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Journal of Pharmaceutical Analysis 2024年第5期14卷 775-779页

作者： Kaicheng Du Yi Zhang Lei Sun Muke Tao Tiantian Zuo Yumeng Wang Zhengfeng Zhang dali Meng School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang110016China NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances Chongqing Institute for Food and Drug ControlChongqing401121China National Institutes for Food and Drug Control Beijing100050China

In traditional Chinese medicine(TCM),Euphorbia fischeriana Steud(***)and Euphorbia ebracteolata Hayata(***),commonly referred to as“Langdu”,are widely extensively utilized for treating lymphatic tuberculosis and ringworm[1].Both plant species are perennial herbaceous plants mainly distributed in northeastern China,Mongolia,Russia(Siberia),and Republic of Korea[2].There have been many reports on the chemical constituents and pharmacological effects of the two plant species,which has made more and more researchers realize that there may be differences between *** and *** some cases,long-term improper use of herbal medicines can even lead to life-threatening conditions[3,4].Therefore,it is essential to employ an effective technology to differentiate between these two plants based on their chemical constituents and biological activities,so as to reduce the harm caused by the mixing and misuse of medicinal ***,the present paper describes a study of the differences between *** and ***,using untargeted plant metabolomics and biological activity *** study aims to provide valuable insight into their equivalence and potential interchangeability in TCM and clinical medication.

关键词： Euphorbia Siberia northeastern

Advancing CRISPR base editing technology through innovative strategies and ideas

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Science China Life Sciences 2024年

作者： Xiongwei Fan Yang Lei Liren Wang Xiushan Wu dali Li The Center for Heart Development College of Life Science Hunan Normal University Shanghai Frontiers Science Research Base of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University Guangdong Provincial Key Laboratory of Pathogenesis Targeted Prevention and Treatment of Heart Disease

The innovation of CRISPR/Cas gene editing technology has developed rapidly in recent years. It is widely used in the fields of disease animal model construction, biological breeding, disease diagnosis and screening, gene therapy, cell localization, cell lineage tracking, synthetic biology, information storage, etc. However, developing idealized editors in various fields is still a goal for future development. This article focuses on the development and innovation of non-DSB editors BE and PE in the platform-based CRISPR system. It first explains the application of ideas for improvement such as “substitution”, “combination”, “adaptation”, and “adjustment” in BE and PE development and then catalogues the ingenious inversions and leaps of thought reflected in the innovations made to CRISPR technology. It will then elaborate on the efforts currently being made to develop small editors to solve the problem of AAV overload and summarize the current application status of editors for in vivo gene modification using AAV as a delivery system. Finally, it summarizes the inspiration brought by CRISPR/Cas innovation and assesses future prospects for development of an idealized editor.

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Lateral circumflex femoral artery perforator flap for the reconstruction of head soft tissue defects:Cross-region venous anastomosis

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 111-115页

作者： Gongxue Zhang Wenhu Jin Ziyang Zhang Lei Shi Rui Yang dali Wang Department of Burn and Plastic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi563000GuizhouChina Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine Zunyi Medical UniversityZunyi563000GuizhouChina

Background:Owing to its unique characteristics,the lateral circumflex femoral artery perforator(LCFAP)flap is often preferred for repairing head wounds with exposed ***,given the vascular distribution in the head,particularly the veins,can lead to postoperative complications such as venous congestion of the *** rates of vascular exploration and necrosis in these flaps are significantly higher than in other body ***,it is crucial to identify a safe and effective method for venous anastomosis of free flaps in the head ***:This retrospective case series study included 10 patients with large head soft tissue defects treated at the Burn and Plastic Surgery Department of the Affiliated Hospital of Zunyi Medical University from January 2020 to December *** head defects were reconstructed using LCFAP flaps,with flap veins anastomosed to the external jugular vein in the neck,either directly or via a bridging ***:Among the 10 adult patients with massive head wound defects,7(70%)were *** patients’mean age was 53.0 years(48–59 years).The wound defects were caused by trauma in 6(60%)patients and by tumors in 4(40%)***,no significant complications occurred,and all LCFAP flap survived without ***:The descending branch of the LCFAP flap effectively repairs massive head wound *** venous anastomosis method for this flap is associated with a low incidence of venous complications and a high patency rate,making it a clinically valuable reference.

