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Analysis of Intron 22 Inversion Mutation of Factor Ⅷ Genein the Patients with Hemophilia A in J&K State of India

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首都医科大学学报 2005年第6期26卷 677-680页

作者： Parvinder Kumer~1,Mohammed Idris~2,Vikas Dogra~1,K.Radha Mani~2,Kulbhushan singh Jamwal~1,Wahied Khawar Balwan~1,T.R.Raina~1,G.R.Chandak~2,Subash Gupta~1(1.Department of Zoology,Human Genetics Research and Counselling Centre, University of Jammu/Govt.Medical College,India 2.Centre for Cellular and Molecular Biology,India) Department of Zoology Human Genetics Research and Counselling Centre University of Jammu/Govt. Medical College India Centre for Cellular and Molecular Biology India

Objective Hemophilia A,an X-linked bleeding disorder,affecting 1 in 5 000 males is caused by heterogeneous mutations in factor Ⅷ *** mutation in intron 22 of F8C gene remains its leading *** aim of this study was to evaluate the frequency and distribution of the intron 22-inversion mutation in the patients and in the family members in the *** 29 hemophilia A patients from Jammu and Kashmir(20 severe,8 moderate and 1 mild) were analyzed for intron 22-inversion *** 11(38%) were positive for the distal type of inversion *** mutation was found in 9/20(45%) patients with severe factor Ⅷ deficiency and 2/8(25%) with moderate severity hemophilia A,whereas the patient with mild hemophilia A was found to be negative for inversion *** of twenty-six female relatives from 11 families of inversion mutation positive patients identified one mother and one sister from one family to be the carrier,suggesting its origin in the mother. Conclusion The present study confirms the intron-22 inversion mutation in F8C gene as the major cause of hemophilia A in the population from Jammu and Kashmir with a higher frequency of inversion mutation in sporadic cases compared to the familial cases.

关键词：血友病基因突变病理机制治疗

Alignment of solid targets under extreme tight focus conditions generated by an ellipsoidal plasma mirror

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Matter and Radiation at Extremes 2019年第2期4卷 30-35页

作者： Deepak kuma. Michal Smid Sushil singh Alexander Soloviev Hannes Bohlin Konstantin Burdonov Gashaw Fente Alexander Kotov Livia Lancia Vit Leedl Sergey Makarov Michael Morrissey Sergey Perevalov Denis Romanovsky Sergey Pikuz Ryousuke Kodama David Neely Paul McKenna Tomas Lastovicka Mikhail Starodubtsev Stefan Weber Motoaki Nakatsutsumi Julien Fuchs ELI Beamlines Institute of Physics5.kvetna 83525241 Dolni BrezanyCzech Republic Institute of Applied Physics of the Russian Academy of Sciences(IAP RAS) 46 Ulyanov Street603950 Nizhny NovgorodRussia LULI-CNRS Ecole PolytechniqueCEA:Universite Paris-SaclayUPMC Univ Paris 06:Sorbonne UniversitiesF-91128 Palaiseau CedexFrance Research Center Toptec Institute of Plasma PhysicsSobotecka 166051101 TurnovCzech Republic Joint Institute for High Temperatures Russian Academy of Science(JIHT RAS) Moscow 125412Russia Division of Electrical Electronic and Information EngineeringGraduate School of EngineeringOsaka UniversityOsakaJapan Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Department of Physics SUPA University of StrathclydeGlasgow G40NGUnited Kingdom European XFEL GmbH Holzkoppel 422869 SchenefeldGermany

The design of ellipsoidal plasma mirrors(EPMs)for the PEARL laser facility is *** EPMs achieve a magnification of 0.32 in focal spot size,and the corresponding increase in focused intensity is expected to be about *** and implementing such focusing optics for short-pulse(<100 fs)systems paves the way for their use in future high-power facilities,where they can be used to achieve intensities beyond 1023W/cm^(2).A retro-imaging-based target alignment system is also described,which is used to align solid targets at the output of the ellispoidal mirrors(with a numerical aperture of 0.75 in this case).

