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Nutritional issues in patients with obesity and cirrhosis

World Journal of Gastroenterology 2018年第30期24卷 3330-3346页

作者： Luigi Schiavo Luca Busetto manuela Cesaretti Shira Zelber-Sagi Liat Deutsch Antonio Iannelli Department of Translational Medical Science University of Campania“Luigi Vanvitelli”Naples 80131Italy Ⅸ Division of General Surgery Vascular Surgery and Applied BiotechnologyNaples University PoliclinicNaples 80131Italy Department of Medicine University of PaduaPadua 35128Italy Center for the Study and the Integrated Management of Obesity University Hospital of PaduaPadua 35128Italy Department of HPB Surgery and Liver Transplantation Hopital BeaujonAP-HPClichy 92110France Department of Nanophysics Italian Institute of TechnologyGenova 16163Italy School of Public Health University of HaifaHaifa 3498838Israel Department of Gastroenterology and Liver disease Tel Aviv Medical Center62431Tel-Aviv 62431Israel The Sackler Faculty of Medicine Tel-Aviv UniversityTel-Aviv 62431Israel Digestive Unit Archet 2 HospitalUniversity Hospital of NiceF-06202NiceFrance Inserm U1065Team 8“Hepatic complications of obesity”Nice F-06204France University of Nice Sophia-Antipolis Nice F-06107France

Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to *** with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver *** obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for chronicliver disease in patients with obesity and a prognostic negative marker for the evolution of liver cirrhosis and the results of liver *** patients with obesity are at high risk for depletion of various fat-soluble,water-soluble vitamins and trace elements and should be supplemented ***,physical activity and protein intake should be carefully monitored in these fragile patients according to recent *** surgery is sporadically used in patients with morbid obesity and cirrhosis also in the setting of liver *** risk of sarcopenia,micronutrient status,and the recommended supplementation in patients with obesity and cirrhosis are discussed in this ***,the indications and contraindications of bariatric surgery-induced weight loss in the cirrhotic patient with obesity are discussed.

关键词： obesity cirrhosis sarcopenia malnutrition bariatric surgery

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Hepatic adenomatosis in glycogen storage disease:Radio-pathological correlation

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 579-581页

作者： João M Louro Ana M Alves JoséR Brandão manuela França Department of Radiology Centro Hospitalar Universitário do Porto EPEPorto 4099-001Portugal Department of Anatomical Pathology Centro Hospitalar Universitário do Porto EPEPorto 4099-001Portugal

Glycogen storage disease type I(GSD type I),also known as von Gierke disease,is an autosomal recessive disorder of the glycogen metabolism pathway,caused by a deficiency of glucose-6-phosphatase(GSD type Ia)or glucose... 详细信息

关键词： 1] metabolism trans

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Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena manuela Samaila Maria Tsekoura Marianna Vlychou Charalampos Matzaroglou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

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Epidermal growth factor receptor pathway substrate 8 (Eps8) expression in maturing testis

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Asian Journal of Andrology 2004年第3期6卷 195-203页

作者： Alain Wunsch Kai Strothmann manuela Simoni Jorg Gromoll Eberhard Nieschlag C.Marc Luetjens Institute of Reproductive Medicine of the University D-48129 MunsterGermanyInstitute of Reproductive Medicine of the UniversityD-48129 MunsterGermanyInstitute of Reproductive Medicine of the UniversityD-48129 MunsterGermanyInstitute of Reproductive Medicine of the UniversityD-48129 MunsterGermanyInstitute of Reproductive Medicine of the UniversityD-48129 MunsterGermanyInstitute of Reproductive Medicine of the UniversityD-48129 MunsterGermany

Aim: Although epidermal growth factor receptors are expressed in the testes, whether they signal through epidermal growth factor receptor pathway substrate 8 (Eps8) is unknown. Here we evaluated the expression pattern of Eps8 in the maturing testis. Methods: The expression of Eps8 was analysed by Northern blotting, immunocy-tochemistry and Western blotting in primary Sertoli cell cultures and in testicular tissue of rodents. Results: Eps8 is specifically expressed in gonocytes, Leydig and Sertoli cells of the neonatal rats and in Leydig and Sertoli cells of the adult rats and mice. Although gonocytes express Eps8, no signal was found in prepubertal or mature spermatogonia and the expression level of Eps8 in Sertoli cells increases with age. No regulation of Eps8 expression in primary immature rat Sertoli cells by Follicle stimulating hormone (FSH) was detected by Western blotting. Conclusion: Eps8 seems to be involved in the growth factor-controlled regulation of cell proliferation and differentiation in the seminiferous epithelium. Eps8 is a possible marker for gonocytes and in Sertoli cells it could be involved in crosstalk with other growth factor pathways.