关键词： Descending branch of lateral External jugular vein Wound repair Perforator flap

Carotenoid isomerase regulates rice tillering and grain productivity by its biosynthesis pathway

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Journal of Integrative Plant Biology 2024年第2期66卷 172-175页

作者： Chaoqing Ding Zhengji Shao Yuping Yan Guangheng Zhang dali Zeng Li Zhu Jiang Hu Zhenyu Gao Guojun Dong Qian Qian Deyong Ren State Key Laboratory of Rice Biology and Breeding ChinaNational Rice Research InstituteHangzhou 310006China

Tillers are unique inflorescence-like branches in grasses,and their number determines the panicle number,plant architecture,and yield(Shang et al.,2021).Tiller formation mainly undergoes axillary meristem(AM)initiation and tiller bud outgrowth(Wang et al.,2018;Yan et al.,2023).The rice(Oryza sativa)KNOX gene OSH1 is expressed in AMs,and an osh1 mutant produces fewer tillers(Tanaka et al.,2015).

关键词： sativa Oryza panicle

The First-in-Human Whole-Body Dynamic Pharmacokinetics Study of Aptamer

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Research 2024年第1期2023卷 119-130页

作者： Ding Ding Haitao Zhao dali Wei Qinglai Yang Cai Yang Ruowen Wang Yumei Chen Lianghua Li Shuxian An Qian Xia Gang Huang Jianjun Liu Zeyu Xiao Weihong Tan Institute of Molecular Medicine(IMM) Renji HospitalState Key Laboratory of Oncogenes and Related GenesShanghai Jiao Tong University School of Medicineand College of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Nuclear Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Center for Molecular Imaging Probes Cancer Research InstituteUniversity of South ChinaHengyangHunan 421001China The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of MedicineShanghai200127China

Serving as targeting ligands,aptamers have shown promise in precision ***,the lack of knowledge of the biosafety and metabolism patterns in the human body largely impeded aptamers’clinical *** bridge this gap,here we report the first-in-human pharmacokinetics study of protein tyrosine kinase 7 targeted SGC8 aptamer via in vivo PET tracking of gallium-68(^(68)Ga)radiolabeled *** specificity and binding affinity of a radiolabeled aptamer,named ^(68)Ga[Ga]-NOTA-SGC8,were maintained as proven in *** preclinical biosafety and biodistribution evaluation confirmed that aptamers have no biotoxicity,potential mutation risks,or genotoxicity at high dosage(40 mg/kg).Based on this result,a first-in-human clinical trial was approved and carried out to evaluate the circulation and metabolism profiles,as well as biosafety,of the radiolabeled SGC8 aptamer in the human *** advantage of the cutting-edge total-body PET,the aptamers’distribution pattern in the human body was acquired in a dynamic fashion.

关键词： metabolism dosage Whole

从“判断”到“共情”:美学如何介入非遗研究

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东岳论丛 2024年第4期45卷 65-74,191,192页

作者：蔡达丽山东大学文艺美学研究中心山东济南250100

尽管作为小传统的非物质文化遗产与自康德以降从先验观念论维度阐述艺术与审美问题的判断美学框架并不契合,但气氛美学作为一种当代美学话语危机境遇中尝试重返鲍姆嘉通意义上“关于美学最初构想”的新感性学,可为美学僭越艺术哲学所规... 详细信息

尽管作为小传统的非物质文化遗产与自康德以降从先验观念论维度阐述艺术与审美问题的判断美学框架并不契合,但气氛美学作为一种当代美学话语危机境遇中尝试重返鲍姆嘉通意义上“关于美学最初构想”的新感性学,可为美学僭越艺术哲学所规定的研究领域提供理论支撑。从“判断”到“共情”,气氛美学为美学走向非遗保护之学理研究提供启示,使之不复囿于经典美学的思辨框架,转而关注多元传统文化氛围空间的可感特性、情动特质与可塑特征,探寻特定族群将其“历史感”与“地方感”情调融入当下境遇的异质化记忆修辞与表征策略。这对于理解特定共同体构筑其心灵美学寓所的独特方式与恋地情结葆育机制,并论证如可能跨越族群认同边界、建构一种可臻至审美者相通之情感共鸣境界的超文化氛围空间,均具重要的理论与实践指导意义。

