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Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis

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World Journal of Clinical Cases 2022年第1期10卷 91-103页

作者： Pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen Yadav Usha Dutta Neelam Varma manavjit singh sandhu Rakesh Kochhar Department of Radiodiagnosis Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Hematology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Surgical Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient *** role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this *** To assess the value of WBC and NLR in predicting response to PCD in *** This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December *** and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall *** and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after *** was calculated by dividing the number of neutrophils by the number of *** association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was *** trend of WBC and NLR was also assessed post *** One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final *** was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)*** pain to PCD interval was 24±69.89 *** was successful in 109 patients(group 1)and 46 patients(group 2)who failed to *** was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ *** WBC and NLR showed an overall decreasing *** was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,*** a cut-off value of 9.87 fo

关键词： Acute pancreatitis Percutaneous catheter drainage White blood cell Neutrophil-lymphocyte ratio Necrotic collection

Imaging-based algorithmic approach to gallbladder wall thickening

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World Journal of Gastroenterology 2020年第40期26卷 6163-6181页

作者： Pankaj Gupta Yashi Marodia Akash Bansal Naveen Kalra Praveen Kumar-M Vishal Sharma Usha Dutta manavjit singh sandhu Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pharmacology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Gallbladder(GB) wall thickening is a frequent finding caused by a spectrum of conditions. It is observed in many extracholecystic as well as intrinsic GB conditions. GB wall thickening can either be diffuse or focal. Diffuse wall thickening is a secondary occurrence in both extrinsic and intrinsic pathologies of GB, whereas, focal wall thickening is mostly associated with intrinsic GB pathologies. In the absence of specific clinical features, accurate etiological diagnosis can be challenging. The survival rate in GB carcinoma(GBC) can be improved if it is diagnosed at an early stage, especially when the tumor is confined to the wall. The pattern of wall thickening in GBC is often confused with benign diseases, especially chronic cholecystitis, xanthogranulomatous cholecystitis, and adenomyomatosis. Early recognition and differentiation of these conditions can improve the prognosis. In this minireview, the authors describe the patterns of abnormalities on various imaging modalities(conventional as well as advanced) for the diagnosis of GB wall thickening. This paper also illustrates an algorithmic approach for the etiological diagnosis of GB wall thickening and suggests a formatted reporting for GB wall abnormalities.

关键词： Gallbladder diseases Cholecystitis Rokitansky-Aschoff sinuses of the gallbladder Xanthogranulomatous cholecystitis Neoplasms Acute cholecystitis

Experimental investigation into the effects of Argemone biodiesel/diesel blends on cyclic variations in a multi-cylinder CRDI engine

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Clean Energy 2023年第2期7卷 363-374页

作者： Abhinav Sharma Prem Kumar Sarbjot singh sandhu Mandeep singh Department of Mechanical Engineering Dr B R Ambedkar National Institute of TechnologyJalandhar-144011PunjabIndia

Internal combustion engines suffer from high cyclic variations that result in higher emissions,lower efficiency,higher fuel consump-tion and poor *** purpose of this study is to investigate how Argemone mexicana biodiesel(AGB)/diesel blended fuels affect the cyclic variability of combustion parameters such as maximum cylinder pressure(Pmax)and indicated mean effective pressure(IMEP)in a four-cylinder turbocharged intercooled common-rail direct injection engine under various engine loading *** chemical and physical properties of AGB produced from *** oil were measured and compared according to the ASTM D6751 *** various volumetric ratios,AGB and diesel fuel were blended as D100,AB10(10%AGB+90%D100),AB20(20%AGB+80%D100)and AB30(30%AGB+70%D100).The IMEP and Pmax time-series data were collected over 200 consecutive cycles at low,partial and high engine loads at a constant engine speed of 2000 *** coefficients of variation(COV)of combustion parameters(Pmax and IMEP)were measured for different AGB/diesel blends and found to be within acceptable *** results show that COV_(Pmax) and COV_(IMEP) decrease as the engine load *** was observed that at low load,AB10 has the lowest COV(Pmax,IMEP),and at partial and high load,AB20 has the lowest COV(Pmax,IMEP)among all the blends.

