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Lysogenic phage therapy towards emerging contaminant bioremediation

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Science China Technological Sciences 2024年第10期67卷 3129-3131页

作者： tang Xiang ZHOU ShunGui Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry University

Emerging contaminants often arise as by-products of technological advances,(bio)transformation products, or replacements for previously regulated chemicals. Once released into the environment, they present a significant threat to human health within the One Health framework. Among various strategies for contaminant remediation, microbial-based initiatives are particularly promising for the removal and remediation of emerging contaminants due to their environmentally friendly characteristics, such as minimal chemical use and reduced energy consumption.

关键词： BACTERIA GENES

Computer vision tasks for intelligent aerospace perception: An overview

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Science China(Technological Sciences) 2024年第9期67卷 2727-2748页

作者： CHEN HuiLin SUN QiYu LI FangFei tang Yang School of Information Science and Engineering East China University of Science and TechnologyShanghai 200237China School of Mathematics East China University of Science and TechnologyShanghai 200237China

Computer vision tasks are crucial for aerospace missions as they help spacecraft to understand and interpret the space environment,such as estimating position and orientation, reconstructing 3D models, and recognizing objects, which have been extensively studied to successfully carry out the missions. However, traditional methods like Kalman filtering, structure from motion, and multi-view stereo are not robust enough to handle harsh conditions, leading to unreliable results. In recent years, deep learning(DL)-based perception technologies have shown great potential and outperformed traditional methods, especially in terms of their robustness to changing environments. To further advance DL-based aerospace perception, various frameworks, datasets,and strategies have been proposed, indicating significant potential for future applications. In this survey, we aim to explore the promising techniques used in perception tasks and emphasize the importance of DL-based aerospace perception. We begin by providing an overview of aerospace perception, including classical space programs developed in recent years, commonly used sensors, and traditional perception methods. Subsequently, we delve into three fundamental perception tasks in aerospace missions: pose estimation, 3D reconstruction, and recognition, as they are basic and crucial for subsequent decision-making and control. Finally, we discuss the limitations and possibilities in current research and provide an outlook on future developments,including the challenges of working with limited datasets, the need for improved algorithms, and the potential benefits of multisource information fusion.

关键词： deep learning perception aerospace missions pose estimation 3D reconstruction recognition

Recent advances in g-C_(3)N_(4)-based direct Z-scheme photocatalysts for environmental and energy applications

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Chinese Journal of Structural Chemistry 2024年第2期43卷 66-84页

作者： Xiaoming Fu Haibo Huang Guogang tang Jingmin Zhang Junyue Sheng Hua tang School of Intelligent Engineering and Technology Jiangsu Vocational College of Finance&EconomicsHuai'anJiangsu223003PR China School of Modem Equipment manufacturing Changzhou Institute of Light Industry Technology ChangzhouJiangsu213164PR China School of Environmental Science and Engineering Qingdao UniversityQingdao266071PR China School of Materials Science and Engineering Hainan UniversityHaikou570228PR China

In the midst of the rapid advancement of photocatalysis,direct Z-scheme heterojunction photocatalysts have emerged as a powerful solution to address environmental challenges and the looming energy *** precise engineering of direct Z-scheme heterojunction photocatalysts proves highly beneficial in optimizing their elec-tronic structure,ultimately enhancing their photocatalytic ***,graphitic carbon nitride(g-C_(3)N_(4))has recently gained recognition as a leading candidate for the creation of direct Z-scheme heterojunctions,owing to its favorable attributes such as a moderate band-gap(2.7 eV),high reduction potential and abundant active *** this review,we offer a concise overview of the fundamental principles and recent advancements in g-C_(3)N_(4)-based direct Z-scheme photocatalytic ***,we delve into the various practical applica-tions of g-C_(3)N_(4)-based direct Z-scheme photocatalysts,specifically in the realms of energy conversion and envi-ronmental *** applications include the removal of contaminant pollutants through photocatalytic degradation,water splitting(comprising H_(2)-generation,O_(2)-evolution,and overall water splitting),and CO_(2)***,we present comprehensive characterization methods and strategies aimed at further enhancing the photocatalytic activity of g-C_(3)N_(4)-based direct Z-scheme photocatalytic *** conclude,this review offers summarizing insights and a brief discussion on future challenges and prospects pertaining to g-C_(3)N_(4)-based direct Z-scheme *** believe that this review will inspire continued exploration and foster a deeper understanding of the groundbreaking possibilities within photocatalytic *** also provides valuable guidance for the design and construction of innovative direct Z-scheme photocatalysts.

