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Platelet membrane-Coated Nanocarriers Targeting Plaques to Deliver Anti-CD47 Antibody for Atherosclerotic Therapy

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Research 2022年第3期2022卷 1-12页

作者： Liang Chen Zhongyi Zhou Cheng Hu manfred F.maitz Li Yang Rifang Luo Yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China max Bergmann Center of Biomaterials Leibniz Institute of Polymer Research DresdenDresden 01069Germany Key Lab.for Advanced Technologies of materials Ministry of EducationSchool of Material Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Atherosclerosis,the principle cause of cardiovascular disease(CVD)worldwide,is mainly characterized by the pathological accumulation of diseased vascular cells and apoptotic cellular *** is associated with the upregulation of CD47,a key antiphagocytic molecule that is known to render malignant cells resistant to programmed cell removal,or“efferocytosis.”Here,we have developed platelet membrane-coated mesoporous silicon nanoparticles(PmSN)as a drug delivery system to target atherosclerotic plaques with the delivery of an anti-CD47 ***,the cell membrane coat prolonged the circulation of the particles by evading the immune recognition and provided an afinity to plaques and atherosclerotic *** anti-CD47 antibody then normalized the clearance of diseased vascular tissue and further ameliorated atherosclerosis by blocking *** an atherosclerosis model established in ApoE^(-/-)mice,PmSN encapsulating anti-CD47 antibody delivery significantly promoted the efferocytosis of necrotic cells in *** the necrotic cells greatly reduced the atherosclerotic plaque area and stabilized the plaques reducing the risk of plaque rupture and advanced ***,this study demonstrated the therapeutic advantages of PmSN encapsulating anti-CD47 antibodies for atherosclerosis therapy,which holds considerable promise as a new targeted drug delivery platform for efficient therapy of atherosclerosis。

关键词： CD47 Antibody holds

Why implantation of bio-loggers may improve our understanding of how animals cope within their natural environment

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Integrative Zoology 2019年第1期14卷 48-64页

作者： marie-Amélie FORIN-WIART manfred R.ENSTIPP Yvon LE mAHO Yves HANDRICH Universitéde Strasbourg CNRSIPHCDépartement EcologiePhysiologie et EthologieUMR 7178StrasbourgFrance Centre d’Etudes Biologiques de Chizé CNRSUMR 7372Villiers en BoisFrance Centre Scientifique de monaco Département de Biologie PolaireMonaco

Bio-loggers are miniaturized autonomous devices that record quantitative data on the state of free-ranging ani-mals(***,position and physiology)and their natural *** is especially relevant for spe-cies where direct visual observation is difficult or ***,ongoing technical development allows the monitoring of numerous parameters in an increasing range of species over extended ***,the ex-ternal attachment of devices might affect various aspects of animal performance(energetics,thermoregulation,foraging as well as social and reproductive behavior),which ultimately affect *** attachment might also increase entanglement risk and the conspicuousness of animals,leaving them more vulnerable to *** contrast,implantation of devices can mitigate many of these undesirable effects and might be prefera-ble,especially for long-term studies,provided that the many challenges associated with surgical procedures can be *** may then allow us to gather data that would be impossible to obtain otherwise and thereby may provide new and ecologically relevant insights into the life of wild ***,we:(i)discuss the pros and cons of attachment methods;(ii)highlight recent field studies that used implanted bio-loggers to address eco-physiological questions in a wide range of species;and(iii)discuss logger implantation in light of ethical considerations.

关键词： behavior bio-logging device implantation eco-physiology long-term deployment

结直肠癌、基质和正常结肠黏膜显微解剖区域N-糖组的显著多样性

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Engineering 2023年第7期26卷 32-43,I0002页

作者： Di Wang Katarina madunic Tao Zhang Guinevere S.m.Lageveen-Kammeijer manfred Wuhrer Center for Proteomics and metabolomics Leiden University Medical CenterLeiden 2300 RCNetherlands Copenhagen Center for Glycomics Department of Cellular and Molecular MedicineUniversity of CopenhagenCopenhagen 2200Denmark

