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Variation of Parameters Formula and Gronwall Inequality for Differential Equations with a General Piecewise Constant Argument

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 561-568页

作者： Kuo-Shou CHIU manuel PINTO Departamento de Matemótica Facultad de Ciencias BósicasUniversidad Metropolitana de Ciencias de la EducacinJ.P.Alessandri 774SantiagoChile Departamento de Matemóticas Facultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A variation of parameters formula and Gronwall type integral inequality are proved for a differential equation involving general piecewise alternately advanced and retarded argument.

关键词： variation of parameters formula Gronwall integral inequality alternately advanced and retarded argument

Frailty and acute coronary syndrome: does gender matter?

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Journal of Geriatric Cardiology 2019年第2期16卷 138-144页

作者： Lourdes Vicent manuel Martinez-Selles Servicio de Cardiologia Hospital General Universitario Gregorio MaraiionCIBERCVMadridSpain Universidad Europea Universidad ComplutenseMadridSpain

There are important sex-related differences in elderly patients with acute coronary syndrome(ACS).Women are older,more frequently frail,and present more comorbidities than *** symptoms at presentation are also more common in female patients,they are leaded to a delayed diagnosis and *** angiography and subsequent revascularization are frequently underused in elderly women and they tend to receive less guidelines-recommended *** prognosis in elderly frail women with ACS is poor,and it is with high mortality and readmissions *** is recurrent ischemic events in which it is more frequent in women than in *** time might be long,and a multidisciplinary approach is desirable to improve prognosis and quality of *** studies are needed in order to clarify the benefit of the different therapies in the group of frail women,and this is particularly true for revascularization,as scientific evidence in this group is very scarce.

关键词： Acute coronary syndrome Frailty The elderly Women

The quest for selective Cs^(+) transport in plants

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Molecular Plant 2021年第4期14卷 552-554页

作者： manuel Nieves-Cordones Francisco Rubio Departamento de Nutricion Vegetal Centro de Edafologia y Biologia Aplicada del Segura-CSICCampus de Espinardo30100 MurciaSpain

Nuclear accidents have led to the release to the environment of radioactive isotopes,mainly radioactive cesium(Cs^(+)),contaminating large areas of soil for very long periods of time(Burger and Lichtscheidl,2018).These contaminated soils contain^(134)Cs^(+)and^(137)Cs^(+)radioisotopes that are readily accumulated into plants and that,through the food chain,are transferred to animals and humans,causing important health problems(Burger and Lichtscheidl,2018).

关键词： readily release transport

Exploiting novel molecular targets in gastrointestinal cancers

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World Journal of Gastroenterology 2007年第44期13卷 5845-5856页

作者： Wen W Ma manuel Hidalgo Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine 1650 Orleans Street CRB 1M88 Baltimore MD 21231 United States

Novel molecular targets are being discovered as we learn more about the aberrant processes underlying various cancers. Efforts to translate this knowledge are starting to impact on the care of patients with gastrointestinal cancers. The epidermal growth factor receptor (EGFR) pathway and angiogenesis have been targeted successfully in colorectal cancer with cetuximab, panitunumab and bevacizumab. Similarly, EGFR-targeting with erlotinib yielded significant survival benefit in pancreatic cancer when combined with gemcitabine. The multi-targeting approach with sorafenib has made it the first agent to achieve significant survival benefit in hepatocellular carcinoma. Efforts to exploit the dysregulated Akt/mTOR pathway in GI cancer therapy are ongoing. These molecular targets can be disrupted by various approaches, including the use of monoclonal antibody to intercept extracellular ligands and disrupt receptor-ligand binding, and small molecule inhibitors that interrupt the activation of intracellular kinases.

关键词： Colorectal Pancreatic Liver cancers Targeted therapy Epidermal growth factor receptor roTOR Angiogenesis

Open avenues for carotenoid biofortification of plant tissues

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Plant Communications 2023年第1期4卷 228-237页

作者： Luca Morelli manuel Rodriguez-Concepcion Institute for Plant Molecular and Cell Biology(IBMCP) CSIC-Universitat Polite`cnica de Vale`ncia46022 ValenciaSpain Department of Biology&CESAM&ECOMARE Universidade de Aveiro3810-193 AveiroPortugal

Plant carotenoids are plastidial isoprenoids that function as photoprotectants,pigments,and precursors of apocarotenoids such as the hormones abscisic acid and *** do not produce carotenoids but need to obtain them from their diet as precursors of retinoids,including vitamin *** also provide numerous other health *** attempts to improve the carotenoid profile of different crops have been carried out by manipulating carotenoid biosynthesis,degradation,and/or ***,we will focus on open questions and emerging subjects related to the use of biotechnology for carotenoid *** impressive achievements,new efforts should be directed to extend the use of genome-editing technologies to overcome regulatory constraints and improve consumer acceptance of the carotenoid-enriched *** challenge is to prevent off-target effects like those resulting from altered hormone levels and metabolic *** on biofortification of green tissues should also look for new ways to deal with the negative impact that altered carotenoid contents may have on *** a carotenoid-enriched product has been obtained,additional effort should be devoted to confirming that carotenoid intake from the engineered food is also *** involves ensuring post-harvest stability and assessing bioaccessibility of the biofortified product to confirm that release of carotenoids from the food matrix has not been negatively *** addressing these challenges will ensure new milestones in carotenoid biotechnology and biofortification.