关键词： beyond mirror extreme

1例甲状腺毒症患儿治疗过程中所伴发的低钙血症

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 19-19页

作者： Kansra S. Devidayal Suri D. singh M. 李开(译) -ACTA PAEDIATR. INT. J. PAEDIATR.2006 95/3 (375- 377) 不详

A 2-mo-old infant born to a mother with Graves’disease and having symptoms of thyrotoxicosis was started on antithyroid ***-threatening hypocalcaemia requiring high-dose calcium infusions developed 1 mo after starting *** alkaline phosphatase and paratharmone levels were *** communication may serve to alert treating physicians about this rare complication in infants with thyrotoxicosis after initiation of antithyroid ***:Severe hypocalcaemia may follow initiation of antithyroid therapy in infants with thyrotoxicosis.

关键词：甲状腺毒症低钙血症治疗过程伴发毒性弥漫性甲状腺肿抗甲状腺治疗血清碱性磷酸酶患儿抗甲状腺药物病情恶化

Effective Use of Near Real-time Monitoring System for Stunting Reduction in Zimbabwe

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Journal of Health Science 2019年第2期7卷 89-100页

作者： Z.Gomora A.Ndlovu C.Siwela J.Makanjera A.Chineka M.Dodzo V.singh I.Ngnie-Teta M.A.Ayoya United Nations Children’s Fund(UNICEF) 6 Fairbridge ParkBelgraviaHarareZimbabwe Food and Nutrition Council Office of the President and CabinetP O Box 6640HarareZimbabwe

Background:In Zimbabwe,26.2 percent of children under five are *** has shown that multi-sector interventions are key to addressing ***,practical implementation is difficult,often occurring through separate disjointed and uncoordinated sector actions with limited access to real time information for ***:To describe the design,implementation,successes,challenges and lessons learned from using a near-real time monitoring(NRTM)system as a monitoring tool for multi-sectoral community based model for stunting reduction in ***:An open source technology was used to obtain the information needed on the multi-sectoral coordination process,provide a common platform to capture and present data on situational factors,community conditions and practices to be acted upon and thus contribute to reducing ***:Significant improvements in community data flows were noted;the system brought together several types of data,concepts,stakeholders and multi-sector energies into focused *** challenges including conceptual issues,initial coordination,financial resources and missed partnership opportunities were *** introduction of the NRTM system resulted in improved data flows for programme monitoring and facilitated multi-sector ***:NRTM is an effective monitoring tool for the multi-sectoral community based model to reduce stunting in Zimbabwe.

关键词： Near real-time monitoring(NRTM) stunting decision-making UNICEF Zimbabwe

青年心肌梗死患者的家族性高胆固醇血症刘青(译),叶鹏(摘、审校)

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中华高血压杂志 2019年第7期27卷 621-621页

作者：刘青(译) 叶鹏(摘/审校) singh A Gupta A Collins BL Qamar A Monda KL Biery D Lopez JAG de Ferranti SD Plutzky J Cannon CP Januzzi JL Jr Di Carli MF Nasir K Bhatt DL Blankstein R 不详

关于在年轻时经历心肌梗死的美国成年人中家族性高胆固醇血症(familial hypercholesterolemia,FH)的患病率和治疗的数据有限。该研究旨在评估临床确定的FH的患病率,并检查他汀类药物使用率和心肌梗死1年后低密度脂蛋白胆固醇(low densit... 详细信息

关于在年轻时经历心肌梗死的美国成年人中家族性高胆固醇血症(familial hypercholesterolemia,FH)的患病率和治疗的数据有限。该研究旨在评估临床确定的FH的患病率,并检查他汀类药物使用率和心肌梗死1年后低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的水平。

关键词：家族性高胆固醇血症心肌梗死患者低密度脂蛋白胆固醇他汀类药物患病率成年人使用率

灌溉、耕作和覆盖物对大豆产量及与土壤质地相关的产水力的影响

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大豆科技 2012年第6期 37-37页

作者： Arora V K singh C B Sidhu A S Thind S S 姚钦

印度Punjab正在减少地下水资源状况，从水稻到其他农作物要求实现低蒸发多样化，并提倡采用节水技术。大豆提供了一个由低等到中等质地土壤的多样化选择。然而，大豆在这些土壤中的产量受制于高的土壤机械阻力和生长季节初期的高土壤温... 详细信息

