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土壤碳储量及其碳固定研究

皖西学院学报 2014年第2期30卷 124-128页

作者：武曼曼马友华王强杨书运徐小牛张贵友安徽农业大学安徽合肥230036

土壤碳库是陆地生态系统中最大且周转时间最慢的碳库,全球碳储量的最低值为719Pg,最高值为2 946Pg,中国土壤总有机碳库最高值接近180Pg。在对现有资料整理的基础上,着重讨论了土壤碳储量及其估计方法,包括森林类型法、土壤类型法、生命... 详细信息

土壤碳库是陆地生态系统中最大且周转时间最慢的碳库,全球碳储量的最低值为719Pg,最高值为2 946Pg,中国土壤总有机碳库最高值接近180Pg。在对现有资料整理的基础上,着重讨论了土壤碳储量及其估计方法,包括森林类型法、土壤类型法、生命带类型法、模型法和遥感影像法等,分析了影响农业土壤固碳主要有气候因素、土壤理化性质因素和农业耕作措施等因素,指出农田土壤的碳固定将成为今后研究的热点,研究土壤与大气、植被碳库之间的碳交换过程,成为我们下一步工作的重点。

关键词：土壤碳储量固碳潜力气候遥感农业

Quorum sensing-based interactions among drugs,microbes,and diseases

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Science China(Life Sciences) 2023年第1期66卷 137-151页

作者： Shengbo wu Shujuan Yang manman Wang Nan Song Jie Feng Hao wu Aidong Yang Chunjiang Liu Yanni Li Fei Guo Jianjun Qiao School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China School of Computer Science and Engineering Central South UniversityChangsha 410083China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Key Laboratory of Systems Bioengineering Ministry of Education(Tianjin University)Tianjin 300072China School of Computer Science and Technology College of Intelligence and ComputingTianjin UniversityTianjin 300350China Department of Engineering Science University of OxfordOxford OX13PJUK Institute of Shaoxing Tianjin UniversityShaoxing 312300China

Many diseases and health conditions are closely related to various microbes,which participate in complex interactions with diverse drugs;nonetheless,the detailed targets of such drugs remain to be *** existing studies have reported causal associations among drugs,gut microbes,or diseases,calling for a workflow to reveal their intricate *** this study,we developed a systematic workflow comprising three modules to construct a Quorum Sensing-based Drug-Microbe-Disease(QSDMD)database(http://***/),which includes diverse interactions for more than 8,000 drugs,163 microbes,and 42 common *** interactions between microbes and more than 8,000 drugs have been systematically studied by targeting microbial QS receptors combined with a docking-based virtual screening technique and in vitro experimental ***,we have constructed a QS-based drug-receptor interaction network,proposed a systematic framework including various drug-receptor-microbe-disease connections,and mapped a paradigmatic circular interaction network based on the QS-DMD,which can provide the underlying QS-based mechanisms for the reported causal *** QS-DMD will promote an understanding of personalized medicine and the development of potential therapies for diverse *** work contributes to a paradigm for the construction of a molecule-receptor-microbe-disease interaction network for human health that may form one of the key knowledge maps of precision medicine in the future.

关键词： quorum sensing drugs microbe-disease association microbe-host interaction gut microbiota personalized medicine

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切花多头菊耐低温品种筛选与组培苗生长差异

浙江农业科学 2024年第8期65卷 1843-1850页

作者：徐智豪付曼曼丁晓瑜吴超郭方其嘉兴嘉德园艺有限公司浙江嘉善314113 浙江省农业科学院浙江杭州310021

以28个切花多头菊品种为试验材料,通过15个农艺性状测量和评分,将性状赋值64分作为品种入选值,筛选出耐低温优良切花多头菊品种18个,表现光反应周期和生育期短或较短,当花芽分化期经历日最低温8℃,花蕾形成和发育正常,切花品质符合市场... 详细信息

以28个切花多头菊品种为试验材料,通过15个农艺性状测量和评分,将性状赋值64分作为品种入选值,筛选出耐低温优良切花多头菊品种18个,表现光反应周期和生育期短或较短,当花芽分化期经历日最低温8℃,花蕾形成和发育正常,切花品质符合市场需要,研究结果可为冬季切花多头菊设施栽培品种选择和组培苗繁育提供参考。

关键词：切花多头菊浙江低温品种筛选综合评价

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罗伟生从脾论治非酒精性脂肪肝

中医药临床杂志 2022年第5期34卷 843-846页

作者：梁皓廖丹丹伍漫漫陈启帆梁瀞云李春林罗伟生广西中医药大学广西南宁530000 广西中医药大学附属瑞康医院广西南宁530000

非酒精性脂肪性肝是一种动态疾病,它可能会发展成非酒精性脂肪肝炎、肝纤维化、肝硬化和肝癌等严重肝脏疾病。随着肥胖率的不断升高以及西方化饮食的影响,患病率呈逐年上升趋势。目前西医学对该病主要致病驱动因素及发病机制仍认识不足... 详细信息

