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Simulation study of slow extraction for the Shanghai Advanced Proton Therapy facility

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Nuclear Science and Techniques 2017年第9期28卷 1-7页

作者： Yu-Hui Yang man-zhou Zhang De-Ming Li Shanghai Institute of Applied Physics Chinese Academy of Sciences Jiading Campus Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China

The Shanghai Advanced Proton Therapy facility employs third-integer slow extraction. In order to achieve accurate treatment, high-quality spill is needed. Therefore,parameters that may affect slow extraction should be investigated by simulation. A computer model of the synchrotron operation slow extraction was constructed with MATLAB~. By simulating the motion of the circulating protons, we could quantify the influence of machine and initial beam parameters on properties of the extracted beam, such as ripple, uniformity, stability, on-and off-time of the spill and spill width in the *** design parameters including the horizontal tunes,power supply ripple, longitudinal RF cavity voltage, RFKO and the chromaticities were determined.

关键词：治疗设备模拟质子提取上海装置 MATLAB 光束参数

Distribution of α-, β-, and γ-Phases in a Multi-flow Injection-molded Hierarchical Structure

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Chinese Journal of Polymer Science 2018年第6期36卷 765-775页

作者： Da-Shan Mi Feng-Yi Hou man zhou Jie Zhang College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

In the current work, a custom-made vibration injection molding device that can provide oscillatory pressure was utilized to create an injection-molded hierarchical structure. Growth competition among α, β, and γ phases in the injection-molded structure can be studied because of the presence of this hierarchical structure, wherein shish-kebab and spherulite layers were arranged alternately along the thickness direction. The γ crystals only existed in layers subjected to high pressure and shear stress, whereas β crystals formed between the shear layers. The change in trend of the γ fraction was similar to that of parent-to-daughter ratio. In addition, this hierarchical and alternating crystal structure can sharply increase the mechanical properties.

关键词： Shish-kebab Growth competition α Phase γ Phase β Phase

A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide

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Chinese Chemical Letters 2006年第3期17卷 302-304页

作者： Guang Yu XU Yi zhou man Cai XU College of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081

A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and （S）-glyceraldehyde acetonide in the pre... 详细信息

关键词： Linezolid antibacterial synthesis ascorbic acid.

Growth morphology and evolution of quasicrystal in as-solidified Y-rich Mg-Zn-Y ternary alloys

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Rare Metals 2007年第5期26卷 435-439页

作者： WAN Diqing YANG Gencang CHEN Sulin ZHU man zhou Yaohe State Key Laboratory of Solidification Processing Northwestern Polytechnical University Xi＇an 710072 China

A petal-like icosahedral quasicrystal with five branches,which is considered to be the representative morphology of the icosahedral quasicrystal,has been observed in the Y-rich Mg-Zn-Y ternary alloys. Moreover,the polygon-like morphology,another pattern of the icosahedral quasicrystal,has also been found in the Y-rich Mg-Zn-Y ternary alloys. The latter morphology results from the evolution of the former one. The growth mechanism of the petal-like morphology of the icosahedral quasicrystal was also discussed. Alloying composition,i.e.,Y element content,is a major factor inducing the morphology evolution of the icosahedral quasicrystal.

关键词： Mg-Zn-Y ternary alloys icosahedral quasicrystal morphology evolution Y element

A novel highly selective fluorescent chemosensor for Hg(Ⅱ) in fully aqueous media

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Chinese Chemical Letters 2007年第10期18卷 1209-1212页

作者： Xiang Ming Meng man zhou Zhu Qing Xiang Guo Department of Chemistry University of Science and Technology of China Hefei 230026 China

A novel fluorescent Hg^2＋ chemosensor based on dithia-dioxa-monoaza crown ether was synthesized in four steps from inexpensive starting materials. This new sensor exhibited very strong fluorescence response to Hg^2＋... 详细信息

关键词： Hg^2+ sensor Fluorescence PET Fluorescein Selectivity

Design and Synthesis of Lipids Bearing Nucleosides as Gene Vectors

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Chinese Chemical Letters 2001年第9期12卷 779-782页

作者： man zhou ZHU Qi Hua WU Qing Xiang GUO Department of Chemistry University of Science and Technology of ChinaHefei 230026

Some novel lipids bearing nucleosides were designed and synthesized as gene vectors, and the structures of these compounds were characterized by UV, IR, 1HNMR, 13CNMR and elemental analysis.

