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Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/Fox01/Rab7 Signal Pathway

Chinese Journal of Integrative Medicine 2020年第4期26卷 283-291页

作者： SUN Da-wei gao qing qi Xin Department of Neurology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin(300120)China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin(301617)China Department of Cardiology Tianjin Union Medical CenterTianjin(300121)China

Objective:To explore the specific molecular mechanisms of Danshensu(DSS)in the treatment of ischemia reperfusion injury(IRI).Methods:IRI model was established with isolated rat hearts by performing global ischaemia for 30 min,and then followed by 60 min ***,H9C2 cells were subjected to 4-h hypoxia followed by 3-h *** 10|i mol/L DSS were added in the reperfusion/reoxygenation step to intervene *** function,structural change and apoptosis were respectively tested by Langendorff System,hematoxylin and eosin(HE)and terminal-deoxynucleotidyl transferase mediated nick endabeling(TUNEL)*** lactate dehydrogenase(LDH),cardiac troponin T(cTnT),reactive oxygen species(ROS),superoxide dismutase(SOD)and glutathione peroxidase(GSH-PX)were detected by enzyme-linked immunosorbent assay(ELISA).Sirt1/FoxO1/Rab7 Signal Pathway was monitored at both protein and mRNA ***:The results showed that IRI not only greatly attenuated cardiac function(LVDP and±dp/dtmax,P<0.01,P<0.05)and increased the level of the marker enzymes(cTnT,LDH,P<0.01)from the coronary effluents,but also markedly induced changes in the structure of cardiomyocytes and contributed to apoptosis,which were mediated by boosted en doge nous ***,after treatment with DSS all above indexes were improved,which was related to activating Sirt1/FoxO1/Rab7 signal pathway accompanied with the enhancement of antioxidant defense system,such as SOD and ***:DSS is able to protect hearts from IRI,which may be attributable to inhibiting excessive ROS through Sirt1/FoxO1/Rab7 signaling.

关键词： Chinese medicine Danshensu ischemia reperfusion injury Sirt1/FoxO1/Rab7 signal pathway reactive oxygen species apoptosis

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Human-Tracking Strategies for a Six-legged Rescue Robot Based on Distance and View

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Chinese Journal of Mechanical Engineering 2016年第2期29卷 219-230页

作者： PAN Yang gao Feng qi Chenkun CHAI Xun State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University

Human tracking is an important issue for intelligent robotic control and can be used in many scenarios, such as robotic services and human-robot cooperation. Most of current human-tracking methods are targeted for mobile/tracked robots, but few of them can be used for legged robots. Two novel human-tracking strategies, view priority strategy and distance priority strategy, are proposed specially for legged robots, which enable them to track humans in various complex terrains. View priority strategy focuses on keeping humans in its view angle arrange with priority, while its counterpart, distance priority strategy, focuses on keeping human at a reasonable distance with priority. To evaluate these strategies, two indexes（average and minimum tracking capability） are defined. With the help of these indexes, the view priority strategy shows advantages compared with distance priority strategy. The optimization is done in terms of these indexes, which let the robot has maximum tracking capability. The simulation results show that the robot can track humans with different curves like square, circular, sine and screw paths. Two novel control strategies are proposed which specially concerning legged robot characteristics to solve human tracking problems more efficiently in rescue circumstances.

关键词： human-tracking legged robot intelligent control algorithm

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Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia

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Neural Regeneration Research 2021年第7期16卷 1252-1257页

作者： qiang gao Aaron Leung Yong-Hong Yang Benson Wui-man Lau qian Wang Ling-Yi Liao Yun-Juan Xie Cheng-qi He Department of Rehabilitation Medicine West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina Institute of Disaster management and Reconstruction Sichuan University–The Hong Kong Polytechnic UniversityChengduSichuan ProvinceChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina

Extremely low frequency electromagnetic fields(ELF-EMF) can improve the learning and memory impairment of rats with Alzheimer's disease, however, its effect on cerebral ischemia remains poorly *** this study, we established rat models of middle cerebral artery occlusion/*** day after modeling, a group of rats were treated with ELF-EMF(50 Hz, 1 mT) for 2 hours daily on 28 successive *** results showed that rats treated with ELF-EMF required shorter swimming distances and latencies in the Morris water maze test than those of untreated *** number of times the platform was crossed and the time spent in the target quadrant were greater than those of untreated *** number of BrdU~+/NeuN~+ cells, representing newly born neurons, in the hippocampal subgranular zone increased more in the treated than in untreated ***-regulation in the expressions of Notch1, Hes1, and Hes5 proteins, which are the key factors of the Notch signaling pathway, was greatest in the treated *** findings suggest that ELF-EMF can enhance hippocampal neurogenesis of rats with cerebral ischemia, possibly by affecting the Notch signaling *** study was approved by the Institutional Ethics Committee of Sichuan University, China(approval No.2019255A) on March 5, 2019.

