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Using real world data to assess cardiovascular outcomes of two antidiabetic treatment classes

World Journal of Diabetes 2018年第12期9卷 252-257页

作者： manfred Paul Stapff CMO TriNetX Inc.

AIM To evaluate the effect on cardiovascular outcomes of sodium-glucose co-transporter-2(SGLT2) inhibitors in a real world setting by analyzing electronic medical *** We used Tri Net X, a global federated research network providing statistics on electronic health records(EHR). The analytics subset contained EHR from approximately 38 Million patients in 35 Health Care Organizations in the United States. The records of 46,909 patients who had taken SGLT2 inhibitors were compared to 189,120 patients with dipeptidyl peptidase(DPP) 4 inhibitors. We identified five potential confounding factors and built respective strata: elderly, hypertension, chronic kidney disease(CKD), and co-medication with either insulin or metformin. Cardiovascular events were countedas stroke(ICD10 code: I63) or myocardial infarction(ICD10: I21) occurring within three years after the first instance of the respective medication in the patients' *** Of the 46909 patients with SGLT2 inhibitors in their EHR, 1667 patients(3.6%) had an ICD code for stroke or for myocardial infarction within the first three years after the first instance of the medication. In the control group, there were 10680 events of 189120 patients(5.6%), which represents a risk ratio of 0.63(95%CI: 0.60-0.66). The overall incidence of stroke or myocardial infarction in the strata with a potential confounding risk factor reached from 4.9% in patients taking metformin to 12.5% in the stratum with the highest risk(concomitant CKD). In all strata, the difference in risk of experiencing a cardiovascular event was similarly in favor of SGLT2 vs control, with Risk Ratio ranging from 0.62 to *** Real world data replicated the results from randomized clinical trials, confirmed the cardiovascular advantages of SGLT2 inhibitors, and showed its applicability to the US population.

关键词： Sodium-glucose co-transporter-2 inhibitors Cardiovascular events Clinical trials Electronic medical records Dipeptidyl peptidase 4 inhibitors Real world evidence Diabetes

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4D Design and Simulation Technologies and Process Design Patterns to Support Lean Construction Methods

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Tsinghua Science and Technology 2008年第S1期13卷 179-184页

作者： manfred Breit manfred Vogel Fritz Hubi Fabian Mrki Micheal Raps i4Ds University of Applied Sciences Northwestern Switzerland

The objective of this ongoing joint research program is to determine how 3D/4D modeling, simulation and visualization of Products (buildings), Organizations and Processes (POP) can support lean construction. Initial findings suggest that Process Design Pattern may have the potential to intuitively support ICT based lean construction. We initiated a 'Process Archeology' in order to reveal the requirements for tools that can support the planning, simulation and control of lean construction methods. First findings show that existing tools provide only limited support and therefore, we started to develop new methodologies and technologies to overcome these shortcomings. Through the introduction of Process Design Patterns, we intent to establish process thinking in the interdisciplinary POP design. Optimized construction processes may be synthesized with semi-automatic methods by applying Process Design Patterns on building structures. By providing process templates that integrate problem solution and expert knowledge, Process Design Patterns may have the potential to ensure high quality process models.

关键词： 4D design process and organization modeling and simulation process design patterns lean construction methods

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Efficiency of surface inactivation disinfectants for bacteria studied in an aquaculture microbiology laboratory

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Journal of Biosafety and Biosecurity 2023年第2期5卷 84-86页

作者： manfred Weidmann Institute of Aquaculture University of StirlingStirlingScotlandUK Medizinische Hochschule Brandenburg Institut für Virologie und MikrobiologieUniversitätsplatz 101986 SenftenbergGermany

Routine microbial inactivation procedures used in microbiology laboratories must be *** this study,the efficacy of surface disinfection using 70%Isopropanol,0.45%Presept,and 1%Virkon was tested against 24 bacterial strains commonly handled in aquaculture microbiology *** was ineffective against Nocardia asteroides NCIMB 1290,while Virkon was not effective against Aeromonas eucrenophila NCIMB 74 or Pediococcus acidilacti R52037.

