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Rice science 2024年第4期31卷 366-370,I0004-I0014页

作者： manisha sharma Dhananjay RATURI Vijay Rani RAJPAL Manju CHAUDHARY Soom Nath RAINA Apekshita SINGH Amity Institute of Biotechnology Amity University Uttar PradeshSector-125UP 201313India Department of Botany Hansraj CollegeUniversity of DelhiDelhi 110007India

In this study, 32 black rice genotypes spanning diverse geographies in India were evaluated at both phenotypic and DNA sequence levels to gain insights into their genetic makeup. Significant variations were observed f... 详细信息

关键词： Indian Morphological Traits

Recent development in asymmetric organocatalytic domino reactions involving 1,6-addition as a key step

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Organic Chemistry Frontiers 2022年第2期9卷 572-592页

作者： Yaseen Hussain Tamanna manisha sharma Akshay Kumar Pankaj Chauhan Department of Chemistry Indian Institute of Technology JammuJagtiNH-44Nagrota BypassJammu181221 J&KIndia Department of Chemistry DAV UniversityPathankot-Jalandhar RoadJalandhar 144001PunjabIndia

Due to their unique activation modes,small organic molecule catalysts(organocatalysts)have proved their potential in facilitating the remote functionalizations of unsaturated acceptors with extended *** organocatalytic 1,6-addition reaction involving the attack of nucleophiles on the δ-carbon of the α,β,γ,δ-unsaturated acceptors has emerged as an excellent strategy to create a stereocenter at the δ-site with high regio-and *** has also opened the window for developing complex domino reactions involving the 1,6-addition *** advancement has been accomplished in the organocatalytic asymmetric 1,6-addition and related domino reactions for the stereocontrolled synthesis of complex molecular structures bearing multiple *** review article summarizes the significant advancement in stereoselective domino reactions involving 1,6-addition as a critical step.

关键词： domino asymmetric stereo

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

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World Journal of Gastroenterology 2007年第11期13卷 1706-1710页

作者： Bhavneesh sharma manisha sharma Mradul Kumar Daga Gopal Krishan Sachdev Elliott Bondi Brookdale University Hospital and Medical Center Division of Pulmonary and Critical Care Medicine State University of New York Brooklyn New York 11212 United States University of Delhi Maulana Azad Medical College Divisions of Pulmonary Medicine and Gastroenterology New Delhi 110002 India

AIM： To study the effect of combined omeprazole（Ome） and domperidone（Dom） therapy on asthma symptoms and pulmonary function in asthmatics with gastroesoph- ageal reflux. METHODS： We selected 198 asthmatics with gastro- esophageal reflux diagnosed by 24-h esophageal pH moni- toring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk （1：1 double-blind randomization）. Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were： mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication （number of puffs）, daytime and nighttime peak expiratory flow rate （PEFR）, postbronchodilator forced expiratory volume in 1 second （FEVl） and postbronchodilator forced vital capacity （FVC） were secondary outcome measures. RESULTS： Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score （17.4% vs 8.9 %）, nighttime asthma symptom score （19.6% vs 5.4%）, reflux symptom score （8.7% vs 1.6%） and rescue medication use （23.2% vs 3.1%） after antireflux therapy compared to mean change in placebo group （P 〈 0.001）. There was significant improvement in morning PEFR （7.9% vs 0.2%）, evening PEFR （9.8% vs 0.5%）, FEW （11.1% vs 3.78%） and FVC （9.3%vs 1.52%） in the antireflux therapy group compared to placebo on comparng the mean change from baseline after 16 wk （P 〈 0.01） CONCLUSION： Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medi- cation use, and improving pulmonary function.

关键词： Asthma Reflux Gastroesophageal reflux disease Antireflux therapy Prokinetic Omeprazole

Comparative Evaluation of Semi Fragile Watermarking Algorithms for Image Authentication

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Journal of Information Security 2012年第3期3卷 189-195页

作者： Archana Tiwari manisha sharma Bhilai Institute of Technology Durg India Chhatrapati Shivaji Institute of Technology Durg India

Technology has no limits today;we have lots of software available in the market by which we can alter any image. People usually copies image from the internet and after some changes they claim that these are their own properties. Insuring digital image integrity has therefore become a major issue. Over the past few years, watermarking has emerged as the leading candidate to solve problems of ownership and content authentications for digital multimedia documents. To protect authenticity of images semi fragile watermarking is very concerned by researchers because of its important function in multimedia content authentication. The aim of this paper is to present a survey and a comparison of emerging techniques for image authentication using semifragile watermarking. In present paper comprehensive overview of insertion and extraction methods used in different semi fragile water marking algorithm are studied using image parameters, potential application, different algorithms are described and focus is on their comparison according to the properties cited above and future directions for developing a better image authentication algorithm are suggested.