关键词： Carbon nitride Photocatalyst Z-scheme systems Environmental remediation Energy conversion

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu man Liu Zheng-Rui Bian Bei-Bei Zhang Qian Yu Yin-Hai Xu Ren-Xian tang Kui-Yang Zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

Response and assembly of abundant and rare taxa in Zaopei under different combination patterns of Daqu and pit mud:from microbial ecology to Baijiu brewing microecosystem

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Food Science and Human Wellness 2024年第3期13卷 1439-1452页

作者： Yu Mu Jun Huang Rongqing Zhou Suyi Zhang Hui Qin Hanlan tang Qianglin Pan Huifang tang College of Biomass Science and Engineering Sichuan UniversityChengdu 610065China National Engineering Research Center of Solid-State manufacturing Luzhou 646000China Luzhou Laojiao Co. Ltd.Luzhou 646699China

The quality and aroma of strong-flavor Baijiu are mainly dependent on Daqu,pit mud(PM),and the interaction of ***,little is known about how their combination patterns affect the microbiome and metabolome of Zaopei,especially the metabolic function of rare ***,an experiment on industrial size was designed to assess the effects of 6 combinations(3 kinds of Daqu×2 kinds of PM)on the composition and assembly of different taxa,as well as the flavor *** results showed that Zaopei's microbiota was composed of a few abundant taxa and enormous rare taxa,and rare bacterial and abundant fungal subcommunities were significantly affected by combination *** assembly processes of abundant/rare taxa and bacterial/fungal communities were distinct,and environmental changes mediated the balance between stochastic and deterministic processes in rare bacteria ***,specific combination patterns improved the flavor quality of Zaopei by enhancing the interspecies interaction,which was closely related to rare taxa,especially rare *** findings highlighted that rare bacteria might be the keystone in involving community interaction and maintaining metabolic function,which provided a scientific foundation for better understanding and regulating the brewing microbiota from the viewpoint of microbial ecology.

关键词： Bioaugmented Daqu Artificial pit mud Abundant and rare taxa Community assembly Metabolic function

Mottled dolomite in the lower Cambrian Longwangmiao formation in the Northern Sichuan Basin,South China

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Petroleum 2024年第1期10卷 19-29页

作者： Xuefei Yang Hao tang Junyi Zhang Yao Du Ruifeng tang Shuang Pan Xiang Zhou Yan Xu State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China Sichuan Provincial Key Laboratory of Gas Geology Southwest Petroleum UniversityChengdu610500China CCDC Chuandong Drilling Company Chongqing401120China Exploration Department Petrochina Southwest Oil&Gasfield CompanyChengdu610051China

At the end of Early Cambrian time,the Sichuan basin(South China)was located in a wide carbonate platform,with hundreds of meters of carbonate *** Longwangmiao Formation carbonate in Sichuan basin is partially to completely dolomitized,displaying a mottled texture in the northern area of the *** mottled dolomitic limestone developed parallel to bedding,with shape irregular boundaries with limestone that has not been *** mottled dolomite is composed of powder crystalline and finely crystalline dolomite,while the matrix limestone is composed of micritic *** isotopic composition of mottled dolomite(δ^(13)C=+0.29‰PDB,δ^(18)O=1.15‰PDB)is similar to that of micrite calcite(δ^(13)C=0.49‰PDB,δ^(18)O=1.45‰PDB).Both isotopic values and trace element data indicate that the dolomitized fluid is originated from sea *** beds contain gypsum pseudomorphs and mud cracks,indicating a shallow and evaporative environment with local high salinity during *** likely took place early,in part as a result of sea water salinity *** fossils thalassinoides horizontalis,thalassinoides callianassa and planolites developed in the Longwangmiao Formation,and the sharp edges of mottled dolomite are similar to these trace *** beds are intensely *** the burrow network,the sediments and burrow fill were coarse and loose with little clay,and it is interpreted here as being easier to be dolomitized than the surrounding *** dolomitization is thus interpreted to have occurred in the burrow system,and the degree of dolomitization was related to the degree of bioturbation,which is controlled by the trace-making creatures.