关键词： Inactivation Aquaculture Bacterial pathogens Aeromonas eucrenophila Nocardia asteroides Pediococcus acidilacti

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Breakthrough in the challenging P450-catalyzed chemoenzymatic synthesis of C14-functionalized steroids

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中国科学:化学英文版 2023年第9期66卷 2435-2436页

作者： manfred T.Reetz Frank Hollmann Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 145480 MülheimGermany Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin 300308China Department of Biotechnology Delft Universityvan der Maasweg 92629 HZ DelftNetherlands

Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.

关键词： steroids catalyzed synthesis

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NIBU: a new approach to representing and analysing interior utility networks within 3D geo-information systems

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International Journal of Digital Earth 2012年第1期5卷 22-42页

作者： Ihab Hamzi Hijazi manfred Ehlers Sisi Zlatanova Institute for Geoinformatics and Remote SensingIGF University of OsnabrueckOsnabrueckGermany OTB Research Institute for HousingUrban and Mobility StudiesDelft University of TechnologyDelftThe Netherlands

Facility management departments’responsibilities include monitoring and maintenance of building infrastructure,such as water,gas or *** often these tasks are completed using paper maps,which make integrated analysis of networks *** to consider interior network structure and provide semantic and connectivity information supporting the required analysis operations are thus *** paper presents an approach relying on Building Information Model(BIM)as a data source for obtaining information about interior *** semantic and connectivity information of BIM is mapped onto a new model called Network for Interior Building Utilities(NIBU).NIBU is based on the semantic categorisation of utilities,and the spatial functions that have to be *** scenarios(‘maintenance operation’,‘emergency response’and‘inspection operation’)are developed to test the proposed *** model and its functions are implemented in spatial *** model is populated directly from a BIM server applying an Industrial Foundation Class(IFC)parser developed *** analysis functions are implemented to support spatial operations:trace upstream,trace downstream,find ancestors,find source and find *** investigation proves that BIM provides both the required semantics and attributes,and connectivity information that can facilitate analysis of interior utility *** provides a simple yet flexible way to manage interior network information,which can be integrated into Digital Earth.

关键词： building information model(BIM) building service system graph spatial DBMS utility network industrial foundation class(IFC)

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A methodology for calibration of traffic micro-simulator for urban heterogeneous traffic operations

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第4期7卷 507-519页

作者： Palak Maheshwary Kinjal Bhattacharyya Bhargab Maitra manfred Boltze ARCADIS Bengaluru 560017India Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India Department of Civil and Environmental Engineering Technische Universitat DarmstadtDarmstadt 64287Germany

Traffic micro-simulation is a widely accepted tool in many countries for the evaluation and assessment of alternative design ***,for several developing countries,replicating heterogeneous,non-lane based traffic in a micro-simulation framework is gaining increased importance and still remains a challenge due to its *** present study demonstrates a methodology to calibrate a traffic micro-simulation model giving due consideration to vehicle-class specific driver behavior in an urban Indian scenario for a midblock section and an intersection approach in *** sensitive parameters affecting the driver behavior were identified for every vehicle type using Latin Hyper cube design,taking vehicle class specific travel time as a performance *** regression models were developed for each vehicle class considering the sensitive driving behavior *** models highlight that the dependency of measure of effectiveness(MOE)of one vehicle type is not only limited to its own driver behavior but also on parameters of other vehicle classes.A genetic algorithm based optimization was adopted to obtain optimal parameter sets for different vehicle *** optimum values were found to vary significantly across all vehicle classes at a 95%confidence *** and multi-criteria calibration principles are also implemented to yield much more realistic results and subsequently minimizing weighted error for all vehicle classes.

关键词： Traffic operation Micro-simulation Heterogeneous traffic Vehicle-class Driver behavior VISSIM

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Eradication of H pylori for the prevention of gastric cancer

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World Journal of Gastroenterology 2006年第32期12卷 5101-5107页

作者： Karolin Trautmann manfred Stolte Stephan Miehlke Medical Department Ⅰ Technical University Hospital Carl Gustav Carus DresdenGermany Institute for Pathology Klinikum Bayreuth Germany

Infection with H pylori is the most important known etiological factor associated with gastric cancer. While colonization of the gastric mucosa with H pylori results in active and chronic gastritis in virtually all individuals infected, the likelihood of developing gastric cancer depends on environmental, bacterial virulence and host specific factors. The majority of all gastric cancer cases are attributable to H pylori infection and therefore theoretically preventable. There is evidence from animal models that eradication of H pylori at an early time point can prevent gastric cancer development. However, randomized clinical trials exploring the prophylactic effect of Hpylori eradication on the incidence of gastric cancer in humans remain sparse and have yielded conflicting results. Better markers for the identification of patients at risk for H pylori induced gastric malignancy are needed to allow the development of a more efficient public eradication strategy. Meanwhile, screening and treatment of H pylori in first-degree relatives of gastric cancer patients as well as certain high-risk populations might be beneficial.

