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Diagnosis Traps in Polyarteritis Nodosa- Original Case Report

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Journal of Life Sciences 2013年第7期7卷 749-753页

作者： Stoicescu manuela Department of Medical Disciplines University of Oradea Oradea 410167 Romania

Purpose： The purpose of this clinical case study is to attract attention to the fact that behind a diagnosis of hypertension a young patient was really diagnosed with a rare systemic vasculitis - polyarteristis nodosa. Topic： Polyarteritis nodosa is a disease more frequent in young men with a preceding acute viral hepatitis B which is AgHbs positive. The characteristic of this disease is the presence of many aneurysms at different sites of the small and medium size artery. It is possible for a palpable purpuric rash to appear at any time in the evolution of the disease. The histopathological examination represents the goal of the diagnosis. Method： The principals methods was to attain the desired result, a cerebral MRI was initially performed in order to view any brain malformations and also for excluded an ischemic or hemorrhagic stroke attack , this was followed via a cerebral vascular angiography, an abdominal ultrasound and CT scan, the results of which led to a renal artery angiography being performed, this led to the need to perform a cerebral artery angiography and finally a histopathological examination of the skin of the legs （biopsy）. Achievement： Through the above listed paramedical examinations I was able to prove the existence of multiple aneurysms in the cerebral arteries, renal arteries and small growth of the left kidney, this being a direct result of the aneurysms, this also meant disruption in kidney blood flow meaning, an increase in systemic blood pressure which was the manifest primary symptom the this young patient such as transitory stroke attack. The skin biopsy finally gave a certain diagnosis of Polyarteritis Nodosa.

关键词： Artery aneurysms polyarteritis nodosa.

Functional properties of peptides obtained from whey proteins by ficin extract hydrolysis

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Food Bioscience 2022年第3期47卷 918-927页

作者： Afaf Kheroufi María E.Brassesco Débora A.Campos Halima Boughellout manuela E.Pintado Laboratoire de Génie Agro-alimentaire équipe Génie des Procédés AlimentairesBiodiversité et Agro environnementInstitut de la Nutritionde l’Alimentation et des Technologies Agroalimentaires INATAAUniversité Frères Mentouri Constantine 1BP 325 Route de Ain El BeyConstantineAlgeria CBQF – Centro de Biotecnologia e Química Fina – Laboratório Associado Escola Superior de BiotecnologiaUniversidade Católica Portuguesa/PortoRua de Diogo Botelho 13274169-005PortoPortugal

Enzymatic whey proteins concentrates (WPC) hydrolysis under optimal conditions of ficin crude extract (FCE) in two ratios E/S (0.5 and 1%) was studied,assessing the impact of hydrolysis on WPC by determination degree of hydrolysis (DH),Fast proteins liquid chromatography (FPLC),Tricine SDS-PAGE,antioxidant activity at sampling time beside,and technological properties (solubility,emulsifying activity index (EAI) and foaming activity (FA)) at the best condition (maximum DH and antioxidant activity) other *** showed,in the first 30 min,DH reached 22.76% at E/S (1%) with a total degradation of α-lactalbumin (α-La) and almost of β-lactoglobulin (β-Lg).A significant increase in antioxidant activity and solubility was observed,while not for EAI,and *** results indicate for the first time that β-Lg is susceptible to hydrolyse by FCE that rarely found for other *** hydrolysates showed very relevant performance,and suggest that could be appropriate production of functional ingredients.

关键词： Whey proteins Ficin Hydrolysis Antioxidant Solubility

Influence of Interrupted Childhood Biographies on Health Development: Evaluation of the Scientific Literature on the Example of Being Taken into Care*

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Journal of Biosciences and Medicines 2024年第7期12卷 108-119页

作者： manuela Loderer Ursula Gresser Dental Office for Orthodontics Dingolfing Germany Outpatient Clinic for Internal Medicine and Medical Expert Reports Munich Germany

