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Latent dimensions between water use and socio-economic development: A global exploratory statistical analysis

Regional Sustainability 2022年第3期3卷 269-280页

作者： Edson Elídio BALATA Hugo PINTO manuela moreira da silva Institute of Engineering Universidade do AlgarveFaro8005-139Portugal Centre for Social Studies University of CoimbraCoimbra3000-995Portugal Faculty of Economics University of AlgarveFaro8005-139Portugal Centre for Marine and Environmental Research(CIMA) University of AlgarveFaro8005-139Portugal Centre of Engineering and Product Development(CEiiA) Matosinhos4450-017Portugal

Water use and socio-economic development are interconnected in complex *** are not easy to identify but it is evident that a nexus between water use and socio-economic development does *** the diversity of national situations relating to these interrelated phenomena,its study should be considered from a global *** article critically reviews the literature and information from official sources on the relevance of water use and circular economy in order to create a global picture,linking water with socio-economic *** from 195 countries were analyzed statistically.A factor analysis defined five essential latent dimensions on the nexus between water use and socio-economic development:development and basic services,population and resources,economic volume,health and well-being,and population *** on the identified factors,countries were classified into six groups:Global South in difficulty,global semi-periphery,advanced economy,Middle East and other Global South developing economy,global weight,and small highly developed *** clustering results clarify connections between water use conditions and socioeconomic *** the variety of national profiles is helpful to reveal the magnitude and urgency of dealing with the nexus between water use and socio-economic development for many countries.

关键词： Water reuse Circular economy Water management Urban water cycle Socio-economic sustainable development Country clusters Factor analysis

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Ingredients from integral valorization of Isabel grape to formulate goat yogurt with stimulatory effects on probiotics and beneficial impacts on human colonic microbiota in vitro

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Food Science and Human Wellness 2023年第4期12卷 1331-1342页

作者： Francyeli Araújo silva Rita de Cássia Ramos do Egypto Queiroga Evandro Leite de Souza Glenise Bierhalz Voss Maria manuela Estevez Pintado Margarida Angélica da silva Vasconcelos Department of Nutrition Federal University of PernambucoRecife 50670-420Brazil Department of Nutrition Health Sciences CenterFederal University of ParaíbaJoão Pessoa 58050-585Brazil Universidade Católica Portuguesa CBQF-Centro de Biotecnologia e Química Fina-Laboratório AssociadoEscola Superior de BiotecnologiaPorto 4169-005Portugal

Isabel grape(IG)products have high contents of phenolic compounds and fiber recognized for their positive impacts on microorganisms associated with health benefits to *** study evaluated the effects of goat yogurts formulated with ingredients from IG integral valorization on the growth and metabolism of different probiotic strains,as well as on the population of selected bacterial groups and metabolic activity of human colonic microbiota in *** yogurts with IG ingredients(IGI)stimulated the growth of tested Lactobacillus and Bifidobacterium probiotic strains during a 48-h cultivation,as well as decreased the pH values and enhanced the organic acid *** yogurts with IGI increased the population of Lactobacillus *** Bifidobacterium *** a 24-h in vitro colonic fermentation.A stable Firmicutes:Bacteroidetes ratio close to 1 was found in media with goat yogurt formulations during the colonic fermentation,being similar to the effect caused by *** yogurt formulations with IGI caused increased production of short-chain fatty acids and sugar consumption during colonic *** yogurts with IGI should be a valuable strategy for development of novel added-value foods with beneficial effects on gut microbiota and human health.

关键词： Goat dairy product Grape Beneficial microorganisms Gut microbiota Modulatory effects

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Recognition of Human Actions through Speech or Voice Using Machine Learning Techniques

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Computers, Materials & Continua 2023年第11期77卷 1873-1891页

作者： Oscar Peña-Cáceres Henry silva-Marchan manuela Albert Miriam Gil Professional School of Systems Engineering Universidad César VallejoPiura20009Perú Escola Tècnica Superior d’Enginyeria Departament d’InformàticaUniversitat de ValènciaBurjassotValencia46100Spain Department of Mathematics Statistics and InformaticsUniversidad Nacional de TumbesTumbes24000Perú Valencian Research Institute for Artificial Intelligence Universitat Politècnica de ValènciaValencia46022Spain