印度Punjab正在减少地下水资源状况，从水稻到其他农作物要求实现低蒸发多样化，并提倡采用节水技术。大豆提供了一个由低等到中等质地土壤的多样化选择。然而，大豆在这些土壤中的产量受制于高的土壤机械阻力和生长季节初期的高土壤温度。这些制约因素可通过灌溉、秸秆覆盖和深耕来缓解。3年的实地研究考察了灌溉、深耕和秸秆覆盖对大豆产量及与土壤质地有关的水分生产力的单一和联合影响。

关键词：土壤质地大豆产量灌溉覆盖物水力耕作秸秆覆盖水资源状况

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竹子作为结构荷载构件：实验性能评估

世界竹藤通讯 2012年第4期10卷 47-47页

作者： Smita Chugh Anurag Kangdya Sanjeev singh C. Korde P. Sudhakar 印度科技研究所乡村发展中心印度尼马大学土木工程系

竹子自古就是建筑材料，但其使用因屋顶的荷载分布受到限制。竹建筑技术的标准化受制于不同地理和环境条件下竹子性能各有不同。另外，由于缺乏成本效益来确定竹结构的安全性，竹子不能大量用在建筑结构中。为解决这些缺点和对竹子作为... 详细信息

竹子自古就是建筑材料，但其使用因屋顶的荷载分布受到限制。竹建筑技术的标准化受制于不同地理和环境条件下竹子性能各有不同。另外，由于缺乏成本效益来确定竹结构的安全性，竹子不能大量用在建筑结构中。为解决这些缺点和对竹子作为建筑荷载构件的研究中不足，本试验研究评估了结构竹横梁的荷载能力，该实验是通过特别设计的测验设备来进行的。通过对横梁结构的荷载分析，取得了可喜的成果，从而证明竹子有极高可能用于建筑结构的荷载构件。将竹子大量用在建筑上不仅能提供更多的经济适用房，还可以解决环境问题。

关键词：竹子绿色建筑经济适用房环境因素

联合应用活体功能与解剖成像对体内基因转染进行评估

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国际医学放射学杂志 2009年第6期 576-576页

作者： S.P.singh M.Ravoori V.Kundra 范惠双 Department of Experimental Diagnostic Imaging The University of Texas M.D.Anderson Cancer Center1515 Holcombe BlvdUnit 368HoustonTX 77030USA

目的评价联合应用活体解剖与功能成像是否有助于对体内基因转染后指针——2型生长抑素受体(SSTR2)的表达进行定量分析。材料与方法所有动物实验获得实验动物管理与使用委员会同意。6只裸鼠均皮下接种2个L3.6pl(人类胰腺癌)肿瘤,向瘤内... 详细信息

目的评价联合应用活体解剖与功能成像是否有助于对体内基因转染后指针——2型生长抑素受体(SSTR2)的表达进行定量分析。材料与方法所有动物实验获得实验动物管理与使用委员会同意。6只裸鼠均皮下接种2个L3.6pl(人类胰腺癌)肿瘤,向瘤内注射嵌载

关键词：基因转染联合应用活体生物分布功能

欧洲博洛尼亚进程与“澳大利亚高等教育毕业声明”--降低高校毕业生流动信息障碍

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现代大学教育 2008年第3期24卷 44-48页

作者：麦可·辛张玲澳大利亚教育研究协会澳大利亚西悉尼大学教育学院娄底417000

本文阐述澳大利亚高等教育在政策上对欧洲博洛尼亚进程,特别是对毕业证书附件政策的回应——构建并实施"澳大利亚高等教育毕业声明"。"声明"旨在满足知识型劳动力的流动需求,推动学术和职业资质(文凭、学位、证书)认证的国际化与透明度... 详细信息

本文阐述澳大利亚高等教育在政策上对欧洲博洛尼亚进程,特别是对毕业证书附件政策的回应——构建并实施"澳大利亚高等教育毕业声明"。"声明"旨在满足知识型劳动力的流动需求,推动学术和职业资质(文凭、学位、证书)认证的国际化与透明度。研究澳大利亚高等教育国际化的创新政策与理念,意在与世界学术同仁一起探讨博洛尼亚进程对亚太地区高等教育的影响。

关键词：博洛尼亚进程澳大利亚高等教育毕业声明流动