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The role of serratiopeptidase in the resolution of inflammation

Asian Journal of Pharmaceutical Sciences 2017年第3期12卷 209-215页

作者： manju tiwari Department of Biochemistry and Genetics Barkatullah University

Inflammation remains a key event during most of the diseases and physiological imbalance. Acute inflammation is an essential physiological event by immune system for a protective measure to remove cause of inflammation and failure of resolution lead to chronic inflammation. Over a period of time, a number of drugs mostly chemical have been deployed to combat acute and chronic inflammation. Recently, enzyme based anti-inflammatory drugs became popular over conventional chemical based drugs. Serratiopeptidase, a proteolytic enzyme from trypsin family, possesses tremendous scope in combating inflammation. Serine protease possesses a higher affinity for cyclooxygenase(COX-Ⅰ and COX-Ⅱ), a key enzyme associated with production of different inflammatory mediators including interleukins(IL),prostaglandins(PGs) and thromboxane(TXs) etc. Currently, arthritis, sinusitis, bronchitis,fibrocystic breast disease, and carpal tunnel syndrome, etc. are the leading inflammatory disorders that affected the entire the globe. In order to conquer inflammation, both acute and chronic world, physician mostly relies on conventional drugs. The most common drugs to combat acute inflammation are Nonsteroidal anti-inflammatory drugs(NSAIDs) alone and or in combination with other drugs. However, during chronic inflammation, NSAIDs are often used with steroidal drugs such as autoimmune disorders. These drugs possess several limitations such as side effects, ADR, etc. In order to overcome these limitations and complications, enzyme based drugs(anti-inflammatory) emerged, and aim for a new high since the last decade. Serine protease, the largest proteolytic family has been reported for several therapeutic applications, including anti-inflammatory. Serratiopeptidase is a leading enzyme which has a very long history in medical as an effective anti-inflammatory drug. Current study emphasizes present scenario and future prospect of serratiopeptidase as an antiinflammatory drug. The study also illustrate

关键词： Inflammation Cyclooxygenase NSAIDs Serratiopeptidase Steroids Enzyme therapeutics

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Glucose 6 phosphatase dehydrogenase (G6PD) and neurodegenerative disorders:Mapping diagnostic and therapeutic opportunities

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Genes & Diseases 2017年第4期4卷 196-203页

作者： manju tiwari Department of Biochemistry and Genetics Barkatullah UniversityBhopalMadhya PradeshIndia

Glucose 6 phosphate dehydrogenase(G6PD)is a key and rate limiting enzyme in the pentose phosphate pathway(PPP).The physiological significance of enzyme is providing reduced energy to specific cells like erythrocyte by maintaining co-enzyme nicotinamide adenine dinucleotide phosphate(NADPH).There are preponderance research findings that demonstrate the enzyme(G6PD)role in the energy balance,and it is associated with bloodrelated diseases and disorders,primarily the anemia resulted from G6PD *** Xlinked genetic deficiency of G6PD and associated non-immune hemolytic anemia have been studied widely across the *** advancement in biology,more precisely neuroscience has revealed that G6PD is centrally involved in many neurological and neurodegenerative *** neuroprotective role of the enzyme(G6PD)has also been established,as well as the potential of G6PD in oxidative damage and the Reactive Oxygen Species(ROS)produced in cerebral *** G6PD deficiency remains a global health issue,however,a paradigm shift in research focusing the potential of the enzyme in neurological and neurodegenerative disorders will surely open a new avenue in diagnostics and enzyme ***,in this study,more emphasis was made on exploring the role of G6PD in neurological and inflammatory disorders as well as non-immune hemolytic anemia,thus providing diagnostic and therapeutic opportunities.

关键词： Glucose 6 phosphate dehydrogenase Hemolytic anemia Metabolic disorders Neurodegenerative disorders

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Insulin receptors in the kidneys in health and disease

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World Journal of Nephrology 2019年第1期8卷 11-22页

作者： Sarojini Singh Rajni Sharma manju Kumari Swasti tiwari Department of Molecular Medicine and Biotechnology Sanjay Gandhi Postgraduate Institute of Medical Sciences

Insulin is an important hormone that affects various metabolic processes,including kidney *** in insulin's action leads to insulin resistance in the target *** defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target *** kidney is a known target of insulin;however,whether the kidney develops "insulin resistance" is *** of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose *** physiological relevance of IRs in the kidney has recently begun to be *** credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance ***,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this *** this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states.

关键词： Insulin receptor Insulin resistance Kidney disease Renal sodium reabsorption Gluconeogenesis Proteinuria Systemic blood pressure

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