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Small cell lung cancer with peripheral neuropathy as the first symptom:Two case reports

World Journal of Clinical Cases 2025年第9期13卷 30-40页

作者： man luo Xiao-Xi Lu Dan-Yang Meng Jin Hu Department of Neurology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina Department of Information Technology Affiliated Hospital of Jiaxing UniversityJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Small cell lung cancer(SCLC)is the most malignant type of lung *** in the latent period and early stage of the tumor,SCLC is prone to produce distant metastases with complex and diverse clinical *** is most closely related to paraneoplastic syndrome,and some cases present as paraneoplastic peripheral neuropathy(PPN).PPN in SCLC appears early,lacks specificity,and often occurs before diagnosis of the primary *** is easy to be misdiagnosed as a primary disease of the nervous system,leading to missed diagnosis and delayed diagnosis and *** SUMMARY This paper reports two cases of SCLC with limb weakness as the first *** first symptoms of one patient were rash,limb weakness,and abnormal *** patient was repeatedly referred to the hospital for limb weakness and rash for>1 year,during which time,treatment with hormones and immunosuppressants did not lead to significant improvement,and the condition gradually *** patient was later diagnosed with SCLC,and the dyskinesia did not worsen as the dermatomyositis improved after antineoplastic and hormone *** second case presented with limb numbness and weakness as the first symptom,but the patient did not pay attention to ***,the patient was diagnosed with SCLC after facial edema caused by tumor thrombus invading the ***,he was diagnosed with extensive SCLC and died 1 year after *** The two cases had PPN and abnormal electromyography,highlighting its correlation with early clinical indicators of SCLC.

关键词： Paraneoplastic peripheral neuropathy Small cell lung cancer Peripheral neuropathy Electromyography Dermatomyositis Case report

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-Rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang man luo Xiao-Wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Adaptive Control of Discrete-time Nonlinear Systems Using ITF-ORVFL

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IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 556-563页

作者： Xiaofei Zhang Hongbin Ma Wenchao Zuo man luo School of Automation Beijing Institute of TechnologyBeijing 100081 School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China School of Automation Beijing Institute of Technologyand also with the State Key Laboratory of Intelligent Control and Decision of Complex Systems(Beijing Institute of Technology)Beijing 100081China School of Automation Beijing Institute of TechnologyBeijing 100081and he is with Beijing Institute of Electronic System EngineeringBeijing 100854China School of Automation Beijing Institute of TechnologyBeijing 100081and she is with Ant GroupBeijing 310013China

Random vector functional ink(RVFL)networks belong to a class of single hidden layer neural networks in which some parameters are randomly *** network structure in which contains the direct links between inputs and outputs is unique,and stability analysis and real-time performance are two difficulties of the control systems based on neural *** this paper,combining the advantages of RVFL and the ideas of online sequential extreme learning machine(OS-ELM)and initial-training-free online extreme learning machine(ITFOELM),a novel online learning algorithm which is named as initial-training-free online random vector functional link algo rithm(ITF-ORVFL)is investigated for training *** link vector of RVFL network can be analytically determined based on sequentially arriving data by ITF-ORVFL with a high learning speed,and the stability for nonlinear systems based on this learning algorithm is *** experiment results indicate that the proposed ITF-ORVFL is effective in coping with nonparametric uncertainty.

关键词： Adaptive control initial-training-free online learning algorithm random vector functional link networks

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Reaction mechanism of methyl nitrite dissociation during co catalytic coupling to dimethyl oxalate:A density functional theory study

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Chinese Journal of Chemical Engineering 2016年第1期24卷 132-139页

作者： Chen Fan man luo Wende Xiao Key Laboratory of Advanced Control and Optimization for Chemical Processes Ministry of Education East China University of Science and Technology (ECUST) School of Chemistry and Chemical Engineering Shanghai Jiao Tong University (SJTU)

