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Radiographic characteristics of neuroendocrine liver metastases do not predict clinical outcomes following liver resection

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 1-12,中插1页

作者： Emily A.Armstrong Eliza W.Beal manisha shah Bhavana Konda Sherif Abdel-Misih Aslam Ejaz Mary E.Dillhoff Timothy M.Pawlik Jordan M.Cloyd The Ohio State University College of Medicine ColumbusOHUSA Department of Surgery Division of Surgical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA Department of Internal Medicine Division of Medical OncologyThe Ohio State University Wexner Medical CenterColumbusOHUSA

Background: Previous research has demonstrated that specific radiographic criteria, including the presence of calcifications and the enhancement pattern on computed tomography (CT) imaging, correlates with clinicopathologic features and outcomes of patients with gastroenteropancreatic neuroendocrine tumors (NET). We sought to investigate whether these radiographic characteristics were prognostic among patients with neuroendocrine liver metastases (NELM) undergoing surgical resection. Methods: The preoperative contrast-enhanced CT scans of all patients who underwent resection of NELM at a single institution between 2000-2015 were retrospectively reviewed. The presence of calcifications was determined on non-contrast phase imaging. Enhancement on the arterial phase scan was categorized as hyperenhancing, hypoenhancing, or mixed. Relevant clinicopathologic characteristics as well as recurrence-free survival (RFS) and overall survival (OS) were compared between groups. Results: Among 82 patients who underwent resection of NELM, 57 had available data on calcifications while 51 had data available on arterial enhancement patterns. Among all patients, median age was 58 (IQR:47-63) and the majority were female (N=48, 59.5%). The most common primary tumor locations were pancreas (N=25, 30.5%) and small bowel (N=27, 32.9%). The most commonly performed operations were right hepatectomy (N=29, 35.4%), bisegmentectomy (N=15, 18.3%), and segmentectomy (N=14, 17.1%). Median tumor number was 4 (IQR: 2-9), median Ki-67 was 5% (IQR: 2-10%), and median size of the largest liver metastasis was 4.5 (IQR: 2.8-7.7) cm. Twelve (21%) patients had tumor calcifications. Among patients with and without calcifications there were no differences in demographics, clinicopathologic characteristics, RFS (P=0.772) or OS (P=0.095). Arterial enhancement was hypoenhancing in 23 (45.1%), hyperenhancing in 10 (19.6%), and mixed in 18 (35.3%). Similarly, there were no differences between arterial enhancemen

关键词： Neuroendocrine tumor (NET) carcinoid hepatectomy radiomics prognosis

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Alternative Strategy for Development of Dielectric Calcium Copper Titanate‑Based Electrolytes for Low‑Temperature Solid Oxide Fuel Cells

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Nano-Micro Letters 2025年第1期17卷 310-332页

作者： Sajid Rauf Muhammad Bilal Hanif Zuhra Tayyab Matej Veis MAKYousaf shah Naveed Mushtaq Dmitry Medvedev Yibin Tian Chen Xia Martin Motola Bin Zhu College of Mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Department of Inorganic Chemistry Faculty of Natural SciencesComenius University BratislavaIlkovicova684215 BratislavaSlovakia Energy Storage Joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096People’s Republic of China Hydrogen Energy Laboratory Ural Federal University620002 EkaterinburgRussia Laboratory of Electrochemical Devices Based on Solid Oxide Proton Electrolytes Institute of High Temperature Electrochemistry620066 EkaterinburgRussia School of Microelectronics Hubei UniversityWuhan 430062People’s Republic of China

The development of low-temperature solid oxide fuel cells(LT-SOFCs)is of significant importance for realizing the widespread application of *** has stimulated a substantial materials research effort in developing high oxide-ion conductivity in the electrolyte layer of *** this context,for the first time,a dielectric material,CaCu_(3)Ti_(4)O_(12)(CCTO)is designed for LT-SOFCs electrolyte application in this *** individual CCTO and its heterostructure materials with a p-type Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ)(NCAL)semiconductor are evaluated as alternative electrolytes in LT-SOFC at 450–550℃.The single cell with the individual CCTO electrolyte exhibits a power output of approximately 263 mW cm^(-2) and an open-circuit voltage(OCV)of 0.95 V at 550℃,while the cell with the CCTO–NCAL heterostructure electrolyte capably delivers an improved power output of approximately 605 mW cm^(-2) along with a higher OCV over 1.0 V,which indicates the introduction of high hole-conducting NCAL into the CCTO could enhance the cell performance rather than inducing any potential short-circuiting *** is found that these promising outcomes are due to the interplay of the dielectric material,its structure,and overall properties that led to improve electrochemical mechanism in CCTO–***,density functional theory calculations provide the detailed information about the electronic and structural properties of the CCTO and NCAL and their heterostructure CCTO–*** study thus provides a new approach for developing new advanced electrolytes for LT-SOFCs.