Aberrant glycosylation is considered to be a hallmark of colorectal cancer(CRC),as demonstrated by various *** the N-glycosylation of cell lines and serum has been widely examined,the analysis of cancer-associated N-glycans from tissues has been hampered by the heterogeneity of tumors and the complexity of N-glycan *** overcome these obstacles,we present a study using laser capture microdissection that makes it possible to largely deconvolute distinct N-glycomic signatures originating from different regions of heterogeneous tissues including cancerous,stromal,and healthy mucosa cells.N-glycan alditols were analyzed by means of porous graphitized carbon liquid chromatographyelectrospray ionization tandem mass spectrometry,enabling the differentiation and structural characterization of isomeric *** total,116 N-glycans were identified that showed profound differences in expression among cancer,stroma,and normal *** comparison with healthy mucosa,the cancer cells showed an increase in a2-6 sialylation and monoantennary N-glycans,as well as a decrease in bisected ***,specific sialylated and(sialyl-)LewisA/X antigen-carrying N-glycans were exclusively expressed in *** comparison with cancer,the stroma showed lower levels of oligomannosidic and monoantennary N-glycans,LewisA/X epitopes,and sulfation,as well as increased expression of(core-)fucosylation and a2-3 *** study reveals the distinct N-glycomic profiles of different cell types in CRC and control tissues,proving the necessity of their separate analysis for the discovery of cancer-associated glycans.

关键词： Colorectal cancer Tumor Porous graphitized carbon liquid chromatography mass spectrometry N-glycomics Antibody response

Electronic properties of wurtzite GaAs： A correlated structural, optical, and theoretical analysis of the same polytypic GaAs nanowire

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Nano Research 2018年第9期11卷 4708-4721页

作者： Alexander Senichev Pierre Corfdir Oliver Brandt manfred Ramsteiner Steffen Breuer Jorg Schilling Lutz Geelhaar Peter Werner max-Planck-lnstitut fur mikrostrukturl)hysik Halle 06120 Germany PauI-Drude-lnstitut for Festkorperelektronik Berlin 10117 Germany Centre for Innovation Competence SiLi-nano Martin-Luther-Universitat Halle 06120 Germany Present address: Birck Nanotechnology Center Purdue University West Lafayette Indiana 47907 USA Present address: Fraunhofer HHI Berlin 10587 Germany Present address: ABB Corporate Research Baden-Dattwi15405 Switzerland

III-V compound semiconductor nanowires are generally characterized by the coexistence of zincblende and wurtzite structures. So far, this polytypism has impeded the determination of the electronic properties of the metastable wurtzite phase of GaAs, which thus remain highly controversial. In an effort to obtain new insights into this topic, we cross-correlate nanoscale spectral imaging by near-field scanning optical microscopy with a transmission electron microscopy analysis of the very same polytypic GaAs nanowire dispersed onto a Si wafer. Thus, spatially resolved photoluminescence spectra could be unambiguously assigned to nanowire segments whose structure is known with lattice-resolved accuracy. An emission energy of 1.528 eV was observed from extended zincblende segments, revealing that the dispersed nanowire was under uniaxial strain presumably due to interaction with its supporting substrate. These crucial information and the emission energy obtained for extended pure wurtzite segments were used to perform envelope function calculations of zincblende quantum disks in a wurtzite matrix as well as the inverse structure. In these calculations, we varied the fundamental bandgap, the electron mass, and the band offset between zincblende and wurtzite GaAs. From this multi-parameter comparison with the experimental data, we deduced that the bandgap between the F8 conduction and A valence band ranges from 1.532 to 1.539 eV in strain-free wurtzite GaAs, and estimated values of 1.507 to 1.514 eV for the F7-A bandgap.

关键词： nanowires crystal-phase quantumstructures wurtzite GaAs strain near-field scanning optical microscopy photoluminescence

Environmental control of daily stem radius increment in the montane conifer Cedrus libani

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Journal of Forestry Research 2020年第4期31卷 1159-1171页

作者： Aylin Güney Serkan Gülsoy Ozdemir Sentürk Armin Niessner manfred Küppers Institute of Botany University of HohenheimStuttgartGermany Faculty of Forestry Isparta University of Applied SciencesIspartaTurkey Golhisar Vocational School Burdur Mehmet Akif Ersoy UniversityBurdurTurkey

