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The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana

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Molecular Plant 2023年第7期16卷 1120-1130页

作者： Shiv mani Dubey Soeun Han Nathan Stutzman Michael J.Prigge Eva Medvecka Matthieu Pierre Platre Wolfgang Busch Matyas Fendrych Mark Estelle Department of Experimental Plant Biology Faculty of SciencesCharles UniversityPragueCzech Republic Section of Cell and Developmental Biology University of California San DiegoLa JollaCAUSA Plant Molecular and Cellular Biology Laboratory and Integrative Biology Laboratory Salk Institute for Biological StudiesLa JollaCAUSA Department of Biology Chungbuk National UniversityCheongjuKorea

The phytohormone auxin triggers root growth inhibition within seconds via a *** members of the TIR1/AFB auxin receptor family,AFB1 has a primary role in this rapidresponse. However, the unique features that confer this specific function have not been *** we show that the N-terminal region of AFB1, including the F-box domain and residues thatcontribute to auxin binding,is essential and sufficient for its specific role in the rapid response. Substitutionof the N-terminal region of AFB1 with that of TIR1 disrupts its distinct cytoplasm-enriched localizationand activity in rapid root growth inhibition by auxin. Importantly, the N-terminal region of AFB1 isindispensable for auxin-triggered calcium influx, which is a prerequisite for rapid root growth ***, AFB1 negatively regulates lateral root formation and transcription of auxin-induced genes,suggesting that it plays an inhibitory role in canonical auxin signaling. These results suggest that AFB1may buffer the transcriptional auxin response, whereas it regulates rapid changes in cell growth thatcontributeto rootgravitropism.

关键词： gravitropism calcium auxin signaling Arabidopsis lateral root

SOME NEW GALLMIDGES (DIPTERA:CECIDO MYIIDAE) FROM INDIA

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Entomotaxonomia 1986年第Z1期 13-22页

作者： M.S.mani

The following species of gallmidges, reared from flower galls on differenplants from India are described as new: Lasioptera loyolai, Mikiola bassia-florae, Asphondylia anotisae,Schizomyia clerodendrae, Schizomyia ciss... 详细信息

关键词： body ab FROM INDIA SOME NEW GALLMIDGES DIPTERA

Association of asymptomatic otitis media with effusion in patients with adenoid hypertrophy

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Journal of Otology 2019年第3期14卷 106-110页

作者： Vadisha Bhat Ivan Paraekulam mani Rajeshwary Aroor Marina Saldanha M.K. Goutham Deepika Pratap Department of ENT KS Hegde

Objective: Clinical symptoms of otitis media with effusion are rarely brought forward to the guardians of young children who the disease is most prevalent in. This often leads to poor scholastic performances and difficult social interactions. The objective of this study was to identify asymptomatic cases of otitis media with effusion present in individuals with adenoid hypertrophy. Material and Methods: In a cross sectional study advocated in Justice *** Hospital, Karnataka India we evaluated one hundred patients above the age of three from August 2016 to December 2017. Candidates who presented with an adenoid nasopharyngeal ratio of more than 0.5 were selected for the study. Individuals who complained of otological symptoms were not considered for the study. Patients cleared of other pathological otological conditions were underwent audiological evaluation with pure tone audiometry and tympanometry for evaluating the middle ear status and hearing loss. Results: The study showed a total of 36% of patients evaluated presented with asymptomatic otitis media with effusion. In candidates who presented with a bilateral B tympanogram, 40% had significant conductive hearing loss of more than 25dB. Conclusion: An objective test such as impedance audiometry in all patients with adenoid hypertrophy would aid in the diagnosis of fluid in the middle ear, so that timely intervention can be done and possible complications be averted.

关键词： OME Adenoid hypertrophy Otitis media with effusion Hearing loss in children Glue ear

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Corneal astigmatic outcomes after femtosecond laser-assisted cataract surgery combined with surface penetrating arcuate keratotomies

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1084-1092页

作者： Nick Stanojcic David O’Brart Chris Hull Vijay Wagh Elodie Azan mani Bhogal Scott Robbie Ji-Peng Olivia Li Department of Ophthalmology Guy’s and St.Thomas’NHS Foundation TrustLondon SE17EHUK Centre for Applied Vision Research School of Health SciencesUniversity of LondonLondon EC1V 0HBUK King’s College London London WC2R 2LSUK