关键词： LT-SOFCs Dielectric CaCu_(3)Ti_(4)O_(12) Semiconductor Ni_(0.8)Co_(0.15)Al_(0.05)LiO_(2−δ) Ionic conductivity Heterostructure electrolyte

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Restless head syndrome:A retrospective study

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World Journal of Methodology 2025年第1期15卷 51-59页

作者： Sanjay Prakash Varoon Vadodaria Niraj Chawda Chetsi S shah Anurag Prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Department of Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower *** typically affects the ***,it can also affect several other body regions,such as the arms,abdomen,face,neck,head,and genital *** are only a few reports of the RLS variant affecting the *** To assess the epidemiological,clinical,and other aspects of the RLS variant affecting the *** We conducted a retrospective study of 17 adult patients(>18 years)who met the RLS criteria and simultaneously experienced RLS-like symptoms in the *** The median age at which symptoms appeared was 41.6 *** and females were equally affected(1.1:1).All 17 patients had uncomfortable sensations in the lower *** or disturbed sleep was the most common comorbidity(n=16,88.2%).However,headache was the most common presenting or primary symptom(n=10,70.5%).Dizziness or an abnormal sensation in the head was the second most common presenting symptom(5 patients,29.4%).Other presenting features were leg pain,backache,and generalized body *** patients responded favorably to dopaminergic *** If RLS-related unpleasant sensations and pain are felt in the head,they may be misinterpreted as headache,dizziness,or psychosomatic *** and headaches in a subset of patients may be two phenotypic manifestations of the same disorder.

关键词： Restless legs syndrome Restless head syndrome Dopamine Headache Migraine Tension-type headache

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Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

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World Journal of Methodology 2025年第1期15卷 88-94页

作者： Chinmay Mahatme Madhurima Kaushik Veerappan Rathinasabapathy Saravanan Karthik Kumar Virna M shah Department of General Ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Neuro-ophthalmology Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia Department of Vitreoretina Aravind Eye HospitalCoimbatore 641014Tamil NāduIndia

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management *** and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated *** the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural *** To study the macular microvascular and structural changes on OCTA in atypical optic *** This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy *** vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using *** There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy *** and MOGAD affected eyes had significant GCIPL thinning compared with healthy *** unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected *** comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected *** Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.

关键词： Optical coherence tomography angiography Atypical optic neuritis Macular microvascular changes Neuromyelitis optica spectrum disorders Myelin oligodendrocyte glycoprotein antibody disorder

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Synthesis of Y3Al5O12∶Eu and Y3Al5O12∶Eu,Si phosphors by combustion method: Comparative investigations on the structural and spectral properties

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Journal of Advanced Ceramics 2016年第4期5卷 248-页

作者： manisha UPASANI Department of Physics Rashtrasant Tukadoji Maharaj Nagpur University Nagpur India

This paper reports the comparative investigations of the structural and spectral properties of Y3Al5O12∶Eu3+ (YAG∶Eu) and Y3Al5O12∶Eu3+,Si4+ (YAG∶Eu,Si) phosphors synthesized by combustion method at low temperature.A pure phase was identified for the YAG∶Eu phosphor with a suitable amount of *** refinement and analytical calculation of different structural parameters were performed to get the idea about the SiO2 substitution in YAG∶*** characteristic red luminescence corresponding to Eu3+ transitions was observed after irradiation with ultra violet (UV) light and enhanced with SiO2 *** formula and nephelauxetic ratio were used to understand the ligand behavior of Eu-O bond in YAG doped *** Judd-Ofelt intensity parameters and color properties of the phosphors were determined in *** efficient synthesis method for YAG∶Eu phosphor,compatible for industrial applications,was proposed.

关键词： yttrium aluminum garnet (Y3Al5O12,YAG) light emitting diode (LED) red phosphor combustion synthesis

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Effect of doping of different rare earth（europium,gadolinium,dysprosium and neodymium） metal ions on structural,optical and photocatalytic properties of LaFeO3 perovskites

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Journal of Rare Earths 2019年第12期37卷 1279-1287页

作者： manisha Dhiman Sonal Singhal Department of Chemistry Panjab University

Different rare earth substituted perovskites LaRExFe1-xO3(where RE=Eu3+,Gd3+,Dy3+,Nd3+and x=0.02,0.04,0.06,0.08,0.1)with orthorhombic structure and narrow band gaps were successfully fabricated via sol-gel autocombustion *** the substituted perovskites are found to exhibit excellent photocatalytic activity towards the oxidative degradation of dye *** excellent increase in the rate constant values of pure perovskite(LaFeO3)photocatalytic reactions is observed with the substitution of rare earth metal *** results are obtained for LaNd0.1Fe0.9O3 which exhibits around 7 times increase in the rate constant values for degradation reaction of SO(1.76×10-1 min-1)and RBY(1.69×10-1 min-1)dyes.

