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Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

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Neural Regeneration Research 2017年第5期12卷 692-695页

作者： Jian-Nan Zhang Jan C.koch Department of Neurology University Medicine GottingenGottingenGermany Department of Neurobiology Beijing Institute for Brain Disorders and Key Laboratory for Neurodegenerative Disease of the Ministry of EducationCapital Medical UniversityBeijingChina Center for Nanoscale Microscopy and Molecular Physiology of the Brain(CNMPB) GottingenGermany

Axonal degeneration is a key pathological feature in many neurological diseases. It often leads to persistent deficits due to the inability of axons to regenerate in the central nervous system. Therefore therapeutic approaches should optimally both attenuate axonal degeneration and foster axonal regeneration. Compelling evidence suggests that collapsin response mediator protein-2（CRMP2） might be a molecular target fulfilling these requirements. In this mini-review, we give a compact overview of the known functions of CRMP2 and its molecular interactors in neurite outgrowth and in neurodegenerative conditions. Moreover, we discuss in detail our recent findings on the role of CRMP2 in acute axonal degeneration in the optic nerve. We found that the calcium influx induced by the lesion activates the protease calpain which cleaves CRMP2, leading to impairment of axonal transport. Both calpain inhibition and CRMP2 overexpression effectively protected the proximal axons against acute axonal degeneration. Taken together, CRMP2 is further characterized as a central molecular player in acute axonal degeneration and thus evolves as a promising therapeutic target to both counteract axonal degeneration and foster axonal regeneration in neurodegenerative and neurotraumatic diseases.

关键词： collapsin response mediator protein-2 CRMP2 axonal regeneration optic nerve cruch axonaldegeneration calpain axonal transport

Plant Surfaces:Structures and Functions for Biomimetic Innovations

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Nano-Micro Letters 2017年第2期9卷 116-155页

作者： Wilhelm Barthlott Matthias Mail Bharat Bhushan Kerstin koch Nees Institute for Biodiversity of Plants Rheinische Friedrich-Wilhelms University of BonnVenusbergweg 2253115 BonnGermany Institute of Crop Science and Resource Conservation(INRES)–Horticultural Science Rheinische Friedrich-Wilhelms University of BonnAuf dem Hugel 653121 BonnGermany

An overview of plant surface structures and their evolution is presented. It combines surface chemistry and architecture with their functions and refers to possible biomimetic applications. Within some 3.5 billion years biological species evolved highly complex multifunctional surfaces for interacting with their environments: some 10 million living prototypes(i.e., estimated number of existing plants and animals) for engineers. The complexity of the hierarchical structures and their functionality in biological organisms surpasses all abiotic natural surfaces: even superhydrophobicity is restricted in nature to living organisms and was probably a key evolutionary step with the invasion of terrestrial habitats some 350–450 million years ago in plants and insects. Special attention should be paid to the fact that global environmental change implies a dramatic loss of species and with it the biological role models. Plants, the dominating group of organisms on our planet, are sessile organisms with large multifunctional surfaces and thus exhibit particular intriguing *** and superhydrophobicity are focal points in this work. We estimate that superhydrophobic plant leaves(e.g., grasses) comprise in total an area of around 250 million km^2, which is about 50% of the total surface of our planet. A survey of structures and functions based on own examinations of almost 20,000 species is provided, for further references we refer to Barthlott et al.(Philos. Trans. R. Soc. A 374: 20160191, 1). A basic difference exists between aquatic nonvascular and land-living vascular plants; the latter exhibit a particular intriguing surface chemistry and architecture. The diversity of features is described in detail according to their hierarchical structural order. The first underlying and essential feature is the polymer cuticle superimposed by epicuticular wax and the curvature of single cells up to complex multicellular structures. A descriptive terminology for t

关键词： Bionics Superhydrophobicity Hierarchical structuring Lotus effect Salvinia effect Evolution

Modelling stratified forest attributes using optical/LiDAR features in a central European landscape

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International Journal of Digital Earth 2012年第2期5卷 106-132页

作者： Hooman Latifi Arne Nothdurft Christoph Straub Barbara koch Department of Remote Sensing and Landscape Information Systems University of FreiburgTennenbacherstraßeFreiburgGermany Department of Biometry and Informatics Forest Research Institute Baden WurttembergWonnhaldestraßeFreiburgGermany