非酒精性脂肪性肝是一种动态疾病,它可能会发展成非酒精性脂肪肝炎、肝纤维化、肝硬化和肝癌等严重肝脏疾病。随着肥胖率的不断升高以及西方化饮食的影响,患病率呈逐年上升趋势。目前西医学对该病主要致病驱动因素及发病机制仍认识不足,治疗尚无特效药,且长期来看副作用大。结合中医学理论,罗伟生教授认为非酒精性脂肪肝虽然病位在肝,但病机关键在脾,源于脾虚失运,气机失调,而致痰、湿、热、淤等病理产物。治疗方案当先“疏其血气,另其调达”;其后“损有余而补其不足”;最终而达到“阴阳平衡”。

关键词：非酒精性脂肪肝重土思想辨证论治中医治疗

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柴胡疏肝散在肝脏疾病中的应用研究进展

陕西中医 2022年第11期43卷 1651-1653页

作者：梁瀞云唐燕司马玲伍漫漫廖丹丹梁皓陈启帆罗伟生广西中医药大学广西南宁530200

柴胡疏肝散出自《景岳全书》,由柴胡、川芎、陈皮、芍药、香附、炙甘草、炒枳壳7味中药组成,其主要功效为疏肝解郁、理气止痛,常用于治疗肝郁气滞引起的两胁肋部疼痛,胸闷善太息,情绪急躁易怒,反酸嗳气,脘腹胀满等。现代药理学研究发现... 详细信息

柴胡疏肝散出自《景岳全书》,由柴胡、川芎、陈皮、芍药、香附、炙甘草、炒枳壳7味中药组成,其主要功效为疏肝解郁、理气止痛,常用于治疗肝郁气滞引起的两胁肋部疼痛,胸闷善太息,情绪急躁易怒,反酸嗳气,脘腹胀满等。现代药理学研究发现,其组方主要包含皂苷类、黄酮类、酚酸类、萜类四种成分,具有抗炎、镇痛、护肝、抗肿瘤等多种药理作用,应用于各种肝脏疾病中可以有效改善患者症状、体征,改善肝功能、肝纤维化、血脂指标,提高患者生存质量。现从柴胡疏肝散近年来在肝纤维化、肝癌、肝硬化、脂肪肝、慢性胆囊炎等肝脏疾病中的相关应用,对柴胡疏肝散的最新研究动态进行综述,为临床应用柴胡疏肝散治疗肝脏疾病提供依据。

关键词：肝纤维化肝癌肝硬化脂肪肝柴胡疏肝散

A comparative study on grid resource utilization rate between China Southern Power Grid and National Grid Plc of UK

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Protection and Control of Modern Power Systems 2018年第1期3卷 286-293页

作者： Long Zhou Di Zhang Weijie wu manman Zhu Hanyu Yang Canbing Li Ge Li Fei Li Mingjian Cui Information Center Guangdong Power Grid Company LimitedGuangzhou 528000China College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Planning and Research Center Guangdong Power Grid Company LimitedGuangzhou 528000China Department of Electrical Engineering Southern Methodist UniversityDallas 75275USA

Grid resource utilization rate plays a key role in power grid *** the proportion of population and the area in China Southern Power Grid(CSG)and National Grid Plc of UK(NG)are nearly,grid resources utilization of CSG is lower than that of *** this paper,the utilization of human resources and equipment resources of CSG and NG have been *** is discovered that there is a large gap between these two *** results show that the utilization in CSG is about 20%to 50%of that in *** it is estimated that if the equipment resources utilization of CSG increases to the level of NG in 2012,the coal consumption and thus CO2 emissions would be reduced by 17 million tons and 21 million tons,*** China is a developing country and Britain is a mature developed country,it is to some extent reasonable that grid resources utilization of CSG is lower than that of *** benefits of improving equipment resources utilization are illustrated in detail,which provided the reference for developing the grid resource utilization in China.

关键词： Electrical equipment Human resources Power grid enterprises Energy saving

Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia

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Journal of Materials Science & Technology 2016年第9期32卷 978-985页

作者： Shaoming Chen manman Gao Zhiyu Zhou Jiabi Liang Ming Gong Xuejun Dai Tangzhao Liang Jiacheng Ye Gang wu Lijin Zou Yingjun Wang Xuenong Zou Orthopedic Department The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology/Orthopedic Research Institute The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510075China Department of Spine Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou 510006China Department of Burn Surgery and Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330000China

