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In <i>Vivo</i>Hypoglycemic Activity of Aqueous Extracts of <i>Chasmanthera dependens</i>in Alloxan Induced Diabetic mice

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Open Journal of Applied Sciences 2021年第7期11卷 832-845页

作者： Dinah J. Sawe Eliud N. m. Njagi Alice N. muchugi moses Ndiema Department of Biochemistry & Clinical Chemistry College of Health Sciences Moi University Eldoret Kenya Department of Biochemistry Biotechnology and Microbiology School of Pure and Applied Sciences Kenyatta University Nairobi Kenya Genetic Resource Unit International Centre for Research in Agroforestry (ICRAF) Nairobi Kenya Department of Human Anatomy College of Health Sciences Moi University Eldoret Kenya

The plant Chasmanthera dependens (Hochst) have been used to manage many diseases including diabetes mellitus without scientific evaluation of its efficacy and safety. The main objective of the project was to determine the antidiabetic activity of Chasmanthera dependens plant in a rat model. Experimental design was used where the stem of the plant was collected, dried, crashed into fine powder, extracted with distilled water at 60°C and lyophilized using a Freeze Dryer, packaged in air tight container and stored at -20°C ready for use. The extract was orally and intraperitoneally screened in alloxan induced diabetic mice for its hypoglycemic activity at doses of 25, 48.4, 93.5, 180.9 and 350 mg per kg body weight. Diabetes in mice was induced using 186.9 mg/kg of alloxan monohydrate. Negative controls included normal and diabetic rats orally and intraperitoneally administered with physiological saline while positive controls included diabetic rats administered with glibenclamide as oral and insulin as intraperitoneal reference drug. The results revealed hypoglycemic activity in Chasmanthera dependens at the five different doses when given either orally or intraperitoneally. In conclusion, the medicinal plant at the various doses demonstrated significant (ρ ≤ 0.05) hypoglycemic activity. The author’s recommendation is continued use of the plant extracts at low therapeutic doses. Consideration should be made to carry out the same studies using higher animals including man.

关键词： Diabetes Hypoglycemia Plant Extract Chasmanthera dependens Albino mice

配加碱化甘蔗渣对冷压含碳球团机械强度的影响

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有色金属科学与工程 2017年第5期8卷 121-126页

作者：凌超薛庆国沈颖峰王静松郭文涛李曼北京科技大学钢铁冶金新技术国家重点实验室北京100083

基于转底炉直接还原工艺,对以碱化甘蔗渣作为黏结剂的含碳球团冷态成型工艺进行探究.首先通过单因素试验考察碱化时间、碱化温度、NaOH质量浓度以及造球压力对球团机械强度的影响.然后采用正交试验方法,确定影响碱化蔗渣黏结性能的这几... 详细信息

基于转底炉直接还原工艺,对以碱化甘蔗渣作为黏结剂的含碳球团冷态成型工艺进行探究.首先通过单因素试验考察碱化时间、碱化温度、NaOH质量浓度以及造球压力对球团机械强度的影响.然后采用正交试验方法,确定影响碱化蔗渣黏结性能的这几个因素的主次顺序,得出最佳工艺参数.实验结果对比后发现:含碳球团的机械强度均随着各单因素水平值的上升先增大后减小.通过正交试验获得了较适宜的工艺参数为,NaOH质量浓度为9%,碱化温度为105℃,碱化时间为4 h,造球压力为15 mPa.此时含碳球团的落下强度与抗压强度能达到22.6次/0.5 m和79.3 N.

关键词：含碳球团黏结剂蔗渣抗压强度落下强度

过表达血红素加氧酶-1对低氧训练小鼠骨骼肌纤维组成的影响

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中国高原医学与生物学杂志 2019年第1期40卷 9-14页

作者：司立宁王嵘秦海兰崔浩甘罗曼赵延礼青海大学附属医院青海西宁810001 青海大学基础医学研究中心青海西宁810016

目的探讨过表达血红素加氧酶-1(Heme Oxygenase-1,HO-1)对低氧训练小鼠骨骼肌纤维组成的影响。方法将8 w雄性过表达HO-1转基因小鼠和野生小鼠分为6组:野生小鼠低氧静息组(C)、过表达HO-1转基因小鼠低氧静息组(H)、野生小鼠低氧训练30 d... 详细信息