关键词： Image Authentication Selective Authentication Content Recovery Robustness Semifragile Watermarking Tamper Detection PSNR

VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： Vijay Kumar sharma manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

Plant studies in Himachal Pradesh,Western Himalaya: a systematic review

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Journal of Mountain Science 2021年第7期18卷 1856-1873页

作者： Himanshu BARGALI manisha MATHELA Rupali sharma Monika sharma Dani YAMING Amit KUMAR Contributed equally to this work Wildlife Institute of India Post box#18Dehradun 248002UttarakhandIndia

Owing to a predicted rise in temperature,increase in precipitation and the escalating anthropogenic stresses,the Himalayan ecosystems are the most threatened non-polar regions of the *** the past,there have been racing extinctions and range shifts of several life forms in this region,particularly of the plant ***,consistent qualitative and quantitative records on botanical baseline data on a regular basis are *** current communication attempts to provide a detailed account on the current state of knowledge and research gaps in floristic studies of Himachal Pradesh,Western *** on an extensive review of more than 140 studies in the form of scientific peer reviewed literature on floristics,medicinal and aromatic plants(MAPs),rare,endangered,threatened and endemic species and ethno-botany,it is revealed that the number of floristic studies in Himachal Pradesh have surged in the past years but studies pertaining to the lower plants remain ***,the remote valleys including micro-watersheds lying in the coldarid regions are relatively less studied in terms of available growing stock and population status of *** traditional ethno-botanical knowledge has been the major concern and,many threatened MAPs need to be accessed globally following IUCN ***,documentation of the conservation status of key MAPs,setting aside conservation areas around viable populations of threatened species,developing germplasm banks of the priority MAPs and monitoring the impacts of climate change has been suggested.

关键词： Biodiversity Ethno-botany Flora Medicinal plants Threatened plants Western Himalaya

Mucormycosis – resurgence of a deadly opportunist during COVID-19 pandemic: Four case reports

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World Journal of Clinical Cases 2021年第36期9卷 11338-11345页

作者： Shalini Upadhyay Tanisha Bharara manisha Khandait Ankit Chawdhry Bharat Bhushan sharma Department ofMicrobiology SGT UniversityGurugram 122505HaryanaIndia Department of Oral and Maxillofacial Surgery SGT UniversityGurugram 122505HaryanaIndia Department of Radiology SGT UniversityGurugram 122505HaryanaIndia

BACKGROUND Coronavirus disease 2019(COVID-19)patients who suffer severe infection or comorbidities have an increased risk of developing fungal *** is a possibility that such infections are missed or misdiagnosed,in which case patients may suffer higher morbidity and ***-19 infection,aggressive management strategies and comorbidities like diabetes render patients prone to opportunistic fungal *** is one of the opportunistic fungal infections that may affect treated COVID *** SUMMARY We present a case series of four adult males who were diagnosed with mucormycosis post-COVID-19 *** the patients had diabetes and a history of systemic corticosteroids for treatment of *** mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.5±14.5(7–30)*** patients underwent debridement and were started on antifungal *** patient was referred to a higher center for further management,but the others responded well to treatment and showed signs of improvement at the last *** Early diagnosis and management of mucormycosis with appropriate and aggressive antifungals and surgical debridement can improve survival.

关键词： Zygomycetes Fungal infection COVID-19 co-infection Diabetes mellitus Case series Case report

Nosocomial diarrhea in children:is astrovirus the leading pathogen?

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 410-411页

作者： Anita Chakravarti manisha Jain Mayank Singh Chauhan Anju sharma Sayani Tewari Department & institution Department of MicrobiologyMaulana Azad Medical CollegeBahadur Shah Zafar MargNew Delhi 110002

Objective:To screen for the presence of mixed infection with ***:The present study included 140 children aged less than 2 years with acute *** samples of all these patients were analyzed for the presence of astroviral antigen by enzyme *** 40 rotavirus positive fecal samples were screened for the presence of ***:In case of acute diarrhea in children the prevalence of astrovirus was around 34% (48/140).It was seen that even in rotavirus positive cases astrovirus co infection was 25% .Conclusions:Astrovirus is a growing problem which is often *** the rotavirus vaccine licensure being imminent astrovirus will emerge out as the single most important cause of viral

