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流程工业 2008年第4期 40-40,42,43页

作者： manfred mühl Dirk Sievers 德国Pall公司业务发展经理 Pall公司生命科学和生物医药产品市场部经理

目前，90％的医药产品生产厂商都要利用活性炭清除杂质和异昧。但与此同时，如何将这些极为细小的活性炭粉末从最终成品中清理出去则成为一个生产过程的遗留问题。本文将向您介绍一种以深层过滤为基础的活性炭过滤方法，为您解决生产中... 详细信息

目前，90％的医药产品生产厂商都要利用活性炭清除杂质和异昧。但与此同时，如何将这些极为细小的活性炭粉末从最终成品中清理出去则成为一个生产过程的遗留问题。本文将向您介绍一种以深层过滤为基础的活性炭过滤方法，为您解决生产中的难题。

关键词：活性炭过滤技术生产厂商医药产品遗留问题生产过程过滤方法深层过滤

Ultrastructural cellular signatures: does cellular form follow function?

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National Science Review 2019年第5期6卷 861-863页

作者： manfred Auer molecular Biophysics and Integrated Bioimaging Division Lawrence Berkeley National Laboratory

In his watershed 1896 essay The Tall Office Building Artistically Considered,protomodern architect Louis Sullivan famously declared that ‘form follows function’.Could this concept also hold true in biology? Have cel... 详细信息

关键词： Ultrastructural cellular signatures does cellular form follow function

4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction methods

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Tsinghua Science and Technology 2008年第S1期13卷 179-184页

作者： manfred Breit manfred Vogel Fritz Hubi Fabian mrki micheal Raps i4Ds University of Applied Sciences Northwestern Switzerland

The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a 'Process Archeology' in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models.

关键词： 4D design process and organization modeling and simulation process design patterns lean construction methods

Selective Suspension in Aqueous Sodium Dodecyl Sulfate According to Electronic Structure Type Allows Simple Separation of metallic from Semiconducting Single-Walled Carbon Nanotubes

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Nano Research 2009年第8期2卷 599-606页

作者： Kai moshammer Frank Hennrich manfred m.Kappes Forschungszentrum Karlsruhe Institut für NanotechnologieD-76021 KarlsruheGermany Institut für Physikalische Chemie Universität KarlsruheD-76128 KarlsruheGermany

Both density gradient centrifugation and gel electrophoresis have been reported to allow high throughput separation of metallic from semiconducting single-walled carbon nanotubes(SWNTs)when using aqueous sodium dodecyl sulphate(SDS)*** show here that both methods rely on an initial dispersion-by-sonication step,which is already selective with respect to electronic structure *** corresponding aqueous SDS“starting”suspensions obtained after sonication and purifi cation by simple centrifugation(70,000 g,1 h)contain semiconducting SWNTs primarily in the form of small bundles whereas metallic SWNTs are predominantly suspended as individual *** gradient centrifugation then separates the bundles from the individual tubes on the basis of differences in their overall buoyant *** electrophoresis separates the longer bundles from the shorter individual tubes on the basis of their different *** also demonstrate that such starting suspensions can be fractionated according to electronic structure type by even simpler techniques such as size exclusion chromatography or gel fi ltration,thus opening the way for simple scale-up.

关键词： Single-walled carbon nanotubes metallic–semiconducting separation electrophoresis density gradient centrifugation size exclusion chromatography

The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on hl-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 maarten DE BOCK manfred von HELLERmANN michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the hl-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the hl-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

melanoma development: stage-dependent cancer competence of the melanocytic lineage

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Signal Transduction and Targeted Therapy 2022年第1期7卷 13-14页

作者： manfred Kunz Department of Dermatology Venereology and AllergologyUniversity Medical Center LeipzigPhilipp-Rosenthal-Str.2304155 LeipzigGermany

In a recent article in Science,Baggiolini et al.^(1) showed that the transforming ability of the BRAFm6QQE oncogene for melanoma development depends on the stage of the transformed melanocyte lineage *** neural crest cells and melanoblasts are vulnerable to malignant transformation in a zebrafish model,melanocytes only developed small patches of nevus-like cells after BRARJ6QQE expression.

关键词： expression. al. melan

^(13)C analysis of cow tail hair and farm slurry can be used to implicitly distinguish between different dairy production systems

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Ecological Processes 2023年第1期12卷 98-109页

作者： Friederike Sieve Johannes Isselstein manfred Kayser Department of Crop Science Grassland ScienceGeorg-August University GöttingenVon-Siebold-Str.837075 GöttingenGermany Geo-Lab University of VechtaDriverstraße 2249377 VechtaGermany