目的探讨过表达血红素加氧酶-1(Heme Oxygenase-1,HO-1)对低氧训练小鼠骨骼肌纤维组成的影响。方法将8 w雄性过表达HO-1转基因小鼠和野生小鼠分为6组:野生小鼠低氧静息组(C)、过表达HO-1转基因小鼠低氧静息组(H)、野生小鼠低氧训练30 d组(C+T30)、野生小鼠低氧训练60 d组(C+T60)、过表达HO-1转基因小鼠低氧训练30 d组(H+T30)和过表达HO-1转基因小鼠低氧训练60 d组(H+T60)。低氧训练(海拔2261m。20m/min,坡度5°,60min/d,5d/w,30d和60d)结束后记录各组小鼠力竭运动时间;行ATP酶染色后计算各型肌纤维的面积百分比;用real time PCR、western blot法检测骨骼肌肌红蛋白(myoglobin)及PGC-1α表达量。结果与各自静息组相比,低氧训练30 d组和60 d组小鼠力竭运动时间均延长(Pmyoglobin的表达增加(P<0.05),同时伴随PGC-1α表达增加(P<0.05),尤以过表达HO-1小鼠显著(P<0.05)。结论过表达HO-1在低氧训练中可显著提高小鼠运动耐力,其机制可能是HO-1通过增加PGC-1α的表达促进骨骼肌红肌纤维增加实现的。

关键词：血红素加氧酶-1 低氧训练骨骼肌纤维

Profile of Factors of Arduous Work among Healthcare Professionals in Healthcare Facilities in Northern Benin in 2021

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Occupational Diseases and Environmental medicine 2024年第1期12卷 41-48页

作者： Gounongbé Ahoya Christophe Fabien mama Cissé Ibrahim Lompo marthe Sandrine Azandjèmè Colette Bèhanzin Luc Faculty of medicine University of Parakou Parakou Benin Health Sciences Training and Research Unit Joseph Ki-Zerbo University Ouagadougou Burkina Faso Regional Institute of Public Health of Ouidah University of Abomey-Calavi Abomey-Calavi Benin National Training School for Senior Technicians in Public Health and Epidemiological Surveillance University of Parakou Parakou Benin

Introduction: Work environments create the basis for arduous nursing work. This is what led us to research the factors of arduousness in the exercise of the health profession in North Benin, through this study. methods: This is a cross-sectional and descriptive study which focused on health professionals in the health zones of Parakou-N’dali and Tchaourou. The sampling was an exhaustive census. All health workers who had given their free and informed consent were included. The data was collected using a questionnaire. The variables studied were the factors of arduous work and socio-professional characteristics. The data collected was processed and analyzed with the Epi info 7.***.0.1 software. Results: A total of 692 were surveyed, the participation rate was 85.11% and the sex ratio (m/F) equal to 0.7. The average age was 38 years old. Nurses made up 32.66% of the sample. They were 86.42% subject to night work and 82.66% to alternating work. Overall, 70.23% worked more than 40 hours per week. Between 78.12% and 96.46% of non-specialist doctors, nurses, midwives and biomedical analysis technicians were required to work night shifts. Nurses, midwives, radiology and laboratory technicians were between 89.53% and 97.35%, organized in alternating work. In the sample, 55.20% complained about the insufficient number of work materials, 26.29% handled harmful chemical substances. Among those surveyed, 58.14% had been attacked. Conclusion: All professional categories of caregivers are subject to arduous work. measures are needed to reverse the situation.

关键词： Hard Work Professionals Health North-Bénin

HPLC-DAD-ELSD法同时测定黄芪中10个成分的含量

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中南药学 2018年第9期16卷 1268-1271页

作者：王亚丽田曼李江王昌利颜永刚张岗陕西中医药大学药学院陕西咸阳712046

目的建立HPLC-DAD-ELSD同时测定黄芪药材中4个黄酮类成分(毛蕊异黄酮葡萄糖苷、芒柄花苷、毛蕊异黄酮、芒柄花素)和6个皂苷类成分(黄芪甲苷、黄芪皂苷Ⅲ、黄芪皂苷Ⅱ、异黄芪皂苷Ⅱ、黄芪皂苷Ⅰ、异黄芪皂苷Ⅰ)含量的方法,比较7批不同... 详细信息

目的建立HPLC-DAD-ELSD同时测定黄芪药材中4个黄酮类成分(毛蕊异黄酮葡萄糖苷、芒柄花苷、毛蕊异黄酮、芒柄花素)和6个皂苷类成分(黄芪甲苷、黄芪皂苷Ⅲ、黄芪皂苷Ⅱ、异黄芪皂苷Ⅱ、黄芪皂苷Ⅰ、异黄芪皂苷Ⅰ)含量的方法,比较7批不同产地的黄芪药材中各有效成分的含量。方法采用HPLC-DAD-ELSD联用法,色谱柱Waters Symmetry C18(250 mm×4.6 mm,5μm),流动相为0.3%冰醋酸(A)-乙腈(B),梯度洗脱,柱温25℃,流速1.0 m L·min^(-1),检测波长260 nm;蒸发光散射检测器(ELSD)漂移管温度60℃,供气压力为25 psi。结果该条件下10个成分的分离度良好,在对应线性范围内与峰面积呈良好的线性关系(r=0.9993~0.9999),平均加样回收率为95.6%~103.3%,RSD为1.1%~2.9%。结论建立的含量测定方法简便,结果准确可靠,重现性好,适用于黄芪中10个成分含量的同时测定,为黄芪药材的全面质量控制奠定了实验基础。

