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Neural Regeneration Research 2017年第5期12卷 723-736页

作者： manoj kumar Jaiswal Molecular Imaging and Neuropathology Division New York State Psychiatry Institute Columbia University New York NY USA Department of Psychiatry Columbia University New York NY USA

Amyotrophic lateral sclerosis（ALS） and motor neuron diseases（MNDs） are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons（UMNs/LMNs）, brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons（MNs）, muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro “disease in dish” and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

关键词： iPSCs stem cells human patients ALS mitochondria motor neuron disease disease modeling neurodegeneration gene editing transplantation drug screening

MATHEMATICAL MODELING OF QUINTIC DUFFING EQUATION AND NUMERICAL SIMULATION USING MULTIPLE SCALES MODIFIED LINDSTEDT–POINCARE METHOD

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International Journal of Modeling, Simulation, and Scientific Computing 2012年第3期3卷 21-37页

作者： manoj kumar PARUL Department of Mathematics Motilal Nehru National Institute of Technology Allahabad-211004 U.P.India

A perturbation algorithm Multiple Scales Modified Lindstedt–Poincare(MSMLP),combination of method of Multiple Scales and modified Lindstedt–Poincare is proposed for the solution of Quintic Duffing equation which combines the advantages of both the *** obtained by the MSMLP method is compared with the Multiple Scales method and accurate closed form approximate solution of the Quintic Duffing *** proposed method produces better results for a wide range of amplitude values of oscillations and strong *** simulation has been performed in MATHEMATICA 7.0.

关键词： Perturbation methods multiple scales method modified Lindstedt-Poincare method perturbation problems.

Thermodynamic behaviour of Rashba quantum dot in the presence of magnetic field

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Chinese Physics B 2016年第5期25卷 262-267页

作者： Sukirti Gumber manoj kumar Pradip kumar Jha Man Mohan Department of Physics & Astrophysics University of Delhi Department of Physics DDU College University of Delhi

The thermodynamic properties of an In Sb quantum dot have been investigated in the presence of Rashba spin–orbit interaction and a static magnetic field. The energy spectrum and wave-functions for the system are obtained by solving the Schrodinger wave-equation analytically. These energy levels are employed to calculate the specific heat, entropy,magnetization and susceptibility of the quantum dot system using canonical formalism. It is observed that the system is susceptible to maximum heat absorption at a particular value of magnetic field which depends on the Rashba coupling parameter as well as the temperature. The variation of specific heat shows a Schottky-like anomaly in the low temperature limit and rapidly converges to the value of 2kB with the further increase in temperature. The entropy of the quantum dot is found to be inversely proportional to the magnetic field but has a direct variation with temperature. The substantial effect of Rashba spin–orbit interaction on the magnetic properties of quantum dot is observed at low values of magnetic field and temperature.

关键词： quantum dot Rashba spin–orbit interaction thermal and magnetic properties

“Armed for the future Coronavirus pandemic”:a promising use of the multimeric SARS-CoV-2 receptor binding domain nanoparticle as a new Pan-Coronavirus vaccine

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2605-2606页

作者： manoj kumar Souhaila Al Khodor Research Department Sidra MedicineDohaQatar

In a recent article in Nature,Saunders et *** a new pan-coronavirus(CoVs)vaccine that elicited abundant neutralizing antibodies(nAbs)and was proven effective in protecting against a variety of coronavirus infections-including severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),SARS-CoV-1,and other related bat-CoVs that could potentially cause the next pandemic1.

关键词： vaccine acute

Development of port fuel injected methanol(M85)-fuelled two-wheeler for sustainable transport

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第3期7卷 298-311页

作者： Tushar agarwal Akhilendra Pratap Singh Avinash kumar agarwal Engine R esearch Laboratory Department of Mechanical EngineeringIndian Institute of Technology KanpurKanpur 208016India

Due to increasingly stringent environmental pollution norms,there is a need for alternate combustion techniques and alternate fuels to keep up with changing *** of the viable solutions for India is the adaptation of methanol as a fuel for automotive ***,in this study a functional two-wheeler prototype was developed,which uses M85(85%v/v methanol and 15%v/v gasoline)in an electronic control unit(ECU)controlled port fuel injected(PFI)*** study included comparative investigations of simulated on-road two-wheeler performance on chassis dynamometer using a gasoline-fuelled motorcycle with stock ECU vis-a-vis M85-fuelled motorcycle using recalibrated *** recalibration exhibited that M85-fuelled vehicle was operated at relatively more advanced spark timing compared to baseline gasoline-fuelled *** results showed that M85-fuelled motorcycle produced relatively higher engine power and higher maximum vehicle speed compared to gasoline-fuelled *** superior acceleration characteristics(especially at higher speeds)of M85-fuelled motorcycle was another important finding of this study,indicating that M85 provided superior throttle response compared to *** analysis of raw tailpipe emissions showed that modified M85-fuelled motorcycle emitted relatively higher hydrocarbon(HC),carbon monoxide(CO)and oxides of nitrogen(NO_x)emissions compared to stock gasoline-fuelled ***,these emissions can be controlled by using adaptation of suitable after-treatment systems.