关键词： Astrovirus Diarrhea Children

Impact of vericiguat on heart failure with reduced ejection fraction:a review

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Global Health Journal 2023年第3期7卷 123-129页

作者： manisha Vohra Mohammad Amir Ian Osoro Amit sharma Ranjeet Kumar Department of Pharmacy Practice ISF College of PharmacyMogaPunjab 142001India

Introduction:Heart failure is a major public health issue with a prevalence of about 26 million people *** nitric oxide availability,lower soluble guanylate cyclase(sGC)activity,and decreased cyclic guanosine monophosphate(cGMP)production are the causes of HF's *** prescribed under the brand name Verquvo was approved by *** and Drug Administration(FDA)in January *** is a novel agent and the first sGC stimulator which helps to treat patients suffering from heart failure with reduced ejection fraction(HFrEF).Objective:The mechanism of action(cGMP pathway)of vericiguat,its clinical trials,its use in the treatment of heart failure,and its possible future aspects in therapeutic recommendations are all covered in this *** will also raise awareness amongst healthcare professionals about the pharmacokinetic and pharmacodynamic parameters,dosing,administration,and drug-related problems of this new ***:Various databases for drug review were used in this review like PubMed,Medline,Google scholar,Drug bank,***,Medscape,and European society of cardiology guidelines.A total of 58 articles were screened out of which 39 articles were included in this ***:This review discusses vericiguat's mechanism of action(cGMP pathway),clinical studies,application in the treatment of heart failure,and potential future considerations in therapeutic *** will also educate healthcare professionals about the new drug's pharmacokinetics and pharmacodynamics,dose,administration,and drug-related ***:After hospitalization for HFrEF,the 5-year survival rate is just 25%,and disease morbidity and death are stil *** adjunctive therapy for individuals with heart failure and a low ejection fraction,vericiguat has a moderate level of ***'s efficacy as an adjunct therapy to different drugs used to cure HF has to be further ***'s safety and dosage in patients w

关键词： Vericiguat Heart failure with reduced ejection fraction Soluble guanylate cyclase stimulator Nitric oxide Cyclicguanosinemonophosphate

Pregnancy outcomes following supplementation of single dose GnRH agonist to sustain the luteal phase in antagonist fresh embryo transfer cycles:A multicentric prospective cohort study

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Asian pacific Journal of Reproduction 2023年第4期12卷 162-169页

作者： Tatapudi S V Parvathi Devi Alka Gahlot Sangita sharma manisha Choudhary Ravikant Soni Meeta sharma Department of Reproductive Medicine&Surgery Mahatma Gandhi Medical College&HospitalJaipurIndia Department of Biochemistry Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia Department of Reproductive Medicine&Surgery Senior EmbryologistMahatma Gandhi Medical College&HospitalJaipurIndia

Objective:To determine whether a single dose of gonadotropin-releasing hormone(GnRH)agonist administered subcutaneously in addition to the regular progesterone supplementation could provide a better luteal support in antagonist protocol fresh embryo transfer ***:This prospective,multicentric,cohort study included total 140 women,70 in each *** ovarian stimulation was carried out as per fixed GnRH antagonist *** trigger was given with *** vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)was performed and day-3 embryos were *** were divided into groups 1 and 2 based on computer generated randomization *** days following oocyte retrieval,group 1 received 0.2 mg decapeptyl subcutaneously in addition to regular progesterone support while group 2 received progesterone *** support was given for 14 days to both groups;if pregnancy was confirmed luteal support was continued till 12 weeks of *** clinical pregnancy rate was the primary *** implantation rate,miscarriage rate,live birth delivery rate,and multiple pregnancy rates were the secondary ***:A total of 140 patients were analysed,70 in each *** pregnancy rates(47.1%vs.35.7%;P=0.17),implantation rates(23.4%vs.18.1%,P=0.24),live birth delivery rates(41.4%vs.27.1%,P=0.08),and multiple pregnancy rates(21.2%vs.16.0%,P=0.74)were higher in group 1 than in group *** 1 had a lower miscarriage rate than group 2(5.7%vs.8.6%;P=0.75).However,these differences were not statistically significant between the two ***:Administration of a single dose of GnRH agonist in addition to regular natural micronized vaginal progesterone as luteal support in GnRH antagonist protocol cycles marginally improves implantation rates,clinical pregnancy rates,and live birth delivery ***,more studies with higher sample sizes are needed before any conclusive statements about GnRH agonist as luteal phase suppo

关键词： GnRH agonist Triptorelin IVF Ovum pick up Luteal phase support Antagonist protocol Cleavage stage Fresh embryo transfer Live birth delivery rate