关键词： cerebral ischemia cognitive function electromagnetic fields hippocampus neurogenesis plasticity repair signaling pathway stroke rat

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Gait Planning for a Quadruped Robot with One Faulty Actuator

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Chinese Journal of Mechanical Engineering 2015年第1期28卷 11-19页

作者： CHEN Xianbao gao Feng qi Chenkun TIAN Xinghua State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University

Fault tolerance is essential for quadruped robots when they work in remote areas or hazardous environments. many fault-tolerant gaits planning method proposed in the past decade constrained more degrees of freedom（DOFs） of a robot than necessary. Thus a novel method to realize the fault-tolerant walking is proposed. The mobility of the robot is analyzed first by using the screw theory. The result shows that the translation of the center of body（CoB） can be kept with one faulty actuator if the rotations of the body are controlled. Thus the DOFs of the robot body are divided into two parts： the translation of the CoB and the rotation of the body. The kinematic model of the whole robot is built, the algorithm is developed to actively control the body orientations at the velocity level so that the planned CoB trajectory can be realized in spite of the constraint of the faulty actuator. This gait has a similar generation sequence with the normal gait and can be applied to the robot at any position. Simulations and experiments of the fault-tolerant gait with one faulty actuator are carried out. The CoB errors and the body rotation angles are measured. Comparing to the traditional fault-tolerant gait they can be reduced by at least 50%. A fault-tolerant gait planning algorithm is presented, which not only realizes the walking of a quadruped robot with a faulty actuator, but also efficiently improves the walking performances by taking full advantage of the remaining operational actuators according to the results of the simulations and experiments.

关键词： quadruped robot fault-tolerant gait mobility kinematic redundancy

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Existence and exponential stability of almost-periodic solutions for MAM neural network with distributed delays on time scales

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Applied Mathematics(A Journal of Chinese Universities) 2021年第1期36卷 70-82页

作者： gao Jin WANG qi-ru LIN Yuan School of Computer Sciences Shenzhen Institute of Information TechnologyShenzhen 518172China School of Mathematics Sun Yat-sen UniversityGuangzhou 510275China Department of Public Courses Shenzhen Institute of Information TechnologyShenzhen 518172China

This paper is concerned with multidirectional associative memory neural network with distributed delays on almost-periodic time *** sufficient conditions on the existence,uniqueness and the global exponential stability of almost-periodic solutions are *** example is presented to illustrate the feasibility and effectiveness of the obtained results.

关键词： multidirectional associative memory neural networks time scales almost-periodic solutions,exponential stability.

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Sensitivity Analysis of a Bioinspired Refractive Index Based Gas Sensor

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Journal of Bionic Engineering 2011年第3期8卷 323-334页

作者： Yang gao qi Xia Guanglan Liao Tielin Shi Wuhan National Laboratory for Optoelectronic Wuhan 430074 P. R. Chinao State Key Laboratory of Digital manufacturing Equipment and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China

It was found out that the change of refractive index of ambient gas can lead to obvious change of the color of Morpho butterfly＇s wing. Such phenomenon has been employed as a sensing principle for detecting gas. In the present study, Rigorous Coupled-Wave Analysis （RCWA） was described briefly, and the partial derivative of optical reflection efficiency with respect to the refractive index of ambient gas, i.e., sensitivity of the sensor, was derived based on RCWA. A bioinspired grating model was constructed by mimicking the nanostructure on the ground scale of Morpho didius butterfly＇s wing. The analytical sensitivity was verified and the effect of the grating shape on the reflection spectra and its sensitivity were discussed. The results show that by tuning shape parameters of the grating, we can obtain desired reflection spectra and sensitivity, which can be applied to the design of the bioinspired refractive index based gas sensor.

关键词： bioinspired gas sensor sensitivity diffraction gratings refractive index subwavelength structures

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A Simplified Control Method to Achieve Stable and Robust Quadrupedal Quasi-passive Walking with Compliant Legs

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Journal of Bionic Engineering 2016年第4期13卷 585-599页

作者： qiao Sun Feng gao Chenkun qi Xianbao Chen State Key Laboratory of Mechanical System and Vibration Shanghai Jiaotong University Shanghai 200240 China

The principle of passive dynamic walking has drawn lots of attentions in the field of robotics for it provides a possibility to realize natural walking. However, stabilizing the quadrupedal passive walking remains challenging. In this paper, a novel control method is proposed to stabilize the quadrupedal quasi-passive walking. Inspired by biological concepts, this method treats the foreleg pair and hindleg pair as two bipedal walkers, and a virtual model controller is designed to maintain the quasi-passive walking of each bipedal walker independently. This control method was then verified by a planar quadrupedal model with compliant legs, which successfully achieved stable periodical walking gaits. It was found that although being con- trolled independently, the movement of fore and hind leg pairs still formed a time-invariant phase shift, showing remarkable resemblance to that of a walking horse. We fiarther analyzed the influences of varying factors on the gait characteristics and stability. These analyses show the control method is robust since it can stabilize the gaits within a wide range of leg compliance parameters and resist considerably large disturbances. In addition, the optimal ranges of the leg compliance parameters for the largest stability margin were also found in this study.