关键词：非遗美学传统文化氛围超文化氛围共情伦理-审美

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民族概念的历史考察:阅读与感想散记

学术月刊 2024年第4期56卷 52-65页

作者：姚大力复旦大学历史地理研究中心上海200433

近现代民族概念在英国最初生成时,是由国家疆域来界定的国民民族。随着19世纪末民族主义主流的族裔化,族裔民族或“民族国家”曾长时期被视为民族或现代国家的典型样态。有学者认为民族主义是20世纪的“政治羞耻”。可是只要国家存在,... 详细信息

近现代民族概念在英国最初生成时,是由国家疆域来界定的国民民族。随着19世纪末民族主义主流的族裔化,族裔民族或“民族国家”曾长时期被视为民族或现代国家的典型样态。有学者认为民族主义是20世纪的“政治羞耻”。可是只要国家存在,人类社会就无法规避国民民族主义和族裔民族主义的意识形态。可以做到的,只能是与上述两种民族主义的激进形式都保持距离,而接受温和的国民民族与温和的族裔民族在现实的社会政治中共存。

关键词：民族概念国民民族族裔民族历史考察

Script-Based GPU-Ready ELM Development for Continuous Code Integration

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Journal of Computer and Communications 2024年第5期12卷 102-106页

作者： Peter Schwartz dali Wang Fengming Yuan Peter Thornton Oak Ridge National Laboratory Environmental Sciences Division Oak Ridge USA

Designing and optimizing complex scientific code for new computing architectures is a challenging task. To address this issue in the E3SM land model (ELM) development, we developed a software tool called SPEL, which facilitates code generation, verification, and performance tuning using compiler directives within a Function Unit Test framework. In this paper, we present a SPEL extension that leverages the version control system (e.g., Git) to autonomous code generation and demonstrate its application to continuous code integration and development of the ELM software system. The study can benefit the scientific software development community.

关键词： E3SM Land Model GPU Code Porting Continuous Code Integration SPEL Scientific Software Refactorization

体育构建中国国家形象的内蕴逻辑、发展历程和实践路径

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体育学刊 2024年第3期31卷 1-6页

作者：靳大力国家体育总局体育文化发展中心北京100061 山东大学马克思主义学院山东济南250100

全球化时代,国家形象是国家软实力的重要内容。体育强国建设对提升中国体育国际影响力有明确的要求。运用国家形象理论,分析体育构建中国国家形象的内蕴逻辑:提升“客观源像”与改善“主观印象”相统一的理论逻辑,“强种强国”目标下“... 详细信息

全球化时代,国家形象是国家软实力的重要内容。体育强国建设对提升中国体育国际影响力有明确的要求。运用国家形象理论,分析体育构建中国国家形象的内蕴逻辑:提升“客观源像”与改善“主观印象”相统一的理论逻辑,“强种强国”目标下“土洋体育”同构的实践逻辑。研究认为,近代以来,体育构建中国国家形象经历了体育救国、体育兴国、体育大国的发展历程,正在向体育强国迈进。基于理论与历史分析,提出体育构建中国国家形象的5条路径:一是提升体育综合实力,夯实中国国家形象体育之维;二是提升体育传播能力,讲好中国体育故事;三是加大体育外交力度,厚植中国国家形象民意基础;四是打造明星项目和明星运动员,凝练国家形象符号;五是开展危机管理,有效应对损害形象的危机事件。

关键词：体育文化国家形象体育传播体育外交

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

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The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia Aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew dali Sun Department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular Diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PDAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PDAC tumor *** findings revealed that PDAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PDAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PDAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PDAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity