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Level of education and mortality after radical prostatectomy

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Asian Journal of Andrology 2017年第2期19卷 173-177页

作者： Michael Froehner Rainer Koch Stefan propping Dorothea Liebeheim Matthias Hfibler Gustavo B Baretton Oliver W Hakenberg manfred p wirth Department of Urology University Hospital 'Carl Gustav Carus' Technische Universit~t Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Medical Statistics and Biometry University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Anesthesiology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of pathology University Hospital 'Carl Gustav Carus' Technische Universitat Dresden Fetscherstrasse 74 D-01307 Dresden Germany Department of Urology University of Rostock Ernst-Heydemann-Strasse 6 D-18055 Rostock Germany

Estimating the risk of competing mortality is of importance in men with early prostate cancer to choose the most appropriate way of management and to avoid over- or under-treatment. In this study, we investigated the impact of the level of education in this context. The study sample consisted of 2630 patients with complete data on level of education （college, university degree, master craftsmen, comparable profession, or others）, histopathological tumor stage （organ confined or extracapsular）, lymph node status （negative or positive）, and prostatectomy specimen Gleason score （〈7, 7, or 8-10） who underwent radical prostatectomy between 1992 and 2007. Overall, prostate cancer-specific, competing, and second cancer-related mortalities were study endpoints. Cox proportional hazard models for competing risks were used to study combined effects of the variables on these endpoints. A higher level of education was independently associated with decreased overall mortality after radical prostatectomy （hazard ratio [HR]： 0.75, 95% confidence interval [95% CI]： 0.62-0.91, p = 0.0037）. The mortality difference was attributable to decreased second cancer mortality （HR： 0.59, 95% Ch 0.40-0.85, p = 0.0052） and noncancer mortality （HR： 0.73, 95% Ch 0.55-0.98, p = 0.0345） but not to differences in prostate cancer-specific mortality （HR： 1.16, 95% Ch 0.79-1.69, p = 0.4536 in the full model）. In conclusion, the level of education might serve as an independent prognostic parameter supplementary to age, comorbidity, and smoking status to estimate the risk of competing mortality and to choose optimal treatment for men with early prostate cancer who are candidates for radical prostatectomy.

关键词： comorbidity competing risk analysis level of education life expectancy mortality proportional hazards model prostate cancer radical prostatectomy smoking socioeconomic status

Graphene's photonic and optoelectronic properties——A review

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Chinese physics B 2020年第3期29卷 13-35页

作者： A J wirth-Lima p p Alves-Sousa W Bezerra-Fraga Department of physics Federal Institute of EducationScience and Technology of Ceara Campus SobralCearaBrazil postgraduate program in Electrical Engineering and Computing Federal University of Ceara(U.F.C.)Sobral CearaBrazil

Due to its remarkable electrical and optical properties,graphene continues to receive more and more attention from researchers around the *** excellent advantage of graphene is the possibility of controlling its charge density,and consequently,the management of its conductivity and dielectric constant,among other *** is noteworthy that the control of these properties enables the obtaining of new optical/electronic devices,which would not exist based on conventional ***,to work in this area of science,it is necessary to have a thorough knowledge regarding the electrical/optical properties of *** this review paper,we show these graphene properties very well detailed.

关键词： absorbance conductivity dielecric constant dispersion relation

Single-cell trajectories of melanoma cell resistance to targeted treatment

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Cancer Biology & Medicine 2022年第1期19卷 56-73页

作者： Maria Schmidt Lena Sünke Mortensen Henry Loeffler-wirth Corinna Kosnopfel Knut Krohn Hans Binder manfred Kunz Interdisciplinary Centre for Bioinformatics University of LeipzigLeipzig 04107Germany Department of Dermatology Venereology and AllergologyUniversity of WürzburgWürzburg 97074Germany Core Unit DNA Technologies Medical FacultyUniversity of LeipzigLeipzig 04103Germany Department of Dermatology Venereology and AllergologyUniversity of Leipzig Medical CenterLeipzig 04103Germany

Objective:Cellular heterogeneity is regarded as a major factor affecting treatment response and resistance in malignant *** developments in single-cell sequencing technology have provided deeper insights into these ***:Here,we analyzed a BRAFV600 E-mutant melanoma cell line by single-cell RNA-seq under various conditions:cells sensitive to BRAF inhibition with BRAF inhibitor vemurafenib and cells resistant to BRAF inhibition with vemurafenib alone or vemurafenib in combination with the MEK1/2 inhibitors cobimetinib or *** reduction by t-distributed stochastic neighbor embedding and self-organizing maps identified distinct trajectories of resistance development clearly separating the 4 treatment conditions in cell and gene state ***:Trajectories associated with resistance to single-agent treatment involved cell cycle,extracellular matrix,and de-differentiation *** contrast,shifts detected in double-resistant cells primarily affected translation and mitogen-activated protein kinase pathway reactivation,with a small subpopulation showing markers of *** findings were validated in pseudotime analyses and RNA velocity ***:The single-cell transcriptomic analyses reported here employed a spectrum of bioinformatics methods to identify mechanisms of melanoma resistance to single-and double-agent *** study deepens our understanding of treatmentinduced cellular reprogramming and plasticity in melanoma cells and identifies targets of potential relevance to the management of treatment resistance.