The development of artificial intelligence(AI)and smart home technologies has driven the need for speech recognition-based *** demand stems from the quest for more intuitive and natural interaction between users and smart devices in their *** recognition allows users to control devices and perform everyday actions through spoken commands,eliminating the need for physical interfaces or touch screens and enabling specific tasks such as turning on or off the light,heating,or lowering the *** purpose of this study is to develop a speech-based classification model for recognizing human actions in the smart *** seeks to demonstrate the effectiveness and feasibility of using machine learning techniques in predicting categories,subcategories,and actions from sentences.A dataset labeled with relevant information about categories,subcategories,and actions related to human actions in the smart home is *** methodology uses machine learning techniques implemented in Python,extracting features using CountVectorizer to convert sentences into numerical *** results show that the classification model is able to accurately predict categories,subcategories,and actions based on sentences,with 82.99%accuracy for category,76.19%accuracy for subcategory,and 90.28%accuracy for *** study concludes that using machine learning techniques is effective for recognizing and classifying human actions in the smart home,supporting its feasibility in various scenarios and opening new possibilities for advanced natural language processing systems in the field of AI and smart homes.

关键词： AI machine learning smart home human action recognition

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-moreira Renato Medas Susana Lopes Filipe Vilas-Boas manuela Baptista Diogo Dias-silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PdaC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PdaC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PdaC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Acetylcholinesterase and Cytotoxic Activity of Chemical Constituents of Clutia lanceolata Leaves and its Molecular Docking Study

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Natural Products and Bioprospecting 2016年第6期6卷 267-278页

作者： Mehtab Parveen Faheem Ahmad Ali Mohammed Malla Shaista Azaz Mahboob Alam Omer A.Basudan manuela Ramos silva Pedro S.Pereira silva Department of Chemistry Aligarh Muslim UniversityAligarh 202002India Division of Bioscience Dongguk UniversityGyeongju 780-714Republic of Korea Pharmacognosy College of PharmacyKing Saud UniversityRiyadh 4451Saudi Arabia CFisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal

Phytochemical investigations of the ethanolic extract of leaves of Clutia lanceolata(Family:Euphorbiaceae)resulted in the isolation of four compounds viz.3,4-dihydroxy-2-methylbenzoic acid(1),2,20-dihydroxy-1,10-binaphthyl(2),1,3,8-trihydroxy-6-methylanthracene-9,10-dione(3)and 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one(4).Although all the isolated compounds were known but this was the first report from this plant *** structures were established on the basis of chemical and physical evidences *** analysis,FT-IR,1 H-NMR,13CNMR and mass spectral *** of compound 2 and 4 was further authenticated by single-crystal X-ray analysis and density functional theory *** isolated compounds(1–4)were screened for AChE enzyme inhibition assay in which compound 3 and 4 were found to be more potent AChE *** docking study of potent AChE inhibitor was performed to find the probable binding mode of the compounds into the active site of ***,the isolated compounds were also screened for in vivo cytotoxicity by brine shrimp lethality assay.

关键词： Clutia lanceolata X-ray crystallography AChE Molecular docking Cytotoxicity

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Fraud investigation in commercial coffee by chromatography

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Food Quality and Safety 2018年第3期2卷 121-133页

作者： Víctor de Carvalho Martins Ronoel Luiz de Oliveira Godoy Ana Cristina Miranda Senna Gouvêa manuela Cristina Pessanha de Araujo Santiago Renata Galhardo Borguini Elaine Cristina de Oliveira Braga Sidney Pacheco Luzimar da silva de Mattos do Nascimento Departamento de Tecnologia de Alimentos Instituto de TecnologiaUniversidade Federal Rural do Rio de JaneiroCEP 23890-000Seropédica-RJBrazil Laboratório de Cromatografia Líquida Embrapa Agroindústria de AlimentosCEP 23020-470Rio de Janeiro-RJBrazil Centro de Tecnologia Instituto de QuímicaUniversidade Federal do Rio de JaneiroCEP 22290-180Rio de Janeiro-RJBrazil