Background: An interrupted family history, as is the case after taking someone into care, can complicate collecting family anamnesis data. In addition, the interrupted family history itself could be considered part of a person’s risk profile. Aim and methods: Literature analysis was conducted to examine whether there are scientific studies on health development after placement in out-of-home-care in order to recognise any existing medical characteristics that may be relevant for internal medical care. Results: There are few scientific publications on the health development of people after being placed in out-of-home-care. Direct reactions to the stress of being taken into custody include nausea and fever. However, effects that go beyond the acute situation and last into adulthood have also been described, such as AD(H)D, asthma, diabetes, cancer, hypertension and cardiovascular diseases (myocardial infarction, stroke), epilepsy and increased overall mortality in adulthood. Studies show that not only previous experience but also the stress of being taken into care is triggers for this. Conclusion: Information about a previous institutionalisation can hence be important for internal medical practice. The available scientific literature shows heterogeneous study methodology and no group of people with experience of out-of-home-placement has yet been scientifically accompanied for a long time period. Further studies on this could help to better weigh up the consequences of omitting and conducting an intervention for child/youth protection as well as to improve the medical care for this group of people.

关键词： Taking into Care Out-of-Home-Care Interrupted Family History Physical Outcomes Internal Medicine

The Arabidopsis pattern recognition receptor EFR enhances fire blight resistance in apple

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Horticulture Research 2021年第1期8卷 2615-2623页

作者： Stefano Piazza manuela Campa Valerio Pompili Lorenza Dalla Costa Umberto Salvagnin Vladimir Nekrasov Cyril Zipfel Mickael Malnoy Research and Innovation Centre Fondazione Edmund MachSan Michele a/AdigeItaly Genetics Department Faculty of AgriSciencesStellenbosch UniversityStellenboschSouth Africa The Sainsbury Laboratory University of East AngliaNorwichUnited Kingdom Institute of Plant and Microbial Biology and Zurich-Basel Plant Science Center University of ZurichZurichSwitzerland Present address:Plant Sciences Department Rothamsted ResearchHarpendenUK

Fire blight disease,caused by the bacterium Erwinia amylovora(***),is responsible for substantial losses in cultivated apples *** important mechanism of plant immunity is based on the recognition of conserved microbial molecules,named pathogen-associated or microbe-associated molecular patterns(PAMPs or MAMPs),through pattern recognition receptors(PRRs),leading to pattern-triggered immunity(PTI).The interspecies transfer of PRRs represents a promising strategy to engineer broad-spectrum and durable disease resistance in ***,the Arabidopsis thaliana PRR for the PAMP elf18 derived from the elongation factor thermal unstable(EF-Tu)proved to be effective in improving bacterial resistance when expressed into Solanaceae and other plant *** this study,we tested whether EFR can affect the interaction of apple with *** by its ectopic expression in the susceptible apple rootstock *** EFR expression led to the activation of PAMP-triggered immune response in apple leaves upon treatment with supernatant of ***,as measured by the production of reactive oxygen species and the induction of known defense *** amount of tissue necrosis associated with *** infection was significantly reduced in the EFR transgenic rootstock compared to the *** results show that the expression of EFR in apple rootstock may be a valuable biotechnology strategy to improve the resistance of apple to fire blight.

关键词： blight resistance pattern

Graphene-Oxide Mediated Chemodivergent Ring-Opening of Cyclobutanols

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Chinese Journal of Chemistry 2023年第11期41卷 1333-1340页

作者： Andrea Brunetti Angela Pintus Lorenzo Lombardi Alessandro Kovtun Federico Mascietti Francesco Bruno Enrico Ravera manuela Melucci Giulio Bertuzzi Marco Bandini Dipartimento di Chimica“Giacomo Ciamician” Alma Mater StudiorumUniversitàdi BolognaVia Selmi 240126BolognaItaly Istituto per la Sintesi e la Fotoreattività(ISOF)–CNR Via Gobetti10140129BolognaItaly Magnetic Resonance Center(CERM) University of FlorenceVia L.Sacconi 650019 Sesto FiorentinoItaly Department of Chemistry“Ugo Schiff” University of FlorenceVia della Lastruccia 350019 Sesto FiorentinoItaly Center for Chemical Catalysis–C3 Alma Mater StudiorumUniversitàdi Bolognavia Selmi 240126BolognaItaly

The chemodivergent ring-opening of cyclobutanols is described under the carbocatalytic assistance of graphene oxide(GO).The protocol enables the synthesis of diversely functionalized dienes or indenes(26 examples)based on the amount of GO ***(XPS and ssNMR)as well as experimental investigations revealed a direct involvement of theπ-domains of GO in tuning the stability of carbocationic intermediates during the reaction.

