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Sperm membrane modulation by Sapindus mukorossi during sperm maturation

Asian Journal of Andrology 2002年第3期4卷 233-235页

作者： manish nivsarkar Neeta Shrivastava Manoj Patel Harish Padh Cherian Bapu B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Thaltej-Gandhinagar Highway Thaltej Ahmedabad-380 054 Gujarat IndiaB.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Thaltej-Gandhinagar Highway Thaltej Ahmedabad-380 054 Gujarat IndiaB.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Thaltej-Gandhinagar Highway Thaltej Ahmedabad-380 054 Gujarat IndiaB.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Thaltej-Gandhinagar Highway Thaltej Ahmedabad-380 054 Gujarat IndiaB.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Thaltej-Gandhinagar Highway Thaltej Ahmedabad-380 054 Gujarat India

Aim: To observe the alterations in the biochemical and biophysical changes in the sperm membrane during sperm maturation in male rats treated with the water extract of the fruit pericarp of S. mukorossi. Methods: Adult male Sprague-Dawley rats were gavaged the aqueous extract of the fruit pericarp of S. mukorossi at a dose of 50 mg/kg/d for 45 days. On day 46, the sperm parameters were observed in different sections of the epididymis and the sperm superoxide dismutase and the lipid peroxidation was determined and compared with the controls. The testis and epididymis were routinely prepared for histological examination under the light microscope. Results: No significant differences in the sperm number and morphology were observed between the control and treated groups. However, a significant inhibition (P<0.05-0.01) of sperm motility in the caput, corpus and cauda regions of the epididymis was seen in the treated group. No significant histopathological changes were found in the testis and epididymis. The important finding was that in the treated animals, the spermatozoa showed an abnormal distribution of the superoxide dismutase activity, being minimum in the caput and maximum in the corpus, which was just opposite to that of the controls. Conclusion: The study provides a unique observation where the plant extract alters the sperm membrane physiology without change the testicular and epididymal morphology.

关键词： Sapindus mukorossi sperm membrane contraceptive sperm motility

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Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route

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Acta Pharmaceutica Sinica B 2014年第2期4卷 151-160页

作者： Rudree Pathak Ranjeet Prasad Dash Manju Misr manish nivsarkar Department of Pharmaceutics National Institute of Pharmaceutical Education and Research-AhmedabadC/O–B.V.Patel Pharmaceutical Education and Research Development(PERD)CentreAhmedabad 380054GujaratIndia Department of Pharmacology and Toxicology B.V.Patel Pharmaceutical Education and Research Development(PERD)CentreAhmedabad 380054GujaratIndia

Intranasal drug administration is receiving increased attention as a delivery method for by-passing the blood–brain barrier and rapidly targeting therapeutics to the ***,rapid mucociliary clearance in the nasal cavity is a major *** purpose of this study was to evaluate the effect of mucoadhesive polymers in enhancing the delivery of nimodipine microemulsion to the brain via the intranasal *** optimized mucoadhesive microemulsion was characterized,and the in vitro drug release and in vivo nasal absorption of drug from the new formulation were evaluated in *** optimized formulation consisted of Capmul MCM as oil,Labrasol as surfactant,and Transcutol P as co-surfactant,with a particle size of 250 nm and zeta potential value of?15 *** vitro and ex vivo permeation studies showed an initial burst of drug release at 30 min and sustained release up to 6 h,attributable to the presence of free drug entrapped in the mucoadhesive *** vivo pharmacokinetic studies in rats showed that the use of the mucoadhesive microemulsion enhanced brain and plasma concentrations of *** results suggest that incorporation of a mucoadhesive agent in a microemulsion intranasal delivery system can increase the retention time of the formulation and enhance brain delivery of drugs.

关键词： Blood–brain barrier Entrapment Permeation Pharmacokinetics Nasal mucosa

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Anti-leukemic and anti-angiogenic effects of D-Limonene on K562-implanted C57BL/6 mice and the chick chorioallantoic membrane model

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Animal Models and Experimental Medicine 2018年第4期1卷 328-333页

作者： Bhavini B.Shah Ruma Baksi Kiranj K.Chaudagar manish nivsarkar Anita A.Mehta Department of Pharmacology L.M.College of Pharmacy Department of Pharmacology and Toxicology B.V.Patel Pharmaceutical Education and Research Development Centre Department of Surgery University of Chicago

Background: D-Limonene, a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of cancers. In this study, we evaluated the in vivo effect of D-Limonene on a K562-induced model of chronic myeloid leukemia(CML) in C57 BL/6 ***: The tail vein injection model of K562 cells in immunocompromised C57 BL/6 mice was developed and evaluated for characteristics of the disease. The mice were treated with D-Limonene and evaluated for haematological parameters. We also evaluated the effect of D-Limonene on angiogenesis using the chick chorioallantoic membrane(CAM) ***: In a complete blood count, a significant dose-dependent reduction in white blood cell, neutrophil and lymphocyte counts, but an elevation in red blood cell count and haemoglobin content was observed with D-Limonene treatment compared to the disease control or untreated group. In the CAM assay, D-Limonene produced a significant dose-dependent reduction in number of blood vessels in treatment groups compared to the vehicle-treated ***: These studies suggest promising anti-leukemic and anti-angiogenic effects of D-Limonene in the treatment of CML.

关键词： angiogenesis C57BL/6 mice chick chorioallantoic membrane chronic myeloid leukemia D-Limonene

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