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Meta-QTL analysis for mining of candidate genes and constitutive gene network development for fungal disease resistance in maize(Zea mays L.)

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The Crop Journal 2023年第2期11卷 511-522页

作者： mamta gupta Mukesh Choudhary Alla Singh Seema Sheoran Deepak Singla Sujay Rakshit ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India School of Agriculture and Environment The University of Western AustraliaPerthWA 6009Australia The UWA Institute of Agriculture The University of Western AustraliaPerthWA 6009Australia School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India

The development of resistant maize cultivars is the most effective and sustainable approach to combat fungal *** the last three decades,many quantitative trait loci(QTL)mapping studies reported numerous QTL for fungal disease resistance(FDR)in ***,different genetic backgrounds of germplasm and differing QTL analysis algorithms limit the use of identified QTL for comparative *** meta-QTL(MQTL)analysis is the meta-analysis of multiple QTL experiments,which entails broader allelic coverage and helps in the combined analysis of diverse QTL mapping studies revealing common genomic regions for target *** the present study,128(33.59%)out of 381 reported QTL(from 82 studies)for FDR could be projected on the maize genome through MQTL *** revealed 38 MQTL for FDR(12 diseases)on all chromosomes except chromosome *** MQTL namely 1_4,2_4,3_2,3_4,and 5_4 were linked with multiple *** of 1910 candidate genes were identified for all the MQTL regions,with protein kinase gene families,TFs,pathogenesis-related,and disease-responsive proteins directly or indirectly associated with *** comparison of physical positions of marker-traits association(MTAs)from genome-wide association studies with genes underlying MQTL interval verified the presence of QTL/candidate genes for particular *** linked markers to MQTL and putative candidate genes underlying identified MQTL can be further validated in the germplasm through marker screening and expression *** study also attempted to unravel the underlying mechanism for FDR resistance by analyzing the constitutive gene network,which will be a useful resource to understand the molecular mechanism of defense-response of a particular disease and multiple FDR in maize.

关键词： Meta-QTL Maize genome Fungal disease resistance Candidate gene Constitutive genes Gene network

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Recent updates on nano-phyto-formulations based therapeutic intervention for cancer treatment

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Oncology Research 2024年第1期32卷 19-47页

作者： ABHISHEK WAHI mamta BISHNOI NEHA RAINA MEGHNA AMRITA SINGH PIYUSH VERMA PIYUSH KUMAR gupta GINPREET KAUR HARDEEP SINGH TULI MADHU gupta Department of Pharmaceutics School of Pharmaceutical SciencesDelhi Pharmaceutical Sciences and Research University(DPSRU)Pushp ViharNew Delhi110017India Department of Pharmaceutical Sciences Gurugram UniversityHaryana122003India Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Graphic Era(Deemed to be University)DehradunUttarakhand248002India Department of Pharmacology Shobhaben Pratapbhai Patel School of Pharmacy&Technology ManagementSVKM’s NMIMSVile Parle(West)Mumbai400056India Department of Bio-Sciences and Technology Maharishi Markandeshwar Engineering CollegeMaharishi Markandeshwar(Deemed to be University)MullanaAmbala133207India

Cancer is a leading cause of death globally,with limited treatment options and several *** agents often result in toxicity which long-term conventional *** are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the *** phytoconstituents act in several ways and deliver optimum effectiveness against ***,the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility,bioavailability,and *** presents a promising avenue for transforming current cancer treatment methods through the incorporation of phytochemicals into nanosystems,which possess a range of advantageous characteristics such as biocompatibility,targeted and sustained release capabilities,and enhanced protective *** holds significant potential for future advancements in cancer ***,this review aims to provide intensive literature on diverse nanocarriers,highlighting their applications as cargos for phytocompounds in ***,it offers an overview of the current advancements in the respective field,emphasizing the characteristics that contribute to favourable outcomes in both in vitro and in vivo ***,clinical development and regulatory concerns are also discussed to check on the transformation of the concept as a promising strategy for combination therapy of phytochemicals and chemotherapeutics that could lead to cancer management in the future.

关键词： Phyto-formulations Cancer Nanocarriers Nanotechnology Clinical development

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On dry machining of AZ31B magnesium alloy using textured cutting tool inserts

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Journal of Magnesium and Alloys 2024年第4期12卷 1608-1618页

作者： Shailendra Pawanr Kapil gupta Department of Mechanical and Industrial Engineering Technology University of JohannesburgDoornfontein CampusJohannesburg 2028 South Africa

Magnesium alloys have many advantages as lightweight materials for engineering applications,especially in the fields of automotive and *** undergo extensive cutting or machining while making products out of *** cutting,a sustainable machining method,causes more friction and adhesion at the tool-chip *** of the promising solutions to this problem is cutting tool surface texturing,which can reduce tool wear and friction in dry cutting and improve machining *** paper aims to investigate the impact of dimple textures(made on the flank face of cutting inserts)on tool wear and chip morphology in the dry machining of AZ31B magnesium *** results show that the cutting speed was the most significant factor affecting tool flank wear,followed by feed rate and cutting *** tool wear mechanism was examined using scanning electron microscope(SEM)images and energy dispersive X-ray spectroscopy(EDS)analysis reports,which showed that at low cutting speed,the main wear mechanism was abrasion,while at high speed,it was *** chips are discontinuous at low cutting speeds,while continuous at high cutting *** dimple textured flank face cutting tools facilitate the dry machining of AZ31B magnesium alloy and contribute to ecological benefits.