AIM:To evaluate corneal astigmatic outcomes of femtosecond laser-assisted arcuate keratotomies(FAKs)combined with femtosecond-laser assisted cataract surgery(FLACS)over 12mo ***:Totally 145 patients with bilateral cataracts and no ocular co-morbidities were recruited to a singlecentre,single-masked,prospective randomized controlled trial(RCT)comparing two monofocal hydrophobic acrylic intraocular *** with corneal astigmatism(CA)of>0.8 dioptres(D)received unpaired,unopened,surface penetrating FAKs at the time of *** acuity,subjective refraction and Scheimpflug tomography were recorded at 1,6,and *** vectoral analyses were ***:Fifty-one patients(61 eyes),mean age 68.2±9.6y[standard deviation(SD)],received *** eyes were available for analysis,except at 12mo when 59 *** were no complications due to *** pre-operative CA was 1.13±0.20 *** was a reduction of astigmatism at all post-operative visits(residual CA 1mo:0.85±0.42 D,P=0.0001;6mo:0.86±0.35 D,P=0001;and 12mo:0.90±0.39,P=0.0001).Alpins indices remained stable over ***,the cohort was under-corrected at all time *** 12mo,61%of eyes were within±15 degrees of pre-operative astigmatic ***:Unpaired unopened penetrating FAKs combined with on-axis phacoemulsification are safe but minimally *** is largely under-corrected in this cohort using an existing unmodified *** effect of arcuate keratotomies on CA remained stable over 12mo.

关键词： femtosecond cataract surgery astigmatic keratotomy laser cataract surgery femtosecond-laser assisted cataract surgery arcuate keratotomy

Advances in Oligoprotection

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Neuroscience & Medicine 2011年第2期2卷 93-103页

作者： Hong Liao Dixit Sanjaya mani 不详

Oligodendrocytes, the myelinating glial cells of the nervous system, in various disease states display great vulnerability to excitotoxic damage, oxidative stress, and inflammatory cytokines. Besides demyelinating diseases where oligoden-drocyte injury is primarily implicated, damage to them also occurs secondarily in various neuropathies. Oligoprotec-tion should, therefore, be looked into something not just as a means for protecting oligodendrocytes alone but also as a common target of protecting neurons and the neurogliovascular unit as a whole. In this review, we provide a descrip-tion on oligodendrocytes, the reasons for their vulnerability, the evolving new concepts of protecting neurovascular unit and recently neurogliovascular unit;the various diseases where oligodendrocyte injury is implicated with a brief idea on different injury mechanisms of oligodendrocytes. Finally, we present the summary of the drugs that have shown promising results in protecting oligodendrocytes or in protecting white matter as a whole in different in-vivo and in-vitro models.

关键词： Oligodendrocytes neurovascular unit oxidative stress excitotoxicity demyelinating diseases stroke spinal cord injury neuropharmacology

Insight into the relationship between non-linear mixed convection and thermal radiation:The case of Newtonian fluid flow due to non-linear stretching

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Propulsion and Power Research 2023年第1期12卷 153-165页

作者： Amit Kumar Pandey Krishnendu Bhattacharyya Anil Kumar Gautam Sohita Rajput mani Shankar Mandal Ali J.Chamkha Dhananjay Yadav Department of Mathematics Institute of ScienceBanaras Hindu UniversityVaranasi-221005Uttar PradeshIndia Department of Mathematics Government General Degree CollegeKalnaeIBurdwan-713405West BengalIndia Faculty of Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait Department of Mathematical and Physical Sciences University of NizwaOman

The current research focuses the light on the characterization of buoyancy-driven non-linear mixed convection and non-linear radiation in a Newtonian flow over a nonlinearly stretching vertical sheet,and this type of flow has useful applications in many industrial processes,such as the paper and pulp industry,polymer industry,electronic device cooling,solar collectors,gas turbine plants,and nuclear *** appropriate transformations,governing PDEs for non-linear mixed convection are reduced to higher-order non-linear ODEs and those are numerically *** with tabular presentations of computed results,the graphical representations are generated to elucidate the effects of involved parameters on convection transport properties and their *** demonstrates that flow velocity increases near the surface and decreases away from the surface as the non-linear convection parameter ***,increments in the thermal buoyancy,temperature ratio and non-linear radiation parameters result in the boost of *** temperature decreases as linear and non-linear buoyancy-related parameters(non-linear convection and thermal buoyancy parameters)are of higher *** contrast,the temperature rises with two non-linear thermal radiation-related parameters(thermal ratio and non-linear radiation parameters).For greater values of the non-linear stretching related parameter,a lower velocity and a higher temperature are *** non-linear convection,thermal buoyancy,thermal ratio and non-linear radiation parameters contribute toward the reduction of the magnitude of surface-drag force and growth of the surface cooling ***,with the non-linearity in surface stretching there are significant percentage hikes of surface-drag force magnitude and surface cooling rate.