Coffee is currently the second largest commodity on the world market today,and there is great concern about the quality of the beans exported from producer countries to Europe and *** such as using blends of different species and adding low-cost raw materials,such as chicory,corn,and soybean,impair the sensory and functional characteristics of the drink made from roasted and ground coffee *** is a need to adopt more efficient analytical methods than the microscopy technique currently *** first chromatographic method used to determine fraud was reported in *** method used paper chromatography to differentiate between coffee and chicory based on the free reducing *** of the 1980s,different methods involving high-performance liquid chromatography and gas chromatography were developed in order to demonstrate geographic authenticity,distinction between species,occurrence of adulteration,and the presence of defective beans by determining the monosaccharides,oligosaccharides,tocopherols,fatty acids,volatiles,diterpenes,sterols,and phenolic substances,among *** far as the authors know,there are no papers published in the literature that have compiled such an extensive set of information about these chromatographic methods as *** the last 2 years,there has been a trend to develop analytical methods for ultra-performance liquid chromatography coupled with tandem mass spectrometry to confirm fraud in coffee,due to high sensitivity and selectivity.

关键词： adulteration coffee chromatographic methods carbohydrates volatile substances

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Intervention in the Loneliness of the Elderly What Strategies, Challenges and Rewards？

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Journal of Health Science 2015年第2期3卷 71-80页

作者： manuela Dias Carla silva Ricardo Dias Helena Oliveira Primary Care Unit of Terceira Island-Angra do Herolsmo Health Center Angra do Heroismo Terceira Azores 9701-869 Portugal Terceira Island Hospital Angra do Herolsmo Terceira Azores 9700-049 Portugal University of the Azores College of Nursing S. Miguel Azores 9504-538 Portugal

The new challenges that the phenomenon of demographic aging imposes on society in general, and health services in particular, can impact active and healthy aging. The project was implemented for two years （2012/2013） and aimed to combat loneliness in the elderly, which constitutes an obstacle to healthy and active aging. Decrease the sense of loneliness of individuals from 65 to 84 years of age, the project was made by using the health planning methodology, starting with a descriptive study （health diagnosis of the independent elderly population） followed by the development, implementation and evaluation of a community intervention project, which included home visits to the elderly, assessment of the level of loneliness in two different times （UCLA scale） and various intergenerational activities of social life （dancing, walking, online courses, games...） using a cross-section of partnerships and community involvement. There was a decrease from 62.8% to 41.9% in the reported overall feeling of loneliness of independent individuals between the ages of 65 and 84 years of age. There was an increase from 50.0% to 86.4% of seniors who now have dreams/life projects. The reduction of social and emotional isolation resulted in the promotion of social networks, which not only encouraged social interaction but also considered the elderly who live alone. The health gains arising from it are evidenced in contributing more proactively and the improvement of the quality of life in the elderly community.

关键词： Elderly health planning loneliness active aging

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Response Proliferative Capacity of Undifferentiated Stem Cells of Obtained Human Adult Dental Follicle

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Stem Cell Discovery 2014年第4期4卷 125-137页

作者： Larissa Kim Higashi de Carvalho Aline Vieira Pinheiro de Araujo manuela Garcia Laveli da silva Rosa Andréa Nogueira Laiso Durvanei Augusto Maria Faculty of Medicine University of Sao Paulo Sao Paulo Brazil Laboratory of Biochemistry and Biophysics Butantan Institute Sao Paulo Brazil