关键词： Magnesium alloy Dry machining Textured tools Flank wear Sustainability

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Direct scaling of residual displacements for bilinear and pinching oscillators

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 129-149页

作者： Mohammad Saifullah Vinay K.gupta Department of Civil Engineering Indian Institute of Technology KanpurKanpur 208016India

The estimation of residual displacements in a structure due to an anticipated earthquake event has increasingly become an important component of performance-based earthquake engineering because controlling these displacements plays an important role in ensuring cost-feasible or cost-effective repairs in a damaged structure after the *** attempt is made in this study to obtain statistical estimates of constant-ductility residual displacement spectra for bilinear and pinching oscillators with 5%initial damping,directly in terms of easily available seismological,site,and model *** of the available models for the bilinear and pinching oscillators are useful when design spectra for a seismic hazard at a site are not *** statistical estimates of a residual displacement spectrum are proposed in terms of earthquake magnitude,epicentral distance,site geology parameter,and three model parameters for a given set of ductility demand and a hysteretic energy capacity coefficient in the case of bilinear and pinching models,as well as for a given set of pinching parameters for displacement and strength at the breakpoint in the case of pinching model *** proposed scaling model is applicable to horizontal ground motions in the western *** earthquake magnitudes less than 7 or epicentral distances greater than 20 km.

关键词： residual displacement spectrum bilinear hysteresis model pinching hysteresis model nonlinear analysis scaling model

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Optimizing calcination of coal by-products for maximizing REE leaching recovery and minimizing Al,Ca,and Fe contamination

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Journal of Rare Earths 2024年第7期42卷 1354-1365,I0006页

作者： Tushar gupta Ahmad Nawab Rick Honaker MP Materials Mountain Pass Mine 67750 Bailey RoadMountain PassCA92366USA Department of Mining Engineering University of KentuckyLexingtonKY40506USA

High-temperature calcination is effective in improving the leaching characteristics of rare earth elements(REEs)from conventional REE-bearing minerals by transforming them into more leachable ***,the recovery of contaminants such as Al,Fe,and Ca also increases *** objective of the study was to maximize the REE extraction while minimizing the concentration of contaminant ions(Al,Ca,and Fe)in the leach *** density fractions of the coarse refuse from the Baker and Fire Clay seam coal refuse were pulverized to a top size of 180μm and used as a feedstock for the *** the samples generated from thermal treatment were leached at 1%(w/v)using 1.2 mol/L sulfuric acid at 75℃ for 2 *** results from a parametric program based on a Box-Behnken design were used for modeling and optimization of three operating parameters associated with the lab-scale calcination *** parameters included temperature(400-800℃),ramp rate(2-10℃/min)and holding time(0-120 min).It was determined that the calcination temperature was the most significant parameter influencing REE *** majority of the heavy rare earth elements(HREEs)were found to be present in an insoluble form in the calcination products and were marginally affected by thermal treatment.A strong correlation between light rare earth elements recovery(LREEs)and Al suggested a possible association with *** optimum operating conditions for high REE recovery with comparatively lower contaminant concentration for 1.6 specific gravity float and 2.2 sink fractions of Baker and Fire Clay seam material were determined to be at 776,800℃ and 407,800℃,calcining temperatures,respectively.A higher optimum temperature of 1.6 float fraction of Baker seam relative to Fire Clay seam material was due to elevated pyrite concentration in Baker seam *** treatment at 400℃ converted pyrite into a soluble intermedium iron oxide,resulting in a high Fe content in the ***

关键词： Calcination Optimization Rare earth elements Coal refuse

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Optimal design of hybrid renewable-energy microgrid system:a techno-economic-environment-social-reliability perspective

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Clean Energy 2024年第1期8卷 66-83页

作者： Manoj gupta Annapurna Bhargava Electrical Engineering Department Rajasthan Technical UniversityKotaRajasthan 324010India Electrical and Electronics Engineering Department IPS Academy Institute of Engineering and Science IndoreMadhya Pradesh 452012India

