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Genetic diversity of PfEMP1-DBL 1-α and its association with severe malaria in a hyperendemic state of India

Asian Pacific Journal of Tropical Medicine 2010年第7期3卷 505-509页

作者： Ronnaly Rout Gunanidhi Dhangadamajhi Biranchi N Mohapatra Shantanu K Kar manoranjan ranjit Regional Medical Research Centre(ICMR) Bhubaneswar-751023Orissa.India SCB Medical College & Hospital.Cuttack-753007 Orissa.India Regional Medical Research Centre(ICMR).Bhubaneswar-751023 Orissa.India

Objective:To find out the extent of duffy-binding-like(DBL) a gene diversity and the resetting potential of the parasite population in association with severe ***:Genotyping of DBLαdomain was done by PCR using three sets of primers(FR,F1R2 and F2R2) and the rosetting frequency was assessed by parasite culture followed by ethidium bromide staining and visualization under a fluorescent ***:The significant association of high parasite density with severe malaria and the positive correlation between rosetting frequency and parasite density in vivo(P = 0.613,P<0.0001) were ***,the parasite strains having multiple fragments of F2R2 region and’b’variant of FR region of DBL 1-αshowed increased rosetting frequency and supported the strain specific association of disease severity. Conclusions:The findings suggest that rosetting mediated higher parasitemia might have contributed to the development of severe *** the rosetting domain of Plasmodium falciparum erythrocyte membrane protein 1(HEMP1),the DBL a binds to multiple host receptors; the significant association of multiple fragments of F2R2 region with severe malaria suggests several receptor-ligand interactions as the possible mechanisms of ***, the high percentage distribution of smaller fragments with mild malaria suggests the lack of adequate rosetting epitopes that might have contributed to low rosetting frequency in mild malaria.

关键词： Plasmodium falciparum Rosetting Parasite density DBL 1-α Severe malaria

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