关键词： quadrupedal walking quasi-passive walking leg compliance independent control

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One-step synthesis of basic magnesium sulfate whiskers by atmospheric pressure reflux

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Particuology 2016年第1期14卷 191-196页

作者： Xinlong Ma Guoqing Ning Chuanlei qi Jinsen gao State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China

We have developed a one-step process for the synthesis of basic magnesium sulfate （5Mg（OH）2-MgSO4-3H20, abbreviated as 513MOS） whiskers from MgSO4,7H20 and MgO by refluxing at atmospheric pressure. The process shows potential for the low-cost mass production of controlled- structure whiskers. Their 0.3-1.0 μm diameter and 40-80 μm length correspond to an aspect ratio of 40-260. The 513MOS whisker morphology is related closely to MgSO4 concentration and reflux time. The optimized MgSO4 concentration is 1.2-1.5 mol/L with a 25-30 h reflux time. X-ray diffractometry revealed that the b-axis is the predominant growth direction of the whiskers. Their growth mechanism is by the relatively slow liquid-phase deposition of Mg2＋, OH-, and SO42-. The long reaction time and high MgSO4 concentration are conducive to the formation of 513MOS whiskers under gentle reaction conditions. Porous MgO whiskers with a fibrous structure were obtained after calcination of the 513MOS whiskers at 1020 ℃.

关键词： Basic magnesium sulfate Whiskers Atmospheric pressure reflux Growth mechanism

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Synthesis and Characterization of Niobium-doped TiO_2 Nanotube Arrays by Anodization of Ti-20Nb Alloys

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Journal of Materials Science & Technology 2012年第10期28卷 865-870页

作者： Zhengchao Xu qi Li Shian gao Jianku Shangi Materials Center for Water Purification Shenyang National Laboratory for Materials ScienceInstitute of MetalResearchChinese Academy of SciencesShenyang 110016China Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Well crystallized niobium-doped TiO; nanotube arrays （TiNbO-NT） were successfully synthesized via the anodization of titanium/niobium alloy sheets, followed with a heat treatment at 550 ℃ for 2 h. Morphology analysis results demonstrated that both the titanium/niobium alloy microstructure and the dissolution strength of electrolyte played major roles in the formation of nanotube structure. A single-phase microstructure was more favorable to the formation of uniform nanotube arrays, while modulating the dissolution strength of electrolyte was required to obtain nanotube arrays from the alloys with multi-phase microstructures. X-ray diffraction （XRD） and X-ray photoelectron （XPS） analysis results clearly demonstrated that niobium dopants （Nb^5＋） were successfully doped into TiO2 anatase lattice by substituting Ti^4＋ in this approach.

关键词： TiO2 Nanotube arrays Anodization Doping

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Palladium nanoparticles supported on amine-functionalized glass fiber mat for fixed-bed reactors on the effective removal of hexavalent chromium by catalytic reduction

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Journal of Materials Science & Technology 2018年第6期34卷 961-968页

作者： Yu gao Wuzhu Sun Weiyi Yang qi Li Environment Functional Materials Division Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Institute of Materials China Academy of Engineering Physics Mianyang 621900 China School of Materials Science and Engineering Shandong University of Technology Zibo 255000 China

Palladium nanoparticles were deposited on the amine-grafted glass fiber mat （GFM-NH2） catalyst support by a conventional impregnation process followed by the borohydride reduction in aqueous solution at room temperature to create the designed Pd/GFM-NH2 catalyst. By the use of large size glass fiber mat without nano/mesopores as the catalyst support, the internal mass transfer limitations due to the existence of nano/mesopores on the catalyst support were eliminated and the Pd/GFM-NH2 catalyst could be easily separated from treated water due to the large size of the catalyst support. Batch experiments demonstrate its good catalytic reduction performance of Cr（VI） with formic acid as the reducing agent. It also demonstrated an efficient Cr（VI） removal and stability in a lab-prepared, packed fixed-bed tube reactor for the continuous treatment of Cr（VI）-containing water. Thus, it has a good potential for the catalytic reduction of Cr（VI） in the water treatment practice.

关键词： Palladium nanoparticle Amine-functionalized glass fiber mat Fixed-bed reactor Hexavalent chromium Catalytic reduction

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