The main objective of this paper is to select the optimal model of a hybrid renewable-energy microgrid(MG)system for a village in *** MG comprises solar photovoltaic(PV)modules,a wind turbine generator,a biomass generator,a battery bank,a diesel generator and an electric *** optimal model selection is based on technical,economic,environmental,social and reliability parameters.A novel spoonbill swarm optimization algorithm is proposed to select the best hybrid MG *** optimization results are compared with particle swarm optimization,the genetic algorithm and the grasshopper optimization *** number or size of components of the optimized MG system is 215 PV modules,92 kW of wind turbine generation,25 kW of biomass generation,267 batteries,22 kW of electric vehicles and 30 kW of diesel *** optimized system was selected based on technical factors such as renewable dispersion(93.5%),the duty factor(5.85)and excess energy(15975 kWh/year)as well as eco-nomic considerations including the net present cost(Rs.34686622)and the cost of energy(9.3 Rs./kWh).Furthermore,environ-mental factors such as carbon emissions(396348 kg/year)and atmospheric particulate matter(22.686 kg/year);social factors such as the human progress index(0.68411),the employment generation factor(0.0389)and local employment generation(15.64643);and reliability parameters including loss of power supply probability(0.01%)and availability index(99.99%)were considered during the selection *** spoonbill swarm optimization algorithm has reduced the convergence time by 1.2 times and decreased the number of iterations by 0.83 times compared with other *** performance of the MG system is validated in the MATLAB®*** results show that the MG system is the optimal system considering technical,economic,environmental,social and reliability ***,the spoonbill swarm optimization algorithm is found to be more efficient than the other

关键词： cost of electricity microgrid reliability spoonbill techno-economic

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Operator Equations Inducing Some Generalizations of Slant Hankel Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 2017-2036页

作者： Gopal DATT Bhawna Bansal gupta Department of Mathematics PGDAV CollegeUniversity of DelhiNew Delhi-110065India Department of Mathematics Miranda HouseUniversity of DelhiDelhi-110007India

An extension of slant Hankel operator,namely,the kth-orderλ-slant Hankel operator on the Lebesgue space L^(2)(T^(n)),where T is the unit circle and n≥1,a natural number,is described in terms of the solution of a system of operator equations,which is subsequently expressed in terms of the product of a slant Hankel operator and a unitary *** study is further lifted in Calkin algebra in terms of essentially kth-orderλ-slant Hankel operators on L^(2)(T^(n)).

关键词： Hankel operator Lebesgue space of n-dimensional torus kth-order slant Hankel operator essentially kth-orderλ-slant Hankel operator

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Multi-head neural networks for simulating particle breakage dynamics

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 130-141页

作者： Abhishek gupta Barada Kanta Mishra School of Mechanical Sciences Indian Institute of Technology(IIT)GoaPonda 403401India School of Chemical and Materials Science Indian Institute of Technology(IIT)GoaPonda 403401India

The breakage of brittle particulate materials into smaller particles under compressive or impact loads can be modelled as an instantiation of the population balance integro-differential *** this paper,the emerging computational science paradigm of physics-informed neural networks is studied for the first time for solving both linear and nonlinear variants of the governing *** conventional methods,the proposed neural network provides rapid simulations of arbitrarily high resolution in particle size,predicting values on arbitrarily fine grids without the need for model *** network is assigned a simple multi-head architecture tailored to uphold monotonicity of the modelled cumulative distribution function over particle *** method is theoretically analyzed and validated against analytical results before being applied to real-world data of a batch grinding *** agreement between laboratory data and numerical simulation encourages the use of physics-informed neural nets for optimal planning and control of industrial comminution processes.

关键词： Particle breakage dynamics Population balance equation Physics-informed neural networks

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Trigonometric tension B-spline collocation approximations for time fractional Burgers’equation

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Journal of Ocean Engineering and Science 2024年第5期9卷 508-516页

作者： Brajesh Kumar Singh Mukesh gupta School of Physical and Decision Sciences Department of MathematicsBabasaheb Bhimrao Ambedkar University Lucknow 226025(UP)INDIA

This manuscript’s aim is to form and examine the numerical simulation of Caputo-time fractional nonlinear Burgers’equation via collocation approach with trigonometric tension B-splines as base ***,L 1 discretization formula is utilized for the time fractional derivative and after linearizing the nonlinear term,the trigonometric tension B-spline interpolants are utilized to get a system of simultaneous linear equations that are solved via Gauss elimination ***,numerical approximation at the desired time level is *** is demonstrated via von-Neumann approach that proposed scheme produces stable *** results of six different test examples having their analytical solutions are compared with the results in the literature to validate the accuracy and efficiency of the scheme.

关键词： Fractional Burgers’equation Trigonometric tension B-spline Collocation scheme Gauss elimination method

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Prediabetes in children and adolescents:A ticking bomb!

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World Journal of Clinical Pediatrics 2024年第2期13卷 11-15页

作者： Anju gupta Nitin Choudhary Nishkarsh gupta Department of Anesthesiology Pain Medicine and Critical CareAll India Institute of Medical ScienceNew Delhi 110076India Department of Onco-Anesthesiology and Palliative Medicine All India Institute of Medical ScienceNew Delhi 110029India

Prediabetes in children and adolescents is on the rise which has drawn significant attention over the past *** is an early warning sign of the underlying pathophysiological changes which in due course of time might compound into type II diabetes *** incidence of prediabetes in adolescents ranges from 4%-23%which is alarmingly high and requires active intervention from the *** have discussed early identification of high-risk patients,prompt screening and active intervention to manage this growing problem.

关键词： Prediabetes Children Adolescents Glucose metabolism Complications

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