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Comparison between Adomian’s Decomposition Method and Toeplitz Matrix Method for Solving Linear Mixed Integral Equation with Hilbert Kernel

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American Journal of Computational Mathematics 2016年第2期6卷 177-183页

作者： Fatheah Ahmed Hendi manal mohamed al-qarni Department of Mathematics Faculty of Science King Abdul Aziz University Jeddah Saudi Arabia Department of Mathematics Faculty of Science King Khaled University Abha Saudi Arabia

This paper proposes the combined Laplace-Adomian decomposition method (LADM) for solution two dimensional linear mixed integral equations of type Volterra-Fredholm with Hilbert kernel. Comparison of the obtained results with those obtained by the Toeplitz matrix method (TMM) demonstrates that the proposed technique is powerful and simple.

关键词： Singular Integral Equation Linear Volterra-Fredholm Integral Equation Adomian Decomposition Method Hilbert Kernel

Numerical Solution of Nonlinear Mixed Integral Equation with a Generalized Cauchy Kernel

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Applied Mathematics 2017年第2期8卷 209-214页

In this article, we present approximate solution of the two-dimensional singular nonlinear mixed Volterra-Fredholm integral equations (V-FIE), which is deduced by using new strategy (combined Laplace homotopy perturbation method (LHPM)). Here we consider the V-FIE with Cauchy kernel. Solved examples illustrate that the proposed strategy is powerful, effective and very simple.

关键词： Singular Integral Equation Linear and Nonlinear V-FIE Homotopy Perturbation Method (HPM) Cauchy Kernel

Correlation between DKK-1 Level and Bone Density Status in Children on Maintenance Haemodialysis

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Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： manal Abd El-Salam Marwa mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou El Fattah Nadia Youssef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteodystrophy (ROD) is a bone disorder resulting from chronic kidney disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialysis (HD). Subjects and Methods: This case-control study involved 40 children with CKD on HD and 40 healthy children as controls. The study measured serum DKK-1 levels and performed a dual-energy X-ray absorptiometry scan (DEXA) in line with routine laboratory investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively, with a p-value of less than 0.001. In the hemodialysis group, 25 patients (62.5%) had low bone mineral density (BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally, there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialysis. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialysis Bone Density Status

Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed ali Jerah manal mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam mohamed ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(Pal applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

Morphological and Phylogenetic Studies of a Copepod Species, Irodes parupenei Ho and Lin (2007), Infecting Parupeneus rubescens in Saudi Arabia

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Journal of Ocean University of China 2022年第2期21卷 457-464页

作者： DKHIL mohamed A alHAFIDH Wejdan al-QURAISHY Saleh alOTAIBI Mashael BANAEEM manal alSalEH Thekra ABDEL-GABER Rewaida Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia

Dammam City is one of the gorgeous coastal areas in the Arabian Gulf of Saudi *** present study aimed to ex-amine one of the copepod species infecting the rosy goatfish that represents a highly consumed fish species by the local population in the Arabian *** copepod species isolated from the infected fish specimens belong to the family Taeniacanthidae and was iden-tified as Irodes parupenei Ho and Lin(2007),primarily based on its morphological,morphometric,and ultrastructural characteris-tics,especially the structures of the dorsal cephalic area,segmentation of the first antenna,the absence of the maxilliped claw in the fe-male specimens,and the setation and spinulation of the legs 2-4 for the adult females are of great significance in the taxonomic *** 18S rRNA gene sequence was analyzed to ensure the precise identity and exact taxonomic status of the copepod *** result showed that this copepod species belong to Taenicanthidae and closely related to Irodes sauridi(gb|JF781550.1)in the same *** details on the specificity of the goatfish for Irodes species and identifying these parasitic taxa using molecular analysis are given in the present study.