关键词： gene expression isoform Sertoli cell gonocyte

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Latent dimensions between water use and socio-economic development: A global exploratory statistical analysis

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Regional Sustainability 2022年第3期3卷 269-280页

作者： Edson Elídio BALATA Hugo PINTO manuela Moreira da SILVA Institute of Engineering Universidade do AlgarveFaro8005-139Portugal Centre for Social Studies University of CoimbraCoimbra3000-995Portugal Faculty of Economics University of AlgarveFaro8005-139Portugal Centre for Marine and Environmental Research(CIMA) University of AlgarveFaro8005-139Portugal Centre of Engineering and Product Development(CEiiA) Matosinhos4450-017Portugal

Water use and socio-economic development are interconnected in complex *** are not easy to identify but it is evident that a nexus between water use and socio-economic development does *** the diversity of national situations relating to these interrelated phenomena,its study should be considered from a global *** article critically reviews the literature and information from official sources on the relevance of water use and circular economy in order to create a global picture,linking water with socio-economic *** from 195 countries were analyzed statistically.A factor analysis defined five essential latent dimensions on the nexus between water use and socio-economic development:development and basic services,population and resources,economic volume,health and well-being,and population *** on the identified factors,countries were classified into six groups:Global South in difficulty,global semi-periphery,advanced economy,Middle East and other Global South developing economy,global weight,and small highly developed *** clustering results clarify connections between water use conditions and socioeconomic *** the variety of national profiles is helpful to reveal the magnitude and urgency of dealing with the nexus between water use and socio-economic development for many countries.

关键词： Water reuse Circular economy Water management Urban water cycle Socio-economic sustainable development Country clusters Factor analysis

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Telomere shortening is associated with corticosterone stress response in adult barn swallows

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Current Zoology 2022年第1期68卷 93-101页

作者： Alessandra COSTANZO Roberto AMBROSINI Marco PAROLINI manuela CAPRIOLI Simona SECOMANDI Diego RUBOLINI Leonida FUSANI Virginie CANOINE Department of Environmental Science and Policy University of Milanvia Celoria 26I-20133 MilanItaly Department of Behavioral and Cognitive Biology University of ViennaAlthanstr.141090 ViennaAustria Konrad Lorenz Institute of Ethology University of Veterinary Medicine ViennaSavoyenstr.1a1160 ViennaAustria

When vertebrates face stressful events,the hypothalamic–pituitary–adrenal(HPA)axis is activated,generating a rapid increase in circulating glucocorticoid(GC)stress hormones followed by a return to baseline ***,repeated activation of HPA axis may lead to increase in oxidative *** target of oxidative stress is telomeres,nucleoprotein complexes at the end of chromosomes that shorten at each cell *** susceptibility of telomeres to oxidizing molecules has led to the hypothesis that increased GC levels boost telomere shortening,but studies on this link are *** studied if,in barn swallows Hirundo rustica,changes in adult erythrocyte telomere length between 2 consecutive breeding seasons are related to corticosterone(CORT)(the main avian GC)stress response induced by a standard capture-restraint ***-individual telomere length did not significantly change between consecutive breeding ***-year individuals showed the highest increase in circulating CORT concentrations following ***,we found a decline in female stress response along the breeding *** addition,telomere shortening covaried with the stress response:a delayed activation of the negative feedback loop terminating the stress response was associated with greater telomere ***,among-individual variation in stress response may affect telomere dynamics.

关键词： allostasis corticosterone Hirundo rustica stress response telomere

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Acute biliary pancreatitis and cholecystolithiasis in a child: one time treatment with laparoendoscopic "Rendez-vous" procedure

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World Journal of Gastroenterology 2006年第11期12卷 1782-1785页

作者： Gaetano La Greca Michele Di Blasi Francesco Barbagallo manuela Di Stefano Saverio Latteri Domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro HospitalVia Messina 829-95100CataniaItaly

Acute biliary pancreatitis （ABP） is rare in childhood and endoscopic sphincterotomy should be avoided in the child due to the risk of both early and late complications but, when necessary, the optimal timing between endoscopic procedure and cholecystectomy is still uncertain, A nine years old child with acute biliary pancreatitis underwent successfull laparo-endoscopic ＂Rendez-Vous＂ procedure in which endoscopic drainage of the common bile duct and laparoscopic cholecystectomy were performed simultaneously. This is the first case reported of laparo-endoscopic RendezoVous in a child. The excellent outcome of this patient and the review of the literature concerning other available options for the treatment of such cases suggest that this procedure offers great advantages, especially in children, of reducing the required number of treatments, the risk of ineffectiveness, the number of anaesthesia, the length of hospital stay and the risk of iatrogenic morbidity.