关键词： Gene vector lipid nucleoside synthesis

Altering the Hierarchical Morphology Distribution of Injection Molded Polyethylene by the Introduction of Crosslink Network and Periodical Shear

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Chinese Journal of Polymer Science 2016年第12期34卷 1479-1489页

作者： Zhi-hao Zhao Fei-fei Wang man zhou Kai-zhi Shen 张杰 College of Polymer Science and Engineer'ing State Key Laboratory of Polymer Materials En~neeringSichuan UniversityChengdu 610065China

High density polyethylene （HDPE） with moderate content of crosslink network （CPE） was successfully prepared through chemical method. Specimens for structural characterization have been molded by conventional injection molding （CIM） and pressure vibration injection molding （PVIM）. Influence of crosslink network on hierarchical morphology distribution and mechanical properties was systematically studied. Polarized light microscopy （PLM） revealed that both CIM and PVIM PE samples have a typical ＂skin-core＂ structure and the thickness of shear layer of CIM PE and PVIM CPE samples obviously increase. Scanning electron microscopy （SEM） showed that shish-kebab structures are clearly observed in shear layer of CIM CPE sample, indicating that the crosslink network can surely improve the formation of shish-kebab structures. Moreover, we suppose that shish-kebab structures emerged in shear and core layer of PVIM CPE sample. Wide- angle X-ray diffraction （WAXD） and small-angle X-ray scattering （SAXS） confirmed that more orientation and shish-kebab structures form even in core layer of PVIM CPE sample, which demonstrated that the hierarchical morphology was apparently altered by periodical shear and crosslink network. Finally, the mechanical properties revealed that this oriented structure increase the tensile strength from 31 MPa of CIM PE sample to 46 MPa of PVIM CPE sample. However, the tensile behavior tended to change from ductile fracture to brittle fracture.

关键词： Shish-kebab Morphology distribution Periodical shear Mechanical properties.

The unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α in nude mice

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Science China(Life Sciences) 2013年第1期56卷 26-31页

作者： WU Hui FU YongMing XIAO Jun zhou man zhou Wei FENG Hao Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education of China College of Life ScienceHunan Normal University

The Kaposi's Sarcoma-associated Herpesvirus (KSHV)-encoded G-protein coupled receptor (vGPCR) is an oncoprotein that is implicated in KSHV-associated malignancies. We previously revealed vGPCR incorporates sulfate groups within its extracellular N-terminal tyrosine residues (Y26 and Y28) and that this tyrosine sulfation is crucial for its tumorigenicity in nude mice. hGRO-binds vGPCR in a sulfotyrosine-dependent manner and promotes its tumorigenicity through autocrine signaling. Interestingly, an unsulfated vGPCR mutant (yydd-vGPCR) attenuated the tumor growth triggered by hGRO-α . In this study, the extracellular N-terminus of vGPCR (wt-vGN) and an unsulfated vGPCR mutant (yydd-vGN) were individually secreted, expressed and purified. A radioactive labeling assay demonstrated that wt-vGN but not yydd-vGN incorporated [ 35 S]-sulfate. In nude mice, NIH3T3 cells expressing yydd-vGN but not wt-vGN could significantly inhibit the tumor growth triggered by hGRO-α . All our data support the conclusion that the unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α .

关键词： KSHV vGPCR hGRO-α sulfotyrosine tumorigenicity

Simultaneously Improving the Tensile and Impact Properties of Isotactic Polypropylene with the Cooperation of co-PP and β-nucleating Agent through Pressure Vibration Injection Molding

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Chinese Journal of Polymer Science 2016年第8期34卷 1001-1013页

作者： man zhou Xin-peng Li Ming Jin Chao Xia Kai-zhi Shen 张杰 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

In this article, crystalline morphology and molecular orientation of isotactic polypropylene （iPP）, random copolymerized polypropylene （co-PP） and ,β-nucleating agent （β-NA） composites prepared by pressure vibration injection molding （PVIM） have been investigated via polarized light microscopy, scanning electron microscopy, wide-angle X-ray diffraction and differential scanning calorimetry. Results demonstrated that the interaction between co-PP and iPP molecular chains was beneficial for the mechanical improvement and the introduction of β-NA further improved the toughness of iPP. In addition, after applying the pressure vibration injection molding （PVIM） technology, the shear layer thickness increased remarkably and the tensile strength improved consequently. Thus, the strength and toughness of iPP/co-PP/β-NA composites prepared by PVIM were simultaneously improved compared to those of the pure iPP prepared by conventional injection molding （CIM）： the impact toughness was increased by five times and tensile strength was increased by 9 MPa. This work provided a new method to further enhance the properties of iPP/co-PP composites through dynamic processing strategy.

关键词： Mechanical properties Orientation structures Periodical shear field Morphology.