关键词： Non-linear mixed convection Non-linear thermal radiation Non-linear stretching sheet Newtonian fluid

Structural and Electrical Properties of Cobalt Ferrite

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Journal of Materials Science & Technology 1996年第6期12卷 417-420页

作者： C.O.Augustin L.K.Srnivasan P.Kamaraj and A.mani (Central Electrochemical Research Institute, Karaikudi-630006, India)(To whom correspondence should be addressed) Central Electrochemical Research Institute Karaikudi-630006 India

Ferrites are a class of cohesive new materiafs required for many specialised applications. Cobalt ferrite (CoFe2O4) has been identified as a substitute for carbon and serves as a non consumable anode for an eco-friendly and energy efficient production of aluminium. Pellets of cobalt ferrite have been prepared by powder metallurgical process and their electrical properties have been investigated from ambient temperature to 1273 K. The structural and morphological features have been studied by X-ray diffraction and scanning electron microscopy The relationships between such properties, chemical composition and sintering temperatures are thoroughly discussed.

关键词： nm Structural and Electrical Properties of Cobalt Ferrite

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Hepatotoxic Alterations Induced by Subchronic Exposure of Rats to Formulated Fenvalerate (20% EC) by Nose Only Inhalation

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Biomedical and Environmental Sciences 2004年第3期17卷 309-314页

作者： U.mani A.K.PRASAD V.SURESHKUMAR P.KUMAR KEWAL LAL B.K.MAJI K.K.DUTTA Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India

Objective Fenvalerate (20% EC) is a synthetic pyrethroid, which is commonly used in India by farmers for the protection of many food and vegetable crops against a wide variety of insects. However, its inhalation toxicity data is very limited in the literature due to the fact that the exposure levels associated with these effects were usually not reported. Hence, inhalation exposure was carried out to investigate the hepatotoxic effects. Method Adult male rats were exposed to fen for 4 h/day, 5 days a week for 90 days by using Flow Past Nose Only Inhalation Chamber. Sham treated control rats were exposed to compressed air in the inhalation chamber for the same period. Results The results indicated hepatomegaly, increased activities of serum clinical enzymes (indicative of liver damage/dysfunction) along with pronounced histopathological damage of liver. Conclusion The hepatotoxic potential of formulated Fen (20% EC) in rats exposed by nose only inhalation is being reported for the first time and warrant adequate safety measures for human beings exposed to this insecticide, particularly by inhalation route.

关键词： Fenvalerate Rat Inhalation Hepatotoxicity

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In vitro C ytotoxic Properties of Crude Polar Extracts of Plants Sourced from Australia

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Clinical Complementary Medicine and Pharmacology 2022年第1期2卷 13-22页

作者： Janice mani Joel Johnson Holly Hosking Kerry Walsh Paul Neilsen mani Naiker School of Health Medical and Applied SciencesCentral Queensland UniversityBruce HwyNorth RockhamptonQueensland 4701Australia Institute of Future Farming Systems Central Queensland UniversityBruce HwyNorth RockhamptonQueensland 4701Australia

Background:Numerous commercial pharmaceuticals-including anticancer,antiviral,and antidiabetic drugs have been developed from traditional plant-derived *** are approximately 25,000 species of flora occurring in Australia,which are adapted to a range of harsh environments,and hence a plethora of novel compounds are still awaiting research in the context of their medicinal ***:The current study therefore aimed to develop a systematic protocol for screening plants with potential *** studies have found polar compounds such as to be the bioactive components responsible for the therapeutic ***:The total phenolic content(TPC)and antioxidant capacity(FRAP)of methanolic extracts of selected plants was first determined.A high correlation between the TPC values and FRAP values of the plant polar extracts were *** viability of the cancer cell lines were assessed using the MTS ***:Cells subjected to Pittosporum angustifolium *** at concentration of 250μg/mL showed no viable cells,comparable to cisplatin(a chemotherapy medication)used as a positive control(10μg/mL).Some promising inhibitory effects were also seen with Murrya koenigii flower and leaves at concentration of 250μg/mL,with only 43.46%and 63.88%cell viability,*** contrast,extracts of Citrus hystrix(leaves)and Sygyz-ium australe(stamen)showed higher percentage cell viabilities(around 82-93%)at same *** phenolic profile of *** B extracts demonstrating greater peak intensity and dominant peaks were tentatively identified as chlorogenic acid,p-coumaric acid,caffeic acid,t-ferulic acid and ***:The Australian species *** extract was the most cytotoxic against HeLa and HT29 cells comparing to the other plant extracts tested.A HPLC profile of the *** extract also showed an array of promising therapeutic phenolic *** work will aim to fractionate and isolate

关键词： Cytotoxic Antioxidant capacity Total phenolics Australian plants Polar extracts