关键词： Methanol Electronic control unit(ECU) Electronic fuel injection(EFI) ECU calibration Engine performance Emission

Experimental investigation and optimization of weld bead characteristics during submerged arc welding of AISI 1023 steel

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Defence Technology（防务技术） 2019年第1期15卷 72-82页

作者： Ankush Choudhary manoj kumar Deepak Rajendra Unune Department of Mechanical-Mechatronics Engineering The LNM Institute of Information Technology

Submerged arc welding(SAW), owing to its high deposition rate and high welding quality, is widely used in the fabrication of pressure vessel, marine vessel, pipelines and offshore structures. However, selection of an optimum combination of welding parameters is critical in achieving high weld quality and productivity. In this work, initially, the SAW experiments were performed using fractional factorial design to analyze the effect of direct and indirect input parameters, namely, welding voltage, wire feed rate,welding speed, nozzle to plate distance, flux condition, and plate thickness on weld bead geometrical responses viz. bead width, reinforcement, and penetration. The bead on plate technique was used to deposit weld metal on AISI 1023 steel plates. The effect of SAW input parameters on response variables were analyzed using main and interaction effects. The linear regression was used to develop the mathematical models for the response variable. Then, the multi-objective optimization of input parameters was carried out using desirability approach, genetic algorithm and Jaya algorithm. The Jaya algorithm offered better optimization results as compared to desirability approach, genetic algorithm.

关键词： Submerged arc welding Optimization Regression Genetic algorithm Jaya algorithm

An analytical solution of multi-dimensional space fractional diffusion equations with variable coefficients

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第1期12卷 229-255页

作者： Pratibha Verma manoj kumar Department of Mathematics Motilal Nehru National Institute of Technology Allahabad Prayagraj 211004 Uttar PradeshIndia

In this paper,we have considered the multi-dimensional space fractional diffusion equations with variable *** fractional operators(derivative/integral)are used based on the Caputo *** study provides an analytical approach to determine the analytical solution of the considered problems with the help of the two-step Adomian decomposition method(TSADM).Moreover,new results have been obtained for the existence and uniqueness of a solution by using the Banach contraction principle and a fixed point *** have extended the dimension of the space fractional diffusion equations with variable coefficients into ***,the generalized problems with two different types of the forcing term have been included demonstrating the applicability and high efficiency of the TSADM in comparison to other existing numerical *** diffusion coefficients do not require to satisfy any certain conditions/restrictions for using the *** are no restrictions imposed on the problems for diffusion coefficients,and a similar procedures of the TSADM has followed to the obtained analytical solution for the multi-dimensional space fractional diffusion equations with variable coefficients.

关键词： Caputo fractional operators space fractional diffusion equations Riesz derivative two-step Adomian decomposition method fixed point theorem

Numerical solution for singular differential equations using Haar wavelet

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International Journal of Modeling, Simulation, and Scientific Computing 2020年第5期11卷 31-45页

作者： Shitesh Shukla manoj kumar Department of Mathematics Motilal Nehru National Institute of Technology Allahabad Prayagraj-211004(U.P) India

The aim of this paper is to obtain the numerical solution of singular ordinary differential equations using the Haar-wavelet *** proposed method is mathematically simple and provides highly accurate *** this method,we derive the Haar operational matrix using Haar *** operational matrix is a basic tool and applied in system analysis to evaluate the numerical solution of differential *** convergence of the proposed method is discussed through its error *** illustrate the efficiency of this method,solutions of four singular differential equations are obtained.

关键词： Haar operational matrix singularity quasilinearization technique piecewise continuous function

Design of a 2-DOF-PID controller using an improved sine-cosine algorithm for load frequency control of a three-area system with nonlinearities

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Protection and Control of Modern Power Systems 2022年第1期7卷 490-507页

作者： Neelesh kumar Gupta manoj kumar Kar Arun kumar Singh Department of Electrical Engineering NIT JamshedpurJamshedpurJharkhand 831014India

This paper proposes an improved sine-cosine algorithm(ISCA)based 2-DOF-PID controller for load frequency control.A three-area test system is built for study,while some physical constraints(nonlinearities)are considered for the investigation of a realistic power *** proposed method is used as the parameter optimizer of the LFC control-ler in different *** 2-DOF-PID controllers are used because of their capability of fast disturbance rejection without significant increase of overshoot in set-point *** 2-DOF-PID controllers’efficacy is observed by examining the responses with the outcomes obtained with PID and FOPID *** simulation results with the suggested scheme are correlated with some of the existing algorithms,such as SCA,SSA,ALO,and PSO in three dif-ferent scenarios,i.e.,a disturbance in two areas,in three areas,and in the presence of physical *** addition,the study is extended to a four-area power *** analysis is performed using the Wilcoxon Sign Rank Test(WSRT)on 20 independent *** confirms the supremacy of the proposed method.

关键词： 2-DOF-PID FOPID Load frequency control WSRT Statistical analysis Improved sine-cosine algorithm

Feasibility of Al−TiC coating on AZ91 magnesium alloy by TIG alloying method for tribological application

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Transactions of Nonferrous Metals Society of China 2020年第6期30卷 1550-1559页

作者： Chinmaya kumar PADHEE manoj MASANTA A.K.MONDAL Department of Mechanical Engineering National Institute of Technology RourkelaRourkela 769008India Department of Metallurgical Engineering Indian Institute of Technology(BHU)VaranasiVaranasi 221005India

An attempt was made to improve the surface properties of the AZ91 Mg alloy through surface alloying of a mixture of Al and TiC with the help of TIG arc as heat *** microstructural evolution of the alloyed layer on the AZ91 alloy was analysed through SEM and XRD *** micro-hardness and the dry sliding wear behaviour were assessed by Vickers micro-hardness tester and pin-on-disc wear test setup,*** is revealed that almost uniform alloyed layer forms on the AZ91 alloy substrate for a specific current and scan speed employed in the present *** alloyed layer exhibits hardness value up to 305 HV0.25,and almost negligible wear as compared to the as-received AZ91 alloy substrate.

关键词： AZ91 magnesium alloy Al-TiC coating TIG alloying micro-hardness dry sliding wear