关键词： Acute biiiary pancreatitis Gallstones ERCP Laparoscopic cholecystectomy Endoscopic sphyncterotomy

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Management of perianal fistulas in Crohn's disease:An upto-date review

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World Journal of Gastroenterology 2015年第5期21卷 1394-1403页

作者： manuela Marzo Carla Felice Daniela Pugliese Gianluca Andrisani Giammarco Mocci Alessandro Armuzzi Luisa Guidi IBD Unit Complesso Integrato ColumbusUniversità Cattolica del Sacro Cuore00168 RomeItaly

Perianal disease is one of the most disabling manifestations of Crohn's disease.A multidisciplinary approach of gastroenterologist,colorectal surgeon and radiologist is necessary for its management.A correct diagnosis,based on endoscopy,magnetic resonance imaging,endoanal ultrasound and examination under anesthesia,is crucial for perianal fistula *** medical and surgical therapies are discussedin this review,including new local treatment modalities that are under investigation.

关键词： Crohn’s disease Perianal fistula Surgery Drug ther

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Comparison of the liver stiffness measurement by transient elastography with the liver biopsy

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World Journal of Gastroenterology 2008年第42期14卷 6513-6517页

作者： Ioan Sporea Roxana ■irli Alexandra Deleanu Adriana Tudora manuela Curescu Marioara Cornianu Daniela Lazǎr Department of Gastroenterology and Hepatology University of Medicine and Pharmacy Timi■oara 300472 Romania Department of Infectious Diseases University of Medicine and Pharmacy Timi■oara 300472 Romania Department of Pathology University of Medicine and Pharmacy Timi■oara 300472 Romania

AIM: To compare the liver stiffness (LS) measurement by transient elastography (TE) to the liver biopsy (LB)-considered the "gold standard" in the evaluation of patients with chronic hepatitis C. METHODS: During a period of 12 mo, we evaluated 199 consecutive patients with chronic hepatitis due to hepatitis C virus (HCV), in which LB and LS assessments (by means of TE) were performed during the same session. RESULTS: Out of 199 patients, a valid measurement of the LS could not be obtained in 8. The mean value of LS in the cohort of 191 valid measurements was 8.45 ± 4.96 kPa, ranging from 2.3 to 38 kPa. The mean value of LS in patients with signifi cant fi brosis at biopsy (161 patients with F ≥ 2 according to Metavir) was 9.02 ± 5.15 kPa, significantly higher than in patients with no or mild fi brosis (30 patients with F < 2 Metavir): 5.39 ± 1.81 kPa (P < 0.0001). For a cut- off value of 6.8 kPa, the LS had a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6% and a specificity of 93.3% for the presence of signifi cant fi brosis (at least F2 Metavir), with a diagnostic performance of 77.3% (AUROC 0.773). Using this cut-off value, we reached the best discrimination between absence of fibrosis/ mild fibrosis (F < 2 Metavir) and the presence ofmoderate to severe fi brosis (F ≥ 2 Metavir). CONCLUSION: In patients with chronic hepatitis due to HCV, a cut-off value of 6.8 kPa measured by TE can differentiate between significant fibrosis and absent or mild fi brosis, with a PPV of 98%, a NPV of 30.1%, a sensitivity of 59.6%, a specificity of 93.3%, and a diagnostic performance of 77.3%.

关键词： Liver stiffness Transient elastography Liver biopsy Chronic C hepatitis FibroScan

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Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole

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World Journal of Gastroenterology 2009年第8期15卷 936-941页

作者： Carlo Calabrese Davide Treré Giuseppina Liguori Veronica Gabusi manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo Department of Clinical Medicine University of Bologna Bologna 40138 Italy Department of Experimental Pathology Clinical Pathology University of Bologna Bologna 40138 Italy Clinical Department of Radiologic and Histopathologic Sciences University of Bologna Bologna 40138 Italy

AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients.

关键词： Gastroesophageal reflux disease Esophagitis Cell proliferation Electron microscopy Pantoprazole

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