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Immune reaction and colorectal cancer:Friends or foes?

World Journal of Gastroenterology 2014年第35期20卷 12407-12419页

作者： Vincenzo Formica Vittore Cereda Antonella Nardecchia manfredi tesauro Mario Roselli Medical Oncology Unit ‘Tor Vergata’ University Hospital Internal Medicine Department ‘Tor Vergata’ University Hospital

The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid *** cancer is one of the most studied neoplasms for the tumor-host immunity *** immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified,still no approved therapies based on host immunity intensification have so far been introduced in clinical ***,a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this *** aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease.

关键词： Colitis-associated colorectal cancer Antitumor immunity Innate immunity Adaptive immunity

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The role of acetazolamide in critical care and emergency medicine

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Journal of Geriatric Cardiology 2024年第11期21卷 1085-1095页

作者： Jacopo Davide Giamello Gabriele Savioli Yaroslava Longhitano Fiorenza Ferrari Salvatore D’Agnano Ciro Esposito manfredi tesauro Christian Zanza Department of Emergency Medicine Azienda Ospedaliera S.Croce e CarleCuneoItaly Emergency Medicine and Surgery IRCCS Fondazione Policlinico San MatteoPaviaItaly Department of Anesthesiology and Perioperative Medicine University of PittsburghPittsburghPA 15260USA Department of Emergency Medicine-Emergency Medicine Residency Program Humanitas University-Research Hospital20089 RozzanoItaly International Renal Research Institute of Vicenza(IRRIV) Department of NephrologyDialysis and TransplantationSan Bortolo HospitalAzienda ULSS Berica VicenzaItaly Department of Anaesthesia Critical Care and EmergencyFoundation IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanItaly Unit of Nephrology and Dialysis ICS MaugeriUniversity of PaviaPaviaItaly Department of Systems Medicine University of Rome"Tor Vergata"RomeItaly Geriatric Medicine Residency Program University of Rome"Tor Vergata"RomeItaly

Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor;over the years,its use in clinical practice has decreased in favor of more recent ***,it is a rather handy drug,which can be useful in several clinical settings when managing critically ill *** objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care ***,the safety profile of this drug has been *** is a narrative review on the use of acetazolamide in the main contexts in which this drug can be useful in emergency situations for patients with potential critical *** the timeline 1999–2024,a search was conducted on the main scientific platforms;resources of greatest relevance for the use of acetazolamide in critical care and emergency medicine were *** most common emergency situations in which a critically ill patient could benefit from acetazolamide therapy are acute heart failure,acute mountain sickness,post hypercapnic metabolic alkalosis,idiopathic intracranial hypertension and acute angle-closure *** a few cases,however,randomized controlled clinical trials have been *** are also other less solid indications based mostly on experience or retrospective *** seems to be an overall safe drug;serious side effects are rare and can be avoided by carefully selecting the patients to be *** represents a precious resource for emergency physicians and intensivists;critical patients with different conditions can in fact benefit from it;furthermore,acetazolamide is a safe drug if administered to correctly selected patients.

关键词： critical prescribed furthermore

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Legionella from Environmental and Clinical Homes for the Mentally Disabled and Comparison of Their Sequence Types

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Journal of Life Sciences 2011年第1期5卷 53-58页

作者： Annalisa Bianchi Marina tesauro Michela Consonni Fabrizio Pregliasco Maria Gabriella Galli Department of Public Health Microbiology and Virology Universita degli Studi di Milano Milano 20133 Italy

In this study the authors compared the sequence types （STs） designed by sequence based typing （SBT） of 4 clinical and 12 environmental strains of Legionella pneumophila serogroup 1 （LP1） which were isolated from hospital facilities for the mentally disabled. The strains were selected after a retrospective surveillance of 565 clinical records （2002-2009） and investigations of water circuit. It was possible to correlate two clinical strains with the corresponding environment, which were collected from showers that had exposed the patients （ST685, ST16） and two clinical strains present in the same structure （STI）. The other environmental strains were isolated from water in the department with confirmed or suspected clinical cases. All the strains （seven） from the first structure had ST188; two from the second structure had ST34; and the last from the third structure, gave an ST694. The results were compared with the European Working Group for Legionella Infections （EWGLI） database： the ST 1, 16, 34 and 188 were already known in literature, among clinical and nosocomial cases, especially for ST 1, the most distributed worldwide. Two STs were new to the database. ST685 was isolated both from a patient and from the water; ST694, which was found exclusively in the environmental compartment of a control structure （no cases of legionellosis and low number of nosocomial pneumonia）, was unknown in the literature and the authors could only speculate on its possible minor virulence and/or distribution. The implementation of SBT and international comparisons may be useful to gain genotypic knowledge of circulating environmental strains, also verifying their presence in the clinical setting.

关键词： Legionella pneumophila genotyping sequence based typing nosocomial infections.

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中国大陆地区的岩石圈强度及其构造含义（英文）

中国大陆地区的岩石圈强度及其构造含义（英文）

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2015中国地球科学联合学术年会

作者：邓阳凡 Magdala tesauro 中国科学院广州地球化学研究所 Utrecht University

We present new thermal and strength models of China's *** integrate thermal model for the crust,using a 3D steady-state heat conduction equation,with estimates for the upper mantle thermal structure obtained by inverting an S-wave tomography *** the new thermal model and attributing to the lithospheric layers a‘soft’and‘hard’rheology,respectively,we estimate the integrated strength of the

关键词：岩石圈中国大陆地区

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1997年9月26日意大利Colfiorito地震:用SAR干涉和GPS模拟的同震地表位移

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世界地震译丛 2000年第5期31卷 28-31页

作者： S.Stramondo M.tesauro P.Briole E.Sansosti S.Salvi R.Lanari M.Anzidei P.Baldi G.Fornaro A.Avallone M.F.Buongiorno G.Franceschetti E.Boschi 乔子云宋胜合不详河北省地震局分析预报中心

1997年翁布里亚—马尔凯地震序列的最大事件是9月26日M_W5.7(00:33GMT)和M_W6.0(09:40GMT)两个地震,它们引起震中周围大面积的严重破坏和地裂缝。我们给出了一个ERS-SAR差分干涉图,图中在Colfiorito盆地内部及周围可见9个干涉条纹,这对... 详细信息

1997年翁布里亚—马尔凯地震序列的最大事件是9月26日M_W5.7(00:33GMT)和M_W6.0(09:40GMT)两个地震,它们引起震中周围大面积的严重破坏和地裂缝。我们给出了一个ERS-SAR差分干涉图,图中在Colfiorito盆地内部及周围可见9个干涉条纹,这对应于25cm的同震地表位移。GPS数据表明最大水平位移是14±1.8cm,最大沉降量为24±3cm。我们用这些测地数据和地震参数来估计断层面的几何特征和走滑分布。模拟的断层深度和最大滑动幅度对第一次地震分别是6.5km和47cm,对第二次地震分别是7km和72cm,这与由地震数据得到的很一致。

关键词：地震序列走滑 GPS 地裂缝地震数据断层面震中地表位移沉降量水平位移

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