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Does progress in microfracture techniques necessarily translate into clinical effectiveness?

World Journal of Orthopedics 2024年第3期15卷 266-284页

作者： Sathish Muthu Vibhu Krishnan Viswanathan manoharan sakthivel Mohammed Thabrez Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia manoharan sakthivel Department of OrthopaedicsGovernment Medical CollegeKarur 639004Tamil NaduIndia Department of Orthopaedics Devadoss Multispecialty HospitalMadurai 625007Tamil NaduIndia Department of Medical Oncology Aster Medcity HospitalKochi 682034India

BACKGROUND Multitudinous advancements have been made to the traditional microfracture(MFx)technique,which have involved delivery of various acellular 2nd generation MFx and cellular MFx-III components to the area of cartilage *** relative benefits and pitfalls of these diverse modifications of MFx technique are still not widely *** To comparatively analyze the functional,radiological,and histological outcomes,and complications of various generations of MFx available for the treatment of cartilage *** A systematic review was performed using PubMed,EMBASE,Web of Science,Cochrane,and *** of any age and sex with cartilage defects undergoing any form of MFx were considered for *** included only randomized controlled trials(RCTs)reporting functional,radiological,histological outcomes or complications of various generations of MFx for the management of cartilage *** meta-analysis(NMA)was conducted in Stata and Cochrane’s Confidence in NMA approach was utilized for appraisal of *** Forty-four RCTs were included in the analysis with patients of mean age of 39.40(±9.46)*** comparing the results of the other generations with MFX-I as a constant comparator,we noted a trend towards better pain control and functional outcome(KOOS,IKDC,and Cincinnati scores)at the end of 1-,2-,and 5-year time points with MFx-III,although the differences were not statistically significant(P>0.05).We also noted statistically significant Magnetic resonance observation of cartilage repair tissue score in the higher generations of microfracture(weighted mean difference:17.44,95%confidence interval:0.72,34.16,P=0.025;without significant heterogeneity)at 1 ***,the difference was not maintained at 2 *** was a trend towards better defect filling on MRI with the second and third generation MFx,although the difference was not statistically significant(P>0.05).CONCLUSION The higher generations of traditional MFx

关键词： Cartilage injury Microfracture Mesenchymal stem cells Platelet-rich plasma Bone marrow aspiration concentrates Clinical outcome Radiological outcome Meta-analysis Network meta-analysis

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Trends in mortality among the geriatric population undergoing Surgical aortic valve replacement (SAVR) and potential racial disparities: a 20-year perspective via the National (Nationwide) Inpatient Sample

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Journal of Geriatric Cardiology 2024年第7期21卷 716-722页

作者： Nomesh Kumar Kamleshun Ramphul FNU Bawna Nitish Behary Paray Mansimran Si-ngh Dulay Jasninder Singh Dhaliwal Shruti Aggarwal Sebastian Mactaggart Suma Sri Chennapragada Shaheen Sombans Renuka Verma Hemamalini sakthivel Raheel Ahmed Department of Internal Medicine Detroit Medical Center Sinai Grace-Wayne State UniversityMichiganUSA In-dependent Researcher TrioletMauritius Independent researcher Farmington HillsMichiganUSA Royal Devon University Healthcare NHS Foundation Trust ExeterUnited Kingdom Royal Brompton Hospital part of Guy’s and St.Thomas’NHS Foundation TrustLondonUnited Kingdom Department of Internal Medicine University of Cali-forniaRiversideUSA Independent Researcher New DelhiIndia Northumbria Hospitals NHS Foundation Trust NewcastleUnited Kingdom Department of Internal Medicine Louisiana State UniversityShreveportUSA Sha-heen Sombans Independent ResearcherHyderabadIndia Department of Internal Medicine Kirk Kerkorian School of Medicine at UNLVLas VegasUSA One Brooklyn Health System/Interfaith Medical Ctr Program BrooklynNYUSA