关键词： Melanoma single-cell transcriptome sequencing treatment response

Current treatment options and response rates in children with chronic hepatitis C

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World Journal of Gastroenterology 2012年第2期18卷 99-104页

作者： Stefan wirth Helios Medical Centre Wuppertal Department of PediatricsWitten-Herdecke UniversityD-42283 WuppertalGermany

Vertical transmission has become the most common mode of transmission of hepatitis C virus (HCV) in *** rate of perinatal transmission from an HCVinfected mother to her child ranges from 2% to 5% and the prevalence of HCV in children in developed countries ranges between 0.1% and 0.4%.Spontaneous viral clearance seems to be dependent on the genotype and has been reported between 2.4%-25%.For chronically infected patients,treatment with recombinant polyethylene glycol (pEG)-interferon α-2b and daily ribavirin has now been approved as standard treatment for children 2-17 years of *** five large prospective studies,a total of 318 children and adolescents aged 3-17 years were treated either with subcutaneous pEG-interferon α-2b at a dose of 1-1.5 μg/kg or 60 μg/m2 once a week in combination with oral ribavirin (15 mg/kg per day) or pEG-interferon α-2a with *** with genotype 1 and 4 received the medication for 48 wk and individuals with genotype 2 and 3 mainly for 24 *** sustained viral response (SVR) was achieved in 193/318 (60.7%) of treated *** for genotype;120/234 (51%) with genotype 1,68/73 (93%) with genotype 2/3,and 6/11 (55%) with genotype 4 showed *** rate was between 7.7% and 17%.Overall,treatment was well tolerated;how-ever,notable side effects were present in approximately 20%.According to recent experiences in the treatment of chronic hepatitis C in children and adolescents,a combination of pEG-interferon α with ribavirin has been found to be well tolerated and highly efficacious,particularly in individuals with genotype 2/***,this treatment can be recommended as standard of care until more effective treatment options will become available for genotype 1 patients.

关键词： Chronic hepatitis C Treatment Children polyethylene glycol-interferon and ribavirin Responserate

Interaction phenomena between liquid droplets and hot particles—Captured via high-speed camera

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particuology 2009年第4期7卷 260-263页

作者： Sebastian Gehrke Karl-Ernst wirth Institute of particle Technology Cauerstrasse 4Erlangen 91058Germany

The interaction of evaporating droplets and hot catalyst particles plays a major role in heterogeneously catalysed reactions. The liquid feed is injected into a gas-solid flow and is mixed with the catalyst. The interaction phenomena determine the evaporation time which should be minimised to keep the reactor vessel small. First measurements with a bed of fixed hot FCC-particles （fluid catalytic cracking） and two model fluids have been conducted. The interactions of ethanol and water droplets with the hot bed surface were captured via a high-speed camera. While the ethanol droplet developed a stable steam cushion due to Leidenfrost phenomena, water showed intense interaction and steam explosions which induced repulsion and atomisation of the droplet.

关键词： particle-droplet-interaction Leidenfrost phenomenon Direct heat transfer Liquid-feed-injection

Comparisons of electrical and optical properties between graphene and silicene A review

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Chinese physics B 2018年第2期27卷 299-313页

作者： wirth-Lima A J Silva M G Sombra A S B Laboratory of Telecommunications and Materials Science and Engineering-www.locem.ufc.br-Fortaleza CearaBrazil Department of physics Science CenterFederal University of Ceara(U.F C.)-FortalezaCear4Brazil State University of Vale do Acarau SobralCeardBrasil

Two-dimensional （2D） metamaterials are considered to be of enormous relevance to the progress of all exact sciences. Since the discovery of graphene, researchers have increasingly investigated in depth the details of electrical/optical proper- ties pertinent to other 2D metamaterials, including those relating to the silicene. In this review are included the details and comparisons of the atomic structures, energy diagram bands, substrates, charge densities, charge mobilities, conductivities, absorptions, electrical permittivities, dispersion relations of the wave vectors, and supported electromagnetic modes related to graphene and silicene. Hence, this review can help readers to acquire, recover or increase the necessary technological basis for the development of more specific studies on graphene and silicene.