Growth response of conifers is species-specific and depends on site and climate *** on daily radial stem growth use different analytical approaches to determine species reactions to environmental *** results contribute to improve forecasts of tree growth under a changing *** 2013 and2014,radial stem growth of 33 mature Cedrus libani individuals growing under different climatic conditions in Turkey and Germany was monitored hourly using high precision point *** radius increments(SRI)were extracted from dendrometer *** annual course of SRI showed site-specific patterns with mean daily values ranging between 9.9 and 29.3μm over the growing *** and principal component analyses indicated that humidity and low temperatures during the growing season favored *** regression analyses demonstrated that precipitation and relative air humidity were the most important factors influencing daily ***-growth relationships were further evaluated using the regression tree *** was the most significant factor on daily SRI for all *** close coupling of SRI to relative air humidity and precipitation underlines the importance of stem water status for radial stem growth of *** which is native to regions with summer *** further explains the superior growth of *** in Germany.

关键词： CART Climate-growth relationship Dendrometer Lebanon cedar Regression tree

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欧洲规范中列车脱轨撞击结构设计的研究

西南交通大学学报 2014年第3期49卷 444-449页

作者：刘艳辉赵世春 manfred Keuser 西南交通大学土木工程学院四川成都610031 慕尼黑联邦国防军大学土木与环境学院慕尼黑85577

为了研究适用于我国情况的高速铁路列车脱轨撞击临近结构的碰撞机理和设计方法,分析了欧洲规范EN1991-1-7中列车脱轨撞击临近结构条款制定所依据的英国铁路集团标准GC/RT5112和国际铁路联盟规程UIC777-2R,包括轨道两侧危险区域、作用荷... 详细信息

为了研究适用于我国情况的高速铁路列车脱轨撞击临近结构的碰撞机理和设计方法,分析了欧洲规范EN1991-1-7中列车脱轨撞击临近结构条款制定所依据的英国铁路集团标准GC/RT5112和国际铁路联盟规程UIC777-2R,包括轨道两侧危险区域、作用荷载、预防措施等,介绍了欧洲规范EN1991-1-7中偶然荷载的设计策略,评述了对欧洲规范产生重要影响的列车脱轨撞击结构作用机理的主要研究成果.研究表明:欧洲规范关于列车脱轨结构撞击临近结构的研究方法和设计策略值得借鉴,但我国高铁站房结构特点、运行速度、道床做法、车辆编组等与欧洲均不同,需要根据我国的情况研究列车脱轨撞击临近结构问题.

关键词：结构设计策略撞击荷载列车脱轨欧洲规范EN1991-1-7

Helicobacter pyloriin gastric corpus of patients 20 years after partial gastric resection

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World Journal of Gastroenterology 2004年第17期10卷 2557-2559页

作者： Christian Kirsch Ahmed madisch Petja Piehler Ekkehard Bayerdrffer manfred Stolte Stephan miehlke medical Department I Technical University HospitalDresdenGermany Community Department of Internal medicine University HospitalMarburgGermany Institute of Pathology Klinikum BayreuthGermany

AIm:To determine the long-term prevalence of Helicobacter pylori(H pylori)gastritis in patients after partial gastric resection due to peptic ulcer,and to compare the severity of Hpylori-positive gastritis in the corpus mucosa between partial gastrectomy patients and matched controls. mETHODS:Endoscopic biopsies were obtained from 57 patients after partial gastric resection for histological examination using hematoxylin/eosin and Warthin-Starry *** was graded according to the updated Sydney *** of corpus gastritis was compared between Hpylori-positive partial gastrectomy patients and Hpylori-positive duodenal ulcer patients matched for age and gender. RESULTS:In partial gastrectomy patients,surgery was performed 20 years(median)prior to *** 25 patients(43.8%)Hpyloriwas detected histologically in the gastric *** atrophy was more common in H pylori-positive compared to H pylori-negative partial gastrectomy patients(Pmy patients compared to duodenal ulcer patients (Pmetaplasia between the two groups. CONCLUSION:The long-term prevalence of Hpylorigastritis in the gastric corpus of patients who underwent partial gastric resection due to peptic ulcer disease is comparable to the general *** expression of Hpylorigastritis in the gastric remnant does not resemble the gastric cancer phenotype.