Background Racial disparities in cardiovascular conditions are well *** similar race-based discrepancies in health outcomes also exist among elderly patients undergoing surgical aortic valve replacement(SAVR) for aortic stenosis remains *** We abstracted data from the National(Nationwide) Inpatient Sample over a 20-year period from 2001 to 2020 using specific ICD-9 and ICD-10 *** included patients aged ≥ 60 and ≤ 80 years with races recorded as White,African American,or Hispanic at the time of their hospitalization for *** analyzed and reported the baseline characteristics,risk-adjusted inhospital mortality,and complications stratified by *** Of 420,181 patients studied,90.0% identified as White,4.0% as African American and 6.0% as *** a decrease in overall in-hospital mortality rates from 3.8% between 2001-2005 to 1.8% between 2016-2020,African Americans had higher odds of all-cause in-hospital deaths compared to Whites(a OR = 1.390,P < 0.001).Additionally,they were more likely to experience cardiogenic shock(a OR = 1.241,P < 0.001) and acute kidney injury(a OR = 1.314,P < 0.001) as well as more likely to require organ support such as IABP use(a OR = 1.336,P < 0.001) or invasive mechanical ventilation(a OR = 1.342,P < 0.001).Interestingly,African Americans were less likely to report events of acute ischemic stroke compared to Whites(a OR = 0.852,P < 0.001).Conclusions Despite a reassuring reduction in overall in-hospital mortality rates of geriatric patients undergoing SAVR for aortic stenosis,racial disparities in health outcomes remain pervasive with minorities more likely to report higher in-hospital morbidity and mortality.

关键词： mortality likely spite

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Comparison of Cognitive Registration Transrectal Ultrasound-Guided Targeted Biopsy of Prostate to Systematic 12-Core Biopsy: A Retrospective, Multicentre Study

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Open Journal of Urology 2024年第7期14卷 381-390页

作者： Kevin Chang Yue Wei Lee Say Bob Devindran manoharan Liong Men Long Teoh Sze Yong Teo Rui Ling Chua Zi Wei Department of Urology Hospital Pulau Pinang George Town Malaysia Department of Urology Georgetown Specialist Hospital George Town Malaysia Department of Radiology Hospital Pulau Pinang George Town Malaysia Department of Radiology Georgetown Specialist Hospital George Town Malaysia

Introduction: Prostate cancer (PCa) is the third most prevalent cancer among Malaysian males, often diagnosed at advanced stages, leading to suboptimal outcomes. While transrectal ultrasound-guided systematic biopsy (TRUS-SB) is the primary diagnostic method, prebiopsy multiparametric magnetic resonance imaging (mpMRI) is gaining popularity in identifying suspicious lesions. This study addresses the lack of comprehensive investigations into the efficacy of cognitive registration TRUS targeted biopsy (COG-TB) compared to conventional TRUS-SB, considering the resource limitations of the Malaysian healthcare system. Materials and Methods: A retrospective cohort study was conducted in two Malaysian healthcare facilities. 116 adult patients with a prostate-specific antigen (PSA) level of more than 4 ng/mL who underwent both COG-TB and TRUS-SB between October 2020 and March 2022 were included. Primary outcomes were cancer detection rate and histopathological outcomes, including Gleason score. Results: COG-TB showed a higher overall cancer detection rate (50%) compared to TRUS-SB (44%). Clinically significant cancer detection rates were similar between COG-TB and TRUS-SB (37.1%). Further analysis revealed that both COG-TB and TRUS-SB detected clinically significant cancer in 30.2% of patients, did not detect it in 56.0%, and had conflicting findings in 16 patients (p Conclusion: COG-TB and TRUS-SB have comparable detection rates for clinically significant prostate cancer, with COG-TB showing a higher tendency to detect insignificant prostate cancer. Further studies comparing these methods are warranted.

关键词： Prostate Cancer Multiparametric MRI Targeted Biopsy Cognitive Fusion Transrectal Ultrasound-Guided Biopsy

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An in vitro Anti-urolithiasis Activity of a Herbal Formulation:Spinacia oleracea *** Coriandrum sativum L.

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 76-84页

作者： Sumathy Raj Monica Shree Gnana Soundara Rajan Suganthi Ramasamy Rimal Isaac Rajamony Suthies Goldy Ramathilaga Ariyamuthu Monisha Sudhagar sakthivel Gandhi Prakash Shoba Manikandan Gurusamy School of Biotechnology Dr.G.R.Damodaran College of ScienceCoimbatoreTamil NaduIndia Department of Biotechnology Dr.N.G.P Arts and Science CollegeCoimbatoreTamil NaduIndia Department of Nanotechnology Noorul Islam Centre for Higher EducationKumaracoilThuckalayKanyakumari DistrictTamil NaduIndia PG and Research Department of Biochemistry Kongunadu Arts and Science CollegeCoimbatoreTamil NaduIndia Department of Biological and Chemical Engineering Mekelle UniversityMekelleEthipoia Department of Zoology Holy Cross College(Autonomous)NagercoilTamilnaduIndia Department of Pharmaceutical Sciences Tshwane University of TechnologyArcadia CampusPretoriaSouth Africa

