检索结果-南通市图书馆

Keyword Search on Both XML and Relational Data

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2011年第4期8卷 264-275页

作者： Liru Zhang Tadashi Ohmori mamoru Hoshi Graduate School of Information Systems The University of Electro-Communications Tokyo 1828585 Japan

Intelligence Comparison between Fish and Robot Using Chaos and Random

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

通讯和计算机（中英文版） 2012年第9期9卷 1025-1037页

作者： mamoru Minami Akira Yanou Jun Hirao Graduate School of Natural Science and Technology Okayama University Japan. Graduate School of Engineering University of Fukui Fukui 910-8507 Japan.

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito mamoru Ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第36期8卷 1610-1616页

作者： Shigeo Sueyoshi Setsu Sawai mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi Fukumura Mikihiro Tsutsumi Fumio Nomura Department of Molecular Diagnosis Graduate School of Medicine Chiba University Clinical Proteomics Research Center Chiba University Hospital Department of Hepatology Kanazawa Medical University

AIM To assess how serum gamma-glutamyltransferase(GGT) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). METHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGT were included for an additional analysis. Serum GGT fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGT, medium-GGT, small-GGT(s-GGT), and free-GGT(f-GGT).RESULTS The results were expressed as a ratio of each fraction including the total GGT(t-GGT). The s-GGT/t-GGT ratioswere lowest for the control group and highest for the ALD group. The differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGT/t-GGT ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGT/f-GGT ratios were markedly increased in the NAFLD group as compared with the control group. The increase of the s-GGT/t-GGT ratios, the decrease of the f-GGT/t-GGT ratios, and the increase of s-GGT/F-GGT ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the *** Serum GGT fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD.

关键词： Gamma-glutamyltransferase f-GGT/t-GGT ratios Alcoholic liver disease Non-alcoholic fatty liver disease Gel filtration liquid chromatography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

喷吹煤粉的大型高炉炉内状况的数值分析

钢铁 1985年第10期20卷 5-8页

作者： mamoru KUWABARA Jicheng HE Iwao MUCHI 李兰滨名古屋大学名古屋大学名古屋大学

1.引言近来,高风温高顶压的大型高炉,采用煤粉喷吹(PCI)技术日益受到重视。为了阐明PCI对高炉操作的全面影响,本文提出

关键词：回旋区吹管焦炭固体燃料大型高炉煤粉颗粒炉内

A force measurement platform for a vitreoretinal surgical simulator using an artificial eye module integrated with a quartz crystal resonator

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2022年第4期8卷 137-149页

作者： Yuta Taniguchi Hirotaka Sugiura Toshiro Yamanaka Shiro Watanabe Seiji Omata Kanako Harada mamoru Mitsuishi Tomoyasu Shiraya Koichiro Sugimoto Takashi Ueta Kiyohito Totsuka Fumiyuki Araki Muneyuki Takao Makoto Aihara Fumihito Arai Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Faculty of Advanced Science and Technology Kumamoto University2-39-1 KurokamiChuo-kuKumamoto-shiKumamoto 860-8555Japan Center for Disease Biology and Integrative Medicine The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8655Japan

To provide quantitative feedback on surgical progress to ophthalmologists practicing inner limiting membrane(ILM)peeling,we developed an artificial eye module comprising a quartz crystal resonator(QCR)force sensor and a strain body that serves as a uniform force transmitter beneath a retinal *** a sufficiently large initial force must be loaded onto the QCR force sensor assembly to achieve stable contact with the strain body,the highly sensitive and wide dynamic-range property of this sensor enables the eye module to detect the slight forceps contact force.A parallel-plate strain body is used to achieve a uniform force sensitivity over the 4-mm-diameter ILM peeling *** these two components allowed for a measurable force range of 0.22 mN to 29.6 N with a sensitivity error within−11.3 to 4.2%over the ILM peeling *** this eye module,we measured the applied force during a simulation involving artificial ILM peeling by an untrained individual and compensated for the long-term drift of the obtained force data using a newly developed *** compensated force data clearly captured the characteristics of several types of motion sequences observed from video recordings of the eye bottom using an ophthalmological *** a result,we succeeded in extracting feature values that can be potentially related to trainee skill level,such as the mean and standard deviation of the pushing and peeling forces,corresponding,in the case of an untrained operator,to 122.6±95.2 and 20.4±13.2 mN,respectively.

关键词： artificial quartz resonator

Pituitary adenylate cyclase-activating polypeptide is an upstream regulator of prodynorphin mRNA expression in neurons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pituitary adenylate cyclase-activating polypeptide is an ups...

中国肿腿蜂属新记录及一新种记述(膜翅目 :肿腿蜂科,肿腿蜂亚科)(英文)

国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： mamoru Fukuchi Masaaki Tsuda Department of Biological Chemistry Graduate School of Medicine and Pharmaceutical Sciencesa Life Science Research CenterUniversity of Toyama

＜正＞Aim:Although dynorphins are widely involved in the control of not only nociceptive neurotransmission but also a variety of brain functions such as memory and emotion,no natural regulator for inducing the mRNA expression ofprodynorphin（Pdyn）,a precursor protein of dynorphins, is ***:Real-time PCR was done to detect the mRNA expression in the primary cultures of

关键词： PACAP prodynorphin neuropeptide PAC1 gene expression cortical neuron

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

昆虫学报 2002年第Z1期45卷 112-114页

作者：许再福何俊华 TERAYAMA mamoru 华南农业大学资源环境学院广州510642 浙江大学植物保护系杭州310029 日本东京大学生物系

记述了采自我国辽宁省的肿腿蜂属一新种 :中华肿腿蜂BethylussinensisXu ,HeetTerayama ,sp .nov .,这是我国肿腿蜂属的首次记录。

关键词：膜翅目肿腿蜂科肿腿蜂属新种中国

New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第45期21卷 12778-12786页

作者： Naoki Sano Takafumi Tamura Naoyuki Toriyabe Takeshi Nowatari Ken Nakayama Tomohito Tanoi Soichiro Murata Yu Sakurai mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi Department of Surgery Doctoral Program in Clinical Science Graduate School of Comprehensive Human Sciences University of Tsukuba Faculty of Pharmaceutical Sciences Hokkaido University

AIM: To investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine ***: We divided Sprague-Dawley rats into 4 groups: control, HA, sphingosine 1-phosphate(S1P), and HA-S1 P. After the administration of each agent, we subjected the rat livers to total ischemia followed by reperfusion. After reperfusion, we performed the following investigations: alanine aminotransferase(ALT), histological findings, Td T-mediated d UTP-biotin nick end labeling(TUNEL) staining, and transmission electron microscopy(TEM). We also investigated the expressionof proteins associated with apoptosis, hepatoprotection, and S1 P accumulation. RESULTS: S1 P accumulated in the HA-S1 P group livers more than S1 P group livers. Serum ALT levels, TUNEL-positive hepatocytes, and expression of cleaved caspase-3 expression, were significantly decreased in the HA-S1 P group. TEM revealed that the liver sinusoidal endothelial cell(LSEC) lining was preserved in the HA-S1 P group. Moreover, the HA-S1 P group showed a greater increase in the HO-1 protein levels compared to the S1 P ***: Our results suggest that HA-S1 P exhibits cytoprotective effects in the liver through the inhibition of LSEC apoptosis. HA-S1 P is an effective agent for hepatic ischemia/reperfusion injury.

关键词： Hyaluronic acid Sphingosine 1-phosphate Liver sinu