关键词： graphene silicene electrical/optical properties

Boosting T cell immunity against cytomegalovirus:a potential strategy combating human aging and age-related diseases

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4417-4418页

作者： Matthias wirth Walburgis Brenner Oliver H.Kramer Department of Hematology Oncology and Cancer ImmunologyCampus Benjamin FranklinCharite-Universitatsmedizin Berlincorporate member of Freie Universitat Berlin and Humboldt-Universitat zu BerlinBerlinGermany University Medical Center Gottingen Department of GeneralVisceral and Pediatric SurgeryGottingenGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)HeidelbergGermany Clinic for Obstetrics and Women's Health University Medical CenterJohannes Gutenberg University MainzLangenbeckstr.155131 MainzGermany Department of Toxicology University Medical CenterMainzGermany

In a recent publication in Cell,Hasegawa and colleagues reveal that cytotoxic CD4-positive cytotoxic T lymphocytes(CD4+CTLs)eliminate senescent fibroblasts with a surface expression of the immunologically important human leukocyte antigen class Il(HLA-)and the human cytomegalovirus glycoprotein B(HCMV-gB).1 This implies that a virome-immune cell interaction controls the fate of human skin cells that are linked to the aging process and associated diseases.

关键词： immunity cytomegalovirus cytotoxic

Short-Term Response of Soil Respiration to Addition of Chars:Impact of Fermentation post-processing and Mineral Nitrogen

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pedosphere 2015年第5期25卷 761-769页

作者： Giacomo LANZA Stephan wirth Arthur GESSLER Jrgen KERN Leibniz Institute for Agricultural Engineering Leibniz Centre for Agricultural Landscape Research (ZALF) Swiss Federal Institute for Forest Snow and Landscape Research WSL

The biodegradability of chars derived from pyrolysis and hydrothermal carbonisation(HTC) was studied in short-term dynamic incubation experiments under controlled conditions. Carbon dioxide C(CO2) emissions from soil-char mixtures in combination with solid digestate or mineral nitrogen(N) fertiliser were measured in dynamic chambers for 10 d. Compared to the original material(maize straw), pyrolysis and HTC chars showed significantly lower CO2 emissions and slower decay dynamics; and compared to the soil control, HTC char increased soil respiration to a significant extent, while pyrolysis char did not. The addition of mineral N resulted in a delayed respiration dynamics for HTC char, while the addition of digestate resulted in an increase in the respired CO2 for pyrolysis char and a decrease for HTC char. For the first time, a peculiar two-stage decay kinetics was observed for HTC char,indicating a highly inhomogeneous substrate consisting at least of two C pools.

关键词： biodegradability CO2 emission decay dynamics hydrothermal carbonisation char pyrolysis char

Affairs happen---to whom？ A study on extrapair paternity in common nightingales

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Current Zoology 2017年第4期63卷 421-431页

作者： Conny LANDGRAF Kerstin WILHELM Jutta wirth Michael WEISS Silke KIppER Leibniz Institute for Zoo and Wildlife Research (IZW) Alfred-Kowalke-StraBe 17 10315 Berlin Germany Animal Behavior Group Free University of Berlin TakustraBe 6 14195 Berlin Germany Institute of Evolutionary Ecology and Conservation Genomics University of UIm Albert Einstein Allee 11 89069 UIm Germany Behavioural Ecology Group Department of Animal Sciences Wageningen University De Elst 1 6708 WD Wageningen The Netherlands Department of Exposition Unit Epidemiology Statistics and Mathematical Modelling Federal Institute for Risk Assessment (BfR) Max-Dohrn-Str. 8-10 10589 Berlin Germany Chair of Zoology School of Life Sciences Weihenstephan Technische Universitat Munchen LieseI-Beckmann-StraBe 4 85350 Freising Germany

Most birds engage in extrapair copulations despite great differences across and within species. Besides cost and benefit considerations of the two sex environmental factors have been found to alter mating strategies within or between populations and/or over time. For socially monogamous species, the main advantage that females might gain from mating with multiple males is probably increasing their offspring＇s genetic fitness. Since male （genetic） quality is mostly not directly meas- urable for female birds, （extrapair） mate choice is based on male secondary traits. In passerines male song is such a sexual ornament indicating male phenotypic and/or genetic quality and song repertoires seem to affect female mate choice in a number of species. Yet their role in extrapair mating behavior is not well understood. In this study, we investigated the proportion of extrapair paternity （Epp） in a population of common nightingales Luscinia megarhynchos. We found that Epp rate was rather high （21.5% of all offspring tested） for a species without sexual dimorphism and high levels of paternal care. Furthermore, the occurrence of Epp was strongly related to the spatial distribution of male territories with males settling in densely occupied areas having higher proportions of extrapair young within their own brood. Also, song repertoire size affected Epp： here larger repertoires of social mates were negatively related to the probability of being cuck- olded. When directly comparing repertoires sizes of social and extrapair mates, extrapair mates tended to have larger repertoires. We finally discuss our results as a hint for a flexible mating strat- egy in nightingales where several factors--including ecological as well as male song features-- need to be considered when studying reproductive behavior in monogamous species with complex song.

关键词： common nightingale direct fitness extrapair paternity Luscinia megarhynchos repertoire size territorial settlement.