关键词：黄芪 HPLC-DAD-ELSD 黄酮类成分皂苷类成分含量测定

支气管上皮细胞和嗜酸性粒细胞联合培养对IL-8释放的影响

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军医进修学院学报 2006年第2期27卷 103-104页

作者：王成彬黄振国叶伟基鲍依希田亚平林伟基解放军总医院生化科北京100853 香港中文大学化学病理学系

目的:探讨支气管上皮细胞和嗜酸性粒细胞联合培养对细胞趋化因子白细胞介素(IL)-8分泌的影响。方法:人支气管上皮细胞系BEAS-2B细胞与人外周血嗜酸性粒细胞联合培养;应用流式细胞微珠实验(CBA)方法定量细胞培养上清液中细胞趋化因子IL-... 详细信息

目的:探讨支气管上皮细胞和嗜酸性粒细胞联合培养对细胞趋化因子白细胞介素(IL)-8分泌的影响。方法:人支气管上皮细胞系BEAS-2B细胞与人外周血嗜酸性粒细胞联合培养;应用流式细胞微珠实验(CBA)方法定量细胞培养上清液中细胞趋化因子IL-8的浓度;用RT-PCR方法分析经与嗜酸性粒细胞联合培养后BEAS-2B细胞中IL-8的基因表达。结果:与嗜酸性粒细胞联合培养后,BEAS-2B细胞中IL-8基因表达显著上调,细胞联合培养上清液中IL-8释放显著增加。结论:嗜酸性粒细胞与支气上皮细胞联合培养可活化支气管上皮细胞中IL-8基因表达和促进其蛋白质分泌。

关键词：支气管上皮细胞嗜酸性粒细胞增多白细胞介素8

Delta variant(B.1.617.2)sublineages do not show increased neutralization resistance

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Cellular & molecular Immunology 2021年第11期18卷 2557-2559页

作者： Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Anzhalika Sidarovich martin S.Winkler Sebastian Schulz Hans-martin Jäck metodi V.Stankov Georg m.N.Behrens Stefan Pöhlmann markus Hoffmann Infection Biology Unit German Primate CenterGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University GöttingenGöttingenGermany Division of molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolHannoverGermany

The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 *** present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in... 详细信息

关键词： Delta neutral resistance

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莲花山钨矿床同位素地质学初步研究

矿床地质 1983年第4期 35-42页

作者：满发胜白玉珍倪守斌黎彤中国科学技术大学地球和空间科学系

莲花山钨矿是1956年在我国首先发现的一种新类型钨矿床。原广东911地质队做了工业评价(1957—1960),黎彤等做了矿床地质学研究,并出版了专著。近年来,这类钨矿床受到国内外矿床学者的广泛注意,在我国其它省份也有类似的钨矿床发现。因此... 详细信息

莲花山钨矿是1956年在我国首先发现的一种新类型钨矿床。原广东911地质队做了工业评价(1957—1960),黎彤等做了矿床地质学研究,并出版了专著。近年来,这类钨矿床受到国内外矿床学者的广泛注意,在我国其它省份也有类似的钨矿床发现。因此,进一步查明这类钨矿床的成因类型和成矿规律,对今后在我国东部广大的中生代酸性火山岩地区内继续寻找同类型钨矿床将有重要指导意义。

关键词：等时年龄单矿物火山岩相同位素地质学核地球化学花岗岩类岩石黑云母花岗岩等时线年龄石英斑岩全岩年龄数据酸性火成岩硫同位素组成

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人工湿地系统对泉河水质净化处理的实践应用

湿地科学与管理 2013年第2期9卷 11-14页

作者：王鑫华高奔邹志国马慧王漫雪济宁市南四湖人工湿地管理处济宁272125 山东省鲁南工程技术研究院济宁272023 济宁市环境保护科学研究所济宁272125 汶上县环境保护局济宁272000

泉河是山东省济宁市汶上县一条重要的河流,工业点源、农业面源污染使得泉河污染,水质超标。为净化水质,建设了泉河河道走廊人工湿地工程,总长度23km,规模319.7hm2,总投资5170万元。主要采用河道滞留塘+表面流人工湿地组合工艺,处理汶上... 详细信息

泉河是山东省济宁市汶上县一条重要的河流,工业点源、农业面源污染使得泉河污染,水质超标。为净化水质,建设了泉河河道走廊人工湿地工程,总长度23km,规模319.7hm2,总投资5170万元。主要采用河道滞留塘+表面流人工湿地组合工艺,处理汶上县污水处理厂外排水、沿河周边农村生活污水及农田退水,污水处理规模2.0万m3/d。工程2010年10月开工,2011年6月建成并正常运行。通过1a多的运行结果表明,该人工湿地工程具有较高的污染负荷去除率,实现了河道的生态修复和沿河生态环境治理,泉河生态环境得到了明显改善。

关键词：人工湿地泉河水质净化实践应用