关键词： Gastric cancer Hpylori Eradication

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NIBU:An Integrated Framework for Representing the Relation Among Building Structure and Interior Utilities in Micro-Scale Environment

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Geo-Spatial Information Science 2011年第2期14卷 98-108页

作者： Ihab HIJAZI Sisi ZLATANOVA manfred EHLERS Institute for Geoinformatics and Remote Sensing (IGF) University of Osnabrueck OTB Research Institute for HousingUrban and Mobility Studies Delft University of Technology

This paper describes a framework for modeling interdependencies between different network systems and building *** provides an approach for the integrated analysis of interior building utilities by describing a framework to model and simulate infrastructure interdependencies and their complex *** is a graph-based spatial model that can support use cases such as providing the location and specifications of interior utilities to a technician who wants to perform a maintenance *** location could be needed for maintenance or replacement,or to investigate the result of damage to the building structure on another utility network,or to estimate the effect of different maintenance operations in different locations along utilities service *** model accounts for two important aspects:first,the relationship between interior utilities and building elements or spaces and second,the building hierarchy structure to which the utilities network is related.A proper hierarchy of the building is developed which supports the generation of human-oriented descriptions of interior utilities,where a method for partitions of large building element and spaces as well as a method to reference a network element to another building are *** connection of the different utilities network systems and buildings are generated using joints,which are based on a containment *** example is presented which shows the effectiveness of this approach for supporting maintenance operations,as well as the independences between the maintenance operation location and the other network *** paper presents the data model and explains the links with current 3D building model standards.

关键词： Building Information Model (BIM) building service system utility network graph city models

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Human-as-a-security-sensor for harvesting threat intelligence

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Cybersecurity 2018年第1期1卷 652-666页

作者： manfred Vielberth Florian Menges Gunther Pernul Universitat Regensburg Universitatstr.3193053 RegensburgDEGermany

Humans are commonly seen as the weakest link in corporate information *** led to a lot of effort being put into security training and awareness campaigns,which resulted in employees being less likely the target of successful *** approaches,however,do not tap the full potential that can be gained through these *** the one hand,human perception offers an additional source of contextual information for detected incidents,on the other hand it serves as information source for incidents that may not be detectable by automated *** approaches only allow a text-based reporting of basic incident information.A structured recording of human delivered information that also provides compatibility with existing SIEM systems is still *** this work,we propose an approach,which allows humans to systematically report perceived anomalies or incidents in a structured *** approach furthermore supports the integration of such reports into analytics ***,we identify connecting points to SIEM systems,develop a taxonomy for structuring elements reportable by humans acting as a security sensor and develop a structured data format to record data delivered by humans.A prototypical human-as-a-security-sensor wizard applied to a real-world use-case shows our proof of concept.

关键词： Cyber threat intelligence Human awareness Human-as-a-security-sensor Security information and event management(SIEM)

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Advancing Digital Earth:beyond the next generation

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International Journal of Digital Earth 2014年第1期7卷 3-16页

作者： manfred Ehlers Peter Woodgate Alessandro Annoni Sven Schade Institute for Geoinformatics and Remote Sensing University of Osnabru˝ckOsnabru˝ckGermany Cooperative Research Centre for Spatial Information Australia and New ZealandMelbourneAustralia Joint Research Centre European CommissionIspraItaly European Environment Agency CopenhagenDenmark

The Digital Earth(DE)movement is gaining *** of it is *** paper examines a number of recent developments including those in health sensors(Wearable Absence,Q-Sensor,and Guardian Angels)and systems frameworks(Gelernter’s Mirror Worlds,Virtual Australia,and New Zealand).Consideration is given to the implications of DE for citizens and on citizen science,including those of ethics.A suite of principles to guide the development of DE is proposed.

关键词： Digital Earth vision virtual spatial science Geomatics social science ethics

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