关键词： Carbocatalysis C-C activation Graphene Carbocations Methodology and reactions

Light-Triggered Reactions Do Not Bias Boron Deficiency-Induced Root Inhibition of Arabidopsis Seedlings Grown in Petri Dishes

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Molecular Plant 2021年第8期14卷 1211-1214页

作者： Zhaojun Liu Ricardo Fabiano Hettwer Giehl manuela Desiree Bienert Nicolaus von Wiren Gerd Patrick Bienert Department of Physiology and Cell Biology Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)06466 GaterslebenGermany Crop Physiology TUM School of Life SciencesTechnical University of Munich85354 FreisingGermany Soil Sciences TUM School of Life SciencesTechnical University of Munich85354 FreisingGermany

Dear Editor,For more than two decades,Arabidopsis thaliana plants have been routinely grown in vitro within transparent Petri dishes containing agar-based solid *** convenient to study root developmental,nutritional and morphological responses to abiotic cues and to elucidate gene functions following reverse and forward genetic approaches,this system exposes roots to light during illumination of the ***,Zheng et al.(2019)raised serious concerns whether root growth behavior and molecular root reactions in this experimental set-up are solely due to the designedly and chemically defined growth substrate composition,in their case phosphate(Pi)deficiency,or due to light-triggered reactions that are artificially-induced by exposing roots to light.

关键词： Arabidopsis roots Root

Polypeptide analysis for nanopore-based protein identification

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Nano Research 2022年第11期15卷 9831-9842页

作者： Mazdak Afshar Bakshloo Safia Yahiaoui Fabien Piguet manuela Pastoriza-Gallego Régis Daniel Jérôme Mathé John J.Kasianowicz Abdelghani Oukhaled CY Cergy Paris Université CNRSLAMBE95000CergyFrance UniversitéParis-Saclay Univ EvryCNRSLAMBE91025Evry-CourcouronnesFrance University of South Florida Dept.of PhysicsTampaFL 33620USA Freiburg Institute for Advanced Studies Universität FreiburgFreiburg 79104Germany

Presently,proteins are identified by cleaving them with proteases,measuring the mass to charge ratio of the fragments with a mass spectrometer,and matching the fragments to segments within known proteins in *** earlier demonstrated that a nanometer-scale pore formed by aerolysin(AeL)can discriminate between,and therefore identify,three similar size proteins from their trypsin-cleaved polypeptide *** this nanopore-protease method,the protein’s identity is instead determined from characteristic ionic current blockade patterns caused by the polypeptide fragments that enter the *** results also suggested that not all of the theoretically expected cleavage products partition into the *** better understand the mechanism by which polypeptide fragments are captured,and how different polypeptides reduce the pore’s ionic current,we studied the effects of 11 identical length polypeptides with different net charges and charge *** show that under certain experimental conditions,negative,positive,and neutral polypeptides are driven into the AeL pore by the same applied voltage *** capture rate and dwell time of polypeptides in the pore depend strongly on the ionic strength,the magnitude of the applied voltage,and the net charge and charge distribution of the *** dwell time distribution depends nonmonotonically on the applied voltage(regardless of the polymer’s net charge),and its maximum value depends on the polypeptide net charge and charge *** maximum dwell time for different polypeptides does not occur at the same applied voltage amplitude,which conceivably might complicate the detection and discrimination of some polypeptide *** additional experiments,computer simulations,and artificial intelligence research are needed to better understand how to optimize the partitioning of enzymatically cleaved fragments into the AeL nanopore,the method is still capable of accurately identifying