关键词： Taenicanthidae Irodes species goatfish parasite specificity 18S rRNA gene

An Energy-Efficient Multi-swarm Optimization in Wireless Sensor Networks

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Intelligent Automation & Soft Computing 2023年第5期36卷 1571-1583页

作者： Reem alkanhel Kalaiselvi Chinnathambi C.Thilagavathi mohamed Abouhawwash Mona A.al duailij manal Abdullah alohali Doaa Sami Khafaga Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Electronics and Communication Engineering Kongu Engineering CollegePerundurai638060India Department of Information Technology M.Kumarasamy College of EngineeringKarur639113India Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Information Systems Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Wireless Sensor Networks are a group of sensors with inadequate power sources that are installed in a particular region to gather information from the *** energy-efﬁcient data gathering methods in large-scale Wireless Sensor Networks(WSN)is one of the most difﬁcult areas of *** every sensor node has aﬁnite amount of *** power is the most signiﬁcant source in the *** is a well-known technique for enhan-cing the power feature in *** the proposed method multi-Swarm optimiza-tion based on a Genetic algorithm and Adaptive Hierarchical clustering-based routing protocol are used for enhancing the network’s lifespan and routing *** using distributed data transmission modiﬁcation,an adaptive hier-archical clustering-based routing algorithm for power consumption is presented to ensure continuous coverage of the entire *** begin,a hierarchical cluster-ing-based routing protocol is presented in terms of balancing node energy *** Multi-Swarm optimization(MSO)based Genetic algorithms are proposed to select an efﬁcient Cluster Head(CH).It also improves the network’s longevity and optimizes the *** a result of the study’sﬁndings,the pro-posed MSO-Genetic algorithm with Hill climbing(GAHC)is effective,as it increases the number of clusters created,average energy expended,lifespan com-putation reduces average packet loss,and end-to-end delay.

关键词： Clustering energy consumption genetic algorithm multi swarm optimization adaptive hierarchical clustering routing cluster head

Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

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World Journal of Gastroenterology 2022年第2期28卷 242-262页

作者： Abeer Babiker Idris alaa B Idris manal A Gumaa Mohammed Babiker Idris Amanda Elgoraish mohamed Mansour Dalia allam Bashir MO Arbab Nazar Beirag El-Amin M Ibrahim mohamed A Hassan Department of Agricultural Science and Technology Institute of Natural and Applied SciencesErciyes UniversityKayseri 38039Turkey Department of Medical Microbiology Faculty of Medical Laboratory SciencesUniversity of KhartoumKhartoum 11111Sudan Department of Neurosurgery Ribat University HospitalKhartoum 11111Sudan BioMérieux Clinical and Application Advisor Al-Jeel Medical Co.Riyadh 11422Saudi Arabia Department of Epidemiology Tropical Medicine Research InstituteKhartoum 11111Sudan Department of Gastroenterology Ibn Sina Specialized HospitalKhartoum 11111Sudan Department of Gastroenterology Modern Medical CentreKhartoum 11111Sudan Biosciences College of HealthMedicine and Life SciencesBrunel UniversityLondon UB83PHUxbridgeUnited Kingdom Department of Translation Bioinformatics Detavax BiotechKayseri 38350Turkey

BACKGROUND Helicobacter pylori(***)is a ubiquitous bacterium that affects nearly half of the world’s population with a high morbidity and mortality *** within the tumor necrosis factor-alpha(TNF-A)promoter region are considered a possible genetic basis for this *** To functionally characterize the genetic variations in the TNF-A 5’-region(-584 to+107)of Sudanese patients infected with *** using in silico *** An observational study was carried out in major public and private hospitals in Khartoum state.A total of 122 gastric biopsies were taken from patients who had been referred for *** DNA was *** of the TNF-A-1030 polymorphism was performed using PCR with confronting two-pair primer to investigate its association with the susceptibility to *** infection in the Sudanese ***,Sanger sequencing was applied to detect single nucleotide polymorphisms in the 5’-region(-584 to+107)of TNF-A in ***-infected *** analyses were used to predict whether these mutations would alter transcription factor binding sites or composite regulatory elements in this region.A comparative profiling analysis was conducted in 11 species using the ECR browser and multiple-sequence local alignment and visualization search engine to investigate the possible ***,a multivariate logistic regression model was constructed to estimate odds ratios and their 95%confidence intervals for the association between TNF-A-1030,sociodemographic characteristics and *** *** were statistically significant if Palyses were performed using Stata version 11 *** A total of seven single nucleotide polymorphisms were observed in the TNF-A 5’-region of Sudanese patients infected with *** one of them(T>A,-76)was located at the in silico-predicted promoter region(-146 to+10),and it was predicted to alter transcription factor b

关键词： 5’-region Promoter TNF-A Helicobacter pylori In silico analysis Sudan

Immediate and delayed micro-tensile bond strength of different luting resin cements to different regional dentin

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The Journal of Biomedical Research 2013年第2期27卷 151-158页