Background:Hard mineral and acid salt deposits that clump together in concentrated urine are known as kidney stones.A complicated chain of physicochemical events,including hyper saturation,nucleation,growth,aggrega-tion,and retention in the urinary tract,leads to urolithiasis,the third most prevalent urinary tract *** traditional medications and therapies are less successful in treating urolithiasis and frequently cause ***:The present study is focused on evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from Spinacia oleracea *** Coriandrum sativum ***:To evaluating the anti-urolithiasis activities of the polyherbal formulation prepared from *** and *** seeds against oxalate crystals by employing an in vitro inhibition,aggregation,and nucleation assay,employing a spectrophotometer followed by microscopic observation,and further monitored by egg semiperme-able membrane model,using cystone as a standard ***:In the present work,the alkaloids,glycosides,flavonoids,glycosides,phenols,saponins,steroids,tannins,terpenoids,and triterpenoids were found in the extracts of *** and *** in vitro assays in the present study clearly indicated that all the mixture extracts readily prevented crystal nucleation,growth and *** aqueous extract of the mixture inhibited significant inhibitory potential against the crystallization ***:It can be said that the phyto-constituents enriched homemade preparation possibly will be used as a medication for the management of kidney stones by dissolving the oxalate stone in the kidney.

关键词： Urolithiasis Polyherbal Egg membrane Spinacia oleracea Coriandrum sativum

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Effect of ammonium based ionic liquids on the rheological behavior of the heavy crude oil for high pressure and high temperature conditions

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Petroleum 2022年第4期8卷 552-566页

作者： Sivabalan sakthivel Sugirtha Velusamy Center for Integrative Petroleum Research(CIPR) College of Petroleum Engineering&GeosciencesKing Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Petroleum Engineering Program Department of Ocean EngineeringIndian Institute of Technology MadrasChennai600036India

Heavy crude oil(HCO)production,processing,and transportation forms several practical challenges to the oil and gas industry,due to its higher *** the shear rheology of this HCO is highly important to tackle production and flow *** environmental and economic viability of the conventional methods(thermal or dilution with organic solvents),force the industry to find an *** present study was constructed to investigate the effect of eco-friendly ionic liquids(ILs)on the HCO's rheology,at high temperature and high *** different alkyl ammonium ILs were screened for HCO's shear rheology at the temperatures of 25-100℃ and for pressures 0.1e10 *** addition of ILs reduced the HCO's viscosity substantially from 25 to 33%from their original HCO ***,it aids to reduce the yield stress to about 15-20%at all the studied experimental ***,the viscoelastic property of the HCO was studied for both strain-sweep and frequencysweep and noticed the ILs helps to increase HCO's loss modulus(G00)by reducing storage modulus(G0),it leads to the reduction of the crossover point around 25-32%than the standard *** the ILs addition with HCO converts its solid-like nature into liquid-like ***,the effect ILs chain length was also studied and found the ILs which has lengthier chain length shows better efficiency on the ***,the microscopic investigation of the HCO sample was analyzed with and without ILs and witnessed that these ILs help to fragment the flocculated HCO into smaller *** findings indicate that the ILs could be considered as the better alternative for efficient oil production,processing,and transportation.

关键词： Crude oil Ionic liquids Loss modulus Microscopy Storage modulus Viscosity reduction

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A green path to extract carbon quantum dots by coconut water:Another fluorescent probe towards Fe^(3+) ions

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Particuology 2021年第5期19卷 251-258页

作者： manoharan Preethi Chinnuswamy Viswanathan Nagamony Ponpandian Department of Nanoscience and Technology Bharathiar UniversityCoimbatore 641046India

In recent years,carbon quantum dots(CQDs)have been of great enthrallment in the fluorescent probe *** precursors with interesting physicochemical properties may be derived from natural *** this research,for the first time,coconut water has been used as a source of carbon to prepare blue fluorescent CQDs without any modification and *** preparation of CQDs is very simple and cost-effective,when compared with other conventional *** reaction parameters temperature and pH were varied to obtain monodispersed spherical CQDs with an average grain size of ∼5 *** CQDs exhibit blue emission with a wavelength of 487 nm with an excitation wavelength of 390 nm and are used for Fe^(3+) ions ***^(3+) ions have been observed to quench the fluorescence intensity of the CQDs than other heavy *** the presence of Fe^(3+) ions,the fluorescent CQDs are quenched due to the interaction of CQDs and Fe^(3+) ions.A spectroscopic result shows that Fe^(3+) ions can be observed within a concentration of 0-700μM,as well as the detection limit is 0.30μ*** CQDs provide a unique pathway for potential application in the environmental monitoring of heavy metal ions.