Dissociation of methyl nitrite is the first step during CO catalytic coupling to dimethyl oxalate followed by hydrogenation to ethyl glycol in a typical coal to liquid process. In this work, the first-principle calculations based on density functional theory were performed to explore the reaction mechanism for the non-catalytic dissociation of methyl nitrite in the gas phase and the catalytic dissociation of methyl nitrite on Pd(111) surface since palladium supported on alpha-alumina is the most effective catalyst for the coupling. For the non-catalytic case, the calculated results show that the CH_3O–NO bond will break with a bond energy of 1.91 eV, and the produced CH_3O radicals easily decompose to formaldehyde, while the further dissociation of formaldehyde in the gas phase is difficult due to the strong C–H bond. On the other hand, the catalytic dissociation of methyl nitrite on Pd(111) to the adsorbed CH_3O and NO takes place with a small energy barrier of 0.03 eV. The calculated activation energies along the proposed reaction pathways indicate that(i) at low coverage, a successive dehydrogenation of the adsorbed CH_3O to CO and H is favored while(ii) at high coverage, hydrogenation of CH_3O to methanol and carbonylation of CH_3O to methyl formate are more preferred. On the basis of the proposed reaction mechanism,two meaningful ways are proposed to suppress the dissociation of methyl nitrate during the CO catalytic coupling to dimethyl oxalate.

关键词： Methyl nitrite Catalytic Non-catalytic Dissociation Density functional theory

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Deep Audio-visual Learning:A Survey

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International Journal of Automation and computing 2021年第3期18卷 351-376页

作者： Hao Zhu man-Di luo Rui Wang Ai-Hua Zheng Ran He Anhui Provincial Key Laboratory of Multimodal Cognitive Computation School of Computer Science and TechnologyAnhui UniversityHefei 230601China Center for Research on Intelligent Perception and Computing(CRIPAC)and National Laboratory of Pattern Recognition(NLPR) Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of the Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Audio-visual learning,aimed at exploiting the relationship between audio and visual modalities,has drawn considerable attention since deep learning started to be used *** tend to leverage these two modalities to improve the performance of previously considered single-modality tasks or address new challenging *** this paper,we provide a comprehensive survey of recent audio-visual learning *** divide the current audio-visual learning tasks into four different subfields:audiovisual separation and localization,audio-visual correspondence learning,audio-visual generation,and audio-visual representation ***-of-the-art methods,as well as the remaining challenges of each subfield,are further ***,we summarize the commonly used datasets and challenges.

关键词： Deep audio-visual learning audio-visual separation and localization correspondence learning generative models representation learning

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Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis

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World Journal of Psychiatry 2024年第4期14卷 563-581页

作者： Long-Xiu Yang man luo Sheng-Yu Li Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Neurology Wuming Hospital of Guangxi Medical UniversityNanning 530199Guangxi Zhuang Autonomous RegionChina

BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and *** ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain *** To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying *** Hematoxylin and eosin staining was utilized to analyze structural brain tissue *** assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western ***,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain *** In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD *** vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and *** this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA ***,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates ***-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB *** This study demonstrates that

关键词： TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species

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Chemical Composition and Antioxidant Activity of Essential Oil from Magnolia grandiflora ***

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Wuhan University Journal of Natural Sciences 2012年第3期17卷 249-254页

作者： luo man SUN Jingfei ZHANG Bin JIANG Like Department of Biomedical Engineering College of Life Science and Technology Jinan University Guangzhou 510632 Guangdong China College of Life Science Anhui Agricultural University Hefei 230036 Anhui China

The chemical composition and antioxidant activity of Magnolia grandiflora *** essential oil were *** combining gas chromatography and mass spectrometry （GC-MS）,16 types of compounds were identified,including 40.91% oxygen-containing terpene derivatives,19.51% terpenes,13.97% esters,13.05% nitrogenous compounds,and 3.64% *** capability of removing hydroxyl free radical was lower than that of V c,but it was closer to V c with increasing *** cell experiment,all essential oil concentration （6.9,13.8,27.7,55.5,111.0,and 222.0 g/mL） groups increased cell proliferation by 26% or more （26.0%,38.8%,44.8%,40.2%,35.8%,and 30.4%,respectively）.In rat experiment,the SD rats group showed an at least 38% rise （38.62%,61.68%,and 62.86%,respectively） in glutathione-peroxisome （GSH-Px）activity,which is more than 24% reduction （29.56%,24.30%,and 36.93%） in malondialdehyde （MDA） content,and no significant difference in SOD activity was *** results show that the essential oil had strong antioxidant activity,without dose effect within the concentration range.

