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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 304-306页

作者： Abdallah al Farai mansour al moundhri GI Program Sultan Comprehensive Cancer Care and Research CenterMuscatOman

We had the pleasure to read the paper published online by Krouse et *** August 2023 in the Lancet Gastroenterology and Hepatology(1).The study labeled as S1316 was a prospective pragmatic comparative effectiveness trial evaluating the surgical versus non-surgical management for patients with malignant small intestinal bowel obstruction(MIO)and having an intra-abdominal or retroperitoneal primary cancer and were aged 18 years or older with a Zubrod performance status 0-2 within 1 week before admission;had a surgical indication;and treatment *** patients were divided in two *** who accepted the randomization were randomly assigned to surgical and non-surgical treatment *** who declined consent for random assignment were offered a prospective observational patient choice pathway where the patients with their caring team decide upon the treatment option.

关键词： Malignant bowel obstruction surgery non-surgical

Hepatocellular carcinoma with complete response to the immunotherapy:the oncologist’s dilemma

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 119-122页

作者： mansour al-moundhri Antonio Cubisino Fabrizio Panaro Medical Oncology Department Sultan Qaboos Comprehensive Cancer CenterSultan Qaboos UniversityMuscatOman Department of Surgery University of Illinois at ChicagoChicagoILUSA Department of Surgery Montpellier University HospitalMontpellierFrance Surgical Oncology Department Sultan Qaboos Comprehensive Cancer CenterSultan Qaboos UniversityMuscatOman

Hepatocellular carcinoma(HCC)is the seventh most common cancer and the fourth leading cause of cancer-related death worldwide(1).During the last decade,many efforts have been made to improve patient survival by conducting clinical trials investigating local and systemic treatment options for patients with unresectable ***,despite significant research efforts,only few treatment approaches have been validated for HCC.

关键词： cancer immunotherapy clinical

Launching of the Sultan Qaboos Comprehensive Cancer Care and Research Center(SQCCCRC)in the Sultanate of Oman to manage HBP type of cancers

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 338-339页

作者： Abdallah al Farai mansour al moundhri Fabrizio Panaro Department of Surgical Oncology Sultan Qaboos Comprehensive Cancer Care and Research CentreMuscatSultanate of Oman Sultan Qaboos Comprehensive Cancer Care and Research Centre MuscatSultanate of Oman Department of Surgery/Division of HBP Surgery and Transplantation St.Eloi HospitalMontpellier University Hospital-School of MedicineMontpellierFrance

In July 2021 a new governmental cancer center,the Sultan Qaboos Comprehensive Cancer Care and Research Centre(SQCCCRC)(Figure 1)open its doors to provide excellent,evidenced-based patient-centered care for cancer patients in the Sultanate of *** is dedicated to treat cancer patients while building an environment to continuously advance clinical and scientific innovation in the treatment of Cancer.

关键词： Cancer Care cancer

Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma

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World Journal of Gastroenterology 2008年第24期14卷 3879-3883页

作者： mansour S al-moundhri A al-Shukaili M al-Nabhani B al-Bahrani IA Burney A Rizivi SS Ganguly Medical Oncology Unit Department of MedicineCollege of Medicine and Health SciencesSultan Qaboos University Department of Microbiology and Immunology (SQU) National Cancer Institute Royal Hospital Department of Epidemiology and Medical Statistics (SQU)

AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P all stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay.

关键词： Gastric cancer Serum Vascular endothelialgrowth factor Oman

Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk

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World Journal of Gastroenterology 2010年第27期16卷 34332-3436页

作者： mansour S al-moundhri Manal al-Khanbashi Mohammed al-Kindi Maryam al-Nabhani Ikram A Burney Abdulaziz al-Farsi Bassim al-Bahrani Medical Oncology Unit Department of MedicineCollege of Medicine and Health SciencesSultan Qaboos University Department of Clinical Genetics College of Medicine and Health SciencesSultan Qaboos University Department of Biochemistry College of Medicine and Health SciencesSultan Qaboos University National Oncology Center Royal Hospital

AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer(GC) risk ***:We analyzed four CDH1 polymorphisms(+54 T>C,-160 C>A,-616 G>C,-3159 T>C) in an Omani population,by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA ***:CDH1-160-AA genotype was associated with an increased risk of GC(OR = 3.6,95% CI:1.1-11.8)(P = 0.03).There was no significant association between the other polymorphisms and GC *** haplotype analysis of +54 T>C,-160 C>A,-616 G>C,-3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5(95% CI:0.7-3.5) and 1.5(95% CI:0.2-3.0),but did not reach statistical ***:The current study suggests that the-160 AA genotype was associated with an increased risk of GC in Oman.

关键词： Gastric cancer Polymorphism CDH1

NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations

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World Journal of Gastroenterology 2007年第19期13卷 2697-2702页

作者： mansour S al-moundhri Mohamed al-Kindi Maryam al-Nabhani Bassim al-Bahrani Ikram A Burney ali al-Madhani Shyam S Ganguly Misbah Tanira Medical Oncology Unit Department of Medicine College of Medicine and Health Sciences Sultan Qaboos University Sultanate of Oman Department of Biochemistry and Genetics Sultan Qaboos University Sultanate of Oman National Cancer Institute Royal Hospital Sultanate of Oman Department of Medicine Sohar Hospital Sultanate of Oman Department of Epidemiology and Medical Statistics Sultan Qaboos University Sultanate of Oman Department of Pharmacology Sultan Qaboos University Sultanate of Oman

AIM： To study whether N-acetyltransferase 2 （NAT2） genotypes and phenotypes are associated with increased risk factor for gastric cancer in Omani patients and to study the clinico-pathological correlations and the prognostic significance of NAT2. METHODS： Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. RESULTS： We observed no significant association between NAT2 genotypes and phenotypes and gastric cancer risk. The IVAT2 phenotype polymorphisms and gastric cancer risk predisposition were not modified by concomitant Hpylori infection and smoking. There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. CONCLUSION： In the current study, NAT2 genotypes and phenotypes are not associated with gastric cancer risk predisposition. Moreover NAT2 phenotypes had no clinicopathological associations or prognostic significance.

关键词： Gastric cancer Polymorphism NAT2 Hpylori Arab Omani