Improvements in the acquisition of three-dimensional(3D)information from the Airborne Laser Scanner(ALS)increase its applications for studying Earth’s *** use of ALS data in natural resource inventories is still in an experimental stage in central ***,a survey was completed in Germany,where plot-level features from LANDSAT Thematic Mapper and ALS data were *** automated process was developed for forest stratification using orthoimages.A genetic algorithm was applied for variable *** subsets of different sizes were employed for simultaneous predictions of structural forest attributes using the‘Random Forest’(RF)*** was assessed by leave-one-out cross-validations on bootstrap resample *** indicate that the stratification of forest notably improved the results of *** improvements were more obvious for the strata-related *** was enhanced as the number of selected variables ***,parsimonious models are still essentially required for practical *** RF errors were slightly greater than those from least squares regression,as the non-parametric methods do not share the same mix of error components as *** the combination of remote sensing and modelling,we conclude that our results are helpful for bridging the gap between regional earth observation and on-the-ground forest structure.

关键词： spatial prediction natural resource inventory ALS Digital Earth data fusion remote sensing

Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids

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Science China Chemistry 2023年第9期66卷 2435-2436页

作者： manfred T.Reetz Frank Hollmann Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 145480 MülheimGermany Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China Department of Biotechnology Delft Universityvan der Maasweg 92629 HZ DelftNetherlands

Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.

关键词： steroids catalyzed synthesis

Efficiency of surface inactivation disinfectants for bacteria studied in an aquaculture microbiology laboratory

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Journal of Biosafety and Biosecurity 2023年第2期5卷 84-86页

作者： manfred Weidmann Institute of Aquaculture University of StirlingStirlingScotlandUK Medizinische Hochschule Brandenburg Institut für Virologie und MikrobiologieUniversitätsplatz 101986 SenftenbergGermany

Routine microbial inactivation procedures used in microbiology laboratories must be *** this study,the efficacy of surface disinfection using 70%Isopropanol,0.45%Presept,and 1%Virkon was tested against 24 bacterial strains commonly handled in aquaculture microbiology *** was ineffective against Nocardia asteroides NCIMB 1290,while Virkon was not effective against Aeromonas eucrenophila NCIMB 74 or Pediococcus acidilacti R52037.

关键词： Inactivation Aquaculture Bacterial pathogens Aeromonas eucrenophila Nocardia asteroides Pediococcus acidilacti

NIBU: a new approach to representing and analysing interior utility networks within 3D geo-information systems

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International Journal of Digital Earth 2012年第1期5卷 22-42页

作者： Ihab Hamzi Hijazi manfred Ehlers Sisi Zlatanova Institute for Geoinformatics and Remote SensingIGF University of OsnabrueckOsnabrueckGermany OTB Research Institute for HousingUrban and Mobility StudiesDelft University of TechnologyDelftThe Netherlands

Facility management departments’responsibilities include monitoring and maintenance of building infrastructure,such as water,gas or *** often these tasks are completed using paper maps,which make integrated analysis of networks *** to consider interior network structure and provide semantic and connectivity information supporting the required analysis operations are thus *** paper presents an approach relying on Building Information Model(BIM)as a data source for obtaining information about interior *** semantic and connectivity information of BIM is mapped onto a new model called Network for Interior Building Utilities(NIBU).NIBU is based on the semantic categorisation of utilities,and the spatial functions that have to be *** scenarios(‘maintenance operation’,‘emergency response’and‘inspection operation’)are developed to test the proposed *** model and its functions are implemented in spatial *** model is populated directly from a BIM server applying an Industrial Foundation Class(IFC)parser developed *** analysis functions are implemented to support spatial operations:trace upstream,trace downstream,find ancestors,find source and find *** investigation proves that BIM provides both the required semantics and attributes,and connectivity information that can facilitate analysis of interior utility *** provides a simple yet flexible way to manage interior network information,which can be integrated into Digital Earth.