关键词： Gastrectomy Helicobacter pylori Adult Aged Aged, 80 and over Female Gastric mucosa Gastritis Helicobacter Infections Humans male middle Aged Peptic Ulcer Prevalence Severity of Illness Index Time Factors

Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第39期11卷 6104-6109页

作者： Gerhild Becker Tarik Soezgen manfred Olschewski Joerg Laubenberger Hubert Erich Blum Hans-Peter Allgaier for the Hcc Study Group Department of medicine Ⅱ Department of Medical Biometry and Statistics and Department of RadiologyUniversity Hospital FreiburgGermany

AIm： To assess whether the effectiveness of a combination of transarterial chemoembolization （TACE） and percutaneous ethanol injection （PEI） in the treatment of unresectable hepatocellular carcinoma （HCC） is superior to TACE alone a randomized controlled trial was performed. mETHODS： The effect of combination therapy on longterm survival rates and duration of hospitalization was evaluated in 52 previously untreated HCCs, randomly allocated to TACE-PEI （27 pts） or TACE alone （25 pts）. RESULTS： The cumulative survival rate of the TACE group was 75.8% at 6 mo, 62.9% at 12 mo, and 18.0% at 24 mo and of the TACE-PEI group 76.9%, 61.5%, and 38.7%, respectively. Comparison of overall survival in both groups showed no statistically significant difference. Regarding the patients with HCCs Okuda stage I （n = 26）, the median survival of the TACE-PEI group was significantly longer （〉24 mo, median not yet reached in the study period） compared to the TACE group （18.4 mo [range 11.6-21.7 mo]; P = 0.04）. TACE-PEI reduced the relative risk for mortality to 0.4 （95% CI 0.15-0.96） compared to patients who received TACE alone. median survival in patients with HCCs Okuda stage Ⅱ or Ⅲ was 5.0 mo in the TACE group （1.7 rno-not defined） compared to 10.4 mo in the TACE-PEI group. CONCLUSION： The combination TACE-PEI improved survival time compared to TACE alone. Our study revealed a statistically significant improved survival in HCCs Okuda stage I. Side effects were minor and the combination therapy did not prolong duration of hospitalization considerably.

关键词： Hepatocellular carcinoma Chemoembolization Ethanol injection Combination therapy

Strictures, diaphragms, erosions or ulcerations of ischemic type in the colon should always prompt consideration of nonsteroidal anti-inflammatory drug-induced lesions

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World Journal of Gastroenterology 2005年第37期11卷 5828-5833页

作者： manfred Stolte Diana Karimi michael Vieth Hildegard Volkholz Klaus Dirschmid Sigrid Rappel Birgit Bethke Institute of Pathology Klinikum Bayreuth GmbH Bayreuth 95445 Germany

AIm： To investigate whether NSAIDs/ASA lesions in the colon can histologically be diagnosed on the basis of ischemic necrosis similar to biopsy-based diagnosis of NSAIDs/ASA- induced erosions and ulcers of the stomach. mETHODS： In the period between 1997 and 2002, we investigated biopsy materials obtained from 611 patients （415 women, 196 men, average age 60.5 years） with endoscopic focal erosions, ulcerations, strictures or diaphragms in the colon. In the biopsies obtained from these lesions, we always established the suspected diagnosis of NSA/D-inducecl lesions whenever necroses of the ischemic type were found. Together with the histological report, we enclosed a questionnaire to investigate the use of medication. The data provided by the questionnaire were then correlated with the endoscopic findings, the location, number and nature of the lesions, and the histological findings. RESULTS： At the time of their colonoscopy, 86.1% of the patients had indeed been taking NSAID/ASA medication for years （43.9%） or months （29.5%）. The most common indication for the use of these drugs was pain （64.3%）, and the most common indication for colonoscopy was bleeding （55.5%）. Endoscopic inspection revealed multiple erosions and/or ulcers in 60.6%, strictures in 15.8%, and diaphragms in 3.0% of the patients. The lesions were located mainly in the right colon including the transverse colon （79.9%）. A separate analysis of age and sex distribution, endoscopic and histological findings for NSAIDs alone, ASA alone, combined NSAID/ASA, and for patients denying the use of such drugs, revealed no significant differences among the groups. CONCLUSION： This uncontrolled retrospective study based on the histological finding of an ischemic necrosis shows that the histologically suspected diagnosis of NSAID-induced lesions in the colon is often correct. The true diagnostic validity of this finding and the differentiation from ischemic colitis should, however, be investigated in a prospective

关键词： Erosion Ulceration Stricture Diaphragm Ischemic necrose NSAIDs ASA