关键词： indicated mean effective pressure cyclic variations biodiesel diesel engine Argemone mexicana biodiesel

Genetic Variation for Anaerobic Germination and Emergence from Deeper Soil Depth in Oryza nivara Accessions

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Rice science 2022年第4期29卷 304-308页

作者： Revanayya MGOTHE Dharminder BHATIA Akashdeep KAMBOJ Nitika sandhu Buta singh DHILLON Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhiana 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhiana 141004India

Anaerobic germination and emergence from deeper soil depth are two important traits for breeding rice suitable for direct seeded *** order to evaluate genetic variation for these traits,a total of 300 Oryza nivara accessions were evaluated along with checks,of which,159 accessions germinated under anaerobic conditions indicating presence of immense variability in *** 159 accessions,69 germinated in submerged conditions and 90 germinated after removing water with availability of aerobic conditions,indicating two different mechanisms operating in ***,out of 300 *** accessions,218 germinated from 6 cm and 95 germinated from 8 cm soil *** accessions that germinated from deeper soil depth had longer mesocotyl and coleoptile lengths.

关键词： soil breeding removing

A genetic algorithm based improved optimal sizing strategy for solar-wind-battery hybrid system using energy filter algorithm

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Frontiers in Energy 2020年第1期14卷 139-151页

作者： Aeidapu MAHESH Kanwarjit singh sandhu Department of Electrical Engineering National Institute of TechnologyKurukshetra136119India

In this paper,the genetic algorithm(GA)is applied to optimize a grid connected solar photovoltaic(PV)-wind-battery hybrid system using a novel energy filter *** main objective of this paper is to minimize the total cost of the hybrid system,while maintaining its *** with the reliability constraint,some of the important parameters,such as full utilization of complementary nature of PV and wind systems,fluctuations of power injected into the grid and the battery’s state of charge(SOC),have also been considered for the effective sizing of the hybrid system.A novel energy filter algorithm for smoothing the power injected into the grid has been *** validate the proposed method,a detailed case study has been *** results of the case study for different cases,with and without employing the energy filter algorithm,have been presented to demonstrate the effectiveness of the proposed sizing strategy.

关键词： PV-wind-battery hybrid system size optimization genetic algorithm

COVID-19 Related Organ Damage

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Advances in Infectious Diseases 2022年第4期12卷 813-823页

作者： Rohit Mittal Harmel singh Chahal Gurpreet singh sandhu University College of Pharmacy Guru Kashi University Talwandi Sabo India Government Polytechnic College for Girls Patiala India Khalsa College of Pharmacy Amritsar India

Coronavirus particles contain four main structural proteins. These are the spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins, all of which are encoded within the 3’ end of the viral genome. The S protein (~150 kDa) utilizes an N-terminal signal sequence to gain access to the ER, and is heavily N-linked glycosylated. In view of the increase in death due to COVID-19 (coronavirus disease), it is important to investigate the potential effects the coronavirus on different organs. A literature search was performed from Elsevier, Pubmed, Springer, and Hindawi, and literature is reviewed using customized search strategies. The search strategy included the following terms Cardiovascular effect, Neurological effect, and kidney. Myocardial damage is a common occurrence in patients with COVID-19 disease hospitalisation. This is characterized by a rise in troponin. Vascular endothelial damage in both small and mid-sized pulmonary vessels was noted together with Disseminated intravascular coagulation (DIC), Deep vein thrombosis (DVT), and Pulmonary embolism (PE), resulting in pulmonary infarction. Liver damage in patients with coronavirus infections might be directly caused by the viral infection of liver cells. Neuronal pathway is an important vehicle for neurotropic viruses to enter the CNS (Central Nervous system). Recent research studies show that apoptosis is implicated in a variety of ocular disorders, including glaucoma, retinitis pigmentosa, cataract development, retinoblastoma, retinal ischemia, diabetic retinopathy, and ocular murine glaucoma. The more the understanding about this new virus and its occurrence, the better the ability of people to cope with it. It’s far hoped that we will conquer COVID-19 soon with the invention of powerful vaccines, pills, and remedies.