关键词： building information model(BIM) building service system graph spatial DBMS utility network industrial foundation class(IFC)

Uptake and transformation of arsenic during the reproductive life stage of Agaricus bisporus and Agaricus campestris

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Journal of Environmental Sciences 2016年第11期28卷 140-149页

作者： Michelle M.Nearing Iris koch Kenneth J.Reimer Environmental Sciences Group Royal Military College of Canada

Fruiting bodies from the Agaricus genus have been found to contain non-toxic arsenobetaine（AB） as a major compound. It is unknown whether AB is formed during the vegetative or reproductive life stages of the fungus, or by the surrounding microbial community, but AB＇s structural similarity to glycine betaine has led to the hypothesis that AB may be adventitiously accumulated as an osmolyte. To investigate the potential formation of AB during the reproductive life stage of Agaricus species, growth substrate and fungi were collected during the commercial growth of Agaricus bisporus and analyzed for arsenic speciation using HPLC-ICP-MS. AB was found to be the major arsenic compound in the fungus at the earliest growth stage of fruiting（the primordium）. The growth substrate mainly contained arsenate（As（V））. The distribution of arsenic in an A. bisporus primordium grown on As（V） treated substrate, and in a mature Agaricus campestris fruiting body collected from arsenic contaminated mine tailings, was mapped using two dimensional XAS imaging. The primordium and stalk of the mature fruiting body were both found to be growing around pockets of substrate material containing higher As concentrations, and AB was found exclusively in the fungal tissues. In the mature A. campestris the highest proportion of AB was found in the cap, supporting the AB as an osmolyte hypothesis. The results have allowed us to pinpoint the fungus life stage at which AB formation takes place,namely reproduction, which provides a direction for further research.

关键词： Arsenobetaine Arsenic Agaricus Fungi HPLC-ICP-MS XAS imaging

A methodology for calibration of traffic micro-simulator for urban heterogeneous traffic operations

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第4期7卷 507-519页

作者： Palak Maheshwary Kinjal Bhattacharyya Bhargab Maitra manfred Boltze ARCADIS Bengaluru 560017India Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India Department of Civil and Environmental Engineering Technische Universitat DarmstadtDarmstadt 64287Germany

Traffic micro-simulation is a widely accepted tool in many countries for the evaluation and assessment of alternative design ***,for several developing countries,replicating heterogeneous,non-lane based traffic in a micro-simulation framework is gaining increased importance and still remains a challenge due to its *** present study demonstrates a methodology to calibrate a traffic micro-simulation model giving due consideration to vehicle-class specific driver behavior in an urban Indian scenario for a midblock section and an intersection approach in *** sensitive parameters affecting the driver behavior were identified for every vehicle type using Latin Hyper cube design,taking vehicle class specific travel time as a performance *** regression models were developed for each vehicle class considering the sensitive driving behavior *** models highlight that the dependency of measure of effectiveness(MOE)of one vehicle type is not only limited to its own driver behavior but also on parameters of other vehicle classes.A genetic algorithm based optimization was adopted to obtain optimal parameter sets for different vehicle *** optimum values were found to vary significantly across all vehicle classes at a 95%confidence *** and multi-criteria calibration principles are also implemented to yield much more realistic results and subsequently minimizing weighted error for all vehicle classes.

关键词： Traffic operation Micro-simulation Heterogeneous traffic Vehicle-class Driver behavior VISSIM

Eradication of H pylori for the prevention of gastric cancer

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World Journal of Gastroenterology 2006年第32期12卷 5101-5107页

作者： Karolin Trautmann manfred Stolte Stephan Miehlke Medical Department Ⅰ Technical University Hospital Carl Gustav Carus DresdenGermany Institute for Pathology Klinikum Bayreuth Germany

Infection with H pylori is the most important known etiological factor associated with gastric cancer. While colonization of the gastric mucosa with H pylori results in active and chronic gastritis in virtually all individuals infected, the likelihood of developing gastric cancer depends on environmental, bacterial virulence and host specific factors. The majority of all gastric cancer cases are attributable to H pylori infection and therefore theoretically preventable. There is evidence from animal models that eradication of H pylori at an early time point can prevent gastric cancer development. However, randomized clinical trials exploring the prophylactic effect of Hpylori eradication on the incidence of gastric cancer in humans remain sparse and have yielded conflicting results. Better markers for the identification of patients at risk for H pylori induced gastric malignancy are needed to allow the development of a more efficient public eradication strategy. Meanwhile, screening and treatment of H pylori in first-degree relatives of gastric cancer patients as well as certain high-risk populations might be beneficial.

关键词： Gastric cancer Hpylori Eradication