关键词： biofortification biotechnology carotenoids plastidial isoprenoids vitamin A

Modeling the dynamics of firms' technological impact

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Chinese Physics B 2021年第12期30卷 111-120页

作者： Shuqi Xu manuel Sebastian Mariani Linyuan Lü Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313001China University Research Priority Program on Social Networks University of ZurichCH-8050 ZurichSwitzerland Beijing Computational Science Research Center Beijing 100193China

Recent studies in complexity science have uncovered temporal regularities in the dynamics of impact along scientific and other creative careers, but they did not extend the obtained insights to firms. In this paper, we show that firms' technological impact patterns cannot be captured by the state-of-the-art dynamical models for the evolution of scientists' research impact, such as the Q model. Therefore, we propose a time-varying returns model which integrates the empiricallyobserved relation between patent order and technological impact into the Q model. The proposed model can reproduce the timing pattern of firms' highest-impact patents accurately. Our results shed light on modeling the differences behind the impact dynamics of researchers and firms.

关键词： firm technological impact patent analysis impact dynamics

A Computational Comparison of Ether and Ester Electrolyte Stability on a Ca Metal Anode

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Energy Material Advances 2021年第1期2021卷 24-36页

作者： Diana Liepinya manuel Smeu Department of Physics Binghamton UniversityBinghamtonNYUSA Department of Materials Science and Engineering University of MarylandCollege ParkMDUSA

Ca-ion batteries(CIBs)have the potential to provide inexpensive energy storage,but their realization is impeded by the lack of suitable *** by recent experimental progress,we perform ab initio molecular dynamics simulations to investigate early decomposition reactions at the anode-electrolyte *** examining different combinations of solvent—tetrahydrofuran(THF)or ethylene carbonate(EC)—and salt—Ca(BH_(4))_(2),Ca(BF_(4))_(2),Ca(BCl_(4))_(2),and Ca(ClO_(4))_(2)—we identify a variety of behavioral trends between electrolyte ***,we perform a separate trajectory with pure THF and gradually increased negative charge;despite an addition of-32e,no THF decomposition is *** analysis reveals that in a reductive environment,THF distributes excess charge evenly across its hydrocarbon backbone,while EC concentrates charge on its ester oxygens and carbonyl carbon,resulting in *** of charge *** for both solvents reveal that EC decomposition products can be reduced by up to five electrons,while those of THF are limited to a single ***,we find Ca(BH4)2 and THF to be the most stable solution investigated herein,corroborating experimental evidence of its suitability as a CIB electrolyte.

关键词： electrolyte backbone realization

Importance of human leukocyte antigen antibodies and leukocyte antigen/killer-cell immunoglobulin-like receptor genes in liver transplantation

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World Journal of Gastroenterology 2023年第5期29卷 766-772页

作者： manuel Muro Isabel Legaz Immunology Service University Clinical Hospital Virgen de la Arrixaca-Biomedical Research Institute of Murcia(IMIB)Murcia 30120Spain Department of Legal and Forensic Medicine Biomedical Research Institute(IMIB)Regional Campus of International Excellence“Campus Mare Nostrum”Faculty of MedicineUniversity of MurciaMurcia 30120Spain

Many mechanisms have been proposed to explain the hypothetical state of hepatic tolerance,which is described by eventual imbalances or deregulation in the balance of cytokines,mediators,effectors,and regulatory cells in the complex milieu of the *** this section,we will comment on the importance of donorspecific anti-human leukocyte antigen(HLA)antibodies(DSA)as well as the compatibility and pairings of HLA and killer-cell immunoglobulin-like receptor(KIR)genotypes in the evolution of liver ***,HLA compatibility,viral infections,and HLA-C/KIR combinations have all been linked to liver transplant rejection and *** have been reports of increased risk of acute and chronic rejection with ductopenia,faster graft fibrosis,biliary problems,poorer survival,and even de novo autoimmune hepatitis when DSAs are present in the *** mean fluorescence intensity(MFI)values of the DSAs and smaller graft size were associated with poorer patient outcomes,implying that high-risk patients with preformed DSAs should be considered for selecting the graft placed and desensitization methods,according to the ***,in a combined kidney-liver transplant,a pretransplant with a visible expression of several DSAs revealed that these antibodies were resistant to *** renal graft was lost owing to antibody-mediated rejection(AMR).The HLA antigens expressed by the transplanted liver graft influenced antibody *** are increasingly diagnosing AMR in liver transplants,and desensitization therapy has even been employed in situations of AMR,particularly in patients with DSAs in kidney-hepatic transplants and high-class II MFI due to *** conclusion,after revealing the negative impacts of DSAs with high MFI,pretransplant virtual crossmatch techniques may be appropriate to improve evolution;however,they may extend cold ischemia periods by requiring the donor to be typed.

关键词： Acute rejection Alloantibodies donor-specific antibodies-donor-specific anti-human leukocyte antigen antibodies Chronic rejection Human leukocyte antigen matching Killer-cell immunoglobulin-like receptor matching Liver transplant

Dissecting symbiosis cell by cell

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Molecular Plant 2023年第2期16卷 308-309页

作者： manuel Frank Dugald Reid Department of Molecular Biology and Genetics Aarhus UniversityUniversitetsbyen 818000Aarhus CDenmark Department of Animal Plant and Soil SciencesSchool of AgricultureBiomedicine and EnvironmentLa Trobe UniversityMelbourneVIC 3086Australia

Symbiotic nitrogen fixation in legumes occurs in specialized root organs called *** development requires coordination across tissues as infection progresses from the epidermis to growing nodules derived from the cortex or ***,functional nodules include a variety of specialized cells,including those that house the nitrogen-fixing *** combination of developmental changes across tissues and specialized functions acquired by nodule cells makes dissecting the process difficult using bulk analysis of gene expression,proteins,and metabolites.

关键词： organs cortex specialized