Background Public interest in the way food is produced on the farm and processed along the food-production chain is *** analysis of isotopic signatures(^(13)C)in cow tail hair provides a method to reconstruct the dietary proportion of maize in cow *** on this,we further investigated whether there is a relationship between isotopic signatures in cow tail hair or farm slurry and the proportion of maize of the total utilized agricultural area per farm[%].We did an on-farm survey on 17 dairy farms in coastal Northwest Germany and collected cow tail hair from dairy cows and slurry samples on each *** farms differed in their feeding regime(C_(3) vs.C_(4) plants),their site conditions(sandy soil=‘Geestland’;organic soil=‘Peatland’;clayey soil=‘marshland’),and in the area cultivated with maize as a proportion of the total utilized agricultural area per *** We found a positive relationship between δ^(13)C values in both cow tail hair and slurry and the annual dietary proportion of maize(R^(2)=0.67;and R^(2)=0.63).Furthermore,we confirmed that there was a relationship betweenδ^(13)C values in cow tail hair and area of maize as a proportion of the total utilized agricultural area per farm(R^(2)=0.69).Conclusion Our findings suggest a general applicability of using isotopic signatures(^(13)C)along a wide gradient of site conditions and productions systems in practice.

关键词： Stable isotopes Natural^(13)C abundance Environmental indicator maize Dietary composition Traceability

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Exposure to sublethal concentration of flupyradifurone alters sexual behavior and cuticular hydrocarbon profile in Heriades truncorum,an oligolectic solitary bee

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Insect Science 2024年第3期31卷 859-869页

作者： Samuel Boff manfred Ayasse Institute of Evolutionary Ecology and Conservation Genomics Ulm UniversityUlmGermany

The aboveground oligolectic bee,Heriades truncorum,is a particularly good model for studying the impact of pesticides on sexual communication,since some aspects of its mating behavior have previously been *** have tested(1)the interference of the pesticide flupyradifurone on male precopulatory behavior and male mating partner preferences,(2)the way that the pesticide interferes in male quality assessment by the female,and(3)the effects of the pesticide on the chemical compounds in the female *** exposed bees of both sexes to a sublethal concentration of *** behaviors were registered in a mating arena with two females(one unexposed and one exposed)and one male(either unexposed or exposed).Unexposed males were quicker to attempt to *** also impacted precopulatory behavior and male quality assessment by *** approached unexposed females more quickly than insecticideexposed *** exposed to insecticide produced lower amounts of some cuticular hydrocarbons(sex pheromone candidates)and appeared less choosy than unexposed *** findings suggest that insecticide exposure affects sexual communication,playing a role both in male preference and in male quality assessment by the female.

关键词： courtship display female choice flupyradifurone male partner preference sex communication sublethal effects

Generation of a long-term daily gridded precipitation dataset for the rTjSj-Upper Indus Basin(UIB)through temporal Reconstruction,Correction I sag&Informed Regionalization-“ReCIR”

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International Soil and Water Conservation Research 2021年第3期9卷 445-460页

作者： Asim Jahangir Khan manfred Koch Department of Geohydraulics and Engineering Hydrology University of Kassel34125KasselGermany

This study attempted to generate a long-term(1961-2010)daily gridded precipitation dataset for the Upper Indus Basin(UIB)with orographic adjustments so as to generate realistic precipitation estimates,enabling hydrological and water resource investigations that can close the water balance,that is difficult,if not impossible to achieve with the currently available precipitation data products for the *** procedure includes temporal reconstruction of precipitation series at points where data were not recorded prior to the mid-nineties,followed by a regionalization of the precipitation series to a smaller scale across the basin(0.125°x 0.125°),while introducing adjustments for the orographic effect and changes in glacier *** reconstruction process involves interpolation of the precipitation at virtual locations of the current(1995-)dense observational network,followed by corrections for frequency and intensity and adjustments for temporal trends at these virtual *** data generated in this way were further validated for temporal and spatial representativeness through evaluation of SWAT-modelled streamflow responses against observed flows across the *** results show that the calibrated SWAT-simulated daily discharge at the basin outlet as well as at different sub-basin outlets,when forcing the model with the reconstructed precipitation of years 1973—1996,is almost identical to that when forcing it with the reference precipitation data(1997-2008).Finally,the spatial distribution pattern of the reconstructed(1961—1996)and reference(1997—2008)precipitation were also found consistent across the UIB,reflecting well the large-scale atmospheric-circulation pattern in the region.

关键词： Precipitation Temporal reconstruction Orographic correction factor(OCF) Soil and water assessment tool(SWAT) Glacier/water mass balance Upper indus basin(UIB)

What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest

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Science China(Life Sciences) 2023年第11期66卷 2692-2693页

作者： manfred Schartl Developmental Biochemistry BiocenterUniversity of WürzburgWürzburg 97074Germany The Xiphophorus Genetic Stock Center Texas State UniversitySan Marcos 78666USA

The leafy seadragon(Phycodurus eques)or Glauert’s seadragon is one of the most ornately camouflaged creatures on this *** is found in temperate South Australian waters,where its colouration and gossamer leaf-shaped appendages give it excellent camouflage on kelp-covered rocky *** seadragons are very poor swimmers and rely on their camouflage to avoid *** lengths up to 50 cm,they are relatively large compared with their next relatives,the pipefish.

关键词： dragon forest planet