关键词： Green preparation of CQDs Coconut water Stirrer-assisted technique Detection of metal ions Quenching efficiency Nonfluorescence

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Selection of Machining Datum and Allocation of Tolerance through Tolerance Charting Technique

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Chinese Journal of Mechanical Engineering 2012年第4期25卷 697-705页

作者： THILAK manoharan SIVAKUMAR Karuppan JAYAPRAKASH Govindharajalu Department of Mechanical Engineering TRP Engineeering CollegeTiruchirappalli-621105TamilNaduIndia Department of Mechanical Engineering Bannari Amman Institute of TechnologySathyamangalam-638401TamilNaduIndia Department of Mechanical Engineering Shivani Engineering CollegeTiruchirappalli-620009TamilNaduIndia

Tolerance charting is an effective tool to determine the optimal allocation of working dimensions and working tolerances such that the blueprint dimensions and tolerances can be achieved to accomplish the cost *** selection of machining datum and allocation of tolerances are critical in any machining process planning as they directly affect any setup methods/machine tools selection and machining *** paper mainly focuses on the selection of optimum machining datums and machining tolerances simultaneously in process planning.A dynamic tolerance charting constraint scheme is developed and implemented in the optimization *** optimization model is formulated for selecting machining datum and tolerances and implemented with an algorithm namely Elitist Non-Dominated Sorting Genetic Algorithm（NSGA-II）.The computational results indicate that the proposed methodology is capable and robust in finding the optimal machining datum set and tolerances.

关键词： tolerance allocation tolerance charting elitist non-dominated sorting genetic algorithm-II.

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An automated detection of glaucoma using histogram features

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 194-200页

作者： Karthikeyan sakthivel Rengarajan Narayanan Electronics and Communication Engineering K.S.R. College of Engineering Electrical and Electronics Engineering Bannari Amman Institute of Technology

Glaucoma is a chronic and progressive optic neurodegenerative disease leading to vision deterioration and in most cases produce increased pressure within the eye. This is due to the backup of fluid in the eye; it causes damage to the optic nerve. Hence, early detection diagnosis and treatment of an eye help to prevent the loss of vision. In this paper, a novel method is proposed for the early detection of glaucoma using a combination of magnitude and phase features from the digital fundus images. Local binary patterns(LBP) and Daugman’s algorithm are used to perform the feature set *** histogram features are computed for both the magnitude and phase components. The Euclidean distance between the feature vectors are analyzed to predict glaucoma. The performance of the proposed method is compared with the higher order spectra(HOS)features in terms of sensitivity, specificity, classification accuracy and execution time. The proposed system results 95.45% output for sensitivity, specificity and classification. Also, the execution time for the proposed method takes lesser time than the existing method which is based on HOS features. Hence, the proposed system is accurate, reliable and robust than the existing approach to predict the glaucoma features.

关键词： Daugman's algorithm Euclidean distance glaucoma higher order spectra histogram features local binary patterns

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Non-densely defined impulsive neutral stochastic functional differential equations driven by fBm in Hilbert space with infinite delay

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Frontiers of Mathematics in China 2015年第2期10卷 351-365页

作者： Yong REN Tingting HOU R. sakthivel Department of Mathematics Anhui Normal University Wuhu 241000 China Department of Mathematics Sungkyunkwan University Suwon 440-746 Korea

We study a class of non-densely defined impulsive neutral stochastic functional differential equations driven by an independent cylindrical fractional Brownian motion （fBm） with Hurst parameter H ∈ （1/2, 1） in the Hilbert space. We prove the existence and uniqueness of the integral solution for this kind of equations with the coefficients satisfying some non-Lipschitz conditions. The results are obtained by using the method of successive approximation.

关键词： Stochastic functional differential equation non-densely defined operator cylindrical fractional Brownian motion (fBm) impulsive effect

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Studies on rock magnetic and paleointensity of some archaeological artifacts from Tamilnadu,India

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 988-993页

作者： Chellachamy manoharan Kasinathan VEERAMUTHU Ramdoss VENKATACHALAPATHY Ramasamy ILANGO Department of Physics Annamalai UniversityAnnamalai Nagar 608002TamilnaduIndia Department of Physics RKM Vivekananda CollegeChennai 600004TamilnaduIndia

This study investigates the magnetic mineralogy and paleointensity values of a collection of archaeological artifacts(pottery) . The actual magnetic carriers and their domain states present in the archaeological pottery were obtained using the low field susceptibility,thermomagnetic curves and acquisition of isothermal remanence. The magnetic mineralogy of all the samples was dominated by ferrimagnetic mineral(magnetite/magnetite with low titanium content) ,which was suitable for paleointensity measurements. The geomagnetic paleointensity value obtained by subjecting them to modified Thellier and Thellier method,is found to be(48.81±0.15) μT.

关键词： Magnetic susceptibility Archaeological pottery Paleointensity

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