作者： Abdelraheem mohamed ali Ibrahim mohamed Hamouda mohamed Hamed Ghazy manal mohamed Abo-Madina Department of Conservative Dentistry Faculty of Dentistry Mansoura University Department of Dental Biomaterials Faculty of Dentistry Mansoura University Department of Conservative Dentistry Faculty of Dentistry Umm Al Qura University Crown & Bridge Department of Conservative Dentistry Faculty of Dentistry Mansoura University

We sought to evaluate immediate and delayed micro-tensile bond strength of Panavia F2.0 and Multilink Sprint resin cement to superficial, deep and cervical dentin. Thirty-six freshly extracted non-carious human molars were sectioned in the mesiodistal direction to expose three different dentin regions including superficial dentin （1 mm below the dentine-enamel junction）, deep dentin （1 mm above the highest pulp horn） and cervical dentin （0.5 mm above the cemento-enamel junction and 0.5 mm below the dentine-enamel junction）. Resin cements were applied on dentin surfaces and composite blocks were luted under constant seating pressure. Each group was divided into three subgroups according to time intervals. Specimens were sectioned to obtain sticks of 1 mm2 in diameter and subjected to microtensile bond strength testing at a cross head speed of 1 mrn/min. Both resin cements showed higher micro-tensile bond strength to superficial dentin than that to deep or cervical dentin （P 〈 0.001）. Micro-ten- sile bond strengths of Panavia F2.0 were higher than those of Multilink Sprint at different dentin regions （P 〈 0.001）. Immediate ＂micro-tensile bond strengths were higher than those of delayed micro-tensile bond strengths for both resin cements （P 〈 0.001）. It was concluded that resin cements with different chemical formulations and applications yield significantly different micro-tensile bond strengths to different dentin regions.

关键词： immediate and delayed micro-tensile bond strength luting resin cements regional dentin

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study

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Chinese Journal of Cancer 2014年第7期33卷 356-364页

作者： Salah mohamed El Sayed Walaa Gamal mohamed Minnat-allah Hassan Seddik al-Shimaa Ahmed Ahmed Asmaa Gamal Mahmoud Wael Hassan Amer manal mohamed Helmy Nabo Ahmed Roshdi Hamed Nagwa Sayed Ahmed ali Abdel-Rahman Abd-allah Department of Medical Oncology and Nuclear Medicine Sohag Faculty of Medicine Sohag University Department of Medical Biochemistry and Molecular biology Sohag Faculty of Medicine Sohag University Department of Surgery Sohag Cancer Center Department of Pediatrics Sohag Teaching Hospital Division of Pediatric Cardiology Department of Pediatrics Maternity and Children Hospital King Abdullah Medical City Al-Madinah Al-Munawwarah Kingdom of Saudi Arabia Department of Pathology Sohag Faculty of Medicine Sohag University

3-Bromopyruvate(3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase(LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells(oxidative stress effect) and competes with the LDH substrates pyruvate and lactate. There is only one published human clinical study showing that 3BP was effective in treating fibrolamellar hepatocellular carcinoma. LDH is a good measure for tumor evaluation and predicts the outcome of treatment better than the presence of a residual tumor mass. According to the Warburg effect, LDH is responsible for lactate synthesis, which facilitates cancer cell survival, progression, aggressiveness, metastasis, and angiogenesis. Lactate produced through LDH activity fuels aerobic cell populations inside tumors via metabolic symbiosis. In melanoma, the most deadly skin cancer, 3BP induced necrotic cell death in sensitive cells, whereas high glutathione(GSH) content made other melanoma cells resistant to 3BP. Concurrent use of a GSH depletor with 3BP killed resistant melanoma cells. Survival of melanoma patients was inversely associated with high serum LDH levels, which was reported to be highly predictive of melanoma treatment in randomized clinical trials. Here, we report a 28-year-old man presented with stage IV metastatic melanoma affecting the back, left pleura, and lung. The disease caused total destruction of the left lung and a high serum LDH level(4,283 U/L). After ethics committee approval and written patient consent, the patient received 3BP intravenous infusions(1-2.2 mg/kg), but the anticancer effect was minimal as indicated by a high serum LDH level. This may have been due to high tumor GSH content. On combining oral paracetamol, which depletes tumor GSH, with 3BP treatment, se

关键词：黑色素瘤治疗文献综述溴代转移性乳酸脱氢酶对乙酰氨基酚 GSH含量