关键词： Rare earth substitution Perovskites Sol-gel autocombustion Structural properties Photocatalysis

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Transformation of Sucrose to Starch and Protein in Rice Leaves and Grains under Two Establishment Methods

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Rice science 2016年第5期23卷 255-265页

作者： manisha KUMARI Bavita ASTHIR Department of Biochemistry Punjab Agricultural University

Six rice varieties, PR120, PR116, Feng Ai Zan, PR115, PAU201 and Punjab Mehak 1 were raised under aerobic and transplanting conditions to assess the effects of planting conditions on sucrose metabolising enzymes in relation to the transformation of free sugars to starch and protein in flag leaves and grains. Activities of sucrose synthase, sucrose phosphate synthase and acid invertase increased till flowering stage in leaves and mid-milky stage（14 d after flowering） in grains and thereafter declined in concomitant with the contents of reducing sugar. Under aerobic conditions, the activities of acid invertase and sucrose synthase（cleavage） significantly decreased in conjunction with the decrease in non-reducing sugars and starch content in all the varieties. Disruption of starch biosynthesis under the influence of aerobic conditions in both leaves and grains and the higher build up of sugars possibly resulted in their favoured utilization in nitrogen metabolism. Feng Ai Zan, PR115 and PR120 maintained higher levels of sucrose synthase enzymes in grains and leaves and contents of metabolites（amino acid, protein and non-reducing sugar） under aerobic conditions, while PR116, Punjab Mehak 1 and PAU201 performed better under transplanting conditions, thus showing their adaptation to environmental stress. Yield gap between aerobic and transplanting rice is attributed primarily to the difference in sink activity and strength. Overall, it appear that up-regulation of sucrose synthase（synthesis） and sucrose phosphate synthase under aerobic conditions might be responsible in enhancing growth and productivity of rice varieties.

关键词： aerobic rice acid invertase protein amino acid starch sucrose synthase sucrose phosphate synthase water soluble carbohydrate sugar

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VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： Vijay Kumar Sharma manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

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Adoption of precision agriculture technologies in India and in some developing countries:Scope,present status and strategies

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Progress in Natural Science:Materials International 2009年第6期19卷 659-666页

作者： Pinaki Mondal manisha Basu Department of Agricultural and Food Engineering Indian Institute of Technology International Centre for Automotive Technology 3. National Research Development Corporation

Rapid socio-economic changes in some developing countries, including India, are creating new scopes for application of precision agriculture (PA). The implications of dramatic shifts for economic development, urbanization and energy consumption in some developing countries are immense. High-tech nature of traditional PA technologies developed in advanced countries created a real challenge for engineers to search suitable PA technologies for developing countries. It is expected that application of balanced soft and hard PA technologies based on the need of specific socio-economic condition of a country will make PA suitable for developing countries also. ‘Soft’ PA depends mainly on visual observation of crop and soil and management decision based on experience and intuition, rather than on statistical and scientific analysis. ‘Hard’ PA utilizes all modern technologies such as GPS, RS, and VRT. Three components, namely, ‘single PA technology’, ‘PA technology package’ (for the user to select one or combination) and ‘integrated PA technology’, have been identified as a part of adoption strategies of PA in the developing countries. Therefore, the objective of this paper is to find out the scope, the present status and the strategies for adoption of PA in India and in some developing countries. Application of PA in cash crop, plantation crop, etc. has been discussed. Application of some medium and low-tech PA tools such as chlorophyll meter and leaf colour chart. in small farms has been included. This exhaustive review of the present status of PA in India and in some developing countries is expected to help to find out the adoption trend and direction of future research. Detailed strategy for the adoption of PA in India has also been proposed.

关键词： Precision agriculture Indian agriculture Developing countries Adoption

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Dynamics of a SIR epidemic model with variable recruitment and quadratic treatment

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International Journal of Biomathematics 2023年第7期16卷 219-247页

作者： manisha Mukherjee Biswajit Mondal Department of Mathematics Raja N.L.Khan Women's College Midnapore 721102 West BengalIndia

The dynamical behavior of a variable recruitment SIR model has been investigated with the nonlinear incidence rate and the quadratic treatment function for a horizontally transmitted infectious disease that sustains for a long period(more than one year).For a long duration,we have incorporated human fertility in variable *** societal effort,*** types of medical infrastructures,have a vital role in controlling such a *** this reason,we have considered the quadratic treatment function,which divides the system into two *** have established the existence and stability of different equilibrium points that depend mainly on the societal effort parameter in both subsystems and also global *** rich dynamics such as forward bifurcation,Hopf bifurcation,limit cycle,and Bogdanov-Takens bifurcation of co-dimension 2 have been established by using bifurcation theory and the biological significance of these dynamics has been *** numerical examples have been considered to illustrate the theoretical ***,we have discussed the advantage of our model with the model by Eckalbar and Eckalbar[Nonlinear Anal.:Real World Appl.12(2011)320332].

关键词： Quadratic treatment function endemic equilibrium point Bogdanov-Takens bifurcation disease-free equilibrium point Hopf bifurcation

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