Objective: The aim of this study was correlation proliferative activity, markers express stem cells, and lipid peroxides of undifferentiated stem cells of human adult dental follicle (DF) following culture. Methods: For this study, we used 8 samples from DF of impacted third molars to maintain culture conditions and evaluated the growth curve, cell viability, production of lipid peroxidation, cell cycle phases, and proliferative index during 25 days of culture. Results: Cells after culture showed characteristics of fibroblast-like type following 25th day of culture. The results of lipid peroxidation showed that stem cells in culture produce 13 nmoles/ml malondialdehyde at the start of culture, increasing until the 12th day and then began a decline that lasted until the 25th day. We revealed that DFSCs presented a significantly higher percentage of cells in S + G2/M phases by the 15th day of culture compared with cells at the start of culture. Cell surface markers revealed that cell lines were negative for HLA-DR and positive for CD90, CD44, and CD105. The expression of p21 protein, involved in the regulation of the cell cycle, showed a significant increase from the 15th to 25th day of culture. Results of cell division rates show a significant increase between the 6th and 15th day of culture. Conclusions: We conclude that the culture remained stable during the 25 days of culture, presenting the markers of stem cells and markers of control, progression, and cell proliferation that there was an increased production of lipid peroxides between the 6th and 12th days;this increase is related to the increased numbers of cells that also occurs during this period. Then, there is a significantly decline in the production of lipid peroxides and the number of cells, which is accompanied by an increase in cell unviability.

关键词： Follicle Dental Stem Cells Lipid Peroxidation Cell Cycle Proliferation

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Attractivity or Repellence: Relation between the Endophytic Fungi of Acalypha, Colocasiaand the Leaf-Cutting Ants—Atta sexdens

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Advances in Entomology 2021年第2期9卷 85-99页

作者： Laura Magnani Machado Thays Neigri da silva daiane Raquel Polezel Amanda A. de Oliveira manuela de O. Ramalho Fernando Carlos Pagnocca Odair Correa Bueno Institute of Bioscience Campus of Rio Claro S&atilde o Paulo State University (UNESP) Rio Claro Brazil Department of Entomology Cornell University Ithaca NY USA

Symbiotic relations are present in the nature and can contribute to the success of the organisms involved. Endophytic fungi live within the leaf tissues without causing any harm to the host plant, and some of them can be a defense mechanism against the attack by the leaf-cutting ants. Ants of the genus Atta are known as leaf-cutting ants and have an obligatory association with the fungus Leucoagaricus gongylophorus, cutting pieces of leaves and bringing them back to the colony to the fungus. The present study aimed to find out the endophytic fungi community of an attractive plant (Acalypha wilkesiana) and a less attractive plant (Colocasia esculenta) to the ants Atta sexdens. We found out that the communities are different in quantity and in composition and 73% of the isolated fungi were from A. wilkesiana, which has fungi known as attractive to leaf-cutting ants, such as genus Colletotrichum, Pestalotiopsis, Phomopsis and Xylaria. On the other hand, in C. esculenta, there was found the genus Fusarium, known to be reject by the leaf-cutting ants, and less fungal diversity than in the attractive plant A. wilkesiana. Therefore, our data suggest that attractivity or repelence of a plant to the leaf-cutting ants could be related to presence or ausence of determinated fungi more than the quantity of fungi present in a leaf.

关键词： Attine Musaica Marginata Interaction Plant-Ant Leaf-Cutting Ants

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What Advice Can We Give to Optimize Our Patients＇ Odds of Aging with Better Health？

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Journal of Life Sciences 2016年第8期10卷 405-410页

作者： Rita manuela Vieira Gomes Oliveira S. Pires S. Alves J. silva R. S. Joao de Braga Family Health Unit 4710-488 Braga Portugal Family Health Unit of Minho Portugal Family Health Unit of Regua Portugal

The world＇s population is ageing rapidly, which will have substantial consequences. According to WHO：＂Process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age＂. The aim of this work is to make a literature review on key measures that contribute to healthy ageing. A search was conducted in the following databases： PubMed, Cochrane, National Guideline Clearinghouse, Trip database, Guideline finders, NICE and WHO database, written in English and published in the last ten years. The following MeSH words were used：＂healthy ageing＂. The search was conducted from July first till end of December 2015. Based on the articles searched there are many measures with potential to achieve gains in healthy ageing such as prevention of falls; vaccination; regular physical activity, eating fruits and vegetables daily, drinking alcohol moderately; never smoking; prevention of social isolation and social exclusion; prevention of elder maltreatment; public support for informal care giving and create strategies to ensure the quality of care for older people. Getting older can come with a variety of health challenges. In the daily practice of family doctor there are many effective interventions that can improve health and wellbeing in elderly people.

关键词： Healthy ageing elderly active ageing.

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