Côte d’Ivoire, maize production in the northern regions has been affected resulting in maize production losses. This study aims to study the seasonal dynamic of Spodoptera frugiperda in maize fields in the sub-Sudanese zone, main zone of maize cultivation in Côte d’Ivoire. The study was done using pheromone trap lures. The results revealed a variation in the moth population at various growth stages during rainy and dry seasons. Notably, the highest numbers of moths were consistently trapped during the whorl stage with counts ranging from 131 ± 35.7 during the rainy season to 70.6 ± 15.01 in the dry season. The lowest numbers of moths were observed during pod maturation, with counts ranging from 30.3 ± 13.05 during the rainy season to 11.7 ± 3.05 in the dry season. Between the 7th and 21st days after sowing, the count of moths displayed a consistent upward trajectory, reaching 188 moths during the rainy season. The damages were particularly observed at whorl stage. The relationship between the numbers of moths and some climatic variables revealed a negative correlation between moths numbers and rainfall (r= −0.44) and relative humidity (r= −0.684). In contrast, there were positive relationships with temperature (r = 0.16), highlighting the significant impact of temperature changes on moth population dynamics. The research highlights the need for integrated pest management strategies that consider climatic factors and growth stages of maize to mitigate the impact of this insect pest on maize.

关键词： Spodoptera frugiperda Moths Climatic Variables Zea mays

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

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Journal of Molecular Cell Biology 2024年第3期16卷 9-23页

作者： Ilaria Frasson Linda Diamante manuela Zangrossi Elena Carbognin Anna Dalla Pietà Alessandro Penna Antonio Rosato Ranieri Verin Filippo Torrigiani Cristiano Salata Marìa Paula Dizanzo Lorenzo Vaccaro Davide Cacchiarelli Sara N.Richter Marco Montagner Graziano Martello Department of Molecular Medicine University of PaduaPadua 35121Italy Department of Biology Armenise/Harvard Pluripotent Stem Cell Biology LaboratoryUniversity of PaduaPadua 35131Italy Department of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35128Italy Veneto Institute of Oncology IOV-IRCCS Padua 35128Italy Department of Comparative Biomedicine and Food Science University of PaduaPadua 35020Italy Telethon Institute of Genetics and Medicine(TIGEM) Armenise/Harvard Laboratory of Integrative GenomicsPozzuoli 80078Italy Department of Translational Medicine University of Naples Federico IINaples 80138Italy School for Advanced Studies Genomics and Experimental Medicine ProgramUniversity of Naples Federico IINaples 80138Italy Microbiology and Virology Unit Padua University HospitalPadua 35128Italy

The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,some of which are resistant to vaccines and drugs targeting viral *** host dependency factors,*** proteins required for viral replication,would help prevent the development of ***,it remains unclear whether different SARS-CoV-2 variants induce conserved cellular responses and exploit the same core host *** this end,we compared three variants of concern and found that the host transcriptional response was conserved,differing only in kinetics and *** regularly interspaced short palindromic repeats screening identified host genes required for each variant during *** of the genes were shared by multiple *** validated our hits with small molecules and repurposed the US Food and Drug Administration-approved *** the drugs were highly active against all the tested variants,including new variants that emerged during the study(Delta and Omicron).Mechanistically,we identified reactive oxygen species production as a key step in early viral *** such as N-acetyl cysteine(NAC)were effective against all the variants in both human lung cells and a humanized mouse *** study supports the use of available antioxidant drugs,such as NAC,as a general and effective anti-COVID-19 approach.

关键词： SARS-CoV-2 variants of concern host dependency factors antivirals N-acetyl cysteine

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狂人米莱的另一面

商业周刊（中文版） 2024年第1期 24-25页

作者： manuela Tobias Ignacio Olivera Doll Vinicius Andrade 晴川(译) 不详

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒... 详细信息

2023年11月19日晚上,在华尔街做交易员的德米安·瑞德尔(Demian Reidel)开心得上下跳,挥舞着拳头,指向哈维尔·米莱(Javier Milei)设在布宜诺斯艾利斯市中心酒店的竞选总部。“我们赢啦!”他喊着,“我的总统!”但不到一周后,瑞德尔就拒绝了米莱让他执掌央行的邀请,选择飞回他在迈阿密的家,眼见着这位当选总统抛弃了其激进经济纲领的关键支柱,瑞德尔倍感丧。

关键词：米莱另一面交易员迈阿密华尔街央行