Although cartilage tissue engineering has been developed for decades, it is still unclear whether angio- genesis was the accompaniment of chondrogenesis in cartilage regeneration. This study aimed to explore the process of anti-angiogenesis during cartilage regenerative progress in cartilage repair extracellular matrix （ECM） materials under Hypoxia. C3H10T1/2 cell line, seeded as pellet or in ECM materials, was added with chondrogenic medium or DMEM medium for 21 days under hypoxia or normoxia environment. Genes and miRNAs related with chondrogenesis and angiogenesis were detected by RT-qPCR technique on Days 7, 14, and 21. Dual-luciferase report system was used to explore the regulating roles of miRNAs on angiogenesis. Results showed that the chondrogenic medium promotes chondrogenesis both in pellet and ECM materials culture. HIF1α was up-regulated under hypoxia compared with normoxia （P 〈 0.05）. Meanwhile, hypoxia enhanced chondrogenesis, miR-140-Sp exhibited higher expression while miR-146b exhibited lower expression. The chondrogenic phenotype was more stabilized in the ECM materials in chondrogenic medium than DMEM medium, with lower VEGFα expression even under hypoxia. Dual-luciferase report assays demonstrated that miR-140-5p directly targets VEGFct by binding its 3＇- UTR. Taken together, chondrogenic cytokines, ECM materials and hypoxia synergistically promoted chondrogenesis and inhibited angiogenesis, miR-140-5p olaved an imnortant role in this process.

关键词： Biomaterials Bio-adaptation Hypoxia Chondrogenesis Angiogenesis miRNAs

全二维气相色谱-飞行时间质谱法检测两种玫瑰精油成分

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香料香精化妆品 2021年第2期 13-24页

作者：乔佳黄豆曹烙文岑延相谢文东麦泽彬李磊黄正旭周振吴曼曼广州禾信仪器股份有限公司广东广州510530 暨南大学质谱仪器与大气环境研究所广东广州510632 北京市产品质量监督检验院北京101300

建立了全二维气相色谱-飞行时间质谱联用法测定土耳其玫瑰精油和苦水玫瑰精油成分的分析方法。样品经过稀释后进样分析,两种玫瑰精油共计检出501种成分,通过质谱数据库比对后选择正反匹配度均大于800的色谱峰,共有329种成分得到鉴定,两... 详细信息

建立了全二维气相色谱-飞行时间质谱联用法测定土耳其玫瑰精油和苦水玫瑰精油成分的分析方法。样品经过稀释后进样分析,两种玫瑰精油共计检出501种成分,通过质谱数据库比对后选择正反匹配度均大于800的色谱峰,共有329种成分得到鉴定,两种精油分别鉴定出246和193种成分。329种成分中醇类74种、烯烃类80种、酯类71种、醛类31种、酮类23种、烷烃类15种、芳香烃类18种、醚类3种、酚类2种、其他类12种,为两种玫瑰精油共有的成分有110种,但共有成分在不同玫瑰精油中的含量存在明显差异。在构成玫瑰精油的10类化合物中,醇类均为含量最高的成分种类,而其他类化合物的种类和含量也存在差异。

关键词：玫瑰精油香气成分全二维气相色谱-飞行时间质谱联用法

A Leaking-Proof Theranostic Nanoplatform for Tumor-Targeted and Dual-Modality Imaging-Guided Photodynamic Therapy

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Biomedical Engineering Frontiers 2023年第1期4卷 187-196页

作者： Duo Jin Yang Zhu manman Liu Wenxin Yu Jiaji Yu Xinwei Zheng Lulu Wang Yun wu Kaiju Wei Junjie Cheng Yangzhong Liu Department of Chemistry University of Science and Technology of ChinaHefei 230001China High Magnetic Field Laboratory Chinese Academy of SciencesHefei 230031China Nano Science and Technology Institute Suzhou Institute for Advanced StudyUniversity of Science and Technology of ChinaSuzhou 215123China

Objective:A protein-based leaking-proof theranostic nanoplatform for dual-modality imaging-guided tumor photodynamic therapy(PDT)has been *** Statement:A site-specific conjugation of chlorin e6(Ce6)to ferrimagnetic ferritin(MFtn-Ce6)has been constructed to address the challenge of unexpected leakage that often occurs during small-molecule drug ***:PDT is one of the most promising approaches for tumor treatment,while a delivery system is typically required for hydrophobic ***,the nonspecific distribution and leakage of photosensitizers could lead to insufficient drug accumulation in tumor ***:An engineered ferritin was generated for site-specific conjugation of Ce6 to obtain a leaking-proof delivery system,and a ferrimagnetic core was biomineralized in the cavity of ferritin,resulting in a fluorescent ferrimagnetic ferritin nanoplatform(MFtn-Ce6).The distribution and tumor targeting of MFtn-Ce6 can be detected by magnetic resonance imaging(MRI)and fluorescence imaging(FLI).Results:MFtn-Ce6 showed effective dual-modality MRI and FLI.A prolonged in vivo circulation and increased tumor accumulation and retention of photosensitizer was *** time-dependent distribution of MFtn-Ce6 can be precisely tracked in real time to find the optimal time window for PDT *** colocalization of ferritin and the iron oxide core confirms the high stability of the nanoplatform in *** results showed that mice treated with MFtn-Ce6 exhibited marked tumor-suppressive activity after laser ***:The ferritin-based leaking-proof nanoplatform can be used for the efficient delivery of the photosensitizer to achieve an enhanced therapeutic *** method established a general approach for the dual-modality imagingguided tumor delivery of PDT agents.

关键词： proof distribution retention