关键词： Mottled dolomite Dolomitization Longwangmiao Formation Early Cambrian Northern Sichuan basin

Hyperbolic tangent Function-Based Protocols for Global/Semi-Global Finite-Time Consensus of Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1381-1397页

作者： Zongyu Zuo Jingchuan tang Ruiqi Ke Qing-Long Han Seventh Research Division Beihang University(BUAA)Beijing 100191China School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia IEEE

This paper investigates the problem of global/semi-global finite-time consensus for integrator-type multi-agent *** hyperbolic tangent function-based protocols are pro-posed to achieve global and semi-global finite-time consensus for both single-integrator and double-integrator multi-agent systems with leaderless undirected and leader-following directed commu-nication *** new protocols not only provide an explicit upper-bound estimate for the settling time,but also have a user-prescribed bounded control *** addition,compared to some existing results based on the saturation function,the pro-posed approach considerably simplifies the protocol design and the stability *** examples and an application demonstrate the effectiveness of the proposed protocols.

关键词： Consensus protocol finite-time consensus hyper-bolic tangent function multi-agent systems.

Serum LDL Promotes Microglial Activation and Exacerbates Demyelinating Injury in Neuromyelitis Optica Spectrum Disorder

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Neuroscience Bulletin 2024年第8期40卷 1104-1114页

作者： man Chen Yun‑Hui Chu Wen‑Xiang Yu Yun‑Fan You Yue tang Xiao‑Wei Pang Hang Zhang Ke Shang Gang Deng Luo‑Qi Zhou Sheng Yang Wei Wang Jun Xiao Dai‑Shi Tian Chuan Qin Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune inflammatory demyelinating disease of the central nervous system(CNS)accompanied by blood-brain barrier(BBB)*** in microglial lipid metabolism is believed to be closely associated with the neuropathology of ***,there is limited evidence on the functional relevance of circulating lipids in CNS demyelination,cellular metabolism,and microglial ***,we found that serum low-density lipoprotein(LDL)was positively correlated with markers of neurological damage in NMOSD *** addition,we demonstrated in a mouse model of NMOSD that LDL penetrates the CNS through the leaky BBB,directly activating *** activation leads to excessive phagocytosis of myelin debris,inhibition of lipid metabolism,and increased glycolysis,ultimately exacerbating myelin *** also found that therapeutic interventions aimed at reducing circulating LDL effectively reversed the lipid metabolic dysfunction in microglia and mitigated the demyelinating injury in *** findings shed light on the molecular and cellular mechanisms underlying the positive correlation between serum LDL and neurological damage,highlighting the potential therapeutic target for lowering circulating lipids to alleviate the acute demyelinating injury in NMOSD.

关键词： Neuromyelitis optica spectrum disorder Low-density lipoprotein Microglia

Water–solid contact electrification and catalysis adjusted by surface functional groups

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Nano Research 2024年第4期17卷 3344-3351页

作者： Yusen Su Andy Berbille Zhong Lin Wang Wei tang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China Georgia Institute of Technology AtlantaGA 30332-0245USA

Chemical functional groups on solid surfaces greatly influence contact electrification(CE)at water–solid *** studies of their effects mainly swapped materials or bonded related molecules to a substrate,introducing other factors of *** work aims at unambiguously demonstrating the role of functional groups in water-polymer *** study the contribution of functional groups,by using ion coupled plasma etching to modify a high-density polyethylene(HDPE)film,a polymer with a naturally quasi-null charge transfer ***(HDPE–F)and hydroxyl(HDPE–OH)functional groups are generated and endowed HDPE with charge withdrawing ***–F withdraws 2.5–2.7 times more charges than HDPE–***,the surface charges accumulated generate electrostatic forces,altering the droplets *** phenomenon provides another approach to study CE,helping to evaluate the contribution of electrons to solid–liquid ***,employing HDPE–F to perform contact-electro-catalysis shows its activity is 2.4 times higher than that of commercial fluorinated films.

关键词： contact-electro-catalysis charge transfer solid–liquid interfaces contact electrification