关键词： Myocardial Damage Corona Virus Liver Kidney

Potential of triptolide in reproductive management of the house rat,Rattus rattus

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Integrative Zoology 2013年第3期8卷 260-276页

作者： Neena SINGLA Gaganpreet KAUR Bhupinder Kaur BABBAR Bhupinder singh sandhu Department of Zoology Punjab Agricultural UniversityLudhianaIndia Department of Veterinary Pathology Guru Angad Dev Veterinary and Animal Science UniversityLudhianaIndia

Mature and healthy male house rats,Rattus rattus(n=160)were fed on bait(cracked wheat:powdered sugar,98:2)containing different concentrations of triptolide(0.1,0.05,0.025 and 0%)for 7 and 14 days in no-choice and bi-choice feeding tests in the *** objective of the study was to record the antifertility affects of triptolide after 30 and 60 days of termination of *** revealed no significant effect of triptolide treatment on weights of testis,epididymis,seminal vesicles and prostate gland of ***,sperm motility,live sperm count,sperm density and sperm morphology in the cauda epididymal fluid were found to differ significantly(P≤0.05)between untreated and treated groups of *** major effect of triptolide on sperm morphology was in the form of sperm head tail separation,which was up to 56.0%in rats treated for 14 days in no-choice and autopsied after 30 days.A significant effect(P≤0.05)of triptolide treatment was observed on the histomorphology of the testis,which included a dose-dependent decrease in diameter of seminiferous tubules,thickness of germinal epithelium and numbers of various spermatogenic *** associations in the seminiferous epithelial cycle were poorly developed in rats ingesting medium(4.7-5.1 mg/100 g bw)and high doses(6.9-7.2 mg/100 g bw)of triptolide than rats ingesting low doses(1.8-2.3 mg/100 g bw)and untreated *** cell stages affected had not recovered fully within the 60 day period following triptolide *** present study suggests the potential of triptolide in reproductive management of Rattus rattus.

关键词： Rattus rattus reproductive organs seminiferous tubules sperm parameters triptolide

Biochemical Responses Associated with Resistance to Nilaparvata lugens (Stal) in Wild Rice Accessions

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Rice science 2020年第6期27卷 449-453页

作者： Rajwinder Kaur sandhu Preetinder singh Sarao Neelam Kumari Department of Entomology Punjab Agricultural UniversityLudhiana 141004India Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhiana 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhiana 141004India

Brown planthopper(BPH),Nilaparvata lugens(Stal),is a destructive insect pest of *** damages the plants by sucking the plant sap from the phloem tissues and results in wilting of plants due to reduced chlorophyll and protein *** attacked plants do not bear any grains and cause'hopper bum*condition(Catindig et al,2009).Both nymphae and adults suck sap primarily at the base of the tillers,and therefore their presence goes *** is also responsible for transmitting various viral diseases like grassy stunt,ragged stunt and wilted stunt(Win et al,2011).The blanket use of insecticides to control this pest has resulted in natural enemy death,environmental pollution,insecticide resistance and population ***,there is dare need to develop alternative management strategy for this pest,and host plant resistance can be the effective,economical and chemical-free approach to control BPH.

关键词： resistance pollution Access

Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review

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World Journal of Hepatology 2019年第1期11卷 1-18页

作者： Aakash Desai Sonia sandhu Jin-Ping Lai Dalbir singh sandhu Department of Internal Medicine Case Western Reserve University/MetroHealth Medical Center Department of Hematology and Oncology Cleveland Clinic/Akron GeneralMedical Center Department of Pathology University of Florida Division of Gastroenterology and Hepatology Case Western Reserve University/MetroHealth Medical Center

Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer, which in turns accounts for the sixth most common cancer *** being the 6 th most common cancer it is the second leading cause of cancer related deaths. HCC typically arises in the background of cirrhosis, however,about 20% of cases can develop in a non-cirrhotic liver. This particular subgroup of HCC generally presents at an advanced stage as surveillance is not performed in a non-cirrhotic liver. HCC in non-cirrhotic patients is clinically silent in its early stages because of lack of symptoms and surveillance imaging; and higher hepatic reserve in this population. Interestingly, F3 fibrosis in non-alcoholic fatty liver disease, hepatitis B virus and hepatitis C virus infections are associated with high risk of developing HCC. Even though considerable progress has been made in the management of this entity, there is a dire need for implementation of surveillance strategies in the patient population at risk, to decrease the disease burden at presentation and improve the prognosis of these patients. This comprehensive review details the epidemiology, risk factors, clinical features,diagnosis and management of HCC in non-cirrhotic patients and provides future directions for research.

关键词： Hepatocellular carcinoma Non-cirrhotic liver Hepatitis B Hepatitis C Risk factors Clinical features Diagnostic modalities Management strategies Future directions