关键词： protein identification nanopores trypsin enzymatic degradation

Low efficacy of levofloxacin-doxycycline-based third-line triple therapy for Helicobacter pylori eradication in Italy

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World Journal of Gastroenterology 2015年第21期21卷 6698-6705页

作者： Omero Alessandro Paoluzi Giovanna Del Vecchio Blanco Emanuela Visconti manuela Coppola Carla Fontana Marco Favaro Francesco Pallone Gastroenterology Unit Department of Internal MedicineUniversity Tor Vergata Department of Experimental Medicine and Surgery University Tor Vergata

AIM:To evaluate a levofloxacin-doxycycline-based triple therapy with or without a susceptibility culture test in non-responders to Helicobacter pylori(***) ***:A total of 142(99 women,43 men; mean 53.0 ± 12.7 years) non-responders to more than two *** eradication therapies underwent susceptibility culture tests or were treated with a seven-day triple therapy consisting of esomeprazole,20 mg b.i.d.,levofloxacin,500 mg b.i.d.,and doxycycline,100 mg b.i.d.,randomly associated with(n = 71) or without(n = 71) Lactobacillus casei *** status was checked in all patients at enrollment and at least 8 wk after the end of *** and tolerability of regimens were also ***:*** eradication was achieved in < 50% of patients [per prototol(PP) = 49%; intention to treat(ITT) = 46%].Eradication rate was higher in patients administered probiotics than in those without(PP = 55% vs 43%; ITT = 54% vs 40%).Estimated primary resistance to levofloxacin was 18% and multiple resistance was 31%.Therapy was well tolerated,and side effects were generally mild,with only one patient experiencing severe ***:Third-line levofloxacin-doxycycline triple therapy had a low *** eradication efficacy,though the success and tolerability of this treatment may be enhanced with probiotics.

关键词： Doxycycline Eradication therapy Urea breath test Esomeprazole Levofloxacin Helicobacter pylori

Repetitive transcranial magnetic stimulation for post-traumatic stress disorder:Lights and shadows

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World Journal of Clinical Cases 2022年第17期10卷 5929-5933页

作者： Carmen Concerto Giuseppe Lanza Francesco Fisicaro manuela Pennisi Alessandro Rodolico Giulia Torrisi Rita Bella Eugenio Aguglia Department of Clinical and Experimental Medicine Psychiatry UnitUniversity of CataniaCatania 95124Italy Department of Surgery and Medical-Surgical Specialties University of CataniaCatania 95123Italy Clinical Neurophysiology Research Unit Oasi Research Institute-IRCCSTroina 94018Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies“G.F.Ingrassia” University of CataniaCatania 95123Italy

We have read with interest the publication that describes the available data related to the use of neuromodulation strategies for the treatment of posttraumatic stress disorder(PTSD).Despite treatment advances,however,a substantial proportion of PTSD patients receiving psychological and/or pharmacological treatment do not reach an adequate clinical *** their paper,the authors draw attention to the current understanding of the use of repetitive transcranial magnetic stimulation(rTMS)as a potential treatment for *** of the previous studies indeed applied both inhibitory(1 Hz)and excitatory(>1 Hz,up to 20 Hz)rTMS to the right and/or left dorsolateral prefrontal *** larger therapeutic effects observed when high-frequency stimulation was applied,the question of which side and frequency of stimulation is the most successful is still *** authors also reported on the after-effect of rTMS related to neuroplasticity and identified the intermittent theta burst stimulation as a technique of particular interest because of it showed the most effective improvement on PTSD ***,although numerous studies have highlighted the possible beneficial use of rTMS protocols for PTSD,the exact mechanism of action remains *** their conclusions,the authors stated that rTMS has been demonstrated to be effective for the treatment of PTSD ***,we believe that further research with homogeneous samples,standardized protocols,and objective outcome measures is needed to identify specific therapeutic targets and to better define significant changes when active and sham stimulation procedures are compared.

关键词： Post-traumatic stress disorder Neuromodulation Repetitive transcranial magnetic stimulation Translational neuroscience Neuroplasticity Metaplasticity