关键词： chemical composition antioxidant activity essential oil Magnolia grandiflora L. seed

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Idiopathic Pulmonary Fibrosis： A Systemic Disease？

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Chinese Medical Journal 2017年第17期130卷 2140-2141页

作者： luo man Peng Hong Department of Respiratory Medicine The Second Xiangya Hospital Central South University Changsha Hunan 410011 China Research Unit of Respiratory Disease Central South University Changsha Hunan 410011 China Diagnosis and Treatment Central of Respiratory Disease Central South University Changsha Hunan 410011 China

INTRODUCTIONIdiopathic puhnonary fibrosis （IPF） is a specific type of chronic progressive fibrosing interstitial pneumonia associated with a histopathologic pattern of usual interstitial pneumonia. IPF is typically considered to be a lung-limited disorder. Although the primary manifestations of IPF are pulmonary in nature. IPF is increasingly recognized as a systemic disease due to its strong association with comorbiditics and coml）lications.

关键词： Idiopathic Pulmonary Fibrosis Gastroesophageal Reflux Disease Genetics

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Optimization of DsbA Purification from Recombinant Escherichia coli Broth Using Box-Behnken Design Methodolog

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Chinese Journal of Chemical Engineering 2013年第2期21卷 185-191页

作者： luo man GUAN Yixin YAO Shanjing Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

Disulfide bond formation protein A （DsbA） is one of the important helper proteins for folding in protein synthesis in vivo. In this study, purification of recombinant DsbA was investigated by examining four important factors with Box-Behnken design method, a statistic-based design of experiments. The optimal operation conditions were obtained by adopting the effectiveness coefficient method on the multi-objective problem, which takes the protein recovery, purification efficiency and throughput of ion-exchange chromatography into account. After the optimization, protein recovery of 96.8% and purity higher than 95% DsbA was achieved, and the productivity was （377.9±1.7） mg soluble DsbA per liter broth. The purified protein was identified by peptide mass fingerprinting matching the record of gil2624856, a mutant of DsbA. The DsbA was preliminarily applied to the refolding of denatured lysozyme in vitro.

关键词： disulfide bond formation protein A protein purification Box-Behnken experiment design response surface methodology multi-object programming

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Combination and distribution of reservoir space in complex carbonate rocks

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Petroleum Science 2016年第3期13卷 450-462页

作者： Lun Zhao Shu-Qin Wang Wen-Qi Zhao man luo Cheng-Gang Wang Hai-Li Cao Ling He Research Institute of Petroleum Exploration and Development CNPC School of Energy Resources China University of Geosciences

This paper discusses the reservoir space in carbonate rocks in terms of types,combination features,distribution regularity,and controlling factors,based on core observations and tests of the North Truva Oilfield,Caspian *** to the reservoir space combinations,carbonate reservoirs can be divided into four types,i.e.,pore,fracture-pore,pore-cavity-fracture,and *** and distribution of these reservoirs is strongly controlled by deposition,diagenesis,and *** evaporated platform and restricted platform facies,the reservoirs are predominately affected by meteoric fresh water leaching in the supergene-para-syngenetic period and by uplifting and erosion in the late stage,making both platform facies contain all the above-mentioned four types of reservoirs,with various pores,such as dissolved cavities and dissolved fractures,or structural fractures occasionally in favorable structural *** open platform facies,the reservoirs deposited continuously in deeper water,in an environment of alternative high-energy shoals（where pore-fracture-type reservoirs are dominant） and low-energy shoals（where pore reservoirs are dominant）.

关键词： Caspian Basin Carbonate rock of platform facies Reservoir space type Reservoir type Controlling factor Distribution regularity

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